Nicholas J Grahame
Affiliation: Indiana University
- Selective breeding for high and low alcohol preference in miceN J Grahame
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
Behav Genet 29:47-57. 1999..Because the mouse genome is relatively well characterized, these selected lines should prove a useful tool for assessment of the genetic basis of, and phenotypes that correlate with, alcohol drinking...
- Limited access alcohol drinking in high- and low-alcohol preferring selected lines of miceN J Grahame
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
Alcohol Clin Exp Res 23:1015-22. 1999..To this end, high- and low-alcohol preferring (HAP and LAP, respectively) mice, selected for differences in 24-hr access alcohol drinking over a 4-week period, were subjected to a limited access alcohol drinking protocol...
- Ethanol locomotor sensitization, but not tolerance correlates with selection for alcohol preference in high- and low-alcohol preferring miceN J Grahame
Department of Medicine, Institute for Psychiatric Research, Indianapolis, IN 46202, USA
Psychopharmacology (Berl) 151:252-60. 2000..The present studies used selected lines of mice to assess genetic correlations among ethanol drinking, ethanol locomotor sensitization, and tolerance to the depressant effects of ethanol...
- Naltrexone and alcohol drinking in mice lacking beta-endorphin by site-directed mutagenesisN J Grahame
Departments of Medicine and Psychiatry, Indiana University School of Medicine, 791 Union Drive PR 311, Indianapolis, IN 46222, USA
Pharmacol Biochem Behav 67:759-66. 2000..Naltrexone reduced alcohol drinking both in BE-deficient and WT mice, suggesting that drinking is mediated, in part, by activation of opioid receptors in both genotypes...
- Alcohol place preference conditioning in high- and low-alcohol preferring selected lines of miceN J Grahame
Institute for Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
Pharmacol Biochem Behav 68:805-14. 2001..Low drinking in LAP mice may emerge from innate taste avoidance of alcohol as a result of selective breeding for low preference, which prevents them from encountering alcohol's rewarding, pharmacological effects...
- Blood alcohol concentrations after scheduled access in high-alcohol-preferring miceNicholas J Grahame
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alcohol 31:99-104. 2003..No sex differences were seen. These findings indicate the utility of this procedure in obtaining pharmacologically relevant blood alcohol concentrations after voluntary oral self-administration of an alcohol solution in mice...
- Intravenous self-administration of ethanol in miceNicholas J Grahame
Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
Curr Protoc Neurosci . 2002..This unit describes a method for assessing the reinforcing effects of alcohol in mice using the most widely accepted procedure for assessing drug reward: intravenous self-administration...
- Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse linesPaula J Bice
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Behav Genet 36:248-60. 2006..19; p<0.0008) than male mice (LOD=1.19). This study provides additional evidence and confirmation that specific regions on chromosomes 9 and perhaps 2 are important for alcohol preference...
- Effects of acamprosate on sensitization to the locomotor-stimulant effects of alcohol in mice selectively bred for high and low alcohol preferenceJ A Chester
Department of Medicine, Indiana University School of Medicine, IB 420, 975 W Walnut Street, Indianapolis, IN 46202, USA
Behav Pharmacol 12:535-43. 2001..These data suggest complex effects of acamprosate on alcohol-stimulated locomotor activity that depend on genotype...
- Affect-related behaviors in mice selectively bred for high and low voluntary alcohol consumptionAdem Can
Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA
Behav Genet 42:313-22. 2012..These data suggest that there may be overlap between genes that predispose to excessive alcohol intake and those underlying affect-related behaviors in the mouse...
- Pharmacologic dissociation between impulsivity and alcohol drinking in high alcohol preferring miceBrandon G Oberlin
Stark Neuroscience Institute, Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, Indiana, USA
Alcohol Clin Exp Res 34:1363-75. 2010..Amphetamine, naltrexone, and memantine were tested in a delay discounting (DD) task for their effects on impulsivity and vigilance. The same drugs and doses were also assessed for effects on alcohol drinking in a 2-bottle choice test...
- Circadian activity rhythms in high-alcohol-preferring and low-alcohol-preferring miceJohn R Hofstetter
Richard L Roudebush VA Medical Center, and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA
Alcohol 30:81-5. 2003..The HAP mice also had a tendency to run more on wheels than did LAP mice. These findings support the suggestion that genes affecting ethanol consumption in mice have pleiotropic effects on circadian period...
- High- and low-alcohol-preferring mice show differences in conditioned taste aversion to alcoholJulia A Chester
Department of Medicine, Indiana University School of Medicine, Indianapolis, 462023, USA
Alcohol Clin Exp Res 27:12-8. 2003..The present study examined the development of conditioned taste aversion (CTA) to various doses of alcohol in two pairs of mouse lines selectively bred for high (HAP) and low (LAP) alcohol preference...
- Effects of intoxicating free-choice alcohol consumption during adolescence on drinking and impulsivity during adulthood in selectively bred high-alcohol preferring miceDavid S O'Tousa
Department of Psychology, IUPUI, Indianapolis, IN, USA
Alcohol Clin Exp Res 37:141-9. 2013..These experiments examined adolescent drinking in a high-drinking, relatively impulsive mouse population and assessed its effects on adult drinking and adult impulsivity...
- Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF testErika Roman
Department of Pharmaceutical Biosciences, Uppsala University, Sweden
Addict Biol 17:33-46. 2012..The marked behavioral differences found in the different alcohol-preferring lines may mimic the heterogeneity observed among human alcoholic subtypes...
- High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting taskB G Oberlin
Department of Psychology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
Alcohol Clin Exp Res 33:1294-303. 2009..In this study, we address this question by testing alcohol-naïve mice from lines showing heritable differences in alcohol intake...
- Lithium, but not Valproate, Reduces Impulsive Choice in the Delay-Discounting Task in MiceMeredith E Halcomb
Department of Psychology, Indiana University Purdue University, Indianapolis, IN, USA
Neuropsychopharmacology 38:1937-44. 2013..Future studies may focus on the ability of putative pharmacotherapies for patients at risk for bipolar disorder or suicide to modify the impulsive choice dimension of this diseases. ..
- Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?Alexis S Green
Psychobiology of Addictions, Department of Psychology, Purdue School of Science, IUPUI, 402 North Blackford Street, LD 120F, Indianapolis, IN 46202, USA
Alcohol 42:1-11. 2008..These findings may also have important implications when researchers decide which phenotypes to use in measuring alcohol-reward relevant behaviors in novel animal models...
- The genomic determinants of alcohol preference in miceBoris Tabakoff
Department of Pharmacology, University of Colorado Denver School of Medicine, Mail Stop F 8303, P O Box 6511, Aurora, CO 80045 0511, USA
Mamm Genome 19:352-65. 2008..The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed...
- Toward understanding the genetics of alcohol drinking through transcriptome meta-analysisMegan K Mulligan
Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 103:6368-73. 2006..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
- EEG and ERP profiles in the high alcohol preferring (HAP) and low alcohol preferring (LAP) mice: relationship to ethanol preferenceCraig J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Brain Res 961:243-54. 2003..Decreased P3 latency in LAPs compared to HAPs and HS/Ibgs mice may be a 'protective factor'...
- The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumptionRyan K Bachtell
Department of Behavioral Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, Oregon 97239, USA
J Neurosci 23:2477-87. 2003..Taken together, these studies provide substantial evidence for involvement of the EW-LS Ucn pathway in alcohol consumption...
- NEUROCHEMISTRY OF ALCOHOL PREFERENCENicholas Grahame; Fiscal Year: 2003..Overall, by increasing basic knowledge of neural, genetic, and behavioral mechanisms underlying excessive drinking, these studies may further development of drug-based treatments for alcoholism. ..
- Neural Basis of Ethanol Sensitization/Drinking in MiceNicholas Grahame; Fiscal Year: 2007..The hypothesis is that associative forms of neural and behavioral plasticity underlie both the acquisition of excessive drinking and LMS, and that the amygdala may lie at the heart of this interaction. ..