Tatiana M Foroud

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk
    Tatiana Foroud
    Indiana University School of Medicine, 410 W 10 Street, Indianapolis, IN 46202, USA
    Stroke 43:2846-52. 2012
  2. pmc Relation over time between facial measurements and cognitive outcomes in fetal alcohol-exposed children
    Tatiana Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Alcohol Clin Exp Res 36:1634-46. 2012
  3. pmc The Familial Intracranial Aneurysm (FIA) study protocol
    Joseph P Broderick
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0525, USA
    BMC Med Genet 6:17. 2005
  4. pmc Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease
    David K Simon
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 11:53. 2010
  5. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
  6. pmc Standard linkage and association methods identify the mechanism of four susceptibility genes for a simulated complex disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, USA
    BMC Genet 6:S142. 2005
  7. pmc Identification of genes for complex disease using longitudinal phenotypes
    Nathan Pankratz
    Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Genet 4:S58. 2003
  8. ncbi request reprint A mutation in myotilin causes spheroid body myopathy
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Neurology 65:1936-40. 2005
  9. pmc Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations
    N Pankratz
    Medical and Molecular Genetics, Indiana University, School of Medicine, Hereditary Genomics Division, 410 W 10th St, MI 4000, Indianapolis, IN 46202, USA
    Neurology 73:279-86. 2009
  10. ncbi request reprint Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet 96:18-23. 2000

Research Grants

  1. NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
    Tatiana Foroud; Fiscal Year: 2007
  2. Identification of Novel Biomarkers in HD
    Tatiana Foroud; Fiscal Year: 2007
  3. 3D Facial Imaging in FASD (U01)
    Tatiana Foroud; Fiscal Year: 2007
  4. NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
    Tatiana Foroud; Fiscal Year: 2007
  5. PD GWAS Consortium
    Tatiana Foroud; Fiscal Year: 2009
  6. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana Foroud; Fiscal Year: 2009
  7. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
  8. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana M Foroud; Fiscal Year: 2010
  9. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana Foroud; Fiscal Year: 2007
  10. Longitudinal Studies Among At-Risk HD Gene Carriers
    Tatiana Foroud; Fiscal Year: 2006

Detail Information

Publications112 found, 100 shown here

  1. pmc Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk
    Tatiana Foroud
    Indiana University School of Medicine, 410 W 10 Street, Indianapolis, IN 46202, USA
    Stroke 43:2846-52. 2012
    ..We sought to confirm previously reported loci, to identify novel risk factors, and to evaluate the contribution of these factors to familial and sporadic IA...
  2. pmc Relation over time between facial measurements and cognitive outcomes in fetal alcohol-exposed children
    Tatiana Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Alcohol Clin Exp Res 36:1634-46. 2012
    ....
  3. pmc The Familial Intracranial Aneurysm (FIA) study protocol
    Joseph P Broderick
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0525, USA
    BMC Med Genet 6:17. 2005
    ..The long-term goal of the Familial Intracranial Aneurysm (FIA) Study is to identify genes that underlie the development and rupture of intracranial aneurysms (IA)...
  4. pmc Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease
    David K Simon
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 11:53. 2010
    ..We investigated the potential contribution of mtDNA variants or mutations to the risk of PD...
  5. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
    ..There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age...
  6. pmc Standard linkage and association methods identify the mechanism of four susceptibility genes for a simulated complex disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, USA
    BMC Genet 6:S142. 2005
    ..This highlights the need in real life situations for careful examination of the phenotypic data prior to genetic analysis...
  7. pmc Identification of genes for complex disease using longitudinal phenotypes
    Nathan Pankratz
    Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Genet 4:S58. 2003
    ..Power to detect linkage can be improved by identifying the most heritable phenotype, ensuring normality of the trait distribution and maximizing the information utilized through novel longitudinal designs for genetic analysis...
  8. ncbi request reprint A mutation in myotilin causes spheroid body myopathy
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Neurology 65:1936-40. 2005
    ..Identification of the mutated gene in this disorder may provide insight regarding abnormal neuromuscular function...
  9. pmc Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations
    N Pankratz
    Medical and Molecular Genetics, Indiana University, School of Medicine, Hereditary Genomics Division, 410 W 10th St, MI 4000, Indianapolis, IN 46202, USA
    Neurology 73:279-86. 2009
    ..Mutations in both alleles of parkin have been shown to result in Parkinson disease (PD). However, it is unclear whether haploinsufficiency (presence of a mutation in only 1 of the 2 parkin alleles) increases the risk for PD...
  10. ncbi request reprint Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet 96:18-23. 2000
    ..Other chromosomal regions with lod scores over 1.50 for at least one Model Included chromosomes 8 (Model III), 16 (Model III), and 20 (Model I). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:18-23, 2000..
  11. ncbi request reprint Chromosome 5 and Parkinson disease
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Eur J Hum Genet 14:1106-10. 2006
    ..Evidence for a locus contributing to the age of onset of PD is modest at best (empirical P-value=0.07)...
  12. ncbi request reprint Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines
    Tatiana Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street IB 155, Indianapolis, IN 46202, USA
    Psychiatr Genet 13:155-61. 2003
    ....
  13. ncbi request reprint Association of alcohol craving with alpha-synuclein (SNCA)
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Alcohol Clin Exp Res 31:537-45. 2007
    ..Studies in humans have provided support for an association between SNCA and craving for alcohol...
  14. ncbi request reprint Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, USA
    Neurology 60:796-801. 2003
    ..The vast majority of the parkin mutations previously identified have been found in individuals with juvenile or early onset PD. Previous screening of later onset PD cohorts has not identified substantial numbers of parkin mutations...
  15. ncbi request reprint Confirmation of subtle motor changes among presymptomatic carriers of the Huntington disease gene
    S C Kirkwood
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, USA
    Arch Neurol 57:1040-4. 2000
    ..To confirm that subtle changes in motor function and reaction time are present in presymptomatic individuals carrying the expanded Huntington disease (HD) allele...
  16. ncbi request reprint Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 24:933-45. 2000
    ..A previous study reported linkage to chromosomes 1, 2, and 7 in a large data set that consisted of 105 families, each with at least three alcoholic members...
  17. ncbi request reprint Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 30:131-40. 2000
    ..This study is the first genome-wide study for QTLs underlying alcohol consumption that has employed noninbred lines. Further localization of these QTLs will likely provide insight and candidate genes for the study of human alcoholism...
  18. pmc Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study
    Tatiana Foroud
    Indiana University School of Medicine, Health Information and Translational Sciences Building HS 4000, 410 West 10th Street, Indianapolis, IN 46202 3002, USA
    Stroke 39:1434-40. 2008
    ..Evidence supports a substantial genetic contribution to the risk of intracranial aneurysm (IA). The purpose of this study was to identify chromosomal regions likely to harbor genes that contribute to the risk of IA...
  19. ncbi request reprint Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 32:57-67. 2002
    ..The QTL on chromosome 18 has a maximum lod score of 2.7 with saccharin consumption. Taken together, these data provide the first results of a genome screen for QTLs contributing to saccharin phenotypes in the rat...
  20. pmc The tachykinin receptor 3 is associated with alcohol and cocaine dependence
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Alcohol Clin Exp Res 32:1023-30. 2008
    ..Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of alcohol and NK3R can also mediate the acute and chronic behavioral effects of cocaine...
  21. pmc Association studies of ALOX5 and bone mineral density in healthy adults
    T Foroud
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Osteoporos Int 19:637-43. 2008
    ..We tested this hypothesis in a sample of healthy men and women and did not find consistent evidence for an association between variation in this gene and either lumbar spine or femoral neck BMD...
  22. ncbi request reprint Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Alcohol Clin Exp Res 31:1773-9. 2007
    ....
  23. pmc Genome screen in familial intracranial aneurysm
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Med Genet 10:3. 2009
    ..Individuals with 1st degree relatives harboring an intracranial aneurysm (IA) are at an increased risk of IA, suggesting genetic variation is an important risk factor...
  24. pmc Differentially expressed genes strongly correlated with femur strength in rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202 5251, USA
    Genomics 94:257-62. 2009
    ....
  25. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
  26. pmc Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, Indiana 46202 5121, USA
    J Clin Endocrinol Metab 90:5921-7. 2005
    ..Recently, we identified significant linkage for hip BMD in premenopausal sister pairs at chromosome 14q (LOD score = 3.5), where the estrogen receptor beta gene (ESR2) is located...
  27. ncbi request reprint Human ALOX12, but not ALOX15, is associated with BMD in white men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 21:556-64. 2006
    ..Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD...
  28. pmc Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans
    JeeSun Jung
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 94:1042-8. 2009
    ..CASR gene variants could influence blood pressure (BP) by affecting Na retention...
  29. doi request reprint Test-retest reliability of saccadic measures in subjects at risk for Huntington disease
    Tanya Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Invest Ophthalmol Vis Sci 50:5707-11. 2009
    ..The goal of this study was to evaluate test-retest reliability of saccadic measures in prediagnostic carriers of the HD gene expansion (PDHD) and normal controls (NC)...
  30. pmc CLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white men
    Kang Chu
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 43:995-8. 2008
    ..However, there is no study to date that has examined whether CLCN7 polymorphisms underlie normal variation of peak BMD in healthy premenopausal white women and in white men...
  31. pmc Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e70269. 2013
    ..With intensive searches taking place for proteomic biomarkers for many diseases, the role of genetic variation takes on new importance and should be considered in interpretation of proteomic results...
  32. pmc Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks
    Vijay K Ramanan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:634-48. 2012
    ....
  33. ncbi request reprint Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families
    Nathan Pankratz
    Indiana University School of Medicine, Department of Medical and Molecular Genetics IB 130, 975 West Walnut Street, Indianapolis, IN 46202 5251, USA
    Hum Mol Genet 12:2599-608. 2003
    ..4) and X (LOD=3.2). These findings demonstrate consistent evidence of linkage to chromosomes 2 and X and also support the hypothesis that gene-by-gene interactions are important in PD susceptibility...
  34. pmc Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
    Physiol Genomics 35:191-6. 2008
    ..This study provides a shortened list of genetic determinants of skeletal traits at the hip and may lead to novel approaches for prevention and treatment of hip fracture...
  35. ncbi request reprint Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats
    Imranul Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:1589-96. 2005
    ..A genome-wide genetic linkage analysis identified several chromosomal regions influencing bone strength and structure in F2 progeny of Fischer 344 x Lewis inbred rats...
  36. ncbi request reprint Analysis of variation in expression of autosomal dominant osteopetrosis type 2: searching for modifier genes
    Kang Chu
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 37:655-61. 2005
    ..Analysis of ADO2 in our pedigrees indicates that the penetrance is 66%, with a highly variable phenotype...
  37. ncbi request reprint Heritability of changes in bone size and bone mass with age in premenopausal white sisters
    Siu L Hui
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Bone Miner Res 21:1121-5. 2006
    ..Femoral neck area expands and BMD decreases in premenopausal women. We used longitudinal DXA measurements on 388 premenopausal white sisters to show significant heritability of the rates of change in femoral neck area, BMC, and BMD...
  38. pmc Genetic loci affecting bone structure and strength in inbred COP and DA rats
    Qiwei Sun
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 42:547-53. 2008
    ..Our study demonstrates strong evidence of linkage for bone structure and strength to multiple rat chromosomes...
  39. pmc Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:850-9. 2008
    ..The purpose of this study is to identify sex-independent and sex-specific quantitative trait loci (QTLs) for femoral neck density, structure, and strength in inbred Copenhagen 2331 (COP) and Dark Agouti (DA) rats...
  40. ncbi request reprint No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample
    Danielle M Dick
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut St, Indianapolis, IN 46202 525, USA
    Am J Med Genet B Neuropsychiatr Genet 132:24-8. 2005
    ..Future studies are planned to test whether these genes are more important in influencing behavioral endophenotypes related to the risk of alcohol dependence...
  41. ncbi request reprint Genetic predisposition to external apical root resorption
    Riyad A Al-Qawasmi
    School of Dentistry, Indiana University, Indianapolis 46202 5186, USA
    Am J Orthod Dentofacial Orthop 123:242-52. 2003
    ..Defining genetic contributions to EARR is an important factor in understanding the contribution of environmental factors, such as habits and therapeutic biomechanics...
  42. pmc Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
    Andrew J Saykin
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 6:265-73. 2010
    ..Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials...
  43. pmc Allelic-based gene-gene interaction associated with quantitative traits
    JeeSun Jung
    Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, Indiana, USA
    Genet Epidemiol 33:332-43. 2009
    ....
  44. ncbi request reprint Genetic effects for femoral biomechanics, structure, and density in C57BL/6J and C3H/HeJ inbred mouse strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 18:1758-65. 2003
    ..Highly significant QTLs were detected with pleiotropic effects on many of these phenotypes, and QTLs with unique effects on specific phenotypes were found as well...
  45. pmc Visual scanning and cognitive performance in prediagnostic and early-stage Huntington's disease
    Tanya Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Mov Disord 24:533-40. 2009
    ..The deficits in visual scanning accounted, at least in part, for the decrease in the DS score...
  46. ncbi request reprint Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease
    Nathan Pankratz
    Indiana University Medical Center, Indianapolis, Indiana, USA
    Mov Disord 21:2257-60. 2006
    ..These results indicate that, although the G2019S mutation remains the most common mutation identified in familial PD patients, other mutations in LRRK2 are infrequent...
  47. pmc Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis 46202 5251, USA
    Am J Hum Genet 71:124-35. 2002
    ..7) and to chromosome 2 (LOD score 2.5). Evidence of linkage was also found to chromosomes 4, 5, and 13 (LOD scores >1.5). Our findings are consistent with those of other linkage studies that have reported linkage to chromosomes 5 and X...
  48. ncbi request reprint Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana, USA
    Mov Disord 21:45-9. 2006
    ..It appears the similarities between PD and AD may be due to an overlap in the diseases' genetic etiology...
  49. pmc alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats
    Tiebing Liang
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 100:4690-5. 2003
    ..These results suggest that differential expression of the alpha-synuclein gene may contribute to alcohol preference in the iP rats...
  50. pmc Confirmation of linkage to chromosome 1q for peak vertebral bone mineral density in premenopausal white women
    Michael J Econs
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
    Am J Hum Genet 74:223-8. 2004
    ..Studies are now ongoing to identify the gene(s) contributing to peak spine BMD in women...
  51. pmc Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease
    Andrea C Solomon
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 46202 5251, USA
    Mov Disord 23:1830-6. 2008
    ..These findings suggest that neurocognitive decline in pre-HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset...
  52. doi request reprint A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 34:2169-78. 2010
    ..In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004)...
  53. pmc Genomewide association study for susceptibility genes contributing to familial Parkinson disease
    Nathan Pankratz
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Hum Genet 124:593-605. 2009
    ..8 x 10(-6); additive model: p = 4.8 x 10(-5)). These data suggest the identification of new susceptibility alleles for PD in the GAK/DGKQ region, and also provide further support for the role of SNCA and MAPT in PD susceptibility...
  54. pmc Linkage screen for BMD phenotypes in male and female COP and DA rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:1382-8. 2008
    ..These results confirm that the genetic influence on BMD in the rat model is quite complex and would seem to be influenced by a number of different genes, some of which have sex-specific effects...
  55. pmc Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 23:1680-8. 2008
    ....
  56. doi request reprint Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking rats
    Paula J Bice
    Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Indianapolis, IN 46202, USA
    Alcohol 44:477-85. 2010
    ..All six genes showed differential expression in at least one brain region. Of the genes tested in this study, Crebbp and Mapk8ip3 may be the most promising candidates with regard to alcohol drinking...
  57. ncbi request reprint From QTL to candidate gene: a genetic approach to alcoholism research
    John P Spence
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatry, Indianapolis, IN 46202, USA
    Curr Drug Abuse Rev 2:127-34. 2009
    ....
  58. pmc Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, USA
    Bone 45:443-8. 2009
    ..The aim of this study was to perform a genome wide scan in healthy men to identify quantitative trait loci (QTL) that were significantly linked to aBMD and to test whether any of these might be sex-specific...
  59. pmc Clinical correlates of depressive symptoms in familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    Mov Disord 23:2216-23. 2008
    ..33; P = 4 x 10(-48)). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms...
  60. pmc Alpha-synuclein and familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Mov Disord 24:1125-31. 2009
    ..29; empirical P-value = 0.01), but not age of onset (P = 0.40). These data suggest that dosage and sequence changes are a rare cause of PD, but variation in the promoter and 3' region of SNCA convey an increased risk for PD...
  61. pmc Multiple step pattern as a biomarker in Parkinson disease
    Tanya Blekher
    Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202 5251, USA
    Parkinsonism Relat Disord 15:506-10. 2009
    ..To evaluate quantitative measures of saccades as possible biomarkers in early stages of Parkinson disease (PD) and in a population at-risk for PD...
  62. pmc Progression in prediagnostic Huntington disease
    Jason Rupp
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    J Neurol Neurosurg Psychiatry 81:379-84. 2010
    ..To examine rates of decline in individuals at risk for Huntington disease (HD)...
  63. pmc Replication of previous genome-wide association studies of bone mineral density in premenopausal American women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 25:1821-9. 2010
    ....
  64. pmc Epistasis between QTLs for bone density variation in Copenhagen x dark agouti F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Mamm Genome 20:180-6. 2009
    ..These results provide new information regarding the mode of action of previously identified QTL in the rat, as well as identifying novel loci that act in combination with known QTL or with other novel loci to contribute to BMD variation...
  65. pmc Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice
    Paula Bice
    Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 33:531-7. 2009
    ..The HAP1 and LAP1 mice are essentially noninbred lines that originated from the outbred colony of HS/Ibg mice, a heterogeneous stock developed from intercrossing 8 inbred strains of mice...
  66. pmc Genome-wide association study of alcohol dependence implicates a region on chromosome 11
    Howard J Edenberg
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, 46202 5122, USA
    Alcohol Clin Exp Res 34:840-52. 2010
    ..Alcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk for alcoholism, these explain only a portion of the risk...
  67. pmc Significant linkage of Parkinson disease to chromosome 2q36-37
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Am J Hum Genet 72:1053-7. 2003
    ..1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility...
  68. pmc Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence
    Leah Wetherill
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 32:2031-40. 2008
    ..Additional studies suggest that cocaine may affect NPY expression...
  69. pmc GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence
    Xiaoling Xuei
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Med Genet B Neuropsychiatr Genet 153:418-27. 2010
    ..04), and a haplotype in GABRR2 was significantly overtransmitted to family members who met a broader definition of alcoholism (P = 0.002) as well as DSM-IV dependence (P = 0.04)...
  70. pmc Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 23:41-7. 2008
    ..Several significant interactions were identified, involving both previously identified and novel QTLs...
  71. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  72. ncbi request reprint Association of GABRG3 with alcohol dependence
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:4-9. 2004
    ..Both linkage and association to the region on chromosome 15q that contains a cluster of GABAA receptor genes have previously been reported, but the role of these genes in alcoholism remains inconclusive...
  73. ncbi request reprint Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, USA
    Hum Mol Genet 15:1539-49. 2006
    ..01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk. Among African-Americans, there was evidence that the ADH1B*3 allele was protective...
  74. ncbi request reprint Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging
    Terry Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202 5251, USA
    J Gerontol A Biol Sci Med Sci 59:227-32. 2004
    ..Our results provide independent evidence that a locus on the long arm of chromosome 4 is associated with better physical aging and/or longevity...
  75. ncbi request reprint Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines
    Paula J Bice
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:248-60. 2006
    ..19; p<0.0008) than male mice (LOD=1.19). This study provides additional evidence and confirmation that specific regions on chromosomes 9 and perhaps 2 are important for alcohol preference...
  76. ncbi request reprint Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats
    Lucinda G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:285-90. 2006
    ..These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that influences the drinking behavior of the iP and iNP rats...
  77. ncbi request reprint Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA
    Mamm Genome 16:578-86. 2005
    ..0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women...
  78. ncbi request reprint Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research
    John Spence
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Addict Biol 10:47-51. 2005
    ..By evaluating differences in gene expression for linkage to a quantitative trait, this combined approach was implemented to identify alpha-synuclein, a candidate gene for alcohol preference...
  79. ncbi request reprint Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 North University Boulevard, Room 5595, Indianapolis, Indiana 46202 5250, USA
    J Clin Endocrinol Metab 90:3060-6. 2005
    ..There are few comparable data in men. This study in men aimed to establish the heritability of peak BMD, identify QTL contributing to normal variation in BMD, and determine which QTL might be sex specific...
  80. ncbi request reprint Peak bone mineral density at the hip is linked to chromosomes 14q and 15q
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Osteoporos Int 15:489-96. 2004
    ..Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes...
  81. ncbi request reprint Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats
    Lucinda G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 27:1710-7. 2003
    ..Previously, a 20-cM genome screen identified quantitative trait loci (QTLs) on chromosomes 5, 10, 12, and 16 by using F2 progeny from HAD1 and LAD1 animals...
  82. pmc A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence
    Howard J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:1783-9. 2008
    ..This indel is, therefore, a functional regulatory variation likely to explain at least part of the association of OPRK1 with alcohol dependence...
  83. ncbi request reprint Contribution of the LRP5 gene to normal variation in peak BMD in women
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:75-80. 2005
    ..Association between SNPs in LRP5 and hip and spine BMD was measured in 1301 premenopausal women. Only a small proportion of the BMD variation was attributable to LRP5 in our sample...
  84. ncbi request reprint Genetics of osteoporosis
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocr Rev 23:303-26. 2002
    ..As with all genetic studies in humans, these scientific advances will need to be made in an environment of legal and ethical safeguards that are acceptable to the general public...
  85. ncbi request reprint Are cognitive changes progressive in prediagnostic HD?
    Julie C Stout
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
    Cogn Behav Neurol 20:212-8. 2007
    ..To characterize neurocognitive signs of disease progression in prediagnosis and early Huntington disease (HD) and compare the sensitivity of 2 disease staging classification schemes for detecting these signs...
  86. ncbi request reprint Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population
    Lucinda G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet 112:138-43. 2002
    ..The ADH1B polymorphism is associated with unpleasant reactions after alcohol consumption, and frequency of alcohol consumption in these Jewish samples...
  87. ncbi request reprint Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Mol Genet 17:963-70. 2008
    ..Thus, variations in NFKB1 appear to affect the risk for alcoholism, particularly contributing to an earlier onset of the disease...
  88. ncbi request reprint Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol
    Tanya Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5175, USA
    Alcohol Clin Exp Res 26:1568-73. 2002
    ..To evaluate the influence of family history of alcoholism (FHA) on the response of saccadic eye movements to alcohol...
  89. ncbi request reprint Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence
    Xiaoling Xuei
    Department of Biochemistry and Molecular Biology, Indiana Unviersity School of Medicine, Indianapolis, IN 46202, USA
    Addict Biol 13:80-7. 2008
    ..04-0.05). Secondary analyses suggested that two adjacent SNPs in intron 1 of OPRL1 were marginally associated with opioid dependence (P = 0.05); none of the SNPs in PNOC were associated with opioid dependence...
  90. ncbi request reprint The opioid system in alcohol and drug dependence: family-based association study
    Xiaoling Xuei
    Indiana University School of Medicine, 1345 W 16th Street, Indianapolis, IN 46202, USA
    Am J Med Genet B Neuropsychiatr Genet 144:877-84. 2007
    ....
  91. pmc Implementation of a shared data repository and common data dictionary for fetal alcohol spectrum disorders research
    Andrew D Arenson
    University Information Technology Services, Indiana University, 535 W Michigan St, Indianapolis, IN 46202, USA
    Alcohol 44:643-7. 2010
    ..CI-FASD researchers are able to integrate and analyze data of different types, using multiple methods, and collected from multiple populations, and data are retained for future reuse in a secure, robust repository...
  92. pmc Visual perception in prediagnostic and early stage Huntington's disease
    BRIAN F O'DONNELL
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, USA
    J Int Neuropsychol Soc 14:446-53. 2008
    ..However, these changes are only observed in individuals diagnosed with HD or who are in the more symptomatic stages of prediagnostic HD...
  93. ncbi request reprint Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting
    Jiuzhou Song
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202 5122, USA
    Am J Med Genet B Neuropsychiatr Genet 117:39-45. 2003
    ..Maternal transmissions provided no evidence for association. These data are consistent with an association between the expressed alleles in the GABA(A)-gene cluster on chromosome 15 and alcoholism that is modulated by genetic imprinting...
  94. ncbi request reprint Linkage mapping of beta 2 EEG waves via non-parametric regression
    Saurabh Ghosh
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Campus Box 8134, St Louis, MO 63110 1093, USA
    Am J Med Genet B Neuropsychiatr Genet 118:66-71. 2003
    ..While regressing out the effect of alcoholism does not affect the linkage findings, the epistatic interactions become statistically insignificant...
  95. ncbi request reprint Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease
    William C Nichols
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Mov Disord 19:649-55. 2004
    ..Taken together, these data suggest that genetic alteration at the Nurr1 locus is not a significant risk factor for the development of Parkinson's disease in our large sample of familial PD patients...
  96. pmc Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
    Bernice Porjesz
    Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 99:3729-33. 2002
    ..Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing...
  97. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
    ..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes...
  98. ncbi request reprint Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition
    Kevin A Jones
    Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
    Int J Psychophysiol 53:75-90. 2004
    ..001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans...
  99. ncbi request reprint Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
    William C Nichols
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Lancet 365:410-2. 2005
    ..Thus, our results suggest that a single LRRK2 mutation causes Parkinson's disease in 5% of individuals with familial disease. Screening for this mutation should be a component of genetic testing for Parkinson's disease...
  100. pmc A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Biol Psychiatry 63:1047-53. 2008
    ..To follow up on this linkage region, we systematically screened single nucleotide polymorphisms (SNPs) across a 2 LOD support interval surrounding the alcohol dependence peak...
  101. pmc A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India
    Am J Med Genet B Neuropsychiatr Genet 147:1301-5. 2008
    ..We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction...

Research Grants33

  1. NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
    Tatiana Foroud; Fiscal Year: 2007
    ..This application seeks to continue a national resource of DNA and cell lines from individuals with AD and their family members. ..
  2. Identification of Novel Biomarkers in HD
    Tatiana Foroud; Fiscal Year: 2007
    ..If we are successful, we will have identified biomarkers that are ideally suited for studies of neuroprotective agents and which could be used in future treatments to delay or eliminate the onset of the symptoms of HD. ..
  3. 3D Facial Imaging in FASD (U01)
    Tatiana Foroud; Fiscal Year: 2007
    ....
  4. NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
    Tatiana Foroud; Fiscal Year: 2007
    ..This application seeks to continue a national resource of DNA and cell lines from individuals with AD and their family members so that researchers can use these samples to find genes that cause AD. ..
  5. PD GWAS Consortium
    Tatiana Foroud; Fiscal Year: 2009
    ....
  6. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana Foroud; Fiscal Year: 2009
    ..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
  7. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
    ..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
  8. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana M Foroud; Fiscal Year: 2010
    ..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
  9. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana Foroud; Fiscal Year: 2007
    ..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
  10. Longitudinal Studies Among At-Risk HD Gene Carriers
    Tatiana Foroud; Fiscal Year: 2006
    ..abstract_text> ..
  11. NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
    P Conneally; Fiscal Year: 2002
    ..b) Obtain additional clinical information from informants regarding symptom progression of LOAD subjects. 4) Develop and maintain an internet resource (web page) to review available NCR resources. ..
  12. GENES FOR ALCOHOLISM SUSCEPTIBILITY
    Tatiana Foroud; Fiscal Year: 2003
    ..These studies will result in more sophisticated genetic analyses of alcoholism related data, as well as the development of optimum sampling designs for more efficient gene identification. ..
  13. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana Foroud; Fiscal Year: 2003
    ..D at the University of Michigan; and 4) Mitochondrial DNA core directed by Douglas Wallace, Ph.D at Emory University, who will analyze mitochondrial DNA. ..
  14. A Cross-Cultural Longitudinal Assessment of FASD (U24)
    Tatiana Foroud; Fiscal Year: 2005
    ..abstract_text> ..
  15. PD GWAS Consortium
    Tatiana M Foroud; Fiscal Year: 2010
    ....