Research Topics
Species | J C GorskiSummaryAffiliation: Indiana University Country: USA Publications
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Detail Information
Publications
The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activityJ Christopher Gorski
Department of Medicine, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, 46202 2879, USA
Clin Pharmacol Ther 74:275-87. 2003..The relative susceptibility of intestinal and hepatic cytochrome P450 (CYP) 3A to induction by rifampin (INN, rifampicin), as a function of age and sex, was investigated with the CYP3A substrate midazolam...- Biotransformation of alprazolam by members of the human cytochrome P4503A subfamilyJ C Gorski
Department of Medicine, Indiana University, Indianapolis 46202, USA
Xenobiotica 29:931-44. 1999..Thus, clinically significant drug drug interactions between alprazolam and other CYP3A substrates are to be expected... - The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivoJ Christopher Gorski
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202 2879, USA
Clin Pharmacol Ther 75:89-100. 2004..The effect of echinacea (Echinacea purpurea root) on CYP activity in vivo was assessed by use of the CYP probe drugs caffeine (CYP1A2), tolbutamide (CYP2C9), dextromethorphan (CYP2D6), and midazolam (hepatic and intestinal CYP3A)... - The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activityZ Wang
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Clin Pharmacol Ther 70:317-26. 2001..St John's wort did not alter the CYP2C9, CYP1A2, or CYP2D6 activities. Reduced therapeutic efficacy of drugs metabolized by CYP3A should be anticipated during long-term administration of St John's wort... - Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shuntsN Chalasani
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Hepatology 34:1103-8. 2001..42+/-0.15). As expected, hepatic CYP3A activity was reduced in cirrhosis. However, in cirrhotic patients with TIPS, there was a marked loss in first-pass metabolism of midazolam as a result of diminished intestinal CYP3A activity... - Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formationD R Jones
Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Wishard Memorial Hospital, Indianapolis, Indiana, USA
J Pharmacol Exp Ther 290:1116-25. 1999..2 microM. The partition ratio for expressed CYP3A4(+b(5)) was substrate concentration dependent and varied from 13 to 86. This study showed that DTZ inhibition of CYP3A substrate metabolism occurs primarily by MIC formation... - In vivo effect of clarithromycin on multiple cytochrome P450sM A Bruce
Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, Indiana 46202-2879, USA
Drug Metab Dispos 29:1023-8. 2001..In conclusion, clarithromycin does not appear to alter the in vivo catalytic activity of CYP1A2, CYP2C9, and CYP2D6 in healthy individuals as assessed by caffeine, tolbutamide, and dextromethorphan, respectively... - Urinary protein binding does not affect response to furosemide in patients with nephrotic syndromeR Agarwal
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Am Soc Nephrol 11:1100-5. 2000..It is concluded that urinary protein binding of loop diuretics is not a major mechanism for the diuretic resistance of NS. In turn, strategies aimed at displacing such binding are unlikely to be clinically helpful... 
Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case reportS R Malireddy
Clinical Pharmacology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Transplant Proc 40:1789-91. 2008....- Effects of albumin/furosemide mixtures on responses to furosemide in hypoalbuminemic patientsN Chalasani
Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5114, USA
J Am Soc Nephrol 12:1010-6. 2001..Therefore, the coadministration of albumin and furosemide for the treatment of cirrhosis, and likely other hypoalbuminemic conditions, should not be used clinically... - Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6M Desai
Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W. 10th Street, Indianapolis, IN 46202-2879, USA
Pharmacogenomics J 3:105-13. 2003..Although the magnitude of the mean QT(c) prolongation on haloperidol relative to placebo is relatively small, it may assume significance in the presence of other risk factors for QT prolongation... - Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitisNaga Chalasani
Division of Gastroenterology Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hepatology 37:544-50. 2003..The significant correlations noted between CYP2E1 and hypoxemia and beta-OH butyrate suggest that these factors play a role in increased CYP2E1 activity that is seen in patients with NASH... 
Interaction between midazolam and clarithromycin in the elderlySara K Quinney
Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, W7123 Myers Building, Indianapolis, IN 46202 2879, USA
Br J Clin Pharmacol 65:98-109. 2008..To assess the relative contribution of intestinal and hepatic CYP3A inhibition to the interaction between the prototypic CYP3A substrate midazolam and clarithromycin in the elderly...- Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazoleJenny Y Chien
Department of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN 46285, USA
Drug Metab Dispos 34:1208-19. 2006..The model may be used prospectively to improve the quantitative prediction of CYP3A inhibition and aid the optimization of study designs for CYP3A-mediated drug-drug interaction studies in drug development... - The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substratesGirum L Lemma
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-2879, USA
Clin Pharmacol Ther 79:218-30. 2006..Short-term administration of verapamil caused net inhibition of intestinal P-gp, whereas long-term administration of verapamil induced P-gp activity... - Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholicsSuthat Liangpunsakul
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hepatology 41:1144-50. 2005..Lymphocyte CYP2E1 and CYP3A4 mRNA levels did not correlate with CYP2E1 and CYP3A activities... - Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expressionAmar G Pinto
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Clin Pharmacol Ther 77:178-88. 2005..The primary in vivo mechanism was not rapidly reversible competitive or irreversible inhibition but was likely formation of metabolic intermediate complexes... - Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampinAli Asghar
Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, 1001 West 10th Street, Indianapolis, IN 46202-2879, USA
Drug Metab Dispos 30:20-6. 2002..Interindividual variability in baseline expression and inducibility of MDR1 and P450 mRNA in human lymphocytes appeared to be substantial and may not reflect the expression of these enzymes in other tissues... - The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activityDonna J Belle
Department of Drug Disposition, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Br J Clin Pharmacol 53:67-74. 2002..936). CONCLUSIONS: Administration of Ovral for 10 days had no impact on intestinal or hepatic CYP3A activity as determined by midazolam metabolism... - The interaction between St John's wort and an oral contraceptiveStephen D Hall
Division of Clinical Pharmacology, Department of Medicine, Myers Building, W7123, Wishard Hospital, 1001 W 10th St, Indianapolis, IN 46202 2879, USA
Clin Pharmacol Ther 74:525-35. 2003.... - The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activityBryan A Ward
Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Pharmacol Exp Ther 306:287-300. 2003..Efavirenz may be a valuable phenotyping tool to study the role of CYP2B6 in human drug metabolism... - Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearanceSilvana Borges
Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Drug Metab Dispos 33:1052-5. 2005..Considering the required sample size and the low correlation with oral clearance, urinary metabolic ratio is not recommended as the primary outcome variable in studies requiring the detection of modest changes in CYP2D6 activity... - Insulin sensitivity is preserved despite disrupted endothelial functionSudha S Shankar
Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, 975 W. Walnut, IB 424 D, Indianapolis, IN 46202, USA
Am J Physiol Endocrinol Metab 291:E691-6. 2006.... - Furosemide responsiveness, non-adherence and resistance during the chronic treatment of heart failure: a longitudinal studyRobert J MacFadyen
Department of Cardiology, City Hospital, Birmingham B18 7QH, UK
Br J Clin Pharmacol 57:622-31. 2004..Patients' clinical outcome was stable and not hospitalized (Group 0); alive but hospitalized (Group 1); or dead during follow up (Group 2)...