Frank Gonzalez

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Glucose and lipopolysaccharide regulate proatherogenic cytokine release from mononuclear cells in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    J Reprod Immunol 103:38-44. 2014
  2. pmc Hyperglycemia-induced oxidative stress is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, AOC Room 6046, 550 N University Boulevard, Indianapolis, IN 46202, USA
    Hum Reprod 27:3560-8. 2012
  3. pmc Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome
    Frank Gonzalez
    Dept of Obstetrics and Gynecology, Indiana Univ School of Medicine, AOC Rm 6046, 550 N Univ Blvd, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 304:E375-83. 2013
  4. doi request reprint Elevated circulating levels of tissue factor in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Appl Thromb Hemost 19:66-72. 2013
  5. pmc Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, AOC Room 6046, 550 N University Boulevard, Indianapolis, IN 46202, USA
    Endocrine 42:726-35. 2012
  6. pmc Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome
    Frank Gonzalez
    Indiana University School of Medicine, Department of Obstetrics and Gynecology, AOC Room 6046, 550 North University Boulevard, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 97:4071-9. 2012
  7. pmc Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 97:2836-43. 2012
  8. pmc Inflammation in Polycystic Ovary Syndrome: underpinning of insulin resistance and ovarian dysfunction
    Frank Gonzalez
    Indiana University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Indianapolis, IN 46202, USA
    Steroids 77:300-5. 2012
  9. pmc Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 302:E297-306. 2012
  10. ncbi request reprint Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, MetroHealth Medical Center, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    J Clin Endocrinol Metab 91:1508-12. 2006

Collaborators

Detail Information

Publications16

  1. pmc Glucose and lipopolysaccharide regulate proatherogenic cytokine release from mononuclear cells in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    J Reprod Immunol 103:38-44. 2014
    ..Excess abdominal adiposity and hyperandrogenism may contribute to atherogenesis in PCOS. ..
  2. pmc Hyperglycemia-induced oxidative stress is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, AOC Room 6046, 550 N University Boulevard, Indianapolis, IN 46202, USA
    Hum Reprod 27:3560-8. 2012
    ..What is the effect of glucose ingestion on leukocytic reactive oxygen species (ROS) generation in normal-weight women with polycystic ovary syndrome (PCOS) with and without excess abdominal adiposity (AA)?..
  3. pmc Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome
    Frank Gonzalez
    Dept of Obstetrics and Gynecology, Indiana Univ School of Medicine, AOC Rm 6046, 550 N Univ Blvd, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 304:E375-83. 2013
    ..Thus, both PCOS and obesity contribute to an atherothrombotic state in which excess abdominal adiposity and hyperandrogenism may be specific risk factors for developing atherothrombosis...
  4. doi request reprint Elevated circulating levels of tissue factor in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Appl Thromb Hemost 19:66-72. 2013
    ..Circulating TF is elevated in PCOS independent of obesity, but both PCOS and obesity contribute to a prothrombotic state. In PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherothrombosis...
  5. pmc Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, AOC Room 6046, 550 N University Boulevard, Indianapolis, IN 46202, USA
    Endocrine 42:726-35. 2012
    ....
  6. pmc Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome
    Frank Gonzalez
    Indiana University School of Medicine, Department of Obstetrics and Gynecology, AOC Room 6046, 550 North University Boulevard, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 97:4071-9. 2012
    ..Inflammation and excess abdominal adiposity (AA) are often present in normal-weight women with polycystic ovary syndrome (PCOS)...
  7. pmc Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 97:2836-43. 2012
    ..Hyperandrogenism and oxidative stress are related in polycystic ovary syndrome (PCOS), but it is unknown whether hyperandrogenemia can activate oxidative stress...
  8. pmc Inflammation in Polycystic Ovary Syndrome: underpinning of insulin resistance and ovarian dysfunction
    Frank Gonzalez
    Indiana University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Indianapolis, IN 46202, USA
    Steroids 77:300-5. 2012
    ..These findings support the contention that inflammation directly stimulates the polycystic ovary to produce androgens...
  9. pmc Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 302:E297-306. 2012
    ..Thus, hyperandrogenemia activates and sensitizes MNC to glucose in this population...
  10. ncbi request reprint Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, MetroHealth Medical Center, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    J Clin Endocrinol Metab 91:1508-12. 2006
    ..Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS)...
  11. pmc Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia
    Frank Gonzalez
    Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Charlton 3 117, 200 First Street SW, Rochester, MN 55905, USA
    Obesity (Silver Spring) 15:2436-44. 2007
    ..The objective was to determine if physiological hyperglycemia induces a proatherogenic inflammatory response in mononuclear cells (MNCs) in obese reproductive-age women...
  12. pmc Evidence of proatherogenic inflammation in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Metabolism 58:954-62. 2009
    ..006), CRP (P < .0009), and PAI-1 (P < .02). We conclude that both PCOS and obesity contribute to a proatherogenic state; but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis...
  13. pmc Hyperandrogenism induces a proinflammatory TNFα response to glucose ingestion in a receptor-dependent fashion
    Frank Gonzalez
    Department of Obstetrics and Gynecology F G, C L S, Indiana University School of Medicine, Indianapolis, Indiana 46202 and Department of Laboratory Medicine and Pathology D M B, H E B, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 99:E848-54. 2014
    ..Hyperandrogenism and inflammation are related in polycystic ovary syndrome (PCOS). Hyperandrogenemia can induce inflammation in reproductive-age women, but the mechanism for this phenomenon is unclear...
  14. pmc Elevated circulating levels of macrophage migration inhibitory factor in polycystic ovary syndrome
    Frank Gonzalez
    Dept of Obstetrics and Gynecology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cytokine 51:240-4. 2010
    ..73, p<0.001). Circulating MIF is elevated in PCOS independent of obesity, but both PCOS and obesity contribute to a proatherogenic state. In PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis...
  15. pmc Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic β-cell dysfunction in polycystic ovary syndrome
    Steven K Malin
    Department of Pathobiology S K M, J P K, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195 Department of Nutrition S K M, J P K, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 and Department of Obstetrics and Gynecology C L S, F G, Indiana University School of Medicine, Indianapolis, Indiana 46202
    J Clin Endocrinol Metab 99:322-9. 2014
    ..Oxidative stress induced by reactive oxygen species (ROS) is involved in the development of pancreatic β-cell dysfunction...
  16. ncbi request reprint Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome
    Frank Gonzalez
    MetroHealth Medical Center, Department of Obstetrics and Gynecology, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA
    J Clin Endocrinol Metab 90:5336-42. 2005
    ..Women with polycystic ovary syndrome (PCOS) are often insulin resistant and have chronic low-level inflammation...