A Bruno

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Using change in the National Institutes of Health Stroke Scale to measure treatment effect in acute stroke trials
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stroke 37:920-1. 2006
  2. ncbi Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Stroke 39:384-9. 2008
  3. ncbi Plasma thrombosis markers following cerebral infarction in African Americans
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive, Room 292, Indianapolis, IN 46202-5111, USA
    Thromb Res 115:73-7. 2005
  4. ncbi How important is hyperglycemia during acute brain infarction?
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Neurologist 10:195-200. 2004
  5. ncbi IV insulin during acute cerebral infarction in diabetic patients
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202-5111, USA
    Neurology 62:1441-2. 2004
  6. ncbi Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction
    Askiel Bruno
    Indiana University School of Medicine, Indianapolis, USA
    Stroke 35:727-30. 2004
  7. ncbi Cerebrovascular complications of alcohol and sympathomimetic drug abuse
    Askiel Bruno
    Stroke Service, Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive, R290C, Indianapolis, IN 46202, USA
    Curr Neurol Neurosci Rep 3:40-5. 2003
  8. ncbi Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients
    Askiel Bruno
    Indiana University School of Medicine, Indianapolis, IN 46202 5111, USA
    Stroke 33:57-60. 2002
  9. ncbi Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial
    A Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurology 59:669-74. 2002
  10. ncbi Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke
    L S Williams
    Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis 46202, USA
    Neurology 59:67-71. 2002

Research Grants

  1. Treatment of Hyperglycemia Ischemic Stroke(THIS)Trial
    Askiel Bruno; Fiscal Year: 2004

Detail Information

Publications22

  1. ncbi Using change in the National Institutes of Health Stroke Scale to measure treatment effect in acute stroke trials
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stroke 37:920-1. 2006
    ..Outcome measures in acute stroke trials are being refined. Changes in neurological deficits might be useful outcome measures because they can measure the entire spectrum of deficits...
  2. ncbi Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Stroke 39:384-9. 2008
    ..Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction...
  3. ncbi Plasma thrombosis markers following cerebral infarction in African Americans
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive, Room 292, Indianapolis, IN 46202-5111, USA
    Thromb Res 115:73-7. 2005
  4. ncbi How important is hyperglycemia during acute brain infarction?
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Neurologist 10:195-200. 2004
    ..Further support for this therapeutic approach comes from clinical studies in acute myocardial infarction and in ventilated postsurgical patients, where lowering hyperglycemia improved outcomes...
  5. ncbi IV insulin during acute cerebral infarction in diabetic patients
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202-5111, USA
    Neurology 62:1441-2. 2004
  6. ncbi Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction
    Askiel Bruno
    Indiana University School of Medicine, Indianapolis, USA
    Stroke 35:727-30. 2004
    ..This pilot study was intended to evaluate the reproducibility of urinary 11-DTB2 over time and to look for evidence of aspirin resistance...
  7. ncbi Cerebrovascular complications of alcohol and sympathomimetic drug abuse
    Askiel Bruno
    Stroke Service, Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive, R290C, Indianapolis, IN 46202, USA
    Curr Neurol Neurosci Rep 3:40-5. 2003
    ....
  8. ncbi Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients
    Askiel Bruno
    Indiana University School of Medicine, Indianapolis, IN 46202 5111, USA
    Stroke 33:57-60. 2002
    ..The aim of the study was to evaluate the relationship between daily aspirin use and urinary excretion of a stable thromboxane metabolite, 11-dehydrothromboxane B(2) (11-DTB2), in African American stroke patients...
  9. ncbi Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial
    A Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurology 59:669-74. 2002
    ..Hyperglycemia during acute ischemic stroke may augment brain injury, predispose to intracerebral hemorrhage (ICH), or both...
  10. ncbi Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke
    L S Williams
    Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis 46202, USA
    Neurology 59:67-71. 2002
    ..Hyperglycemia at the time of acute ischemic stroke has been linked to worse outcome in both human and animal studies...
  11. ncbi Carotid endarterectomy--an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    S Chaturvedi
    Department of Neurology, Wayne State University, USA
    Neurology 65:794-801. 2005
    ..Low dose aspirin (81 to 325 mg) is preferred for patients before and after carotid endarterectomy to reduce the rate of stroke, myocardial infarction, and death (Level A)...
  12. ncbi Protocol violations in community-based rTPA stroke treatment are associated with symptomatic intracerebral hemorrhage
    A M Lopez-Yunez
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stroke 32:12-6. 2001
    ..Recombinant tissue plasminogen activator (rTPA) is an established treatment for acute ischemic stroke. The rate and type of protocol violations in rTPA use and their effect on patient outcomes in this setting are not well understood...
  13. ncbi Cerebrovascular and cardiovascular complications of alcohol and sympathomimetic drug abuse
    Ayrn D O'Connor
    Department of Emergency Medicine, Iniana University School of Medicine, Indianapolis, IN, USA
    Med Clin North Am 89:1343-58. 2005
    ..Because many complications of alcohol and stimulant abuse are preventable and reversible, it is important to screen for these in patients with cerebrovascular and cardiovascular disease...
  14. ncbi Percent change on the National Institutes of Health Stroke Scale: a useful acute stroke outcome measure
    Askiel Bruno
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Stroke Cerebrovasc Dis 18:56-9. 2009
    ..Changes in neurologic deficits might be useful outcome measures in acute stroke because they can measure within-subject changes on the entire spectrum of the scales starting at baseline...
  15. ncbi Management of hyperglycemia during acute stroke
    Askiel Bruno
    Department of Neurology, Medical College of Georgia, 1120 15th Street, BI 3076, Augusta, GA 30912, USA
    Curr Cardiol Rep 11:36-41. 2009
    ..One randomized efficacy trial has been reported and additional trials are needed. In the meantime, an intermediate approach to managing acute stroke hyperglycemia with subcutaneous insulin seems reasonable...
  16. ncbi Stroke patients' knowledge of stroke. Influence on time to presentation
    L S Williams
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Stroke 28:912-5. 1997
    ..Little is known about stroke patients' general knowledge about stroke, their interpretation of stroke symptoms, and how these factors influence the timing of their decision to seek medical attention...
  17. ncbi Outcome of extracranial cervicocephalic arterial dissections: a follow-up study
    Fernando Gonzales-Portillo
    Department of Neurology, The University of Arizona Health Sciences Center, Tucson 85724-5023, USA
    Neurol Res 24:395-8. 2002
    ..The short- and long-term outcome are usually favorable with either anticoagulant or platelet antiaggregant therapy. A medical initial approach to the management of extracranial CCAD is recommended for most patients...
  18. ncbi Improving modified Rankin Scale assessment with a simplified questionnaire
    Askiel Bruno
    Department of Neurology, Medical College of Georgia, 1120 15th Street BI 3076, Augusta, GA 30912, USA
    Stroke 41:1048-50. 2010
    ..The modified Rankin Scale (mRS) is a popular primary stroke outcome measure, but its usefulness is limited by suboptimal reliability (inter-rater agreement)...
  19. ncbi About hyperglycemia during acute stroke
    Askiel Bruno
    Stroke 38:e138; author reply e139. 2007
  20. ncbi Factors influencing outcome and treatment effect in PROACT II
    Lawrence R Wechsler
    University of Pittsburgh, Pittsburgh, PA, USA
    Stroke 34:1224-9. 2003
    ..The purpose of the current study was to examine baseline factors to determine predictors of good outcome and response to treatment...
  21. ncbi Predicting rtPA associated ICH in acute stroke
    Askiel Bruno
    Stroke 35:2762; author reply 2762-3. 2004
  22. ncbi A supervised method for calculating perfusion/diffusion mismatch volume in acute ischemic stroke
    Judy R James
    Department of Biomedical Engineering, Indiana University-Purdue University, IUPUI) Indianapolis, IN, USA
    Comput Biol Med 36:1268-87. 2006
    ..Clinical data show that raters using our tool are consistent, fast (15min per subject) and indistinguishable from an expert using manual segmentation...

Research Grants1

  1. Treatment of Hyperglycemia Ischemic Stroke(THIS)Trial
    Askiel Bruno; Fiscal Year: 2004
    ..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months. ..