ANTHONY FIRULLI

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart
    Anthony B Firulli
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio 78229, USA
    Int Rev Cytol 214:1-62. 2002
  2. pmc Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
    Beth A Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Department of Pediatrics, Indiana Medical School, 1044 W Walnut R4 371, Indianapolis, Indiana 46202 5225, USA
    Nat Genet 37:373-81. 2005
  3. pmc Combinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation
    Anthony B Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5225, USA
    Birth Defects Res C Embryo Today 72:151-61. 2004
  4. pmc Phosphoregulation of Twist1 provides a mechanism of cell fate control
    Anthony B Firulli
    Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Division of Pediatric Cardiology, Department of Anatomy, Indiana Medical School, Indianapolis, IN 46202 5225, USA
    Curr Med Chem 15:2641-7. 2008
  5. ncbi request reprint A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors
    Anthony B Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 2666, Indianapolis, IN 46202 5225, USA
    Gene 312:27-40. 2003
  6. ncbi request reprint PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation
    Beth A Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, Room 2666, Indianapolis, IN 46202, USA
    Mol Cell 12:1225-37. 2003
  7. pmc An absence of Twist1 results in aberrant cardiac neural crest morphogenesis
    Joshua W Vincentz
    Riley Heart Research Center, Riley Hospital for Children, Department of Pediatrics Pediatric Cardiology, Indiana Medical School, 1044 W Walnut St, Indianapolis, IN 46202 5225, USA
    Dev Biol 320:131-9. 2008
  8. pmc Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities
    Beth A Firulli
    Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Department of Pediatrics, Division of Cardiology, Indiana Medical School, 1044 E Walnut, Indianapolis, IN 46202 5225, USA
    J Biol Chem 282:27536-46. 2007
  9. pmc Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development
    Joshua W Vincentz
    Riley Heart Research Center, Herman B Wells Center for Pediatric Research Division of Pediatrics Cardiology, Department of Anatomy, Indiana Medical School, Indianapolis, Indiana 46202 5225, USA
    Dev Dyn 237:3809-19. 2008
  10. pmc A twist of insight - the role of Twist-family bHLH factors in development
    Ralston M Barnes
    Riley Heart Research Center, Department of Anatomy, Indiana Medical School, Indianapolis, USA
    Int J Dev Biol 53:909-24. 2009

Research Grants

  1. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2009
  2. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2007
  3. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2006
  4. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2002
  5. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    Anthony B Firulli; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart
    Anthony B Firulli
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio 78229, USA
    Int Rev Cytol 214:1-62. 2002
    ..This review focuses on what is known about the transcription factors implicated in heart formation and the role they play in this intricate genetic program...
  2. pmc Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
    Beth A Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Department of Pediatrics, Indiana Medical School, 1044 W Walnut R4 371, Indianapolis, Indiana 46202 5225, USA
    Nat Genet 37:373-81. 2005
    ....
  3. pmc Combinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation
    Anthony B Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5225, USA
    Birth Defects Res C Embryo Today 72:151-61. 2004
    ....
  4. pmc Phosphoregulation of Twist1 provides a mechanism of cell fate control
    Anthony B Firulli
    Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Division of Pediatric Cardiology, Department of Anatomy, Indiana Medical School, Indianapolis, IN 46202 5225, USA
    Curr Med Chem 15:2641-7. 2008
    ..Relating the observed phenotypes of defective Twist function with this complex regulatory mechanism will add insight into our understanding of the critical functions of this complex transcription factor...
  5. ncbi request reprint A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors
    Anthony B Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 2666, Indianapolis, IN 46202 5225, USA
    Gene 312:27-40. 2003
    ....
  6. ncbi request reprint PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation
    Beth A Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, Room 2666, Indianapolis, IN 46202, USA
    Mol Cell 12:1225-37. 2003
    ..Mutations in phosphorylated residues result in altered HAND1 dimerization and biological function. Taken together, these results suggest that site-specific phosphorylation regulates HAND factor functional specificity...
  7. pmc An absence of Twist1 results in aberrant cardiac neural crest morphogenesis
    Joshua W Vincentz
    Riley Heart Research Center, Riley Hospital for Children, Department of Pediatrics Pediatric Cardiology, Indiana Medical School, 1044 W Walnut St, Indianapolis, IN 46202 5225, USA
    Dev Biol 320:131-9. 2008
    ..Within the Twist1(-/-) neural crest cell populations that do emigrate to the OFT, a Hand-expressing subpopulation displays defective maturation, tracking, and, presumably, cell-cell adhesion, further compromising cNCC morphogenesis...
  8. pmc Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities
    Beth A Firulli
    Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Department of Pediatrics, Division of Cardiology, Indiana Medical School, 1044 E Walnut, Indianapolis, IN 46202 5225, USA
    J Biol Chem 282:27536-46. 2007
    ..Taken together, this study shows that the Twist1 dimer affinity for a given partner can modulate the DNA binding affinity and that Twist1 dimer choice determines phenotypic outcome during limb development...
  9. pmc Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development
    Joshua W Vincentz
    Riley Heart Research Center, Herman B Wells Center for Pediatric Research Division of Pediatrics Cardiology, Department of Anatomy, Indiana Medical School, Indianapolis, Indiana 46202 5225, USA
    Dev Dyn 237:3809-19. 2008
    ..Collectively, these data support a hypothesis where physical, functional, and genetic interactions between Nkx2.5 and Mef2c are necessary for ventricle formation...
  10. pmc A twist of insight - the role of Twist-family bHLH factors in development
    Ralston M Barnes
    Riley Heart Research Center, Department of Anatomy, Indiana Medical School, Indianapolis, USA
    Int J Dev Biol 53:909-24. 2009
    ..Additionally, we focus on the phospho-regulatory mechanisms that tightly control posttranslational modification of Twist-family member bHLH proteins...
  11. pmc Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 102:752-60. 2008
    ..Thus, peri(lacZ) knockouts provide a new model of viable latent valve disease...
  12. pmc Cardiovascular development and the colonizing cardiac neural crest lineage
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    ScientificWorldJournal 7:1090-113. 2007
    ..Here we review the current literature, the neural crest-related role of the Pax3 transcription factor, and discuss potential function/s of cardiac neural crest-derived cells during cardiovascular developmental remodeling...
  13. pmc Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer
    Andrew Lindsley
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 307:340-55. 2007
    ....
  14. pmc Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development
    Ralston M Barnes
    Riley Heart Research Center, Wells Center for Pediatric Research, Division of Pediatric Cardiology, Departments of Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis, 46202 5225, USA
    Circ Res 108:940-9. 2011
    ..The basic helix-loop-helix (bHLH) transcription factors Hand1 and Hand2 are essential for embryonic development. Given their requirement for cardiogenesis, it is imperative to determine their impact on cardiovascular function...
  15. pmc Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons
    Tyler J Hendershot
    Department of Neurosciences, Program in Neurosciences and Degenerative Disease, University of Toledo Health Sciences Center, Toledo, OH 43614, USA
    Dev Biol 319:179-91. 2008
    ..Hand2 has a pivotal function in a non-linear cross-regulatory network of DNA binding proteins that affect cell autonomous control of differentiation and cell type-specific gene expression...
  16. ncbi request reprint HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a
    Haiming Xu
    Department of Anatomy and Neurobiology, Medical College of Ohio, 3000 Arlington Ave, Toledo, OH 43614, USA
    Dev Biol 262:183-93. 2003
    ..Our data suggest that HAND2 regulates cell type-specific expression of norepinephrine in concert with Phox2a by a novel mechanism...
  17. ncbi request reprint The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene
    Bijoy D Thattaliyath
    Department of Physiology, Mail code 7756, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Mol Cell Cardiol 34:1335-44. 2002
    ..5, showing a functional relationship between HAND2 and Nkx2.5 supporting the genetic observation, that mice null for both HAND2 and Nkx2.5 lack ventricle specification...
  18. ncbi request reprint Another hat for myocardin
    Anthony B Firulli
    J Mol Cell Cardiol 34:1293-6. 2002
  19. ncbi request reprint HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy
    Bijoy D Thattaliyath
    Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail code 7756, San Antonio, TX 78229 3900, USA
    Biochem Biophys Res Commun 297:870-5. 2002
    ....

Research Grants13

  1. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2009
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  2. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2007
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  3. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2006
    ..This understanding is essential for the development of genetic screens and treatments for the many forms of congenital heart disease present in the human population. ..
  4. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2002
    ..This understanding is essential for the development of genetic screens and treatments for the many forms of congenital heart disease present in the human population. ..
  5. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    Anthony B Firulli; Fiscal Year: 2010
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..