T Foroud

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Differences in duration of Huntington's disease based on age at onset
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Neurol Neurosurg Psychiatry 66:52-6. 1999
  2. ncbi Genetics of alcoholism: a review of recent studies in human and animal models
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Addict 8:261-78. 1999
  3. ncbi A quantitative trait locus for alcohol consumption in selectively bred rat lines
    L G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 22:884-7. 1998
  4. ncbi Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines
    P Bice
    Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Room 407, 975 W Walnut Street, Indianapolis, Indiana 46202, USA
    Mamm Genome 9:949-55. 1998
  5. ncbi Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 30:131-40. 2000
  6. ncbi Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22
    H J Edenberg
    Indiana University School of Medicine, Indianapolis 46202 5122, USA
    Am J Med Genet 74:238-46. 1997
  7. ncbi Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis
    D L Koller
    Indiana University School of Medicine, Indianapolis 46202, USA
    J Clin Endocrinol Metab 85:3116-20. 2000
  8. ncbi Use of variable marker density, principal components, and neural networks in the dissection of disease etiology
    N Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical School, Indianapolis, Indiana, USA
    Genet Epidemiol 21:S732-7. 2001
  9. ncbi Genes influencing Parkinson disease onset: replication of PARK3 and identification of novel loci
    N Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN, USA
    Neurology 62:1616-8. 2004
  10. pmc Association studies of ALOX5 and bone mineral density in healthy adults
    T Foroud
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Osteoporos Int 19:637-43. 2008

Detail Information

Publications41

  1. pmc Differences in duration of Huntington's disease based on age at onset
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Neurol Neurosurg Psychiatry 66:52-6. 1999
    ....
  2. ncbi Genetics of alcoholism: a review of recent studies in human and animal models
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Addict 8:261-78. 1999
    ..Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference...
  3. ncbi A quantitative trait locus for alcohol consumption in selectively bred rat lines
    L G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 22:884-7. 1998
    ..Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans...
  4. ncbi Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines
    P Bice
    Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Room 407, 975 W Walnut Street, Indianapolis, Indiana 46202, USA
    Mamm Genome 9:949-55. 1998
    ..It therefore appears likely that, in addition to the QTL on Chr 4, multiple loci of small to moderate effect, such as those on Chrs 3 and 8, underlie the difference in alcohol consumption in the P/NP lines...
  5. ncbi Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 30:131-40. 2000
    ..This study is the first genome-wide study for QTLs underlying alcohol consumption that has employed noninbred lines. Further localization of these QTLs will likely provide insight and candidate genes for the study of human alcoholism...
  6. ncbi Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22
    H J Edenberg
    Indiana University School of Medicine, Indianapolis 46202 5122, USA
    Am J Med Genet 74:238-46. 1997
    ..Thus, several regions showed modest evidence for linkage to bipolar disorder in this initial genomic scan of these chromosomes, including broad regions near previous reports of possible linkage...
  7. ncbi Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis
    D L Koller
    Indiana University School of Medicine, Indianapolis 46202, USA
    J Clin Endocrinol Metab 85:3116-20. 2000
    ..Our study is the largest genome screen to date for genes underlying variations in peak BMD and represents an important step toward identifying genes contributing to osteoporosis in the general population...
  8. ncbi Use of variable marker density, principal components, and neural networks in the dissection of disease etiology
    N Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical School, Indianapolis, Indiana, USA
    Genet Epidemiol 21:S732-7. 2001
    ....
  9. ncbi Genes influencing Parkinson disease onset: replication of PARK3 and identification of novel loci
    N Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN, USA
    Neurology 62:1616-8. 2004
    ..8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility...
  10. pmc Association studies of ALOX5 and bone mineral density in healthy adults
    T Foroud
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Osteoporos Int 19:637-43. 2008
    ..We tested this hypothesis in a sample of healthy men and women and did not find consistent evidence for an association between variation in this gene and either lumbar spine or femoral neck BMD...
  11. ncbi Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 24:933-45. 2000
    ..A previous study reported linkage to chromosomes 1, 2, and 7 in a large data set that consisted of 105 families, each with at least three alcoholic members...
  12. pmc Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment
    K Nho
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN 46202 3082, USA
    Mol Psychiatry 18:781-7. 2013
    ..The combination of next-generation sequencing and quantitative imaging phenotypes holds significant promise for discovery of variants involved in neurodegeneration...
  13. ncbi Parametric linkage analysis and disequilibrium methods to identify loci for complex disease
    J McClintick
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Genet Epidemiol 21:S528-33. 2001
    ..A haplotype, strongly associated with the disease phenotype whose proximal end was within 39 base pairs of the functional allele for simulated major gene 6, was identified in the isolated population...
  14. ncbi Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder
    J I Nurnberger
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Am J Psychiatry 158:718-24. 2001
    ..Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic linkage...
  15. ncbi Genome screen for quantitative trait loci underlying normal variation in femoral structure
    D L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 16:985-91. 2001
    ..8). This study is the first genome screen for loci underlying variation in femoral structure and represents an important step toward identifying genes contributing to the risk of osteoporotic hip fracture in the general population...
  16. ncbi Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength
    I Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 39:93-9. 2006
    ..These findings represent an important first step in localizing and identifying genes that influence hip fragility...
  17. ncbi Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet 96:18-23. 2000
    ..Other chromosomal regions with lod scores over 1.50 for at least one Model Included chromosomes 8 (Model III), 16 (Model III), and 20 (Model I). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:18-23, 2000..
  18. ncbi A mutation in myotilin causes spheroid body myopathy
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Neurology 65:1936-40. 2005
    ..Identification of the mutated gene in this disorder may provide insight regarding abnormal neuromuscular function...
  19. ncbi Confirmation of subtle motor changes among presymptomatic carriers of the Huntington disease gene
    S C Kirkwood
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, USA
    Arch Neurol 57:1040-4. 2000
    ..To confirm that subtle changes in motor function and reaction time are present in presymptomatic individuals carrying the expanded Huntington disease (HD) allele...
  20. ncbi Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats
    C H Turner
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, USA
    J Bone Miner Res 16:1532-9. 2001
    ..The results strongly suggest that selected crosses of inbred strains of rats will provide useful models for studying genetic influences on bone strength and structure...
  21. ncbi Association of the kappa-opioid system with alcohol dependence
    X Xuei
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Psychiatry 11:1016-24. 2006
    ....
  22. ncbi Chromosome 6 workshop report
    J I Nurnberger
    Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet 88:233-8. 1999
    ..Interest continues to center on 6p 24-22 for schizophrenia. Another area of possible linkage to both schizophrenia and bipolar disorder exists at 6q 21-22. Neither of these areas maybe considered confirmed at this time...
  23. ncbi Linkage of structure at the proximal femur to chromosomes 3, 7, 8, and 19
    D L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 18:1057-65. 2003
    ..0); and on chromosome 8, to femoral head width (LOD = 6.0). The current findings emphasize the importance of increasing sample size to replicate linkage findings and identify new regions of linkage...
  24. ncbi Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 32:57-67. 2002
    ..The QTL on chromosome 18 has a maximum lod score of 2.7 with saccharin consumption. Taken together, these data provide the first results of a genome screen for QTLs contributing to saccharin phenotypes in the rat...
  25. pmc Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    S Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
    Neurology 76:69-79. 2011
    ..We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42)...
  26. ncbi Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, USA
    Neurology 60:796-801. 2003
    ..The vast majority of the parkin mutations previously identified have been found in individuals with juvenile or early onset PD. Previous screening of later onset PD cohorts has not identified substantial numbers of parkin mutations...
  27. ncbi Saccades in presymptomatic and early stages of Huntington disease
    T Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202 5251, USA
    Neurology 67:394-9. 2006
    ..To evaluate quantitative measures of eye movements as possible biomarkers in prediagnostic and early stages of Huntington disease (HD)...
  28. pmc Copy number variation in familial Parkinson disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e20988. 2011
    ..Thus, only the CNVs within the PARK2 locus could be molecularly validated and associated with PD susceptibility...
  29. ncbi Progression of symptoms in the early and middle stages of Huntington disease
    S C Kirkwood
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut St IB 130, Indianapolis, IN 46202
    Arch Neurol 58:273-8. 2001
    ..To delineate the progression of symptoms in the early and middle stages of Huntington disease (HD)...
  30. pmc Clinical correlates of depressive symptoms in familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    Mov Disord 23:2216-23. 2008
    ..33; P = 4 x 10(-48)). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms...
  31. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  32. ncbi LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8
    W C Nichols
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Neurology 69:1737-44. 2007
    ..It is critical to catalog the types of mutations found in LRRK2 that can cause PD, so as to provide insight regarding disease susceptibility and potential novel treatments...
  33. ncbi Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
    W C Nichols
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    Nat Genet 15:277-80. 1997
    ..97 at theta = 0 with the marker D2S389; multipoint linkage analysis yielded a maximum lod score of 7.86 with the marker D2S311. Haplotype analysis established a minimum candidate interval of approximately 25 cM...
  34. ncbi Locus heterogeneity of autosomal dominant osteopetrosis (ADO)
    K E White
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    J Clin Endocrinol Metab 84:1047-51. 1999
    ..Our results demonstrate that there is locus heterogeneity of this disorder; therefore, mutations in at least two different genes can give rise to the ADO phenotype...
  35. pmc Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
    K Haugarvoll
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurology 70:1456-60. 2008
    ..Several dominantly inherited pathogenic substitutions have been identified in different domains of the Lrrk2 protein. Herein, we characterize the clinical and genetic features associated with Lrrk2 p.R1441C...
  36. ncbi A sex-adjusted and age-adjusted genome screen for nested alcohol dependence diagnoses
    J Corbett
    Washington University School of Medicine, St Louis, MO 63110, USA
    Psychiatr Genet 15:25-30. 2005
    ..The region on chromosome 8 near the marker D8S1988 is homologous to a section of rat chromosome 5 to which an alcohol consumption phenotype has been linked...
  37. pmc Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families
    W C Nichols
    Division of Human Genetics, Children s Hospital Medical Center, Cincinnati, OH, USA
    J Med Genet 39:489-92. 2002
  38. ncbi Localization of an ataxia-telangiectasia gene to chromosome 11q22-23
    R A Gatti
    Department of Pathology, UCLA School of Medicine 90024
    Nature 336:577-80. 1988
    ..This has allowed us to localize a gene for AT to chromosomal region 11q22-23...
  39. ncbi Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
    G G Levy
    Howard Hughes Medical Institute, Departments of Internal Medicine and Human Genetics, and Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nature 413:488-94. 2001
    ..We show that deficiency of ADAMTS13 is the molecular mechanism responsible for TTP, and suggest that physiologic proteolysis of VWF and/or other ADAMTS13 substrates is required for normal vascular homeostasis...
  40. ncbi A genome-wide screen for genes influencing conduct disorder
    D M Dick
    Indiana University, 975 West Walnut St, IB 130, Indianapolis, IN 46202 5251, USA
    Mol Psychiatry 9:81-6. 2004
    ..Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood...
  41. ncbi The North American Multiple System Atrophy Study Group
    S Gilman
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0489, USA
    J Neural Transm 112:1687-94. 2005
    ....