Neal X Chen
Affiliation: Indiana University
Chen N, Moe S. Vascular calcification: pathophysiology and risk factors. Curr Hypertens Rep. 2012;14:228-37 pubmed publisher
Chen N, O Neill K, Chen X, Moe S. Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells. J Bone Miner Res. 2008;23:1798-805 pubmed publisher
..In conclusion, our results suggest that mineralization in VSMCs requires both active MVs and an interaction of the MVs with type I collagen, and both steps require annexin activity. ..
Chen N, Chen X, O Neill K, Atkinson S, Moe S. RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC). Am J Physiol Renal Physiol. 2010;299:F674-80 pubmed publisher
..These results demonstrate that the RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification. ..
Chen N, Moe S, Eggleston Gulyas T, Chen X, Hoffmeyer W, Bacallao R, et al
. Calcimimetics inhibit renal pathology in rodent nephronophthisis. Kidney Int. 2011;80:612-9 pubmed publisher
..Thus, treating pcy mice with R-568 was effective in reducing cyst progression in this rodent model of NPHP. Direct studies will be needed to determine whether these results can be applied to the human disease. ..
Chen N, O Neill K, Chen X, Kiattisunthorn K, Gattone V, Moe S. Transglutaminase 2 accelerates vascular calcification in chronic kidney disease. Am J Nephrol. 2013;37:191-8 pubmed publisher
..These data demonstrate a role of TGM2 in the pathogenesis of vascular calcification in CKD through enhancement of MV-ECM calcification. ..
Chen N, Kircelli F, O Neill K, Chen X, Moe S. Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells. Kidney Int. 2010;77:436-42 pubmed publisher