Research Topics
Species | Meredith R GolombSummaryAffiliation: Indiana University Country: USA Publications
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Publications
Very early arterial ischemic stroke in premature infantsMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Pediatr Neurol 38:329-34. 2008..Seventeen (77%) had cerebral palsy, 10 (45%) had epilepsy, and 17 (77%) had cognitive impairment. Arterial ischemic stroke appears to add to the neurologic disabilities commonly associated with prematurity...
Sickle cell trait is a risk factor for early strokeMeredith R Golomb
Department of Neurology, Riley Hospital, Indiana University School of Medicine, Indianapolis 46202, USA
Arch Neurol 62:1778-9. 2005
In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsyMeredith R Golomb
Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
Arch Phys Med Rehabil 91:1-8.e1. 2010..Golomb MR, McDonald BC, Warden SJ, Yonkman J, Saykin AJ, Shirley B, Huber M, Rabin B, AbdelBaky M, Nwosu ME, Barkat-Masih M, Burdea GC. In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy...- Perinatal stroke in twins without co-twin demiseMeredith R Golomb
Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 35:75-7. 2006..Twin gestation without co-twin demise may be a risk factor for perinatal stroke, and might help explain the higher incidence of cerebral palsy in twins... - Asymptomatic sinovenous thrombosis in a healthy neonateMeredith R Golomb
Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neurology 66:1186. 2006 - Outcomes of children with infantile spasms after perinatal strokeMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
Pediatr Neurol 34:291-5. 2006..However, a subgroup of children with spasms caused by delayed presentation of "presumed perinatal stroke" appears to have better epilepsy and cognitive outcomes... - Accuracy of ICD-9 codes for identifying children with cerebral sinovenous thrombosisMeredith R Golomb
Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
J Child Neurol 22:45-8. 2007..Furthermore, it is important to search for the code in any position as limiting searches to the primary position misses most cases... - A child with coexistent hemihypotrophy and parapontine epidermoidMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 34:499-501. 2006..Magnetic resonance imaging of the brainstem revealed a large right parapontine epidermoid. The possible relationship between the hemihypotrophy and the epidermoid is discussed... - Accuracy and yield of ICD-9 codes for identifying children with ischemic strokeMeredith R Golomb
Division of Pediatric Neurology, Indiana University School of Medicine, Riley Hospital for Children Room 1757702 Barnhill Drive, Indianapolis, IN 46202, USA
Neurology 67:2053-5. 2006..Code accuracy ranged from 37 to 88%; each code missed more than half of AIS identified by the combined code search. Studies are needed to determine whether other local and national ICD-9 databases have similar limitations... - Outcomes of perinatal arterial ischemic stroke and cerebral sinovenous thrombosisMeredith R Golomb
Indiana University School of Medicine, Building XE, Room 040, 575 West Dr, Indianapolis, IN 46202, USA
Semin Fetal Neonatal Med 14:318-22. 2009..Rehabilitation can ameliorate deficits, and advances in rehabilitation technology and in adult stroke rehabilitation offer promise to pediatric perinatal stroke patients... - Male predominance in childhood ischemic stroke: findings from the international pediatric stroke studyMeredith R Golomb
Indiana University School of Medicine, Building XE 040, 575 West Drive, Indianapolis, IN 46202, USA
Stroke 40:52-7. 2009..We sought to study gender within a large international series of confirmed cases of pediatric ischemic stroke... - Two cousins with neonatal stroke, PAI-1 4G variant and MTHFR A1298C mutationMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
J Child Neurol 22:753-5. 2007..Her cousin was homozygous for the plasminogen activator inhibitor-1 4G variant and heterozygous for the methylenetetrahydrofolate reductase A1298C and factor V Leiden mutations... - Association of cerebral palsy with other disabilities in children with perinatal arterial ischemic strokeMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 37:245-9. 2007..21-69.21) than children with delayed presentation. Children with cerebral palsy after perinatal stroke are likely to have an additional disability; those with neonatal presentation are more likely to have a severe disability... - Cerebral palsy after perinatal arterial ischemic strokeMeredith R Golomb
Division of Pediatric Neurology, Indiana University School of Medicine, 575 West Drive, Indianapolis, IN 46202, USA
J Child Neurol 23:279-86. 2008..60; 95% CI, 2.28-72.92) and large-branch infarction (OR, 8.78; 95% CI, 2.18-43.67) were associated with cerebral palsy. These data will aid physicians in planning long-term rehabilitative care for children with perinatal stroke... - A 10-year-old girl with coexistent moyamoya disease and Graves' diseaseMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Riley Hospital, Indianapolis, Indiana, USA
J Child Neurol 20:620-4. 2005..Serum antiphospholipid antibody screen demonstrated mild elevations of antiocardiolipin IgG. Possible mechanisms predisposing individuals to concurrent moyamoya and Graves' disease are discussed... - Perinatal stroke in baby, prothrombotic gene in mom: does this affect maternal health insurance?Meredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neurology 65:13-6. 2005..Maternal prothrombotic disorders may contribute to stroke in the fetus before and during birth. Many of the mothers of children with perinatal stroke have no previous history of pathologic thrombosis... - Cranial ultrasonography has a low sensitivity for detecting arterial ischemic stroke in term neonatesMeredith R Golomb
The Hospital for Sick Children, Toronto, ON, USA
J Child Neurol 18:98-103. 2003..3% versus 11.7%; P =.031). Neonates with suspected infarction should be evaluated with CT or MRI... - Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girlMeredith R Golomb
The Hospital for Sick Children, Toronto, Ontario
J Child Neurol 18:420-3. 2003..Neurologic examination remained normal 1 year later. Cerebral damage was avoided with the use of emergency intra-arterial tissue plasminogen activator for cerebral artery thrombosis in this child... - Independent walking after neonatal arterial ischemic stroke and sinovenous thrombosisMeredith R Golomb
Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202, USA
J Child Neurol 18:530-6. 2003.... - The contribution of prothrombotic disorders to peri- and neonatal ischemic strokeMeredith R Golomb
Department of Neurology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Semin Thromb Hemost 29:415-24. 2003..Possible approaches to preventing and treating perinatal and neonatal stroke are presented... - Perinatal stroke and the risk of developing childhood epilepsyMeredith R Golomb
Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Pediatr 151:409-13, 413.e1-2. 2007..To describe the prevalence of epilepsy after 6 months of age in children with perinatal stroke and examine whether perinatal data predict epilepsy onset and resolution... - Alternative therapy use by Chinese-Canadian children with stroke and cerebrovascular diseaseMeredith R Golomb
The Hospital for Sick Children, Toronto, ON
J Child Neurol 18:714-7. 2003..Physicians should be aware that parents of children with stroke may be using alternative therapies to treat their children and may be unwilling or unable to report all therapies used... - Maintained hand function and forearm bone health 14 months after an in-home virtual-reality videogame hand telerehabilitation intervention in an adolescent with hemiplegic cerebral palsyMeredith R Golomb
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Child Neurol 26:389-93. 2011..The implications of this work for the future of rehabilitation in children with neurological disabilities are discussed in this article... - Clinical findings in Pelizaeus-Merzbacher diseaseMeredith R Golomb
Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
J Child Neurol 19:328-31. 2004..Additional problems reported regarded feeding (eight patients) and sleep (three patients). Further work is needed to clarify the variations in disease course and the relationship of genotype to phenotype... - A child with Friedreich's ataxia and epilepsyMeredith R Golomb
Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
J Child Neurol 20:248-50. 2005..We suggest that his gray-matter heterotopia might be related to his diagnosis of Friedreich's ataxia and that his early onset of symptoms might be related to the length of his guanine-adenine-adenine (GAA) triplet repeat expansion... - Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boysMeredith R Golomb
Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, Riley Hospital for Children, Room 1757, 702 Barnhill Drive, Indianapolis, IN 46202, USA
J Child Neurol 19:493-7. 2004..It is not known whether boys are at higher risk of developing arterial ischemic stroke and cerebral sinovenous thrombosis or are simply more likely to present with symptoms resulting in diagnosis. These issues need further study... - A 9-year-old boy with a history of large perinatal stroke, infantile spasms, and high academic achievementMeredith R Golomb
Department of Neurology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202, USA
J Child Neurol 20:444-6. 2005..The development of infantile spasms after large-branch middle cerebral artery stroke does not always predict future mental retardation... - Epilepsy in children with delayed presentation of perinatal strokeKarima C Fitzgerald
Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Child Neurol 22:1274-80. 2007..Cognitive disability often accompanies epilepsy in these children... - Family history is a poor screen for prothrombotic genes in children with strokeSheila C Johal
Department of Medical Genetics, Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Pediatr 148:68-71. 2006..To evaluate family history of early pathological thrombosis as a screen for genetic prothrombotic risk factors in children with stroke... - Like father, like son: periventricular nodular heterotopia and nonverbal learning disorderMarcia V McCann
Department of Neurology, Division of Pediatric Neurology, Indiana University, Indianapolis, Indiana 46202, USA
J Child Neurol 23:950-3. 2008..We present a father and son with bilateral periventricular nodular heterotopia and similar visual-spatial learning deficits, consistent with nonverbal learning disability... - Neonatal arterial ischemic stroke and sinovenous thrombosis associated with meningitisKarima C Fitzgerald
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, 575 West Drive, Indianapolis, IN, USA
J Child Neurol 22:818-22. 2007..7% (4/52) of cases of cerebral sinovenous thrombosis in our perinatal stroke database. Further work is needed to clarify when infarction occurs during meningitis and which children are at highest risk... - Failure of a clot retrieval device in an adolescent stroke patientMarcia V Felker
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, Indiana 46202, USA
Pediatr Neurol 43:435-8. 2010..This is a novel report of a complication of mechanical clot retrieval treatment in a child. Further research is needed to determine the safety and effectiveness of intracranial endovascular clot retrieval devices in children... - Age-related variation in presenting signs of childhood arterial ischemic strokeJennifer A Zimmer
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 37:171-5. 2007..These findings may aid in the recognition of stroke in young children... - Neonatal sinovenous thrombosis: presentation and association with imagingMichelle E Nwosu
Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 39:155-61. 2008..Neither timing of presentation nor presence or absence of severe seizures can be used to predict findings on radiographic imaging... - Feeding problems in children with neonatal arterial ischemic strokeMonica Barkat-Masih
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Child Neurol 25:867-72. 2010..12-9.90) but did not predict speech delay (P = .97) or cerebral palsy (P = .70). Feeding problems are important sequelae of neonatal stroke, but neonatal feeding problems in this group do not predict speech delay or cerebral palsy... - The impact of Pelizaeus-Merzbacher disease on the familyLisa M McGuire
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, and the Roudebush Veterans Affairs Medical Center Health Services Research and Development Service, Indianapolis, Indiana 46202, USA
Pediatr Neurol 36:101-5. 2007.... - Use of a telephone nursing line in a pediatric neurology clinic: one approach to the shortage of subspecialistsMegan A Letourneau
Division of Neurology, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
Pediatrics 112:1083-7. 2003..Use of a nursing line can aid in the provision of care to complicated subspecialty patients. Additional strategies are needed to optimize delivery of care to high-need medical populations... - Cerebral sinovenous thrombosis in the neonateKarima C Fitzgerald
Division of Pediatric Neurology, University School of Medicine, Indianapolis, IN 46202, USA
Arch Neurol 63:405-9. 2006..Further work is needed to develop standardized guidelines for the evaluation and treatment of neonatal SVT... - Grade IV fetal intracranial hemorrhage with good cognitive functionErica T Ting
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 42:231-3. 2010..We discuss how perinatal care may have contributed to her good outcome... - Cerebral sinovenous thrombosis associated with isopropanol ingestion in an infantMichelle E Nwosu
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Child Neurol 24:349-53. 2009..To our knowledge, there have been no reports describing cerebral sinovenous thrombosis as a complication of isopropanol ingestion. The possible association of isopropanol ingestion and sinovenous thrombosis is discussed... - Teaching neuroImage: MRI visualization of papilledema associated with cerebral sinovenous thrombosis in a childJennifer A Zimmer
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN46202, USA
Neurology 71:e12-3. 2008 - Neuropsychologic outcomes in a case series of twins discordant for perinatal strokeTasneem L Talib
Division of Pediatric Neurology, Department of Neurology, Roudebush Veterans Affairs Medical Center Health Services, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 38:118-25. 2008..Twin gestation may be a risk factor for poor cognitive outcome after perinatal stroke. Large infarct size and comorbid epilepsy may have contributed to some of the poor cognitive outcomes in this cohort... - ASKing the kids: how children view their abilities after perinatal strokeMonica Barkat-Masih
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
J Child Neurol 26:44-8. 2011..02), and children with large versus small branch unilateral middle cerebral artery stroke (P = .03). Further work is needed to understand why these children's performance does not match perceived capability... - Measuring gross motor recovery in young children with early brain injuryMeredith R Golomb
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Pediatr Neurol 31:311-7. 2004..In this article, the issues involved in choosing an outcome measure are reviewed, and four of the most common gross motor outcomes measures used in young children are discussed... - Simultaneous toxicities in a child on multiple anticonvulsantsSarah Isis R Delima
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Child Neurol 23:1054-7. 2008..This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk... - Seizures triggered by July 4th fireworks in an 8-year-old girl with perinatal strokeJared R Brosch
Indiana University School of Medicine, Department of Neurology, Division of Pediatric Neurology, Indianapolis, Indiana 46202, USA
J Child Neurol 26:638-41. 2011..The seizures stopped when the child's eyes were covered and she was taken away from the scene. The importance of photic- and pattern-induced seizures in children is discussed... - Chiari in the family: inheritance of the Chiari I malformationAimee J Szewka
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 34:481-5. 2006..Less common presentations of Chiari malformation type I are discussed, as well as the possible pathogenesis of Chiari malformation type I and associated syringomyelia... - Carotid dissection and stroke after tonsillectomy and adenoidectomyKaren S Carvalho
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Riley Hospital, Indianapolis, Indiana 46202, USA
Pediatr Neurol 37:127-9. 2007..We discuss the risk factors that may predispose patients to these complications... - Nursing issues in caring for children with moyamoya vasculopathy and their familiesSelina Y C Hune
Sunnybrook Health Science Centre, Toronto, Ontario, Canada
J Neurosci Nurs 39:33-9. 2007..Nurses who understand this lived experience increase their own knowledge of the disease so they can manage the complex medical issues, educate families about the disease, and provide emotional support... - American childhood football as a possible risk factor for cerebral infarctionJared R Brosch
Indiana University School of Medicine, Department of Neurology, Division of Pediatric Neurology and Indiana University Health Physician, Indianapolis, IN 46202, USA
J Child Neurol 26:1493-8. 2011..The literature on stroke associated with childhood sports and football in particular is reviewed, and the multiple mechanisms by which football can contribute to ischemic stroke are discussed... - A 15-year-old boy with central nervous system vasculopathy presenting with dysarthria-clumsy hand syndromeMeredith R Golomb
Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
J Child Neurol 17:241-3. 2002..Lacunar infarction in an older adult is not the only mechanism leading to dysarthria-clumsy hand syndrome... - A child with Diamond-Blackfan anemia, methylenetetrahydrofolate reductase mutation, and perinatal strokeMatthew W Butrum
Riley Hospital for Children, Indianapolis, IN, USA
J Child Neurol 18:800-2. 2003..An echocardiogram demonstrated a patent foramen ovale versus an atrial septal defect with left to right shunting. Perinatal stroke may be a rare complication of Diamond-Blackfan anemia in the setting of other risk factors... - Unexpected good motor and cognitive function in an extremely premature child with a history of perinatal cerebellar hemispheric infarction and multiple other risk factors for poor outcomeAbigail E Ley
Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, Riley Hospital, Indianapolis, Indiana 46202, USA
J Child Neurol 27:402-4. 2012..The etiology and outcomes of cerebellar infarction in extremely premature neonates, and possible contributors to this child's function, are discussed... - Two children with both arm ischemia and arterial ischemic stroke during the perinatal periodMarilyn J McKasson
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
J Child Neurol 26:1548-54. 2011..This report examines the approach to diagnosis and treatment in each of these and makes suggestions for the similar cases in the future... - Subacute onset of abnormal gait and head drop in a 3-year-old with history of extreme prematurityJared R Brosch
Indiana University School of Medicine, Department of Neurology, Indianapolis, IN 46202, USA
J Child Neurol 26:373-6. 2011..As more extremely premature infants survive with chronic feeding and respiratory issues, this presentation may become more common... - Is it ADEM, POLG, or both?Mandy O Harris
Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, 575 West Dr, Indianapolis, IN 46202, USA
Arch Neurol 67:493-6. 2010..To describe a child with apparent brain biopsy-confirmed acute disseminated encephalomyelitis (ADEM) but genetic confirmation of compound heterozygosity for DNA mutations of the polymerase gamma (POLG) gene... - The risk of recurrent venous thromboembolism after paediatric cerebral sinovenous thrombosisMeredith R Golomb
Lancet Neurol 6:573-5. 2007 - Effect of intracranial bleeds on the health and quality of life of boys with hemophiliaShoshana Revel-Vilk
Pediatric Hematology/Oncology Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
J Pediatr 144:490-5. 2004..CONCLUSION: The poorer long-term outcomes of boys with hemophilia appropriately treated for ICH, especially in the domain of QoL, suggest that new strategies to prevent ICH and to manage ICH effectively in this population are needed... - Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the YoungE Steve Roach
Stroke 39:2644-91. 2008..Protocols for dosing of heparin and warfarin in children are suggested. Also included are recommendations on the evaluation and management of perinatal stroke and cerebral sinovenous thrombosis in children... - Early stroke and cerebral vasculopathy in children with facial hemangiomas and PHACE associationBeth A Drolet
Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA
Pediatrics 117:959-64. 2006.... - Reading impairment in the neuronal migration disorder of periventricular nodular heterotopiaDeborah K Sokol
Neurology 66:294; author reply 294. 2006
Research Grants
- Outcomes of Perinatal StrokeMeredith Golomb; Fiscal Year: 2007..During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. ..