Paul R Crisostomo

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Stem cell mechanisms and paracrine effects: potential in cardiac surgery
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 28:375-83. 2007
  2. ncbi In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind, USA
    Surgery 142:215-21. 2007
  3. ncbi VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 295:H2308-14. 2008
  4. ncbi Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions
    Paul R Crisostomo
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Heart Circ Physiol 295:H1726-35. 2008
  5. ncbi TNFR1 signaling resistance associated with female stem cell cytokine production is independent of TNFR2-mediated pathways
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1124-30. 2008
  6. ncbi Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism
    Paul R Crisostomo
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Physiol Cell Physiol 294:C675-82. 2008
  7. ncbi Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1)
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall 215, Indianapolis, IN 46202, USA
    J Mol Cell Cardiol 42:142-9. 2007
  8. ncbi Proestrus female rats are more resistant to right ventricular pressure overload
    Rahul Sharma
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Shock 30:318-23. 2008
  9. ncbi Mechanisms of sex differences in TNFR2-mediated cardioprotection
    Meijing Wang
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Circulation 118:S38-45. 2008
  10. ncbi The effects of endogenous sex hormones and acute hypoxia on vasoconstriction in isolated rat pulmonary artery rings
    Ketan M Patel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 146:121-6. 2008

Collaborators

Detail Information

Publications58

  1. ncbi Stem cell mechanisms and paracrine effects: potential in cardiac surgery
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 28:375-83. 2007
    ....
  2. ncbi In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind, USA
    Surgery 142:215-21. 2007
    ..Female MSCs produce more growth factor when stressed; therefore, we hypothesized that myocardial protection provoked by female MSCs would be greater than that elicited by male MSCs...
  3. ncbi VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 295:H2308-14. 2008
    ..Therefore, VEGF is a critical paracrine mediator in facilitating postischemic myocardial recovery and likely plays a role in mediating the observed age threshold during stem cell therapy...
  4. ncbi Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions
    Paul R Crisostomo
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Heart Circ Physiol 295:H1726-35. 2008
    ..Moreover, ESCs in cell culture demonstrated greater pluripotency than MSCs. ESC paracrine protective mechanisms in surgical ischemia are superior to those of adult stem cells...
  5. ncbi TNFR1 signaling resistance associated with female stem cell cytokine production is independent of TNFR2-mediated pathways
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1124-30. 2008
    ..The absence of TNFR2 signaling appears to play a greater role in male MSC cytokine production. As a result, male, but not female stem cell cytokine production may be mediated through TNFR2 signaling cascades...
  6. ncbi Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism
    Paul R Crisostomo
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Physiol Cell Physiol 294:C675-82. 2008
    ..Moreover, ERK, JNK, and NF kappa B inhibitor alone did not activate MSC VEGF expression over controls. Various stressors activate human MSCs to increase VEGF, FGF2, HGF, and IGF-1 expression, which depends on an NFkB mechanism...
  7. ncbi Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1)
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall 215, Indianapolis, IN 46202, USA
    J Mol Cell Cardiol 42:142-9. 2007
    ....
  8. ncbi Proestrus female rats are more resistant to right ventricular pressure overload
    Rahul Sharma
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Shock 30:318-23. 2008
    ..Understanding these differences may allow for the implementation of novel therapeutic treatment options that are designed to attenuate RV cardiovascular collapse...
  9. ncbi Mechanisms of sex differences in TNFR2-mediated cardioprotection
    Meijing Wang
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Circulation 118:S38-45. 2008
    ....
  10. ncbi The effects of endogenous sex hormones and acute hypoxia on vasoconstriction in isolated rat pulmonary artery rings
    Ketan M Patel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 146:121-6. 2008
    ..Therefore, we measured isometric force displacement in normal males, castrated males, normal females, and ovarectomized females...
  11. ncbi Are neonatal stem cells as effective as adult stem cells in providing ischemic protection?
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 152:325-30. 2009
    ....
  12. ncbi TGF-alpha increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms
    Yue Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1115-23. 2008
    ..Our data suggest that TGF-alpha increases VEGF production in MSCs via MEK- and PI3-K- but not ERK- or JNK-dependent mechanisms...
  13. ncbi Selective estrogen receptor-alpha and estrogen receptor-beta agonists rapidly decrease pulmonary artery vasoconstriction by a nitric oxide-dependent mechanism
    Tim Lahm
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1486-93. 2008
    ..NO inhibition eliminates these effects, suggesting a central role for NO in mediating the pulmonary vascular effects of both ER-alpha and ER-beta...
  14. ncbi beta-Blockers in sepsis: reexamining the evidence
    Nathan M Novotny
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Shock 31:113-9. 2009
    ..It is the purpose of this review to discuss the effects of beta-blockers on the following: (1) metabolism, (2) glucose regulation, (3) the inflammatory response, (4) cardiac function, and (5) mortality in sepsis...
  15. ncbi Tumor necrosis factor receptor 1 signaling resistance in the female myocardium during ischemia
    Meijing Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Circulation 114:I282-9. 2006
    ..Females have a lower incidence of heart failure and a higher heart failure survival than males. We hypothesized that TNFR1 signaling resistance occurs in the female myocardium during ischemia...
  16. ncbi Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia
    Graham S Erwin
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 152:319-24. 2009
    ..We hypothesize that E2-exposed MSCs infused into hearts prior to ischemia may demonstrate increased vascular endothelial growth factor (VEGF) production and greater protection of myocardial function compared to untreated MSCs...
  17. ncbi Stem cells improve right ventricular functional recovery after acute pressure overload and ischemia reperfusion injury
    George M Wairiuko
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 141:241-6. 2007
    ....
  18. ncbi Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression
    Ben M Tsai
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Surg Res 145:130-4. 2008
    ....
  19. ncbi Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Gastrointest Liver Physiol 293:G657-62. 2007
    ..TNF receptor ablation modifies BMSC cytokine production. Identifying the proper stimulus and signaling cascades for the production of desired growth factors may be beneficial in maximizing the therapeutic potential of stem cells...
  20. ncbi High passage number of stem cells adversely affects stem cell activation and myocardial protection
    Paul R Crisostomo
    Department of Surgery, Center for Immunobiology, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Shock 26:575-80. 2006
    ..Acute murine MSC infusion confers protection in isolated rat hearts. However, high passage number has an adverse effect on MSC activation and protection. This portends limited ex vivo expansion before possible therapeutic use...
  21. ncbi Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production
    Rinki Ray
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1498-503. 2008
    ..By manipulating the mechanisms that BMSCs use to produce growth factors, we may be able to engineer stem cells to produce maximum growth factors during therapeutic use...
  22. ncbi Neonatal stem cells exhibit specific characteristics in function, proliferation, and cellular signaling that distinguish them from their adult counterparts
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1491-7. 2008
    ..Neonatal stem cells may aid in decreasing the local inflammatory response during ischemia, and could possibly be expanded more rapidly than adult cells prior to therapeutic use...
  23. ncbi The effect of chronic exogenous androgen on myocardial function following acute ischemia-reperfusion in hosts with different baseline levels of sex steroids
    Un Hui Nam
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 142:113-8. 2007
    ....
  24. ncbi Exogenous estrogen rapidly attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction
    Tim Lahm
    Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 30:660-7. 2008
    ..A better understanding of how E2 modulates the pulmonary vasomotor response may allow for future therapeutic interventions in acute pulmonary hypertensive crises or in pulmonary arterial hypertension...
  25. ncbi Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Gastrointest Liver Physiol 292:G958-63. 2007
    ..Furthermore, chelator-induced intestinal epithelial cell cytokine expression depends on p38, ERK, and JNK MAPK pathways...
  26. ncbi Estrogen receptor beta mediates acute myocardial protection following ischemia
    Meijing Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Surgery 144:233-8. 2008
    ..It remains unknown, however, whether ER beta also may be protective following the more severe insult of complete global, normothermic ischemia/reperfusion injury in the isolated mouse heart...
  27. ncbi Nitric oxide suppresses the secretion of vascular endothelial growth factor and hepatocyte growth factor from human mesenchymal stem cells
    Yue Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 30:527-31. 2008
    ..This study constitutes an initial report regarding the effect of NO on human MSC growth factor production...
  28. ncbi The effects of estrogen on pulmonary artery vasoreactivity and hypoxic pulmonary vasoconstriction: potential new clinical implications for an old hormone
    Tim Lahm
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Crit Care Med 36:2174-83. 2008
    ..A better mechanistic understanding may allow for future therapeutic interventions in pulmonary hypertensive crises after cardiac surgery and during acute lung injury as well as in patients with pulmonary arterial hypertension...
  29. ncbi Sex dimorphisms in activated mesenchymal stem cell function
    Paul R Crisostomo
    Department of Surgery, Center for Immunobiology, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Shock 26:571-4. 2006
    ..Sex differences in progenitor cell function may have important implications in understanding the observed sex differences in the host's response to injury...
  30. ncbi Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism
    Meijing Wang
    Department of Surgery, Indiana University School of Medicine, IN, USA
    Am J Physiol Regul Integr Comp Physiol 291:R880-4. 2006
    ..These data demonstrate that progenitor cells are potent sources of VEGF, HGF, and IGF-I. TNF, a prominent tissue cytokine, strongly stimulated production of growth factors by hMSCs and hAPCs via a p38 MAPK-dependent mechanism...
  31. ncbi TNF receptor 2, not TNF receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia
    Megan L Kelly
    The Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 33:602-7. 2010
    ..TNFR1 signaling may damage MSC paracrine effects and decrease MSC-mediated cardioprotection, whereas TNFR2 likely mediates beneficial effects in MSCs...
  32. ncbi Females exhibit relative resistance to depressive effects of tumor necrosis factor-alpha on the myocardium
    Ian C Sando
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 150:92-9. 2008
    ....
  33. ncbi The critical role of vascular endothelial growth factor in pulmonary vascular remodeling after lung injury
    Tim Lahm
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 28:4-14. 2007
    ....
  34. ncbi Postischemic infusion of 17-beta-estradiol protects myocardial function and viability
    Andrew M Terrell
    Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall 203, Indianapolis, IN 46202, USA
    J Surg Res 146:218-24. 2008
    ..We hypothesize that postischemic administration of 17beta-estradiol will decrease myocardial ischemia/reperfusion injury and improve left ventricular cardiac function...
  35. ncbi Angiopoietin-1 in the treatment of ischemia and sepsis
    Nathan M Novotny
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 31:335-41. 2009
    ....
  36. ncbi Therapeutic concepts for hypoxic pulmonary vasoconstriction involving ion regulation and the smooth muscle contractile apparatus
    Eric D Morrell
    Sections of General and Cardiothoracic Surgery, Department of Surgery, Indiana University Medical Center, Indianapolis, IN 46202, USA
    J Mol Cell Cardiol 40:751-60. 2006
    ....
  37. ncbi Right ventricular TNF resistance during endotoxemia: the differential effects on ventricular function
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1893-7. 2007
    ..No significant differences in IL-6, TNFR1, or TNFR2 levels were noted between endotoxin-exposed ventricles. This is the first study to demonstrate that right and left ventricular function differs after endotoxin exposure...
  38. ncbi Stem cells as a potential future treatment of pediatric intestinal disorders
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pediatr Surg 43:1953-63. 2008
    ....
  39. ncbi Selective protein kinase C inhibition attenuates pulmonary artery cytokine expression without affecting hypoxic pulmonary vasoconstriction
    Ben M Tsai
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Shock 27:36-9. 2007
    ....
  40. ncbi Differential IL-6 and VEGF secretion in adult and neonatal mesenchymal stem cells: role of NFkB
    Nathan M Novotny
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cytokine 43:215-9. 2008
    ..VEGF and IL-6 secretion in aBMSCs is dependent on the classic NFkB pathway. However, neonatal BMSC VEGF and IL-6 secretion is stimulant-specific and utilization of the NFkB pathway is more complex...
  41. ncbi Stem cell therapy in myocardial repair and remodeling
    Nathan M Novotny
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Am Coll Surg 207:423-34. 2008
  42. ncbi Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia
    Meijing Wang
    Department of Surgery, Indiana University Medical Center, Indianapolis, IN, USA
    Shock 25:454-9. 2006
    ..These findings may not only have mechanistic implications regarding the benefit of progenitor cells but may also have clinical therapeutic implications before planned ischemic events...
  43. ncbi Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury
    Yue Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Shock 34:548-57. 2010
    ..We review our current understanding of the TLR signaling pathways and their roles in the pathophysiology of cardiac ischemia/reperfusion injury, as well as discuss several mechanisms for TLR activation and regulation...
  44. ncbi Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury
    Michael J Guzman
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 150:286-92. 2008
    ..We hypothesize that infusion of exogenous VEGF immediately prior to ischemia will improve myocardial functional recovery...
  45. ncbi The right heart and its distinct mechanisms of development, function, and failure
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 146:304-13. 2008
    ....
  46. ncbi Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: the effects of sex and menstrual cycle
    Tim Lahm
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Endocrinol Metab 293:E865-71. 2007
    ..05). We conclude that sex and menstrual cycle affect PA vasoconstriction in isolated PA rings. Even physiological increases in circulating estrogen levels attenuate PA vasoconstriction under both normoxic and hypoxic conditions...
  47. ncbi Jak/STAT/SOCS signaling circuits and associated cytokine-mediated inflammation and hypertrophy in the heart
    Andrew M Terrell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Shock 26:226-34. 2006
    ....
  48. ncbi The struggle for iron: gastrointestinal microbes modulate the host immune response during infection
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, Emerson Hall 215, Indianapolis, IN 46202, USA
    J Leukoc Biol 81:393-400. 2007
    ..This review will describe the immune response to gastrointestinal infection, the mechanisms that the gastrointestinal system uses to absorb intraluminal iron, and the critical role iron plays in the infectious process...
  49. ncbi Preconditioning versus postconditioning: mechanisms and therapeutic potentials
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Am Coll Surg 202:797-812. 2006
  50. ncbi Postconditioning in females depends on injury severity
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 134:342-7. 2006
    ..The attractive potential for the clinical application of postconditioning, however, warrants further studies to elucidate the mechanistic pathways and differences in males and female rats...
  51. ncbi Surgically relevant aspects of stem cell paracrine effects
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind, USA
    Surgery 143:577-81. 2008
  52. ncbi Sex steroids and stem cell function
    Rinki Ray
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Mol Med 14:493-501. 2008
    ..In this review, we focus on the effects of estrogen and testosterone on various stem and progenitor cell types, and their relevant intracellular mechanisms...
  53. ncbi Experimental therapies for hypoxia-induced pulmonary hypertension during acute lung injury
    Eric D Morrell
    Section of Cardiothoracic Surgery, Department of Surgery, Indiana University Medical Center, Indianapolis, Indiana
    Shock 25:214-26. 2006
    ....
  54. ncbi Cytokines in necrotizing enterocolitis
    Troy A Markel
    Department of Surgery, Indiana University School of Medicine, the Indiana Center for Vascular Biology and Medicine, Indianapolis, IN, USA
    Shock 25:329-37. 2006
    ..This article will therefore focus on the key cytokines involved with NEC, in an attempt to present the current literature and studies that support their involvement...
  55. ncbi p38 mitogen-activated protein kinase mediates the sustained phase of hypoxic pulmonary vasoconstriction and plays a role in phase I vasodilation
    Eric D Morrell
    Department of Surgery, Section of Cardiothoracic Surgery, Indiana University Medical Center, Indianapolis, Indiana, USA
    J Surg Res 134:335-41. 2006
    ..We conclude that p38 MAP kinase may be a key mediator in the pathogenesis of HPV and that further understanding may lead to new therapies for HPV associated with acute lung injury...
  56. ncbi Left ventricular rupture: immediately before and after
    Paul R Crisostomo
    VA Medical Center and Indiana University School of Medicine, Indianapolis, IN, USA
    J Am Coll Surg 207:784. 2008
  57. ncbi Brief exposure to exogenous testosterone increases death signaling and adversely affects myocardial function after ischemia
    Paul R Crisostomo
    Department of Surgery, Indiana University School of Medicine, Indianapolis, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1168-74. 2006
    ....
  58. ncbi Stem cell delivery to the heart: clarifying methodology and mechanism
    Paul R Crisostomo
    Crit Care Med 35:2654-6. 2007