P Connolly

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Comparison of a new triazole, posaconazole, with itraconazole and amphotericin B for treatment of histoplasmosis following pulmonary challenge in immunocompromised mice
    P Connolly
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Antimicrob Agents Chemother 44:2604-8. 2000
  2. ncbi request reprint Effects of CD4 and CD8 T lymphocyte depletion on the course of histoplasmosis following pulmonary challenge
    C Schnizlein-Bick
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Med Mycol 41:189-97. 2003
  3. ncbi request reprint Chronic infection and reactivation in a pulmonary challenge model of histoplasmosis
    M Durkin
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Infect Dis 183:1822-4. 2001
  4. ncbi request reprint Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Laboratory, and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Clin Infect Dis 33:1910-3. 2001
  5. ncbi request reprint Elimination of false-positive Histoplasma antigenemia caused by human anti-rabbit antibodies in the second-generation Histoplasma antigen assay
    L J Wheat
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Transpl Infect Dis 8:219-21. 2006
  6. pmc Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Library and Veterans Affairs Medical Center, Indianapolis 46202 2879, USA
    Antimicrob Agents Chemother 45:2354-7. 2001
  7. pmc Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum
    J Wheat
    Department of Medicine and Pathology, Indiana University School of Medicine, Indianapolis, USA
    Antimicrob Agents Chemother 41:410-4. 1997
  8. ncbi request reprint Effect of CD40 ligand on the course of murine histoplasmosis
    L J Wheat
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Med Mycol 40:501-5. 2002
  9. pmc Improved detection of Histoplasma antigenemia following dissociation of immune complexes
    S Swartzentruber
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Clin Vaccine Immunol 16:320-2. 2009
  10. doi request reprint Diagnosis of acute pulmonary histoplasmosis by antigen detection
    S Swartzentruber
    MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana 46241, USA
    Clin Infect Dis 49:1878-82. 2009

Collaborators

Detail Information

Publications13

  1. pmc Comparison of a new triazole, posaconazole, with itraconazole and amphotericin B for treatment of histoplasmosis following pulmonary challenge in immunocompromised mice
    P Connolly
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Antimicrob Agents Chemother 44:2604-8. 2000
    ..Posaconazole at 0.1 mg/kg/day reduced fungal colony counts and antigen levels in spleens but not in lungs. This study shows posaconazole activity for the treatment of histoplasmosis in immunosuppressed animals...
  2. ncbi request reprint Effects of CD4 and CD8 T lymphocyte depletion on the course of histoplasmosis following pulmonary challenge
    C Schnizlein-Bick
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Med Mycol 41:189-97. 2003
    ..This model appears suitable for investigation of immunity to H. capsulatum, and should be useful for evaluation of treatment in the immunocompromised host...
  3. ncbi request reprint Chronic infection and reactivation in a pulmonary challenge model of histoplasmosis
    M Durkin
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Infect Dis 183:1822-4. 2001
    ..Thus, 16 of 32 immunocompetent mice exhibited progressive infection. CD4 and/or CD8 depletion exacerbated infection, but a chronic progressive and ultimately fatal infection occurred in half the immunocompetent mice...
  4. ncbi request reprint Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Laboratory, and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Clin Infect Dis 33:1910-3. 2001
    ..Cross-resistance to itraconazole was not seen. In conclusion, fluconazole is less active than itraconazole for Histoplasma capsulatum and induces resistance during therapy, which accounted for treatment failure in some patients...
  5. ncbi request reprint Elimination of false-positive Histoplasma antigenemia caused by human anti-rabbit antibodies in the second-generation Histoplasma antigen assay
    L J Wheat
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Transpl Infect Dis 8:219-21. 2006
    ..Physicians should be aware of the potential for false-positive results in sandwich immunoassays in specimens from patients who have received RATG...
  6. pmc Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole
    L J Wheat
    Indiana University School of Medicine, Histoplasmosis Reference Library and Veterans Affairs Medical Center, Indianapolis 46202 2879, USA
    Antimicrob Agents Chemother 45:2354-7. 2001
    ..2 U in the itraconazole group (P = 0.0005). The more rapid clearance of fungemia supports the use of liposomal amphotericin B rather than itraconazole for initial treatment of moderately severe or severe histoplasmosis...
  7. pmc Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum
    J Wheat
    Department of Medicine and Pathology, Indiana University School of Medicine, Indianapolis, USA
    Antimicrob Agents Chemother 41:410-4. 1997
    ..9 microM and 55.5 microM, respectively. Resistance to fluconazole may develop during treatment and results from decreased sensitivity of ergosterol synthesis...
  8. ncbi request reprint Effect of CD40 ligand on the course of murine histoplasmosis
    L J Wheat
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Med Mycol 40:501-5. 2002
    ..In summary, CD40L had minimal or no effect on the course of infection in this murine model of histoplasmosis...
  9. pmc Improved detection of Histoplasma antigenemia following dissociation of immune complexes
    S Swartzentruber
    MiraVista Diagnostics, Indianapolis, Indiana 46241, USA
    Clin Vaccine Immunol 16:320-2. 2009
    ..Precision and reproducibility were good and excellent, respectively. These findings demonstrate improvement in sensitivity without reduction in specificity, precision, or reproducibility after heat-EDTA treatment...
  10. doi request reprint Diagnosis of acute pulmonary histoplasmosis by antigen detection
    S Swartzentruber
    MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana 46241, USA
    Clin Infect Dis 49:1878-82. 2009
    ..Because treatment is indicated in most patients with moderately severe or severe APH, antigen detection for rapid diagnosis could be helpful...
  11. ncbi request reprint False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies
    L J Wheat
    Mira Vista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Transpl Infect Dis 6:23-7. 2004
    ..False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG...
  12. ncbi request reprint Factors associated with severe manifestations of histoplasmosis in AIDS
    L J Wheat
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Infect Dis 30:877-81. 2000
    ..2; 95% CI, 0.1-0.6). Findings associated with severe histoplasmosis should be recognized early and the cases managed aggressively...
  13. ncbi request reprint Cadaveric fibula, locking plate, and allogeneic bone matrix for anterior cervical fusions after cervical discectomy for radiculopathy or myelopathy
    S Shapiro
    Section of Neurosurgery, Indiana University Medical Center, Indianapolis, USA
    J Neurosurg 95:43-50. 2001
    ..It remains to be determined if demineralized ABM has a significant effect in enhancing fusion...