Charles Goodlett

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Alteration of gene expression by alcohol exposure at early neurulation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    BMC Genomics 12:124. 2011
  2. ncbi request reprint Alcohol teratogenesis: mechanisms of damage and strategies for intervention
    Charles R Goodlett
    Department of Psychology, Indiana University Purdue University at Indianapolis, 402 North Blackford Street, Indianapolis, Indiana 46202, USA
    Exp Biol Med (Maywood) 230:394-406. 2005
  3. ncbi request reprint Neonatal alcohol exposure impairs acquisition of eyeblink conditioned responses during discrimination learning and reversal in weanling rats
    Kevin L Brown
    Department of Psychology, University of Delaware, Newark, DE 19716, USA
    Dev Psychobiol 49:243-57. 2007
  4. pmc Eyeblink classical conditioning and interpositus nucleus activity are disrupted in adult rats exposed to ethanol as neonates
    John T Green
    Department of Psychology, Indiana University, Bloomington, Indiana 47405 7007, USA
    Learn Mem 9:304-20. 2002
  5. ncbi request reprint Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats
    John T Green
    Department of Psychology, Indiana University, 1101 E 10th Street, Bloomington, IN 47405 7007, USA
    Brain Res 956:302-11. 2002
  6. ncbi request reprint Moderate alcohol exposure compromises neural tube midline development in prenatal brain
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 144:43-55. 2003
  7. ncbi request reprint Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats
    Tuan D Tran
    Department of Psychology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 29:117-29. 2005
  8. ncbi request reprint Selective and enduring deficits in spatial learning after limited neonatal binge alcohol exposure in male rats
    Timothy B Johnson
    Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202 3275, USA
    Alcohol Clin Exp Res 26:83-93. 2002
  9. ncbi request reprint Binge-like ethanol exposure during the early postnatal period impairs eyeblink conditioning at short and long CS-US intervals in rats
    Tuan D Tran
    Department of Psychology, East Carolina University, Greenville, NC 27858, USA
    Dev Psychobiol 49:589-605. 2007
  10. doi request reprint Strain differences in developmental vulnerability to alcohol exposure via embryo culture in mice
    Yuanyuan Chen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Alcohol Clin Exp Res 35:1293-304. 2011

Research Grants

Detail Information

Publications16

  1. pmc Alteration of gene expression by alcohol exposure at early neurulation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    BMC Genomics 12:124. 2011
    ..To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model that allows control over alcohol and embryonic variables...
  2. ncbi request reprint Alcohol teratogenesis: mechanisms of damage and strategies for intervention
    Charles R Goodlett
    Department of Psychology, Indiana University Purdue University at Indianapolis, 402 North Blackford Street, Indianapolis, Indiana 46202, USA
    Exp Biol Med (Maywood) 230:394-406. 2005
    ....
  3. ncbi request reprint Neonatal alcohol exposure impairs acquisition of eyeblink conditioned responses during discrimination learning and reversal in weanling rats
    Kevin L Brown
    Department of Psychology, University of Delaware, Newark, DE 19716, USA
    Dev Psychobiol 49:243-57. 2007
    ....
  4. pmc Eyeblink classical conditioning and interpositus nucleus activity are disrupted in adult rats exposed to ethanol as neonates
    John T Green
    Department of Psychology, Indiana University, Bloomington, Indiana 47405 7007, USA
    Learn Mem 9:304-20. 2002
    ..These results indicate that the disruption in eyeblink conditioning after early exposure to ethanol is reflected in alterations in interpositus nucleus activity...
  5. ncbi request reprint Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats
    John T Green
    Department of Psychology, Indiana University, 1101 E 10th Street, Bloomington, IN 47405 7007, USA
    Brain Res 956:302-11. 2002
    ..For 21 rats that received paired eyeblink conditioning, a highly significant correlation (+0.80) was found between the number of deep nuclear cells and learning rate in eyeblink conditioning...
  6. ncbi request reprint Moderate alcohol exposure compromises neural tube midline development in prenatal brain
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 144:43-55. 2003
    ....
  7. ncbi request reprint Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats
    Tuan D Tran
    Department of Psychology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 29:117-29. 2005
    ..The purpose of this study was to determine whether dietary supplementation with vitamin E concurrent with binge EtOH exposure on PD 4 to 9 in rats would attenuate the cerebellar cell death and ECC deficits...
  8. ncbi request reprint Selective and enduring deficits in spatial learning after limited neonatal binge alcohol exposure in male rats
    Timothy B Johnson
    Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202 3275, USA
    Alcohol Clin Exp Res 26:83-93. 2002
    ..This study tested whether binge exposure limited to the latter half of this period (PD 7-9) produced selective spatial learning deficits that endured into adulthood...
  9. ncbi request reprint Binge-like ethanol exposure during the early postnatal period impairs eyeblink conditioning at short and long CS-US intervals in rats
    Tuan D Tran
    Department of Psychology, East Carolina University, Greenville, NC 27858, USA
    Dev Psychobiol 49:589-605. 2007
    ..These deficits are consistent with the previously documented ethanol-induced damage to the cerebellar-brainstem circuit essential for Pavlovian ECC...
  10. doi request reprint Strain differences in developmental vulnerability to alcohol exposure via embryo culture in mice
    Yuanyuan Chen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Alcohol Clin Exp Res 35:1293-304. 2011
    ....
  11. pmc Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 32:1361-71. 2008
    ....
  12. pmc Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder
    Bruce Anthony
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 44:659-71. 2010
    ..Furthermore, these findings suggest that discriminant analysis may be useful in predicting alcohol exposure in either mouse substrains...
  13. pmc Alcohol exposure alters cell cycle and apoptotic events during early neurulation
    Bruce Anthony
    Department of Anatomy, Indiana University School of Medicine, Indiana University Purdue University, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol Alcohol 43:261-73. 2008
    ..In this study, we examined cell cycle proteins pertinent to the G1-S phase transition and apoptosis, to determine if cell cycle misregulation can be attributed to apoptotic induction and growth defects...
  14. ncbi request reprint Persistent impairment of hippocampal neurogenesis in young adult rats following early postnatal alcohol exposure
    Anna Y Klintsova
    Psychology Department, University of Delaware, Newark, Delaware 19716, USA
    Alcohol Clin Exp Res 31:2073-82. 2007
    ..The goal of this study was to examine the effect of postnatal binge-like alcohol exposure on cell proliferation and neurogenesis in hippocampal dentate gyrus during adolescence and young adulthood...
  15. ncbi request reprint Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: II. A quantitative stereological study of synaptic plasticity in female rat cerebellum
    Anna Y Klintsova
    Beckman Institute, University of Illinois, 405 N Mathews Avenue, Urbana Champaign, IL 61801, USA
    Brain Res 937:83-93. 2002
    ....
  16. pmc Eyeblink classical conditioning in the preweanling lamb
    Timothy B Johnson
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
    Behav Neurosci 122:722-9. 2008
    ....

Research Grants11

  1. TESTING FASD THERAPEUTIC AGENTS: NEONATAL RODENT MODELS
    Charles Goodlett; Fiscal Year: 2005
    ..A key advantage of integrated approaches across the Consortium is that as promising candidate molecular agents emerge, these animal models can provide in vivo tests of their therapeutic effectiveness. ..
  2. ALCOHOL AND DEVELOPMENT--EFFECTS ON CEREBELLAR SYSTEMS
    Charles Goodlett; Fiscal Year: 2002
    ..Aim 5 will test whether the cerebellar effects are observed with gestational exposur or whether exposure that extends into the hypothesized critical period of vulnerability is required for cerebellar damage. ..
  3. ALCOHOL & DEVELOPMENT:EFFECTS ON CEREBELLAR SYSTEMS
    Charles Goodlett; Fiscal Year: 2007
    ..animal model outcomes can guide and inform future studies of effects of prenatal alcohol exposure in infants and children, because the behavioral procedures and neural circuits underlying eyeblink conditioning are similar in both species ..