KENNETH G CORNETTA

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, IB 130, 975 W Walnut St, Indianapolis, IN, 4620, USA
    Transgenic Res 22:737-45. 2013
  2. pmc Balancing personalized medicine and personalized care
    Kenneth Cornetta
    Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Acad Med 88:309-13. 2013
  3. pmc Replication-competent lentivirus analysis of clinical grade vector products
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Ther 19:557-66. 2011
  4. ncbi request reprint A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase
    K Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cancer Gene Ther 13:886-95. 2006
  5. ncbi request reprint Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT)
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, USA
    Biol Blood Marrow Transplant 11:149-60. 2005
  6. ncbi request reprint Regulatory issues for clinical gene therapy trials
    Kenneth Cornetta
    Departments of Medicine, Microbiology and Immunology, and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Gene Ther 13:1143-9. 2002
  7. ncbi request reprint Regulatory issues in human gene therapy
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut Street, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 31:51-6. 2003
  8. pmc Identifying viral integration sites using SeqMap 2.0
    Troy B Hawkins
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bioinformatics 27:720-2. 2011
  9. ncbi request reprint Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not
    Wen Tao
    Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Room 302, Indianapolis, IN 46202, USA
    Stem Cells 25:670-8. 2007
  10. ncbi request reprint Desensitization to imatinib in patients with leukemia
    Robert P Nelson
    Hematological Malignancy Program Immunology, Division of Hematology Oncology, Indiana University Hospital, Clarion Health Partners, USA
    Ann Allergy Asthma Immunol 97:216-22. 2006

Research Grants

  1. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2007
  2. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2006
  3. NATIONAL GENE VECTOR LABORATORY
    Kenneth Cornetta; Fiscal Year: 2000
  4. NGVL: GENE THERAPY STUDY IN HIV INDIVIDUALS
    Kenneth Cornetta; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. pmc Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, IB 130, 975 W Walnut St, Indianapolis, IN, 4620, USA
    Transgenic Res 22:737-45. 2013
    ..Results of these experiments provide further evidence as to the safety of HIV-1 based vectors in animal and human applications. ..
  2. pmc Balancing personalized medicine and personalized care
    Kenneth Cornetta
    Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Acad Med 88:309-13. 2013
    ..Because these efforts are generally independent, the authors offer recommendations for physicians and educators so that personalized medicine can be implemented in a manner that meets patient expectations for personalized care...
  3. pmc Replication-competent lentivirus analysis of clinical grade vector products
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Ther 19:557-66. 2011
    ..We discuss the limitations and challenges of the current assay, and suggest modifications that may improve the suitability of this assay for screening US Food and Drug Administration (US FDA)-licensed products...
  4. ncbi request reprint A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase
    K Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cancer Gene Ther 13:886-95. 2006
    ..These findings demonstrate the feasibility and safety of utilizing MGMT-transduced CD34+ peripheral blood progenitor cells in the setting of chemotherapy...
  5. ncbi request reprint Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT)
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, USA
    Biol Blood Marrow Transplant 11:149-60. 2005
    ..The findings of high treatment-related mortality and slow engraftment kinetics indicate that CBT should continue to be performed in specialized centers with a research focus on cord blood cells...
  6. ncbi request reprint Regulatory issues for clinical gene therapy trials
    Kenneth Cornetta
    Departments of Medicine, Microbiology and Immunology, and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Gene Ther 13:1143-9. 2002
    ..The challenges faced by academic research are outlined, including new and proposed regulations which impact human gene therapy investigators...
  7. ncbi request reprint Regulatory issues in human gene therapy
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut Street, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 31:51-6. 2003
    ..This paper will review the current oversight agencies and identify areas of evolving regulations that pose particular challenges to gene therapy investigators...
  8. pmc Identifying viral integration sites using SeqMap 2.0
    Troy B Hawkins
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bioinformatics 27:720-2. 2011
    ..Individual sequence reads are masked to remove non-genomic sequence, aligned to the host genome and assembled into contiguous fragments used to pinpoint the position of integration...
  9. ncbi request reprint Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not
    Wen Tao
    Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Room 302, Indianapolis, IN 46202, USA
    Stem Cells 25:670-8. 2007
    ..Therefore, EGFP has no detectable deteriorative effects on HSCs, and is nearly an ideal long-term expression tracer for hematopoietic cells; however, DsRed-Express fluorescent protein is not suitable for these cells...
  10. ncbi request reprint Desensitization to imatinib in patients with leukemia
    Robert P Nelson
    Hematological Malignancy Program Immunology, Division of Hematology Oncology, Indiana University Hospital, Clarion Health Partners, USA
    Ann Allergy Asthma Immunol 97:216-22. 2006
    ..Imatinib is associated with a variety of adverse cutaneous reactions, including urticaria, maculopapular exanthem, generalized exanthematous pustulosis, exfoliative dermatitis, and Stevens-Johnson syndrome...
  11. ncbi request reprint Decreased homing of retrovirally transduced human bone marrow CD34+ cells in the NOD/SCID mouse model
    Kristin M Hall
    Department of Microbiology and Immunology, Division of Hematology Oncology, Indian University School of Medicine, Indianapolis, 46202, USA
    Exp Hematol 34:433-42. 2006
    ..Because engraftment is dependent upon successful homing of graft cells to the bone marrow (BM), we examined whether retroviral-mediated gene transfer (RMGT) induces a homing defect in CD34(+) cells...
  12. ncbi request reprint Augmented high-dose regimen of cyclophosphamide, carmustine, and etoposide with autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma
    Michael J Robertson
    Bone Marrow and Stem Cell Transplantation Program, Indiana University Medical Center, 1044 West Walnut Street, Indianapolis, IN 46202, USA
    Leuk Lymphoma 46:1477-87. 2005
    ..Prospective study of the association between inferior progression-free survival and infusion of higher CD34 + cell doses in stem cell autografts is warranted...
  13. ncbi request reprint Interleukin 12 immunotherapy after autologous stem cell transplantation for hematological malignancies
    Michael J Robertson
    Bone Marrow and Stem Cell Transplantation Program, Lymphoma Program, and the Division of Hematology Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 8:3383-93. 2002
    ..To determine the safety, maximum tolerated dose,and biological effects of recombinant human IL-12 after autologous stem cell transplantation for cancer...
  14. pmc Efficient and stable gene expression into human osteoclasts using an HIV-1-based lentiviral vector
    Kang Chu
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    DNA Cell Biol 27:315-20. 2008
    ..This protocol provides a new tool for studies of osteoclast biology. Further work in this area may open new avenues for the study of osteoclast gene signaling and gene therapy of disorders of osteoclast function...
  15. ncbi request reprint Lentiviral vectors pseudotyped with glycoproteins from Ross River and vesicular stomatitis viruses: variable transduction related to cell type and culture conditions
    Christoph A Kahl
    Department of Medical and Molecular Genetics, Indianapolis, IN 46202, USA
    Mol Ther 11:470-82. 2005
    ..Furthermore, the uniquely restricted host range of RRV-pseudotyped vectors may aid in the design of novel cell-selective transduction strategies...
  16. ncbi request reprint Certification assays for HIV-1-based vectors: frequent passage of gag sequences without evidence of replication-competent viruses
    Lakshmi Sastry
    Department of Microbiology and Immunology, Indianapolis, Indiana 46202, USA
    Mol Ther 8:830-9. 2003
    ..These findings have important implications for the design and safety of HIV-1-based vectors intended for clinical applications...
  17. ncbi request reprint Detection of ecotropic replication-competent retroviruses: comparison of s(+)/l(-) and marker rescue assays
    Lilith Reeves
    Division of Hematology Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Gene Ther 13:1783-90. 2002
    ..For laboratories analyzing clinical materials, this report may prove useful in establishing detection assays for Eco-RCR...
  18. ncbi request reprint Evaluation of plasmid DNA removal from lentiviral vectors by benzonase treatment
    Lakshmi Sastry
    Department of Microbiology and Immunology, Wells Center for Pediatric Research, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA
    Hum Gene Ther 15:221-6. 2004
    ..However, because there is minimal transfer of plasmid DNA to transduced cells under ex vivo transduction conditions, DNA removal from lentiviral vectors may not be essential for all ex vivo clinical applications...
  19. pmc Resistance to human immunodeficiency virus type 1 (HIV-1) generated by lentivirus vector-mediated delivery of the CCR5{Delta}32 gene despite detectable expression of the HIV-1 co-receptors
    Qingwen Jin
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Gen Virol 89:2611-21. 2008
    ..The lentiviral-CCR5Delta32 vectors offer a method of generating HIV-resistant cells by delivery of the CCR5Delta32 gene that may be useful for stem cell- or T-cell-based gene therapy for HIV-1 infection...
  20. doi request reprint Production of retroviral vectors for clinical use
    Kenneth Cornetta
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Methods Mol Biol 433:17-32. 2008
    ..We describe two manufacturing methods for producing material for Phase I/II clinical trials and suggest ways for investigators to adapt these methods for multiple applications...
  21. ncbi request reprint Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization
    Liying Cai
    Indiana Center for Vascular Biology and Medicine, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 975 W Walnut Street IB 441, Indianapolis, Indiana 46202, USA
    Stem Cells 25:3234-43. 2007
    ..This finding directly supports the emerging concept that local factor secretion by donor cells is a key element of cell-based therapies. Disclosure of potential conflicts of interest is found at the end of this article...
  22. pmc Human immunodeficiency virus type 1-derived lentivirus vectors pseudotyped with envelope glycoproteins derived from Ross River virus and Semliki Forest virus
    Christoph A Kahl
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Virol 78:1421-30. 2004
    ..Together, our data suggest that RRV and SFV glycoproteins might be suitable as alternatives to VSV-G for pseudotyping lentivirus vectors...

Research Grants19

  1. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2007
    ..abstract_text> ..
  2. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2006
    ..abstract_text> ..
  3. NATIONAL GENE VECTOR LABORATORY
    Kenneth Cornetta; Fiscal Year: 2000
    ....
  4. NGVL: GENE THERAPY STUDY IN HIV INDIVIDUALS
    Kenneth Cornetta; Fiscal Year: 2007
    ..The institution listed is for the Center, which is not necessarily the institution for the investigator. Support for Dr. Zaia in an experimental gene therapy study in HIV-infected individuals. ..