L Cheng

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi request reprint Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum?
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 180:1235-40. 2008
  2. doi request reprint Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 25:1432-8. 2012
  3. ncbi request reprint OCT4: biological functions and clinical applications as a marker of germ cell neoplasia
    L Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pathol 211:1-9. 2007
  4. ncbi request reprint Prostatic intraepithelial neoplasia: an update
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Prostate Cancer 3:26-30. 2004
  5. ncbi request reprint Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder
    Liang Cheng
    Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Cancer 101:183-8. 2004
  6. ncbi request reprint Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer 101:2006-10. 2004
  7. ncbi request reprint Loss of 14-3-3sigma in prostate cancer and its precursors
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Cancer Res 10:3064-8. 2004
  8. ncbi request reprint Allelic loss of the active X chromosome during bladder carcinogenesis
    Liang Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Arch Pathol Lab Med 128:187-90. 2004
  9. ncbi request reprint Molecular genetic evidence for different clonal origin of components of human renal angiomyolipomas
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 25:1231-6. 2001
  10. ncbi request reprint Risk of prostate carcinoma death in patients with lymph node metastasis
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 91:66-73. 2001

Detail Information

Publications123 found, 100 shown here

  1. doi request reprint Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum?
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 180:1235-40. 2008
    ....
  2. doi request reprint Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 25:1432-8. 2012
    ..Concordant chromosome 12p alterations between the fibrous stroma and epithelial elements provide further evidence that both epithelial and fibrous components of teratoma are derived from a common progenitor...
  3. ncbi request reprint OCT4: biological functions and clinical applications as a marker of germ cell neoplasia
    L Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pathol 211:1-9. 2007
    ..Additionally, OCT4 immunostaining shows promise as a useful tool in managing patients known to be at high risk for the development of invasive GCTs...
  4. ncbi request reprint Prostatic intraepithelial neoplasia: an update
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Prostate Cancer 3:26-30. 2004
    ..As a precursor lesion, HGPIN is currently a target for chemopreventive strategies, including antiandrogens and nutritional supplementation...
  5. ncbi request reprint Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder
    Liang Cheng
    Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Cancer 101:183-8. 2004
    ..The biologic potential of PUNLMP of the urinary bladder is controversial. To the authors' knowledge, information regarding the genetic changes of PUNLMP tumors of the bladder is limited...
  6. ncbi request reprint Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer 101:2006-10. 2004
    ..OCT4 is a nuclear transcription factor that is expressed in pluripotent embryonic germ cells. In this study, the author sought to determine the usefulness of OCT4 immunohistochemistry in the diagnosis of metastatic germ cell tumors...
  7. ncbi request reprint Loss of 14-3-3sigma in prostate cancer and its precursors
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Cancer Res 10:3064-8. 2004
    ..The role of 14-3-3sigma in prostatic carcinogenesis is uncertain...
  8. ncbi request reprint Allelic loss of the active X chromosome during bladder carcinogenesis
    Liang Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Arch Pathol Lab Med 128:187-90. 2004
    ..Previous studies have shown that loss of the X chromosome is involved in the carcinogenesis of certain human malignancies...
  9. ncbi request reprint Molecular genetic evidence for different clonal origin of components of human renal angiomyolipomas
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 25:1231-6. 2001
    ..The coexistence of tumor subclones with morphologic heterogeneity can lead to the formation of a clinically detectable tumor...
  10. ncbi request reprint Risk of prostate carcinoma death in patients with lymph node metastasis
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 91:66-73. 2001
    ..Results of published reports on survival among patients with lymph node metastasis are difficult to assess because of treatment selections. The extent to which lymph node status will have an impact on a patient's survival is uncertain...
  11. ncbi request reprint Preoperative prediction of surgical margin status in patients with prostate cancer treated by radical prostatectomy
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 18:2862-8. 2000
    ..We sought to determine the preoperative factors associated with surgical margin status in patients who underwent radical prostatectomy for prostate cancer...
  12. doi request reprint Lymphatic vessel density in radical prostatectomy specimens
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 39:610-5. 2008
    ..In contrast to other malignancies, quantitation of lymphangiogenesis in prostatic adenocarcinoma does not appear to offer useful prognostic information...
  13. ncbi request reprint Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis 46202, USA
    Cancer 101:957-62. 2004
    ..Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder...
  14. ncbi request reprint Androgen withdrawal inhibits tumor growth and is associated with decrease in angiogenesis and VEGF expression in androgen-independent CWR22Rv1 human prostate cancer model
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Anticancer Res 24:2135-40. 2004
    ..01) We conclude androgen withdrawal reduced both VEGF and microvessel density, and this was associated with decreased cellular proliferation in androgen-independent CWR22Rv1 human prostate cancer tumor in vivo...
  15. ncbi request reprint Interphase fluorescence in situ hybridization analysis of chromosome 12p abnormalities is useful for distinguishing epidermoid cysts of the testis from pure mature teratoma
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
    Clin Cancer Res 12:5668-72. 2006
    ..In this study, we investigated the clinical utility of interphase fluorescence in situ hybridization (FISH) analysis of chromosome 12p abnormalities for distinguishing epidermoid cysts of the testis from pure mature teratoma...
  16. ncbi request reprint Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    J Urol 174:2181-5. 2005
    ..We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy...
  17. ncbi request reprint Molecular genetic evidence supporting the neoplastic nature of stromal cells in 'fibrosis' after chemotherapy for testicular germ cell tumours
    L Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pathol 213:65-71. 2007
    ....
  18. ncbi request reprint Preoperative prediction of small volume cancer (less than 0.5 ml) in radical prostatectomy specimens
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Urol 174:898-902. 2005
    ..We examined various clinical parameters and prostate biopsy features to determine which variables are most predictive of small volume (less than 0.5 ml) cancer at prostatectomy...
  19. ncbi request reprint Anatomic distribution and pathologic characterization of small-volume prostate cancer (<0.5 ml) in whole-mount prostatectomy specimens
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:1022-6. 2005
    ..Small-volume prostate cancers are often multifocal and bilateral, with predilection for the peripheral zone. Of these small-volume cases, 16% had Gleason pattern 4 and might, therefore, be clinically significant...
  20. ncbi request reprint The combined percentage of Gleason patterns 4 and 5 is the best predictor of cancer progression after radical prostatectomy
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 N University Blvd, Indianapolis, IN 46202, USA
    J Clin Oncol 23:2911-7. 2005
    ..We evaluated the significance of the relative proportion of high-grade cancer (Gleason patterns 4 and/or 5) in predicting cancer progression in prostate cancer patients treated with radical prostatectomy...
  21. pmc Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, Indiana 46202, USA
    Am J Pathol 166:1533-9. 2005
    ..Concordant genetic alterations and X chromosome inactivation between small-cell carcinoma and coexisting urothelial carcinoma suggest that both tumor components originate from the same cells in the urothelium...
  22. ncbi request reprint OCT4: a novel biomarker for dysgerminoma of the ovary
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Am J Surg Pathol 28:1341-6. 2004
    ..OCT4 may aid in the detection of small foci of metastatic dygerminoma in extraovarian sites and may also help distinguish dysgerminoma from other primary and metastatic tumors of the ovary...
  23. ncbi request reprint Predicting the survival of bladder carcinoma patients treated with radical cystectomy
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 88:2326-32. 2000
    ..Clinical outcomes vary for patients treated with radical cystectomy. The authors sought to identify factors associated with the survival of patients treated with radical cystectomy for urothelial carcinoma of the urinary bladder...
  24. ncbi request reprint The cell cycle inhibitors p21WAF1 and p27KIP1 are associated with survival in patients treated by salvage prostatectomy after radiation therapy
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Cancer Res 6:1896-9. 2000
    ..06 and 0.01, respectively). These findings indicate that p21 and p27 expression levels are significant predictors of survival for patients selected for salvage prostatectomy for recurrent prostate cancer...
  25. ncbi request reprint Squamous papilloma of the urinary tract is unrelated to condyloma acuminata
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:1679-86. 2000
    ..To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma...
  26. ncbi request reprint Diagnosis of prostate cancer in needle biopsies after radiation therapy
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 23:1173-83. 1999
    ..Conversely, Gleason grade in postirradiation needle biopsy specimens appeared to provide useful predictive information and should be reported...
  27. ncbi request reprint Paraganglioma of the urinary bladder: can biologic potential be predicted?
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:844-52. 2000
    ..Paraganglioma of the urinary bladder is rarely encountered and its biologic behavior is uncertain. The authors sought to determine the prognostic factors that would predict patient outcome...
  28. ncbi request reprint Predicting cancer progression in patients with stage T1 bladder carcinoma
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Oncol 17:3182-7. 1999
    ..We sought to identify factors associated with cancer progression in a series of patients with stage T1 bladder carcinoma treated with a contemporary therapeutic approach...
  29. ncbi request reprint Natural history of urothelial dysplasia of the bladder
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 23:443-7. 1999
    ..The authors conclude that urothelial dysplasia is a significant risk for the development of CIS and invasive urothelial carcinoma, and patients with urothelial dysplasia should be followed up closely...
  30. ncbi request reprint Allelic imbalance in the clonal evolution of prostate carcinoma
    L Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 85:2017-22. 1999
    ..To understand better the genetic basis of the clonal evolution of prostate carcinoma, the authors analyzed the pattern of allelic loss in 25 matched primary and metastatic prostate tumors...
  31. ncbi request reprint Tumor size predicts the survival of patients with pathologic stage T2 bladder carcinoma: a critical evaluation of the depth of muscle invasion
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 85:2638-47. 1999
    ..Evidence has accumulated that cancers invading the superficial muscle wall (T2a) behave similarly to those invading the deep muscle wall (T2b). Quantitative analysis of the depth of invasion in relation to patient outcome is needed...
  32. ncbi request reprint Atypical nephrogenic metaplasia of the urinary tract: a precursor lesion?
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:853-61. 2000
    ..Nephrogenic metaplasia with cytologic atypia (atypical nephrogenic metaplasia) is occasionally encountered and its biologic potential is uncertain...
  33. ncbi request reprint Hemangioma of the urinary bladder
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 86:498-504. 1999
    ..Hemangioma of the urinary bladder is rare and the long term outcome of patients is unknown...
  34. ncbi request reprint Cell proliferation in prostate cancer patients with lymph node metastasis: a marker for progression
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Cancer Res 5:2820-3. 1999
    ..52 and 0.17, respectively). Our data indicate that assessment of cell proliferation in nodal metastasis is predictive of clinical outcome in prostate cancer patients with regional lymph node metastasis...
  35. ncbi request reprint Predictors of cancer progression in T1a prostate adenocarcinoma
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 85:1300-4. 1999
    ..In the current study the authors attempted to identify such predictors of cancer progression in a large series of untreated patients with lengthy follow-up...
  36. ncbi request reprint Cancer heterogeneity and its biologic implications in the grading of urothelial carcinoma
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:1663-70. 2000
    ..Urothelial carcinoma of the bladder often contains areas with different histologic grades. The influence of cancer heterogeneity on grading and its relation to patient outcome is uncertain...
  37. ncbi request reprint Extranodal extension in lymph node-positive prostate cancer
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Mod Pathol 13:113-8. 2000
    ..In contrast, nodal cancer volume was predictive of distant metastasis-free survival and cancer-specific survival...
  38. ncbi request reprint Conserved genetic findings in metastatic bladder cancer: a possible utility of allelic loss of chromosomes 9p21 and 17p13 in diagnosis
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Pathol Lab Med 125:1197-9. 2001
    ..Molecular analysis of microsatellite alterations of biologically distinct tumor cell subpopulations from the same patient may aid in the determination of tumor origin and further our understanding of the genetic basis of cancer progression...
  39. ncbi request reprint Histogenesis of sarcomatoid urothelial carcinoma of the urinary bladder: evidence for a common clonal origin with divergent differentiation
    M T Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA, and Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    J Pathol 211:420-30. 2007
    ..Divergent patterns of discordant allelic loss of microsatellite markers imply that heterogeneous pathogenetic pathways may exist in the evolution of this enigmatic neoplasm...
  40. pmc The influence of extent of surgical margin positivity on prostate specific antigen recurrence
    R E Emerson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
    J Clin Pathol 58:1028-32. 2005
    ..Positive surgical margins are an adverse prognostic factor in patients undergoing prostatectomy for prostate cancer. The extent of margin positivity varies and its influence on clinical outcome is uncertain...
  41. ncbi request reprint Diagnosis and grading of bladder cancer and associated lesions
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:493-507. 1999
    ..Uniformity of pathologic reporting should improve the comparability of different studies and therapies and provide more accurate information to urologists in managing patients...
  42. ncbi request reprint Molecular evidence for the independent origin of extra-ovarian papillary serous tumors of low malignant potential
    J Gu
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Natl Cancer Inst 93:1147-52. 2001
    ..The remaining six patients had random patterns of X-chromosome inactivation in the peritoneal and ovarian tumors. CONCLUSIONS: Our data suggest that peritoneal and ovarian tumors of low malignant potential arise independently...
  43. ncbi request reprint Dedifferentiation in the metastatic progression of prostate carcinoma
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 86:657-63. 1999
    ..Detailed histologic analysis of primary prostate carcinoma and synchronous lymph node metastases may improve our understanding of the complex process of cancer progression and metastasis...
  44. doi request reprint Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma
    Muhammad T Idrees
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 41:139-44. 2010
    ..The results indicated a clonal origin of the tumors, which supports that angiosarcoma, as well as the teratomas, arose from the testicular germ cell tumors...
  45. ncbi request reprint Nephroblastoma arising in a germ cell tumor of testicular origin
    Robert E Emerson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 28:687-92. 2004
    ..These data support a common clonal origin for nephroblastoma and the other germ cell tumor components...
  46. ncbi request reprint Substaging of T1 bladder carcinoma based on the depth of invasion as measured by micrometer: A new proposal
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 86:1035-43. 1999
    ..A significant number of T1 bladder carcinoma patients are understaged by transurethral resection of the bladder (TURB), indicating a substantial need for more accurate staging...
  47. ncbi request reprint Cytokeratin 7 and cytokeratin 20 in primary urinary bladder carcinoma and matched lymph node metastasis
    J Jiang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Ind. 46202, USA
    Arch Pathol Lab Med 125:921-3. 2001
    ..All cases showed positive CK7 immunoreactivity in the primary cancers and matched lymph node metastases. CONCLUSIONS:-CK20 immunoreactivity is reliably observed in metastases from bladder cancer when the primary tumor expresses CK20...
  48. pmc Overexpression of Pim-1 during progression of prostatic adenocarcinoma
    T L Cibull
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    J Clin Pathol 59:285-8. 2006
    ..In order to further our understanding of its role in prostate cancer, we investigated Pim-1 expression in normal, premalignant, and malignant prostate tissue...
  49. ncbi request reprint Prostate needle biopsies: multiple variables are predictive of final tumor volume in radical prostatectomy specimens
    Chistopher K Poulos
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 101:527-32. 2004
    ..The current study attempted to identify the biopsy variables that are most predictive of final tumor volume...
  50. ncbi request reprint Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasms
    K A Iczkowski
    Department of Pathology and Laboratory Medicine, University of Florida and Veterans Administration Medical Center, Gainesville, Florida 32608 1197, USA
    Mod Pathol 14:1043-51. 2001
    ..In conclusion, inflammatory pseudotumor, although overlapping with sarcoma in presentation, age range, and size, does not metastasize and remains histologically distinct from low-grade sarcoma...
  51. doi request reprint Evidence for common clonal origin of multifocal lung cancers
    Xiaoyan Wang
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 101:560-70. 2009
    ..Lung cancer is the most common cause of cancer death in the United States. Multiple anatomically separate but histologically similar lung tumors are often found in the same patient. The clonal origin of multiple lung tumors is uncertain...
  52. ncbi request reprint Radial distance of extraprostatic extension measured by ocular micrometer is an independent predictor of prostate-specific antigen recurrence: A new proposal for the substaging of pT3a prostate cancer
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Surg Pathol 31:311-8. 2007
    ..The strength of its prognostic value for PSA recurrence makes it a potential criterion for incorporation into a future tumor, lymph node, metastasis staging system...
  53. ncbi request reprint Predicting cancer progression in patients with penile squamous cell carcinoma: the importance of depth of invasion and vascular invasion
    R E Emerson
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mod Pathol 14:963-8. 2001
    ..We conclude that depth of invasion and vascular invasion are significant predictors of cancer progression for penile squamous cell carcinoma...
  54. ncbi request reprint Papillary urothelial neoplasms of low malignant potential. Clinical and biologic implications
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 86:2102-8. 1999
    ..Knowledge of the long term outcomes of patients with papillary urothelial neoplasms of low malignant potential (LMP) is limited...
  55. ncbi request reprint Urothelial papilloma of the bladder. Clinical and biologic implications
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 86:2098-101. 1999
    ..An international consensus has been reached regarding diagnostic criteria for papilloma of the urinary bladder. However, the incidences of recurrence and progression in patients with urothelial papilloma are uncertain...
  56. ncbi request reprint The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens
    Rebecca A Marks
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 38:1207-11. 2007
    ....
  57. ncbi request reprint Maximum tumor diameter is an independent predictor of prostate-specific antigen recurrence in prostate cancer
    Lori E Eichelberger
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:886-90. 2005
    ..13-2.56, P=0.01), controlling for risk factors, Gleason score, and surgical margin status. We conclude that maximum tumor diameter is a significant predictor of biochemical recurrence in patients with prostate cancer...
  58. ncbi request reprint OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 28:935-40. 2004
    ..OCT4 immunostaining has comparable sensitivity but greater consistency compared with CD30 in the diagnosis of embryonal carcinoma...
  59. ncbi request reprint The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disorders
    Pin Pen Hsieh
    Department of Pathology and Laboratory Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mod Pathol 20:929-35. 2007
    ..Also, dysregulation of downstream pathways such as Bcl-xL may be important to CMPD disease pathogenesis in the spleen...
  60. doi request reprint Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 41:716-23. 2010
    ..Chromosome 12p fluorescence in situ hybridization combined with OCT4, CD30, and glypican 3 immunostains is useful in confirming the diagnosis of ovarian embryonal carcinoma...
  61. ncbi request reprint Molecular evidence supporting the neoplastic nature of odontogenic keratocyst: a laser capture microdissection study of 15 cases
    J Henley
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
    Histopathology 47:582-6. 2005
    ..Genetic alterations of OKC have not been well studied. We examined the frequency and pattern of allelic imbalance on five different chromosome regions from 15 patients with OKC...
  62. doi request reprint Outcome analysis of patients with transformed teratoma to primitive neuroectodermal tumor
    Y Ehrlich
    Department of Urology, Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA
    Ann Oncol 21:1846-50. 2010
    ..The emergence of a primitive neuroectodermal tumor (PNET) within a germ-cell tumor (GCT) is rare. We assess the prognosis and response to treatment...
  63. pmc The presence of benign prostatic glandular tissue at surgical margins does not predict PSA recurrence
    K M Kernek
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, University Hospital 3465, 550 North University Blvd, Indianapolis, IN 46202, USA
    J Clin Pathol 58:725-8. 2005
    ..Serum prostate specific antigen (PSA) increases after radical prostatectomy are thought to indicate recurrent disease, although some suggest they result from benign prostatic epithelial tissue left at surgical margins...
  64. ncbi request reprint Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?
    Nicole R Howell
    Department of Pathology, Stony Brook University Hospital, New York, NY, USA
    Int J Gynecol Pathol 26:134-40. 2007
    ..Our results suggest that an immunohistochemical panel consisting of TTF-1, CEA, CA-125, and OCT-4 is helpful in distinguishing most pulmonary and ovarian carcinomas with clear cell features...
  65. ncbi request reprint Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1029-37. 2007
    ....
  66. ncbi request reprint OCT4 is superior to CD30 in the diagnosis of metastatic embryonal carcinomas after chemotherapy
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 37:662-7. 2006
    ..OCT4 is a useful diagnostic marker to identify metastatic embryonal carcinomas after chemotherapy, with a better sensitivity than CD30...
  67. ncbi request reprint Visual estimation of tumour extent is not an independent predictor of prostate specific antigen recurrence
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BJU Int 96:1253-7. 2005
    ....
  68. pmc Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate
    Ryan P McCarthy
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Blvd, Indianapolis, IN 46202, USA
    Am J Pathol 165:1395-400. 2004
    ..While both epithelium and stroma are clonal proliferations, they appear to have different clonal origins...
  69. ncbi request reprint Down-regulation of fragile histidine triad expression in prostate carcinoma
    Rebecca L Fouts
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 97:1447-52. 2003
    ..Numerous studies have indicated that the FHIT gene on chromosome 3p may play an important role in human neoplasia, although very few studies have investigated the FHIT gene in prostate carcinoma...
  70. ncbi request reprint OCT4: A sensitive and specific biomarker for intratubular germ cell neoplasia of the testis
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin Cancer Res 10:8544-7. 2004
    ..The present study aimed to establish OCT4 as a sensitive and specific maker for IGCNU, a putative precursor for adult germ cell tumors...
  71. doi request reprint Does the size matter?: Prostate weight does not predict PSA recurrence after radical prostatectomy
    Darrell D Davidson
    Dept of Pathology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Am J Clin Pathol 133:662-8. 2010
    ..Although increasing prostate weight correlates with increased patient age and higher preoperative PSA level, it does not independently predict postoperative cancer recurrence...
  72. ncbi request reprint Steam heat with an EDTA buffer and protease digestion optimizes immunohistochemical expression of basal cell-specific antikeratin 34betaE12 to discriminate cancer in prostatic epithelium
    K A Iczkowski
    Department of Pathology, Mayo Clinic Rochester, Minnesota 55905, USA
    Mod Pathol 12:1-4. 1999
    ..This helps to prevent misinterpretation of histologic mimics of cancer, such as atrophic acini and high-grade prostatic intraepithelial neoplasia, that result from false-negative staining...
  73. ncbi request reprint Treatment changes in prostatic hyperplasia and cancer, including androgen deprivation therapy and radiotherapy
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:465-79. 1999
    ..Pathologists must be aware of these distinct changes because of the reliance placed on nuclear and nucleolar size in the identification of prostate cancer, particularly in small specimens and lymph node metastases...
  74. ncbi request reprint Invasion of fat justifies assignment of stage pT3a in prostatic adenocarcinoma
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Pathology 38:309-11. 2006
    ....
  75. ncbi request reprint Is prostate-specific antigen (PSA) density better than the preoperative PSA level in predicting early biochemical recurrence of prostate cancer after radical prostatectomy?
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    BJU Int 97:480-4. 2006
    ....
  76. ncbi request reprint Adrenal myelolipomas show nonrandom X-chromosome inactivation in hematopoietic elements and fat: support for a clonal origin of myelolipomas
    Elena Bishop
    Department of Pathology and Laboratory Medicine, Division of Hematopathology, 702 Barnhill Drive, Riley 0969, Indianapolis, IN 46202, USA
    Am J Surg Pathol 30:838-43. 2006
    ..Myelolipomas are morphologically different from the normal bone marrow. The majority of myelolipomas also have nonrandom X-chromosome inactivation, suggesting a clonal origin for these tumors...
  77. ncbi request reprint PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma
    Chong Xian Pan
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 10:1333-7. 2004
    ..It is a novel growth factor that stimulates cell proliferation, confers epithelial tumorigenesis, and promotes tumor invasion. Here we investigate the potential of PCDGF as a therapeutic target for prostate cancer...
  78. ncbi request reprint Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model
    Rajasubramaniam Shanmugam
    Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Prostate 66:1498-511. 2006
    ..Nuclear Factor kappa B (NFkappaB) is a eukaryotic transcription factor that is constitutively active in human cancers and can be inhibited by the naturally occurring sesquiterpene lactone, parthenolide (P)...
  79. ncbi request reprint Elevated expression of angiogenin in prostate cancer and its precursors
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 11:8358-63. 2005
    ..In this study, we have investigated the expression of angiogenin in prostatic adenocarcinoma, high-grade prostatic intraepithelial neoplasia, and adjacent benign prostatic epithelium in a large cohort of prostatectomy specimens...
  80. ncbi request reprint Clonal origin of metastatic testicular teratomas
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, and Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Clin Cancer Res 12:5377-83. 2006
    ..Neither the genetic relationships among the different components in metastatic lesions nor the relationships between primary and metastatic GCT components have been elucidated...
  81. ncbi request reprint Preoperative prediction of Gleason grade in radical prostatectomy specimens: the influence of different Gleason grades from multiple positive biopsy sites
    Chistopher K Poulos
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:228-34. 2005
    ..We recommend that the highest Gleason score from all positive biopsy sites should be used when assigning an initial score using needle biopsies...
  82. doi request reprint Sarcomatoid carcinoma of the upper urinary tract: clinical outcome and molecular characterization
    Xiaoyan Wang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 40:211-7. 2009
    ..Gains of chromosome 3, 7, and 17 and loss of chromosome 9p21 were commonly observed in these tumors. Our findings suggest that targeted therapy may be a rational strategy in the management of these patients...
  83. ncbi request reprint Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 702 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 7:824-30. 2001
    ..Given these results, we conclude that Ape1/ref-1 may be a diagnostic marker for early prostate cancer and play a role, through its repair, redox, or both functions, in the physiology of the early development of prostate cancer...
  84. ncbi request reprint Neurofibroma of the urinary bladder
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis, USA
    Cancer 86:505-13. 1999
    ..Neurofibroma of the urinary bladder is rare. Only isolated case reports have appeared. Information regarding the long term follow-up of patients with neurofibroma is limited...
  85. ncbi request reprint Does the presence of extranodal extension in pathological stage B1 nonseminomatous germ cell tumor necessitate adjuvant chemotherapy?
    Stephen D W Beck
    Department of Urology, Indiana University, Indianapolis, Indiana 46202, USA
    J Urol 177:944-6. 2007
    ..We decided to evaluate the significance of extranodal extension on disease-free survival in patients with pathological stage B nonseminomatous germ cell tumor who did not receive adjuvant chemotherapy...
  86. ncbi request reprint Expression of KISS1 and MMP-9 in non-small cell lung cancer and their relations to metastasis and survival
    Suqin Zheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
    Anticancer Res 30:713-8. 2010
    ..4.7%, p<0.05). Our data suggest that KISS1 and MMP-9 may serve as potential prognostic and therapeutic markers in lung cancer...
  87. ncbi request reprint Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry, and morphologic analysis
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1861-7. 2007
    ..Morphologic features, as well as immunohistochemical stains (including stains for Ki-67, p53, and cytokeratin 20) and/or UroVysion FISH can help to distinguish inverted papilloma from urothelial carcinoma with an inverted growth pattern...
  88. doi request reprint Apparent surgical cure for metastatic small cell lung cancer
    Mukta Pant-Purohit
    Indiana University School of Medicine, Indianapolis, Inidana, USA
    J Thorac Oncol 3:682-3. 2008
  89. ncbi request reprint Anti-LOX-1 therapy in rats with diabetes and dyslipidemia: ablation of renal vascular and epithelial manifestations
    Jesus H Dominguez
    Department of Medicine, Indiana University School of Medicine and Indianapolis Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 294:F110-9. 2008
    ..Our study indicates that anti-LOX-1 (vascular and epithelial) therapy may effectively reverse critical pathogenic elements of nephropathy in diabetes and dyslipidemia...
  90. ncbi request reprint Phase I/II trial of high intensity focused ultrasound for the treatment of previously untreated localized prostate cancer
    Michael O Koch
    Department of Urology, Indiana University School of Medicine and Focus Surgery, Inc, Indianapolis, Indiana 46202, USA
    J Urol 178:2366-70; discussion 2370-1. 2007
    ..We examined the safety and potential efficacy of transrectally delivered high intensity focused ultrasound for the full gland ablation of previously untreated localized prostate cancer...
  91. ncbi request reprint Molecular genetic evidence supporting the neoplastic nature of the Leydig cell component of ovarian Sertoli-Leydig cell tumors
    Robert E Emerson
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Int J Gynecol Pathol 26:368-74. 2007
    ..Similarly, the heterologous components, when present, appear to share clonal origin with the Sertoli cell components...
  92. pmc Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma
    Jiazhong Jiang
    Department of Pathology, Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 160:667-71. 2002
    ..Our data are consistent with the contention that group IIA sPLA2 expression is elevated in neoplastic prostatic tissue and support the hypothesis that dysregulation of sPLA2 may play a role in prostatic carcinogenesis...
  93. ncbi request reprint Endometrial glandular dysplasia: a putative precursor lesion of uterine papillary serous carcinoma. Part II: molecular features
    Sharon X Liang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Int J Surg Pathol 12:319-31. 2004
    ..The clinical significance of EmGD needs further studies...
  94. ncbi request reprint Analysis of loss of heterozygosity and X chromosome inactivation in spleens with myeloproliferative disorders and acute myeloid leukemia
    Dennis P O'Malley
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:1562-8. 2005
    ..Comparison of spleen and bone marrow specimens by LOH demonstrated additional abnormalities in the spleen compared to the marrow...
  95. ncbi request reprint Clonal origin of lymph node metastases in bladder carcinoma
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 104:1901-10. 2005
    ..Molecular analysis of microsatellite alterations and X-chromosome inactivation status of distinct tumor cell populations from the same patient may further our understanding of the genetic basis of carcinoma progression and metastasis...
  96. ncbi request reprint Molecular genetic evidence for the independent origin of multifocal papillary tumors in patients with papillary renal cell carcinomas
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 11:7226-33. 2005
    ..Molecular analysis of microsatellite and chromosome alterations and X-chromosome inactivation status in separate tumors in the same patient can be used to study the genetic relationships among the coexisting multiple tumors...
  97. ncbi request reprint Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate
    Rebecca Arora
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 100:2362-6. 2004
    ..The current study was undertaken to compare the Gleason grades of individual adenocarcinoma foci in a given specimen with the overall Gleason grades (primary and secondary) of that specimen...
  98. ncbi request reprint Evaluation of HER-2/neu expression in prostatic adenocarcinoma: a requested for a standardized, organ specific methodology
    Katya M Sanchez
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 95:1650-5. 2002
    ..Some evidence suggests a role for HER-2/neu overexpression in prostate carcinoma progression. Reported rates of HER-2/neu overexpression in patients with prostate carcinoma vary greatly...
  99. ncbi request reprint Evaluation of hydrogel tissue sealant in porcine laparoscopic partial-nephrectomy model
    Jonathan E Bernie
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Endourol 19:1122-6. 2005
    ....
  100. ncbi request reprint Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors
    Kevin M Kernek
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 17:1309-13. 2004
    ....
  101. ncbi request reprint Tertiary Gleason pattern 5 is a powerful predictor of biochemical relapse in patients with Gleason score 7 prostatic adenocarcinoma
    Eyas M Hattab
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 175:1695-9; discussion 1699. 2006
    ..In this study we examined the differences in clinical outcome between primary Gleason grade 3 and 4 tumors in patients who underwent radical prostatectomy, and determined the influence of tertiary Gleason pattern 5 on patient outcome...