W J Groh

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Arrhythmias in the muscular dystrophies
    William J Groh
    Department of Medicine, Division of Cardiology, Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana Electronic address
    Heart Rhythm 9:1890-5. 2012
  2. ncbi Survival and CTG repeat expansion in adults with myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Division Cardiology, Krannert Institute of Cardiology, Indiana University, 1800 North Capitol, Room E300C, Indianapolis, Indiana 46202, USA
    Muscle Nerve 43:648-51. 2011
  3. ncbi Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis 46202, USA
    N Engl J Med 358:2688-97. 2008
  4. ncbi Characteristics of volunteers responding to emergencies in the Public Access Defibrillation Trial
    William J Groh
    The Department of Medicine, Krannert Institute of Cardiology, Indiana University, 1800 N Capitol Avenue, Room E406, Indianapolis, IN, USA
    Resuscitation 72:193-9. 2007
  5. ncbi Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, 1800 North Capitol, Room E406, Indianapolis, Indiana 46202, USA
    Muscle Nerve 31:719-24. 2005
  6. ncbi Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias
    W J Groh
    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis 46202 4800, USA
    J Cardiovasc Electrophysiol 10:1335-9. 1999
  7. ncbi Attitudes of law enforcement officers regarding automated external defibrillators
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, IN 46202, USA
    Acad Emerg Med 9:751-3. 2002
  8. ncbi Severity of cardiac conduction involvement and arrhythmias in myotonic dystrophy type 1 correlates with age and CTG repeat length
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis 46202, USA
    J Cardiovasc Electrophysiol 13:444-8. 2002
  9. ncbi Limited response to cardiac arrest by police equipped with automated external defibrillators: lack of survival benefit in suburban and rural Indiana--the police as responder automated defibrillation evaluation (PARADE)
    W J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, IN 46202 4800, USA
    Acad Emerg Med 8:324-30. 2001
  10. ncbi Heart rate variability declines with increasing age and CTG repeat length in patients with myotonic dystrophy type 1
    Bradley A Hardin
    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann Noninvasive Electrocardiol 8:227-32. 2003

Research Grants

  1. CARDIOVASCULAR RESEARCH TRAINING
    Douglas Zipes; Fiscal Year: 2003

Detail Information

Publications31

  1. ncbi Arrhythmias in the muscular dystrophies
    William J Groh
    Department of Medicine, Division of Cardiology, Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana Electronic address
    Heart Rhythm 9:1890-5. 2012
    ..In all the muscular dystrophies, respiratory muscle involvement can impact quality and quantity of life and needs to be factored in when considering a prophylactic device...
  2. ncbi Survival and CTG repeat expansion in adults with myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Division Cardiology, Krannert Institute of Cardiology, Indiana University, 1800 North Capitol, Room E300C, Indianapolis, Indiana 46202, USA
    Muscle Nerve 43:648-51. 2011
    ..It is unknown whether an association exists between survival and CTG repeat expansion...
  3. ncbi Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis 46202, USA
    N Engl J Med 358:2688-97. 2008
    ..Sudden death can occur as a consequence of cardiac-conduction abnormalities in the neuromuscular disease myotonic dystrophy type 1. The determinants of the risk of sudden death remain imprecise...
  4. ncbi Characteristics of volunteers responding to emergencies in the Public Access Defibrillation Trial
    William J Groh
    The Department of Medicine, Krannert Institute of Cardiology, Indiana University, 1800 N Capitol Avenue, Room E406, Indianapolis, IN, USA
    Resuscitation 72:193-9. 2007
    ..To evaluate the characteristics of volunteers responding to emergencies in the North American Public Access Defibrillation (PAD) Trial...
  5. ncbi Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, 1800 North Capitol, Room E406, Indianapolis, Indiana 46202, USA
    Muscle Nerve 31:719-24. 2005
    ..These results suggest that factors other than CTG repeat length play a role in the severity and progression of the degenerative skeletal and cardiac muscle disease in DM1...
  6. ncbi Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias
    W J Groh
    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis 46202 4800, USA
    J Cardiovasc Electrophysiol 10:1335-9. 1999
    ..We tested whether patients with known ventricular tachyarrhythmias who were receiving amiodarone were less likely to manifest TWA as compared with those not receiving amiodarone...
  7. ncbi Attitudes of law enforcement officers regarding automated external defibrillators
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, IN 46202, USA
    Acad Emerg Med 9:751-3. 2002
    ..To assess the knowledge and attitudes of law enforcement officers regarding treating out-of-hospital cardiac arrest (OHCA) and using automated external defibrillators (AEDs)...
  8. ncbi Severity of cardiac conduction involvement and arrhythmias in myotonic dystrophy type 1 correlates with age and CTG repeat length
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis 46202, USA
    J Cardiovasc Electrophysiol 13:444-8. 2002
    ..We studied whether the severity of cardiac involvement in myotonic dystrophy correlates with the severity of the genetic abnormality cytosine-thymine-guanine (CTG) repeat expansion...
  9. ncbi Limited response to cardiac arrest by police equipped with automated external defibrillators: lack of survival benefit in suburban and rural Indiana--the police as responder automated defibrillation evaluation (PARADE)
    W J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, IN 46202 4800, USA
    Acad Emerg Med 8:324-30. 2001
    ..To assess the out-of-hospital cardiac arrest (OHCA) survival advantage after providing police with automated external defibrillators (AEDs) in rural and suburban Indiana...
  10. ncbi Heart rate variability declines with increasing age and CTG repeat length in patients with myotonic dystrophy type 1
    Bradley A Hardin
    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann Noninvasive Electrocardiol 8:227-32. 2003
    ..Cardiac myopathy manifesting as arrhythmias is common in the neurological disease, myotonic dystrophy type 1 (DM1). The purpose of the present study was to evaluate heart rate variability (HRV) in patients with DM1...
  11. ncbi A comparison of T-wave alternans, signal averaged electrocardiography and programmed ventricular stimulation for arrhythmia risk stratification
    M R Gold
    Department of Medicine, University of Maryland Medical System, Baltimore 21201, USA
    J Am Coll Cardiol 36:2247-53. 2000
    ..The goal of this study was to compare T-wave alternans (TWA), signal-averaged electrocardiography (SAECG) and programmed ventricular stimulation (EPS) for arrhythmia risk stratification in patients undergoing electrophysiology study...
  12. ncbi Evaluation of [11C]hemicholinium-15 and [18F]hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart
    Mingzhang Gao
    Department of Radiology, Indiana University, Indianapolis, IN 46202, USA
    Bioorg Med Chem 15:1289-97. 2007
    ..These results suggest that the localization of HC-15 tracers in the heart is mediated by non-specific processes, and the visualization of HC-15 tracers on the heart is related to non-specific binding of HACU...
  13. ncbi Prevalence of structural cardiac abnormalities in patients with myotonic dystrophy type I
    Deepak Bhakta
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind 46202, USA
    Am Heart J 147:224-7. 2004
    ..We studied which clinical and electrocardiographic features are associated with structural cardiac abnormalities...
  14. ncbi Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3
    Qi Huang Zheng
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bioorg Med Chem Lett 17:2220-4. 2007
    ..The preliminary evaluation of both tracers through biodistribution studies in 9L-glioma rats has been performed, and the uptakes in the heart and tumor were observed, while very low brain uptake was seen...
  15. ncbi Facile synthesis and initial PET imaging of novel potential heart acetylcholinesterase imaging agents [11C]pyridostigmine and its analogs
    Ji-Quan Wang
    Department of Radiology, Krannert Institute of Cardiology2, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nucl Med Biol 31:957-64. 2004
    ..These results suggest the new tracers delineate the heart very clearly and could be potential heart AChE imaging agents...
  16. ncbi Increased mortality with left ventricular systolic dysfunction and heart failure in adults with myotonic dystrophy type 1
    Deepak Bhakta
    Department of Medicine, Division Krannert Institute of Cardiology, Indiana University, Indianapolis, IN 46202, USA
    Am Heart J 160:1137-41, 1141.e1. 2010
    ..We studied the prevalence of these conditions and associated findings in a large population with DM1...
  17. ncbi Excessive charge time delaying ventricular tachycardia therapy
    V R Panchal
    Department of Internal Medicine, Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis 46202, USA
    J Cardiovasc Electrophysiol 12:1078-9. 2001
    ..The excessive charge time was secondary to ICD capacitor malfunction. The generator was explanted and replaced, and the patient recovered uneventfully...
  18. ncbi Use of an insertable loop recorder in a myotonic dystrophy patient
    Djavid Hadian
    Krannert Institute of Cardiology, and the Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-4800, USA
    J Cardiovasc Electrophysiol 13:72-3. 2002
    ..Successful radiofrequency ablation of the focal atrial tachycardia and implantation of a dual-chamber implantable cardioverter defibrillator was performed...
  19. ncbi A pilot study in hemodialysis of an electrophysiological tool to measure sudden cardiac death risk
    A N Friedman
    Division of Nephrology, Indiana University, Indianapolis, IN, USA
    Clin Nephrol 68:159-64. 2007
    ..The hemodialysis procedure may play a role in the elevated risk of sudden cardiac death seen in hemodialysis patients...
  20. ncbi Cardiac function tests in neuromuscular diseases
    Deepak Bhakta
    Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 North Capitol, Room E406, Indianapolis, IN 46202, USA
    Neurol Clin 22:591-617, vi. 2004
    ..This article outlines the tests available to assess cardiac involvement associated with neuromuscular diseases and offers guidelines for management once they are discovered...
  21. ncbi Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl)pyridinium
    Ji-Quan Wang
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bioorg Med Chem Lett 15:4510-4. 2005
    ..The results suggest that [(11)C]MDDP delineates the heart very clearly, and the uptakes of [(11)C]MDDP in rat heart might be related to non-specific binding...
  22. ncbi Factors associated with poor survival in women experiencing cardiac arrest in a rural setting
    Sharon L Cline
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana, USA
    Heart Rhythm 2:492-6. 2005
    ..CONCLUSIONS: In a rural population, women suffering OHCA have a dismal survival rate likely because of multiple unfavorable arrest characteristics...
  23. ncbi Thoracic spinal cord stimulation reduces the risk of ischemic ventricular arrhythmias in a postinfarction heart failure canine model
    Ziad F Issa
    Krannert Institute of Cardiology, Indiana University, Indianapolis, Ind 46202, USA
    Circulation 111:3217-20. 2005
    ..SCS reduced sinus rate and systolic blood pressure, changes consistent with the previously known antisympathetic effect of SCS, which may have contributed to the antiarrhythmic benefits...
  24. ncbi Adverse events associated with lay emergency response programs: the public access defibrillation trial experience
    Mary Ann Peberdy
    Virginia Commonwealth University Health System, Box 908204, Richmond, VA 23298, USA
    Resuscitation 70:59-65. 2006
    ..The adverse event (AE) profile of lay volunteer CPR and public access defibrillation (PAD) programs is unknown. We undertook to investigate the frequency, severity, and type of AE's occurring in widespread PAD implementation...
  25. ncbi Implementation of community-based public access defibrillation in the PAD trial
    Lynne D Richardson
    Department of Emergency Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1620, New York, NY 10029, USA
    Acad Emerg Med 12:688-97. 2005
    ....
  26. ncbi Measuring survival rates from sudden cardiac arrest: the elusive definition
    Michael R Sayre
    Department of Emergency Medicine, The Ohio State University, 150 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Resuscitation 62:25-34. 2004
    ..The definition of OOH-CA survival rates depends both upon the numerator (surviving cases) and the denominator (all cases)...
  27. ncbi A comparison of first-responder automated external defibrillator (AED) application rates and characteristics of AED training
    E Brooke Lerner
    Department of Emergency Medicine, Department of Community and Preventive Medicine, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 655, Rochester, NY 14642, USA
    Prehosp Emerg Care 7:453-7. 2003
    ..To determine whether there were associations between the characteristics of first-responder automated external defibrillator (AED) training and AED application rates...
  28. ncbi Automated external defibrillator (AED) utilization rates and reasons fire and police first responders did not apply AEDs
    E Brooke Lerner
    Department of Emergency Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, USA
    Prehosp Emerg Care 6:378-82. 2002
    ..To determine the rate at which fire and police first responders (FRs) apply automated external defibrillators (AEDs) and to ascertain reasons for not applying them...
  29. ncbi Law Enforcement Agency Defibrillation (LEA-D): position statement and best practices recommendations from the National Center for Early Defibrillation
    Mary M Newman
    National Center for Early Defibrillation, University of Pittsburgh, Department of Emergency Medicine, Pennsylvania 15213, USA
    Prehosp Emerg Care 6:346-7. 2002
  30. ncbi Law Enforcement Agency Defibrillation (LEA-D): proceedings of the National Center for Early Defibrillation Police AED Issues Forum
    Vincent N Mosesso
    National Center for Early Defibrillation, University of Pittsburgh, Department of Emergency Medicine, Pennsylvania 15213, USA
    Prehosp Emerg Care 6:273-82. 2002
    ..It is time for law enforcement agency defibrillation to become the rule, not the exception...
  31. ncbi ST-segment elevation myocardial infarction: recommendations on triage of patients to heart attack centers: is it time for a national policy for the treatment of ST-segment elevation myocardial infarction?
    Timothy D Henry
    Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota 55407, USA
    J Am Coll Cardiol 47:1339-45. 2006
    ..We believe it is time to establish a national policy for treatment of patients with STEMI to develop a coordinated system of care similar to that of the level 1 trauma system...

Research Grants1

  1. CARDIOVASCULAR RESEARCH TRAINING
    Douglas Zipes; Fiscal Year: 2003
    ..In addition, the program is ideally suited to effectively recruit under-represented minorities. We proposed to train 3 postdoctoral Fellows each year for 2 years as part of this grant. ..