David B Burr

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Effects of the combination treatment of raloxifene and alendronate on the biomechanical properties of vertebral bone
    Tamim Diab
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 26:270-6. 2011
  2. doi request reprint Bone remodelling in osteoarthritis
    David B Burr
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Rev Rheumatol 8:665-73. 2012
  3. ncbi request reprint The importance of subchondral bone in the progression of osteoarthritis
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202 5120, USA
    J Rheumatol Suppl 70:77-80. 2004
  4. ncbi request reprint Targeted and nontargeted remodeling
    D B Burr
    Departments of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 30:2-4. 2002
  5. ncbi request reprint The contribution of the organic matrix to bone's material properties
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 31:8-11. 2002
  6. pmc Mandibular necrosis in beagle dogs treated with bisphosphonates
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Orthod Craniofac Res 12:221-8. 2009
  7. ncbi request reprint Does early PTH treatment compromise bone strength? The balance between remodeling, porosity, bone mineral, and bone size
    David B Burr
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 3:19-24. 2005
  8. pmc Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS259, Indianapolis, Indiana 46202, USA
    J Orthop Res 27:1288-92. 2009
  9. ncbi request reprint Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?
    David B Burr
    Department of Anatomy and Cell Biology, Department of Orthopedic Surgery, Indiana University School of Medicine, Building 5035, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Rheum Dis Clin North Am 29:675-85. 2003
  10. ncbi request reprint Bone quality: understanding what matters
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 4:184-6. 2004

Research Grants

  1. Remodeling Suppression--Damage and bone toughness
    David Burr; Fiscal Year: 2002
  2. MECHANOTRANSDUCTION IN BONE
    David Burr; Fiscal Year: 2003
  3. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2007
  4. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2006
  5. Remodeling Suppression--Damage and bone toughness
    David Burr; Fiscal Year: 2006
  6. MUSCULOSKELETAL TRAINING GRANT
    David Burr; Fiscal Year: 2006
  7. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2004
  8. Remodeling Suppression: Collagen Effects on Fracture Energy
    David B Burr; Fiscal Year: 2010
  9. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2005

Collaborators

Detail Information

Publications90

  1. pmc Effects of the combination treatment of raloxifene and alendronate on the biomechanical properties of vertebral bone
    Tamim Diab
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 26:270-6. 2011
    ..05). We conclude that the combination treatment of raloxifene and alendronate has beneficial effects on bone volume, resulting in improvement in the structural properties of vertebral bone...
  2. doi request reprint Bone remodelling in osteoarthritis
    David B Burr
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Rev Rheumatol 8:665-73. 2012
    ..This Review provides an overview of current knowledge on OA and discusses the role of subchondral bone in the initiation and progression of OA. A hypothetical model of OA pathogenesis is proposed...
  3. ncbi request reprint The importance of subchondral bone in the progression of osteoarthritis
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202 5120, USA
    J Rheumatol Suppl 70:77-80. 2004
  4. ncbi request reprint Targeted and nontargeted remodeling
    D B Burr
    Departments of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 30:2-4. 2002
  5. ncbi request reprint The contribution of the organic matrix to bone's material properties
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 31:8-11. 2002
    ..Collagen changes that occur with age and reduce bone's toughness may be an important factor in the risk of fracture in older women with low bone mass...
  6. pmc Mandibular necrosis in beagle dogs treated with bisphosphonates
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Orthod Craniofac Res 12:221-8. 2009
    ..The development of an animal model that mimics important aspects of BP-related osteonecrosis of the jaw is important to understanding the pathogenesis of osteonecrosis...
  7. ncbi request reprint Does early PTH treatment compromise bone strength? The balance between remodeling, porosity, bone mineral, and bone size
    David B Burr
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 3:19-24. 2005
    ....
  8. pmc Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS259, Indianapolis, Indiana 46202, USA
    J Orthop Res 27:1288-92. 2009
    ....
  9. ncbi request reprint Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?
    David B Burr
    Department of Anatomy and Cell Biology, Department of Orthopedic Surgery, Indiana University School of Medicine, Building 5035, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Rheum Dis Clin North Am 29:675-85. 2003
    ..In this view, the mechanical overload that initiates microdamage of the subchondral bone provokes a biological response that potentiates the progression of articular cartilage damage in OA...
  10. ncbi request reprint Bone quality: understanding what matters
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 4:184-6. 2004
  11. ncbi request reprint Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 33:960-9. 2003
    ..We conclude that treatment for 1 year with high doses of bisphosphonates which suppress bone remodeling up to 90% increases tissue mineralization, but does not change the nature of the mineral crystal...
  12. ncbi request reprint Does microdamage accumulation affect the mechanical properties of bone?
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biomech 31:337-45. 1998
    ..We also conclude that damage accumulates more rapidly in tensile cortices, but crack growth is greater in compressive cortices...
  13. ncbi request reprint Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis
    David B Burr
    Department of Anatomy and Cell Biology, Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Osteoarthritis Cartilage 12:S20-30. 2004
    ....
  14. ncbi request reprint Summary of ASBMR Task Force on ONJ
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 7:354-5. 2007
  15. ncbi request reprint Why bones bend but don't break
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 11:270-85. 2011
    ....
  16. doi request reprint Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading
    Anthony Feher
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Bone 46:203-7. 2010
    ....
  17. ncbi request reprint Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia
    Ken Iwata
    Indiana University School of Medicine, IN 46202, USA
    Bone 39:1053-8. 2006
    ..This may help to explain the reason that the anabolic effects of teriparatide are blunted when administered concurrently with or following a course of bisphosphonates in humans...
  18. ncbi request reprint Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels
    Jiliang Li
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocrinology 144:1226-33. 2003
    ..This study indicates that L-type VSCCs mediate load-induced bone formation in vivo. Furthermore, PTH enhances load-induced bone adaptation through involvement of L-type VSCCs...
  19. ncbi request reprint Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate
    Matthew R Allen
    Department of Anatomy and Cell Biology, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Bone 39:872-9. 2006
    ....
  20. pmc Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 25:98-105. 2010
    ..These results document nearly complete intracortical remodeling suppression resulting from monthly intravenous zoledronic acid dosing, with changes being most dramatic at the mandible...
  21. pmc Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Calcif Tissue Int 82:354-60. 2008
    ....
  22. pmc Morphological assessment of basic multicellular unit resorption parameters in dogs shows additional mechanisms of bisphosphonate effects on bone
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Calcif Tissue Int 86:67-71. 2010
    ....
  23. doi request reprint Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Bone 49:128-32. 2011
    ....
  24. doi request reprint Bisphosphonates do not alter the rate of secondary mineralization
    Robyn K Fuchs
    Department of Physical Therapy, School of Health and Rehabilitation Science, Indiana University, 1140 W Michigan, Coleman Hall 326, Indianapolis, IN, USA
    Bone 49:701-5. 2011
    ....
  25. ncbi request reprint Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading
    Helene Follet
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 40:1172-7. 2007
    ....
  26. ncbi request reprint Raloxifene enhances vertebral mechanical properties independent of bone density
    Matthew R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Bone 39:1130-5. 2006
    ..015). Based on these data, we conclude that raloxifene produces improvements in bone mechanical properties in ways that do not involve increases in BMD...
  27. ncbi request reprint Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures
    T Mashiba
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 29:271-8. 2001
    ..These findings suggest that suppression of bone remodeling by EHDP allows microdamage accumulation, but that osteoid accumulation reduces production of microdamage...
  28. pmc In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs
    Mohammad Aref
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 56:449-53. 2013
    ..These data build on previous work that has documented positive effects of raloxifene on material properties by showing that these changes exist after 6 months...
  29. ncbi request reprint In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy
    Robyn K Fuchs
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202
    Matrix Biol 27:34-41. 2008
    ....
  30. ncbi request reprint Interrelationships between bone microarchitecture and strength in ovariectomized monkeys treated with teriparatide
    Peiqi Chen
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Bone Miner Res 22:841-8. 2007
    ..However, the data taken together showed the importance of cortical bone volume for vertebra to assess pharmacological effects on bone quality...
  31. ncbi request reprint Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:809-16. 2005
    ..This indicates that a moderate exercise program may be an effective preventative strategy for stress fractures...
  32. pmc Recovery of trabecular and cortical bone turnover after discontinuation of risedronate and alendronate therapy in ovariectomized rats
    Robyn K Fuchs
    Department of Anatomy and Cell Biology, Indiana University Medical School, Indianapolis, Indiana, USA
    J Bone Miner Res 23:1689-97. 2008
    ..Despite reductions in BMD and increases in bone turnover, ultimate force of the fifth lumbar vertebra remained significantly higher in all drug-treated animals through 16 wk after withdrawal...
  33. pmc Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 66:987-94. 2008
    ..An increasing number of reports have implicated bisphosphonates as contributing to osteonecrosis of the jaw. The goal of this study was to evaluate mandible necrosis in beagle dogs treated for 3 years with oral alendronate (ALN)...
  34. doi request reprint The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 67:61-70. 2009
    ....
  35. ncbi request reprint Effects of broad frequency vibration on cultured osteoblasts
    Shigeo M Tanaka
    Department of Orthopedic Surgery, Biomaterials and Biomechanics Research Center, Indiana University School of Medicine, 541 Clinical Drive, Room 600, Indianapolis, IN 46202 5111, USA
    J Biomech 36:73-80. 2003
    ..This suggestion implies a potential contribution of stochastic resonance to the mechanical sensitivity of osteoblasts...
  36. pmc Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models
    Susan Reinwald
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS 5045B, Indianapolis, IN 46202 5120, USA
    Am J Physiol Endocrinol Metab 296:E765-74. 2009
    ..Because the metabolic origin of the T2D-like state that develops in the ZDSD rat strain is highly relevant to adult-onset diabetes, it is a particularly attractive novel model for future preclinical research...
  37. ncbi request reprint Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles
    T Mashiba
    Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 28:524-31. 2001
    ....
  38. ncbi request reprint Microdamage accumulation in the monkey vertebra does not occur when bone turnover is suppressed by 50% or less with estrogen or raloxifene
    Jiliang Li
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Metab 23:48-54. 2005
    ..We conclude that suppressing bone turnover by 40% or less offers protection against microdamage accumulation that could result in an increased risk of vertebral fracture...
  39. pmc Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing
    Maxime A Gallant
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS 5035, Indianapolis, IN 46202, USA
    Bone 53:301-5. 2013
    ..Collectively these results provide a starting point for understanding how RPI relates to traditional mechanical testing results...
  40. doi request reprint Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don't know
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Bone 49:56-65. 2011
    ..This paper reviews the literature on these topics, and identifies gaps in knowledge that can be addressed with further research...
  41. ncbi request reprint Periosteum: biology, regulation, and response to osteoporosis therapies
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 35:1003-12. 2004
    ..Improving our understanding of mechanisms controlling periosteal expansion will likely provide insights necessary to enhance current and develop novel interventions to further reduce the risk of osteoporotic fractures...
  42. ncbi request reprint Raloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone
    Matthew R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Endocrinology 148:3908-13. 2007
    ..This may help explain how raloxifene reduces osteoporotic fractures despite modest changes in bone mass...
  43. ncbi request reprint Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs have opposing effects during stress fracture repair
    Jiliang Li
    Department of Biology, School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, USA
    J Orthop Res 25:1559-67. 2007
    ..LIPUS accelerated stress fracture healing, whereas the NSAID delayed repair. When used in combination, the beneficial LIPUS effect was not impaired by the detrimental NSAID effect...
  44. ncbi request reprint Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment
    Matthew R Allen
    Department of Anatomy, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Bone Miner Res 22:1759-65. 2007
    ..This suggests microdamage accumulation peaks during the early period of bisphosphonate treatment and does not continue to accumulate with longer periods of treatment...
  45. ncbi request reprint Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035 Indianapolis, IN 46202, USA
    Bone 36:311-6. 2005
    ....
  46. ncbi request reprint Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs
    T Mashiba
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Calcif Tissue Int 77:180-5. 2005
    ..f in the ilium. These results clearly indicate that bone remodeling data obtained from iliac crest biopsy could be used to estimate the activation frequency and microdamage burden in the vertebral column...
  47. ncbi request reprint Effects of human parathyroid hormone (1-34), LY333334, on bone mass, remodeling, and mechanical properties of cortical bone during the first remodeling cycle in rabbits
    T Mashiba
    Department of Anatomy and Cell Biology, Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 28:538-47. 2001
    ..There is no mechanical risk during the first remodeling cycle associated with intermittent PTH treatment in animals with normal bone mass...
  48. doi request reprint Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties
    Maxime A Gallant
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS 5035, Indianapolis, IN 46202, USA
    Bone 61:191-200. 2014
    ....
  49. ncbi request reprint A model for mechanotransduction in bone cells: the load-bearing mechanosomes
    Fred M Pavalko
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine IUSM, Indianapolis, Indiana 46202, USA
    J Cell Biochem 88:104-12. 2003
    ..We identify specific candidate proteins fitting the profile of load-signaling mechanosomes...
  50. ncbi request reprint Imaging bone microdamage in vivo with positron emission tomography
    Jiliang Li
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Bone 37:819-24. 2005
    ..The high-resolution [18F]NaF PET shows promise as a non-invasive means to image bone microdamage...
  51. ncbi request reprint L-type calcium channels mediate mechanically induced bone formation in vivo
    Jiliang Li
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 17:1795-800. 2002
    ....
  52. ncbi request reprint Shorter, more frequent mechanical loading sessions enhance bone mass
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Med Sci Sports Exerc 34:196-202. 2002
    ..We investigated whether the osteogenic response to a simulated high-impact exercise program lasting 4 months could be enhanced by dividing the daily protocol into brief sessions of loading, separated by recovery periods...
  53. pmc Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs
    M R Allen
    Department of Anatomy and Cell Biology, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Osteoporos Int 22:693-702. 2011
    ..Our results, showing significantly compromised osseous healing within the socket as well as presence of exposed bone and development of a sequestrum in one animal, provide a building block toward understanding osteonecrosis of the jaw...
  54. pmc Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra
    T Diab
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Osteoporos Int 20:647-52. 2009
    ..Alendronate treatment resulted in similar levels of turnover in both sites, suggesting that a lower limit of bone turnover suppression with alendronate may exist...
  55. ncbi request reprint Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra
    M R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Osteoporos Int 19:329-37. 2008
    ..These results show that pharmacological suppression of turnover alters the organic matrix component of bone...
  56. ncbi request reprint Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs
    M R Allen
    Dept of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Osteoporos Int 19:95-9. 2008
    ..Our results show that at equivalent bone densities, vertebrae from beagles treated with bisphosphonate have equivalent bone strength and reduced bone energy absorption compared to those from untreated animals...
  57. doi request reprint Strontium ranelate does not stimulate bone formation in ovariectomized rats
    R K Fuchs
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Osteoporos Int 19:1331-41. 2008
    ..We evaluated the effects of SrR on the skeleton in ovariectomized (OVX) rats and evaluated the influence of dietary calcium...
  58. ncbi request reprint In vivo measurement of human tibial strains during vigorous activity
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis 46227, USA
    Bone 18:405-10. 1996
    ..These results show that strain is maintained below 2000 microstrain even under conditions of strenuous activity. Strain rates are higher than previously recorded in human studies, but well within the range reported for running animals...
  59. ncbi request reprint Do bone cells behave like a neuronal network?
    C H Turner
    Department of Orthopaedic Surgery, Indiana University School of Medicine and The Biomechanics and Biomaterials Research Center, Indianapolis 46202, USA
    Calcif Tissue Int 70:435-42. 2002
    ..mechanical loading, disuse, and PTH, compared with long bones. We speculate that the history of weight bearing imparts long-term cellular memory to the bone cell network that modulates the cellular response to a wide variety of stimuli...
  60. ncbi request reprint Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location
    Y F Hsieh
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 16:2291-7. 2001
    ..The threshold strain is largest distally, where locomotor bone strains are typically higher and smallest proximally where locomotor bone strains are lower...
  61. ncbi request reprint Recovery periods restore mechanosensitivity to dynamically loaded bone
    A G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Exp Biol 204:3389-99. 2001
    ..The results demonstrate the importance of recovery periods for (i) restoring mechanosensitivity to bone cells and (ii) maximizing the osteogenic effects of mechanical loading (exercise) regimens...
  62. ncbi request reprint Modeling fatigue damage evolution in bone
    R M Pidaparti
    Department of Mechanical Engineering, Purdue University, Indianapolis, Indiana 46202, USA
    Biomed Mater Eng 11:69-78. 2001
    ..The quantitative relationship between stiffness loss, loading cycles and microdamage parameter developed in this study may be useful for fatigue life and failure stress predictions...
  63. ncbi request reprint Proprioception, gait kinematics, and rate of loading during walking: are they related?
    J L Riskowski
    Department of Biomedical Engineering, Purdue University, Lafaytte, IN, USA
    J Musculoskelet Neuronal Interact 5:379-87. 2005
    ..However, it remains unclear whether poor proprioception causes a high ROL or if a high ROL damages the mechanoreceptors involved in proprioception, but the apparent relationship is significant and warrants further investigation...
  64. ncbi request reprint Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage
    J Li
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis 46202 USA
    Calcif Tissue Int 69:281-6. 2001
    ..These data further suggest that the complete suppression of targeted remodeling could account for the increased microdamage burden...
  65. ncbi request reprint Fatigue data analysis of canine femurs under four-point bending
    R M Pidaparti
    Department of Mechanical Engineering, Purdue University, Indianapolis, IN 46202 5132, USA
    Biomed Mater Eng 10:43-50. 2000
    ..Thus, we conclude that the derived relationships between stiffness loss and loading cycles might be useful for the prediction of bone failure under cyclic bending subjected to an initial strain of 2700 microstrain...
  66. ncbi request reprint The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis 46202, USA
    Microsc Res Tech 37:343-57. 1997
    ....
  67. ncbi request reprint Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib
    M R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Calcif Tissue Int 79:255-61. 2006
    ....
  68. pmc Circulating ╬▒Klotho influences phosphate handling by controlling FGF23 production
    Rosamund C Smith
    Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Clin Invest 122:4710-5. 2012
    ..These findings have important implications for the regulation of ╬▒KL and FGF23 in disorders of phosphate handling and biomineralization...
  69. ncbi request reprint Stress fractures: pathophysiology, epidemiology, and risk factors
    Stuart J Warden
    Department of Physical Therapy, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 4:103-9. 2006
    ..This article discusses these extrinsic and intrinsic risk factors, as well as the pathophysiology and epidemiology of stress fractures...
  70. ncbi request reprint Increased biological activity of subchondral mineralized tissues underlies the progressive deterioration of articular cartilage in osteoarthritis
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medecine, Indianapolis, IN, USA
    J Rheumatol 32:1156-8; discussion 1158-9. 2005
  71. ncbi request reprint Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 17:1545-54. 2002
    ..Modest increases in aBMD and BMC can improve biomechanical properties substantially if the new bone formation is localized to the most biomechanically relevant sites, as occurs during load-induced bone formation...
  72. ncbi request reprint Intermittently administered human parathyroid hormone(1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 16:157-65. 2001
    ..We conclude that intermittently administered PTH(1-34) increases intracortical porosity in a dose-dependent manner but does not reduce the strength or stiffness of cortical bone...
  73. doi request reprint Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes
    Armando Diaz Gonzalez
    Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, 723 W Michigan Street SL220D, Indianapolis, IN 46202, USA
    J Biomech 47:681-6. 2014
    ..These findings indicate that diabetes-induced changes in material strength and modulus were driven by alterations at the nanoscale. ..
  74. ncbi request reprint Shear strength and fatigue properties of human cortical bone determined from pure shear tests
    C H Turner
    Department of Orthopaedic Surgery, Indiana University, Indianapolis 46202, USA
    Calcif Tissue Int 69:373-8. 2001
    ....
  75. ncbi request reprint Effects of biomechanical stress on bones in animals
    David B Burr
    Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 30:781-6. 2002
    ..The data also suggest that activities involving higher loading rates are more effective for increasing bone formation, even if the duration of the activity is short...
  76. ncbi request reprint The effects of dynamic axial loading on the rat growth plate
    Naoko Ohashi
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 17:284-92. 2002
    ..Only the largest load (17N) caused morphological changes in the distal growth plate cartilage. There was no association found between mineralization and type X collagen localization or capillary invasion and VEGF expression...
  77. ncbi request reprint Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading
    J Li
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Calcif Tissue Int 70:320-9. 2002
    ....
  78. ncbi request reprint Chemical makeup of microdamaged bone differs from undamaged bone
    Meghan E Ruppel
    National Synchrotron Light Source, Brookhaven National Laboratory, Bldg 725 D, Upton, NY 11973, USA
    Bone 39:318-24. 2006
    ..Even so, because microdamage results in an altered bone composition, an accumulation of microdamage might result in a long-term reduction in bone quality...
  79. pmc A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover
    Senthil K Eswaran
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech 40:3424-31. 2007
    ....
  80. ncbi request reprint Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH(1-34) for 18 months
    Eleftherios P Paschalis
    Mineralized Tissues Laboratory, Hospital for Special Surgery, New York, New York 10021, USA
    J Bone Miner Res 18:769-75. 2003
    ..These were fully reversible when the 1-microg rhPTH(1-34) treatment was withdrawn, but only partially reversed when the 5-microg rhPTH(1-34) dose was withdrawn...
  81. ncbi request reprint Reconstructed bone end loads on the canine forelimb during gait
    John C Coleman
    Department of Biomedical Engineering, Tulane University, Suite 500 Boggs Center, New Orleans, LA 70118 5674, USA
    J Biomech 36:1837-44. 2003
    ..J. Biomech. 35 (2002) 1677), but with further refinements the method could be used to reconstruct the in vivo loading conditions in living subjects...
  82. ncbi request reprint Osteoblast responses one hour after load-induced fluid flow in a three-dimensional porous matrix
    Shigeo M Tanaka
    Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Calcif Tissue Int 76:261-71. 2005
    ....
  83. ncbi request reprint The effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib
    Tasuku Mashiba
    Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Bone Miner Metab 23:36-42. 2005
    ....
  84. ncbi request reprint Age-related change in the damage morphology of human cortical bone and its role in bone fragility
    Tamim Diab
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
    Bone 38:427-31. 2006
    ..Age-related changes in damage morphology may therefore be an important contributor to the increased bone fragility in the elderly...
  85. ncbi request reprint Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women with osteoporosis
    Jan J Stepan
    Institute of Rheumatology, Charles University, Faculty of Medicine, Prague, Czech Republic
    Bone 41:378-85. 2007
    ..04 for Cr.Dn and P=0.03 for Cr.S.Dn). We conclude that increased microdamage accumulation may occur in low BMD patients treated with alendronate...
  86. ncbi request reprint Positive effects of intravenous zoledronic acid on bone remodeling and structure: are different effects on osteoblast activity to other oral bisphosphonates responsible?
    Peter R Ebeling
    J Bone Miner Res 23:2-5. 2008
  87. ncbi request reprint The 37th International Sun Valley Workshop on Skeletal Tissue Biology. Foreward
    David B Burr
    J Musculoskelet Neuronal Interact 7:295. 2007
  88. ncbi request reprint Low bone turnover and microdamage? How and where to assess it?
    David B Burr
    J Bone Miner Res 23:1150-1; author reply 1152-3. 2008
  89. doi request reprint Failure of mineralized collagen fibrils: modeling the role of collagen cross-linking
    Thomas Siegmund
    School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA
    J Biomech 41:1427-35. 2008
    ..As a consequence the toughness of bone that has more non-enzymatically mediated collagen cross-links will be drastically reduced...
  90. ncbi request reprint Characterization of dynamic three-dimensional strain fields in the canine radius
    John C Coleman
    Department of Biomedical Engineering, Tulane University, Suite 500, Boggs Center, New Orleans, LA 70118 5674, USA
    J Biomech 35:1677-83. 2002
    ....

Research Grants15

  1. Remodeling Suppression--Damage and bone toughness
    David Burr; Fiscal Year: 2002
    ..We anticipate that these experiments will allow us to determine how much remodeling can be suppressed, and for how long, without causing an increase in microdamage accumulation, or a significant decrease in bone's mechanical properties. ..
  2. MECHANOTRANSDUCTION IN BONE
    David Burr; Fiscal Year: 2003
    ..Data generated by this Program are intended to define some mechanisms by which fluid forces can regulate gene expression, and will attempt to validate these mechanisms by in vivo studies. ..
  3. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2007
    ..A Plenary lecture by Dr. David Baylink on the first evening is followed by a poster session and wine and cheese reception. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..
  4. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2006
    ..A Plenary lecture by Dr. Lynda Bonewald on the first evening is followed by a poster session and wine and cheese reception. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..
  5. Remodeling Suppression--Damage and bone toughness
    David Burr; Fiscal Year: 2006
    ..abstract_text> ..
  6. MUSCULOSKELETAL TRAINING GRANT
    David Burr; Fiscal Year: 2006
    ..Two presentations were nominated for Young Investigator Awards by the ASBMR and the ORS. ..
  7. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2004
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..
  8. Remodeling Suppression: Collagen Effects on Fracture Energy
    David B Burr; Fiscal Year: 2010
    ..This has relevance in understanding the fragility of bone that occurs in post-menopausal osteoporosis, and in Type II diabetes. ..
  9. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2005
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..