N Chalasani

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals
    Howard C Masuoka
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann N Y Acad Sci 1281:106-22. 2013
  2. pmc Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series
    Naga Chalasani
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4100, Indianapolis, IN 46202, USA
    Ann Intern Med 156:857-60, W297-300. 2012
  3. ncbi request reprint Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study
    N Chalasani
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 31:7-11. 2000
  4. pmc Risk factors for idiosyncratic drug-induced liver injury
    Naga Chalasani
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 138:2246-59. 2010
  5. pmc Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease
    Naga Chalasani
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 139:1567-76, 1576.e1-6. 2010
  6. ncbi request reprint Peginterferon alfa-2a for hepatitis C after liver transplantation: two randomized, controlled trials
    Naga Chalasani
    Indiana University Medical Center, Indianapolis, USA
    Hepatology 41:289-98. 2005
  7. ncbi request reprint Statins and hepatotoxicity: focus on patients with fatty liver
    Naga Chalasani
    Indiana University School of Medicine, Indianopolis, IN 46202, USA
    Hepatology 41:690-5. 2005
  8. ncbi request reprint Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
    Naga Chalasani
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 37:544-50. 2003
  9. pmc Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 135:1924-34, 1934.e1-4. 2008
  10. pmc Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008

Research Grants

Detail Information

Publications73

  1. pmc Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals
    Howard C Masuoka
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann N Y Acad Sci 1281:106-22. 2013
    ..A number of pharmacologic therapies have been investigated to treat NASH, and agents such as vitamin E and thiazolidinediones have shown promise in select patient subgroups...
  2. pmc Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series
    Naga Chalasani
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4100, Indianapolis, IN 46202, USA
    Ann Intern Med 156:857-60, W297-300. 2012
    ..It is a proprietary blend of 2 flavonoids, baicalin and catechins, which are derived from the botanicals Scutellaria baicalensis and Acacia catechu, respectively...
  3. ncbi request reprint Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study
    N Chalasani
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 31:7-11. 2000
    ..The indices of severity of liver disease were not associated with CCA in patients with PSC. Serum CA 19-9 appeared to have good ability to discriminate PSC patients with and without CCA...
  4. pmc Risk factors for idiosyncratic drug-induced liver injury
    Naga Chalasani
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 138:2246-59. 2010
    ..Nonetheless, DILI is challenging to investigate because of its rarity, the lack of experimental models, the number of medications that might cause it, and challenges to diagnosis...
  5. pmc Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease
    Naga Chalasani
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 139:1567-76, 1576.e1-6. 2010
    ..We conducted a pilot GWAS in patients with NAFLD, characterized by histology, who were enrolled in the NASH Clinical Research Network (CRN) Database Study...
  6. ncbi request reprint Peginterferon alfa-2a for hepatitis C after liver transplantation: two randomized, controlled trials
    Naga Chalasani
    Indiana University Medical Center, Indianapolis, USA
    Hepatology 41:289-98. 2005
    ..Randomized controlled studies are needed to establish the efficacy of pegylated interferon and ribavirin in patients who have undergone OLT...
  7. ncbi request reprint Statins and hepatotoxicity: focus on patients with fatty liver
    Naga Chalasani
    Indiana University School of Medicine, Indianopolis, IN 46202, USA
    Hepatology 41:690-5. 2005
  8. ncbi request reprint Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
    Naga Chalasani
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 37:544-50. 2003
    ..The significant correlations noted between CYP2E1 and hypoxemia and beta-OH butyrate suggest that these factors play a role in increased CYP2E1 activity that is seen in patients with NASH...
  9. pmc Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 135:1924-34, 1934.e1-4. 2008
    ..This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled...
  10. pmc Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008
    ..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
  11. pmc Are there ethnicity-based differences in the evaluation of individuals with abnormal liver biochemistries?
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, USA
    J Hepatol 47:123-7. 2007
    ..This study examined if there is an ethnicity-based difference in obtaining liver biochemistries or evaluating abnormal liver biochemistries by primary care physicians...
  12. ncbi request reprint Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, WD OPW 2005, 1001 West 10th Street, Indianapolis, IN 46202, USA
    Gastroenterology 126:1287-92. 2004
    ..We conducted a study to test the hypothesis that patients with elevated baseline liver enzymes have higher risk of statin hepatotoxicity...
  13. pmc The effects of midodrine on the natriuretic response to furosemide in cirrhotics with ascites
    V L Misra
    Indiana University School of Medicine, Indianapolis, USA
    Aliment Pharmacol Ther 32:1044-50. 2010
    ..Diminished glomerular filtration rate (GFR) is thought to mediate resistance to loop diuretics. Midodrine, a commonly used alpha-1 agonist, has been shown to improve GFR in non-azotemic patients with cirrhosis...
  14. ncbi request reprint Management of hepatitis C infection after liver transplantation
    Mazen Alsatie
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Drugs 67:871-85. 2007
    ..Determination of optimal doses of both pegylated interferon and ribavirin, and guidance on when to stop treatment, as well as improving tolerability are important steps in achieving higher response rates and minimising drug toxicity...
  15. ncbi request reprint Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts
    N Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hepatology 34:1103-8. 2001
    ..42+/-0.15). As expected, hepatic CYP3A activity was reduced in cirrhosis. However, in cirrhotic patients with TIPS, there was a marked loss in first-pass metabolism of midazolam as a result of diminished intestinal CYP3A activity...
  16. ncbi request reprint Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III)
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Sci 329:111-6. 2005
    ..In this study, we examined the relationship between unexplained elevations in ALT level and the metabolic syndrome and the relationship between unexplained elevations in ALT level and microalbuminuria...
  17. ncbi request reprint Predictors of outcome in patients with unresectable hepatocellular carcinoma receiving transcatheter arterial chemoembolization
    H Shen
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Aliment Pharmacol Ther 26:393-400. 2007
    ..Transcatheter arterial chemoembolization (TACE) has been shown to improve survival in patients with unresectable hepatocellular carcinoma (HCC)...
  18. pmc Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease
    Michael Charlton
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hepatology 47:484-92. 2008
    ..The association between DHEA-S and severity of NAFLD persisted after adjusting for age. A relationship between disease/fibrosis severity and DHEA-S levels was not seen in patients with cholestatic liver diseases...
  19. ncbi request reprint Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity
    Dhanashri Kolwankar
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Gastroenterol Hepatol 5:388-93. 2007
    ..There is significant interindividual variability in CYP3A expression. However, human studies that systematically examined the relationship between hepatic steatosis and hepatic CYP3A activity are lacking...
  20. ncbi request reprint Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics
    Suthat Liangpunsakul
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 41:1144-50. 2005
    ..Lymphocyte CYP2E1 and CYP3A4 mRNA levels did not correlate with CYP2E1 and CYP3A activities...
  21. pmc Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    Raj Vuppalanchi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 49:306-17. 2009
    ..Conclusion: Health care providers should not only focus on liver disease but also concentrate on aggressively modifying and treating their cardiovascular risk factors...
  22. ncbi request reprint Relationship between unexplained elevations in alanine aminotransferase and serum leptin in U.S. adults: results from the Third National Health and Nutrition Examination Survey (NHANES III)
    Suthat Liangpunsakul
    Divisions of Gastroenterology Hepatology and Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Gastroenterol 38:891-7. 2004
    ..We conducted a case-control study to evaluate the relationship between unexplained elevations in ALT and serum leptin in NHANES III participants...
  23. ncbi request reprint Increase in hepatic arterial blood flow after transjugular intrahepatic portosystemic shunt creation and its potential predictive value of postprocedural encephalopathy and mortality
    N H Patel
    Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Vasc Interv Radiol 12:1279-84. 2001
    ....
  24. ncbi request reprint Impact of endoscopic therapy on the survival of patients with primary sclerosing cholangitis
    A R Baluyut
    Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastrointest Endosc 53:308-12. 2001
    ..65%, respectively; p = 0.027). CONCLUSION: These data suggest that repeated endoscopic attempts to maintain biliary patency may improve the survival of patients with PSC and dominant strictures...
  25. ncbi request reprint Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 99:1497-502. 2004
    ..Therefore, we conducted a study to measure the circulating levels of lipid peroxidation products and their metabolic and nutritional correlates in patients with NASH and controls...
  26. ncbi request reprint Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 10:404-7. 2004
    ..RATG induction therapy is associated with good patient and graft survival, a low incidence of rejection, and minimal side effects. In addition, RATG induction is safe in patients transplanted for HCV...
  27. pmc Epidemiology of idiosyncratic drug-induced liver injury
    Lauren N Bell
    Divisions of Gastroenterology Hepatology and Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Semin Liver Dis 29:337-47. 2009
    ..In this article, the epidemiology of DILI, both in the general population and in potentially high-risk subgroups, is reviewed...
  28. ncbi request reprint Initial experience with EUS-guided Tru-cut biopsy of benign liver disease
    John DeWitt
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana, USA
    Gastrointest Endosc 69:535-42. 2009
    ..Histologic biopsy of the liver is often essential for diagnosing hepatic parenchymal disease. Tissue acquisition is traditionally obtained by a surgical, transvascular, or percutaneous route...
  29. doi request reprint Deep vein thrombosis and pulmonary embolism in cirrhosis patients
    David Gulley
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Dig Dis Sci 53:3012-7. 2008
    ..However, to date, no studies have been carried out that objectively address this issue. We conducted a study to examine the relationship between cirrhosis and DVT/PE events...
  30. doi request reprint The impact of videorecording on the quality of colonoscopy performance: a pilot study
    Douglas K Rex
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Gastroenterol 105:2312-7. 2010
    ..Colonoscopy provides imperfect protection against colorectal cancer and is operator dependent. Colonoscopies typically are poorly documented. We aimed to determine whether videorecording impacts short-term performance of colonoscopy...
  31. pmc Serum proteomic profiling in patients with drug-induced liver injury
    L N Bell
    Division of Gastroenterology Hepatology, Indiana University, Indianapolis, USA
    Aliment Pharmacol Ther 35:600-12. 2012
    ..Idiosyncratic drug-induced liver injury (DILI) is a complex disorder that is difficult to predict, diagnose and treat...
  32. ncbi request reprint Effects of albumin/furosemide mixtures on responses to furosemide in hypoalbuminemic patients
    N Chalasani
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5114, USA
    J Am Soc Nephrol 12:1010-6. 2001
    ..Therefore, the coadministration of albumin and furosemide for the treatment of cirrhosis, and likely other hypoalbuminemic conditions, should not be used clinically...
  33. ncbi request reprint Effect of rosiglitazone on serum liver biochemistries in diabetic patients with normal and elevated baseline liver enzymes
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine The Regenstrief Institute for Health Care, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 100:1317-21. 2005
    ..We conducted a study to test if diabetics with elevated liver enzymes have increased risk for hepatotoxicity from rosiglitazone (only TZD available on our formulary)...
  34. ncbi request reprint Langerhans' cell histiocytosis involving the pituitary, thyroid, lung, and liver
    Sujatha Sampathkumar
    Division of Endocrinology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocr Pract 8:217-21. 2002
    ..To report the development, in an adult patient, of Langerhans' cell histiocytosis (LCH) involving the thyroid and most probably the pituitary gland, lungs, and liver...
  35. ncbi request reprint Nonalcoholic fatty liver disease in individuals with severe obesity
    Paul Haynes
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Liver Dis 8:535-47, viii. 2004
    ..This article discusses the prevalence, histologic spectrum, and natural history of NAFLD in subjects with severe obesity as well as the hepatic effects of drastic weight loss induced by bariatric surgery or severe calorie restriction...
  36. doi request reprint Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals
    Craig Lammert
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Hepatology 47:2003-9. 2008
    ..4%, and 13.2% in < or =10, 11-49, and > or =50 mg/day groups, respectively, P = 0.03)...
  37. ncbi request reprint Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States?
    Raj Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 102:558-62; quiz 693. 2007
    ..We conducted a study of adults with new-onset jaundice at a nonreferral community hospital to better understand the epidemiology of acute DILI...
  38. ncbi request reprint Relationship between hepatitis C and microalbuminuria: results from the NHANES III
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:285-90. 2005
    ..Microalbuminuria is common in patients with diabetes and metabolic syndrome; however, no studies have examined the relationship between microalbuminuria and hepatitis C infection...
  39. pmc Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network
    R Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Aliment Pharmacol Ther 32:1174-83. 2010
    ..Case reports suggest that duloxetine hepatotoxicity may arise, but risk factors, presenting features and clinical course are not well-described...
  40. ncbi request reprint Positron emission tomography for detecting occult hepatocellular carcinoma in hepatitis C cirrhotics awaiting for liver transplantation
    S Liangpunsakul
    Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, IN 46202, USA
    Transplant Proc 35:2995-7. 2003
    ..Additionally, these data suggest that some hepatitis C cirrhotics with persistently elevated AFP but no detectable lesions by conventional CT scan may show occult HCC using lipiodol-enhanced CT scans...
  41. ncbi request reprint Use of insulin sensitizers in NASH
    Mouen Khashab
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, WD OPW 2005, 1001 West 10th Street, Indianapolis, IN 46202, USA
    Endocrinol Metab Clin North Am 36:1067-87; xi. 2007
    ..It then presents a detailed discussion on the efficacy and safety of different insulin sensitizers in patients who have NASH...
  42. pmc Effects of liver biopsy sample length and number of readings on sampling variability in nonalcoholic Fatty liver disease
    Raj Vuppalanchi
    Indiana University School of Medicine, Indianapolis, Indiana 46202 2859, USA
    Clin Gastroenterol Hepatol 7:481-6. 2009
    ..Using percutaneous liver biopsy samples from patients with suspected NAFLD, we examined the relationship between histological yield and length of biopsies, number of cores and number of independent readings...
  43. pmc Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease
    Lauren N Bell
    Division of Clinical Pharmacology, Indiana University, Indianapolis, IN, USA
    Hepatology 51:111-20. 2010
    ..Future validation of these potential biomarkers is needed such that these proteins may be used in place of liver biopsy to facilitate diagnosis and treatment of patients with NAFLD...
  44. pmc Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content
    Lauren N Bell
    Division of Clinical Pharmacology, Indiana University, Indianapolis, IN 46202, USA
    Ann Surg 251:1041-8. 2010
    ..To evaluate the effects of surgical weight loss on hepatic lipid peroxidation levels and cytochrome P-450 protein expression in patients with nonalcoholic fatty liver disease (NAFLD)...
  45. ncbi request reprint Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes
    Raj Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Med Sci 329:62-5. 2005
    ..Our study tested the hypothesis that patients with elevated liver enzymes are not at higher risk for hepatotoxicity from lovastatin...
  46. ncbi request reprint Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis
    William R Kessler
    Department of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Clin Gastroenterol Hepatol 2:625-31. 2004
    ..The aim of this study was to compare clinical, biochemical, and histological features in patients with autoimmune hepatitis presenting with either acute or chronic hepatitis...
  47. ncbi request reprint Effect of cirrhosis and liver transplantation on the gender difference in QT interval
    Adegboyega Q Adigun
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Cardiol 95:691-4. 2005
    ..The study showed that (1) physiologic gender difference in the QTc interval is abolished in cirrhosis, and it is not restored after liver transplantation, and (2) gender hormone concentrations had no effect on the QTc interval...
  48. ncbi request reprint Combination therapy with lamivudine and famciclovir for chronic hepatitis B infection
    Hong Shen
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Clin Gastroenterol Hepatol 2:330-6. 2004
    ..In vitro data suggest that lamivudine and famciclovir might synergistically inhibit hepadnaviral replication. We reviewed our experience with lamivudine and famciclovir in 24 patients with chronic hepatitis B infection...
  49. ncbi request reprint Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis?
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, WD OPW 2005, 1001 West 10th Street, Indianapolis, IN 46202, USA
    Am J Gastroenterol 98:2771-6. 2003
    ..It has been suggested that leptin plays a role in the pathogenesis of NASH; however, adequate studies are lacking. We therefore conducted a study to explore the role of serum leptin in the pathogenesis of human NASH...
  50. ncbi request reprint Improved patient survival after acute variceal bleeding: a multicenter, cohort study
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 98:653-9. 2003
    ..Therefore, a retrospective, multicenter study was conducted to define the outcomes of variceal bleeding and to describe the patterns of current practice in the management of variceal bleeding...
  51. ncbi request reprint Predictors and implications of severe hypersplenism in patients with cirrhosis
    Suthat Liangpunsakul
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Med Sci 326:111-6. 2003
    ..Additionally, the implications of severe hypersplenism are unknown. Therefore, we conducted a study to evaluate the predictors and implications of severe hypersplenism in patients with cirrhosis...
  52. ncbi request reprint Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples
    Raj Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Gastroenterol 41:206-10. 2007
    ..Therefore, we examined the relationship between hepatic triglyceride (TG) content and nonbiochemical assessment of steatosis in 38 human liver samples...
  53. pmc Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein
    A G Pinto
    Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Wishard Memorial Hospital, Indianapolis, Indiana, USA
    Br J Clin Pharmacol 59:440-6. 2005
    ..To determine the effect of diltiazem on intestinal CYP3A activity and protein and mRNA expression in vivo in healthy subjects...
  54. ncbi request reprint A meta-analysis of endoscopic variceal ligation for primary prophylaxis of esophageal variceal bleeding
    T F Imperiale
    Divisions of General Internal Medicine and Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, the Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA
    Hepatology 33:802-7. 2001
    ..Subsequent research should further compare ligation and beta-blockers to determine the effect on mortality, and measure ligation's cost-effectiveness...
  55. ncbi request reprint Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study
    Raj Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, IN 46202, USA
    J Clin Gastroenterol 39:237-42. 2005
    ..Studies are limited that evaluated the role of adiponectin in the pathogenesis of nonalcoholic steatohepatitis (NASH)...
  56. ncbi request reprint Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression
    Amar G Pinto
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Pharmacol Ther 77:178-88. 2005
    ..This study was designed to identify determinants of variability in the extent of intestinal wall CYP3A inhibition by clarithromycin, such as CYP3A5 genotype, and the mechanism of inhibition...
  57. pmc Lipid-lowering agents that cause drug-induced hepatotoxicity
    Sidharth S Bhardwaj
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1001 West 10th Street, WD OPW 2005, Indianapolis, IN 46202, USA
    Clin Liver Dis 11:597-613, vii. 2007
    ..Several recent studies and expert opinion currently fully endorse statin use in patients who have nonalcoholic fatty liver disease and other chronic liver disease if clinically indicated...
  58. ncbi request reprint Metabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatohepatitis
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 98:1849-55. 2003
    ..We conducted a study to characterize the metabolic response to a mixed meal in nondiabetic patients with NASH (NDN) and to identify anthropometric determinants of insulin resistance in these patients...
  59. ncbi request reprint Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study
    Naga Chalasani
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, 1481 West 10th Street, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 91:2279-85. 2006
    ..Insulin resistance is associated with alterations in proteins involved in lipid metabolism including glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), which is involved in triglyceride metabolism...
  60. ncbi request reprint Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients
    Brian R Weston
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 98:2440-7. 2003
    ..The purpose of this study was to compare nurse-administered propofol to midazolam and meperidine for sedation in patients with chronic liver disease undergoing diagnostic upper GI endoscopy...
  61. ncbi request reprint Biliary tract complications after orthotopic liver transplantation with choledochocholedochostomy anastomosis: endoscopic findings and results of therapy
    Rungsun Rerknimitr
    Division of Gastroenterology Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202 5000, USA
    Gastrointest Endosc 55:224-31. 2002
    ..This is a retrospective examination of experience with ERCP in patients with biliary tract complications after orthotopic liver transplantation to determine type and frequency of complications and outcome after endoscopic therapy...
  62. pmc Serum proteomic analysis of diet-induced steatohepatitis and metabolic syndrome in the Ossabaw miniature swine
    Lauren N Bell
    Indiana Univ School of Medicine, Indianapolis, 46202, USA
    Am J Physiol Gastrointest Liver Physiol 298:G746-54. 2010
    ..This serum proteomic analysis provides additional information about the pathogenesis of NASH and further characterizes our large animal model of diet-induced steatohepatitis and metabolic syndrome in Ossabaw pigs...
  63. doi request reprint Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events
    Craig Lammert
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Hepatology 51:615-20. 2010
    ..Compared with medications without biliary excretion, compounds with biliary excretion (n = 50) had significantly higher frequency of jaundice (74% versus 40%, P = 0.0001)...
  64. doi request reprint Variability in the upper limit of normal for serum alanine aminotransferase levels: a statewide study
    Anand Dutta
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 50:1957-62. 2009
    ..After controlling for chemical analyzer type, there was no significant relationship between ALT ULN values and the method used for its establishment...
  65. pmc Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine
    Lydia Lee
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 50:56-67. 2009
    ..Conclusion: Ossabaw pigs fed a modified atherogenic diet develop severe metabolic syndrome and abnormal liver histology with close resemblance to human nonalcoholic steatohepatitis (NASH)...
  66. pmc Nonalcoholic fatty liver disease and cardiovascular risk
    Vijay Laxmi Misra
    Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Clarian IU Digestive Diseases Center, 1050 Wishard Boulevard, RG 4100, Indianapolis, IN 46202, USA
    Curr Gastroenterol Rep 11:50-5. 2009
    ..Health care providers managing patients with NAFLD should recognize this increased cardiovascular risk and should undertake early, aggressive risk factor modification...
  67. ncbi request reprint Validation of a multivariate model predicting presence and size of varices
    James R Burton
    Division of Gastroenterology and Hepatology, University of Colorado Health Sciences University, Denver, CO 80262, USA
    J Clin Gastroenterol 41:609-15. 2007
    ..A model developed by our group identified low platelets and advanced Child-Pugh class (CPC) as being associated with large varices...
  68. ncbi request reprint Nonalcoholic fatty liver disease as a component of the metabolic syndrome
    Mouen A Khashab
    Indiana University School of Medicine, RG 4100, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    Curr Gastroenterol Rep 10:73-80. 2008
    ..This review also discusses management options for the syndromes, including treating the individual components of the metabolic syndrome in NAFLD patients...
  69. doi request reprint Insulin resistance, hepatitis C, and liver transplantation
    Mazen Alsatie
    Liver Transpl 14:136-7. 2008
  70. ncbi request reprint Complete reversal of glycogen hepatopathy with pancreas transplantation: two cases
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 83:84-6. 2007
    ..The patients underwent isolated pancreas transplantation, following which, we have been able to demonstrate complete histological resolution of glycogen hepatopathy associated with control of glucose metabolism...
  71. ncbi request reprint Metabolic syndrome following liver transplantation is associated with major vascular events
    Suthat Liangpunsakul
    Liver Transpl 13:1078-9. 2007
  72. ncbi request reprint Severe liver injury after initiating therapy with atomoxetine in two children
    Joel R Lim
    Division of Pediatric Gastroenterology Hepatology Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202 5225, USA
    J Pediatr 148:831-4. 2006
    ..Atomoxetine may cause clinically significant hepatotoxicity either by metabolic idiosyncrasy or by inducing autoimmune hepatitis...
  73. ncbi request reprint Autoimmune hepatitis triggered by statins
    Vamsee Alla
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Gastroenterol 40:757-61. 2006
    ..3 similar previously reported cases are reviewed. We conclude that the 3 cases reported here and 3 similar previously reported cases, indicate that severe, ongoing AIH on rare occasions can be triggered by statins...

Research Grants10

  1. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga Chalasani; Fiscal Year: 2007
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
  2. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga Chalasani; Fiscal Year: 2009
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
  3. Collaborative Clinical Research on Hepatotoxicity
    Naga Chalasani; Fiscal Year: 2007
    ..We also propose a strategy for identifying genetic variations that may cause drug hepatotoxicity using an established NIGMS Pharmacogenetic Core Laboratory. ..
  4. Patient-Oriented Research of Liver Disease
    Naga Chalasani; Fiscal Year: 2007
    ..abstract_text> ..
  5. Clinical Research on Non-Alcoholic Steatohepatitis
    Naga Chalasani; Fiscal Year: 2007
    ..The secondary end-points are changes in insulin resistance, lipid peroxidation, determinants of oxidative stress, anthropometric measurements, liver biochemistry, and the measures of quality of life. ..
  6. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga P Chalasani; Fiscal Year: 2010
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..