Hal Broxmeyer

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Stem Cells Dev 22:998-1006. 2013
  2. ncbi Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Exp Med 210:205-8. 2013
  3. ncbi Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Nat Med 18:1786-96. 2012
  4. ncbi Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Stem Cells Dev 21:1597-603. 2012
  5. ncbi CD1d expression on and regulation of murine hematopoietic stem and progenitor cells
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood 119:5731-41. 2012
  6. ncbi DEK regulates hematopoietic stem engraftment and progenitor cell proliferation
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Stem Cells Dev 21:1449-54. 2012
  7. ncbi Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood Cells Mol Dis 48:25-9. 2012
  8. ncbi Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses
    C H Kim
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Exp Med 190:681-90. 1999
  9. ncbi Identification of a massive reserve of hematopoietic progenitors in mice
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:105-10. 2005
  10. ncbi Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities
    H E Broxmeyer
    Department of Microbiology Immunology, Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis 46202 5254, USA
    Exp Hematol 27:1113-23. 1999

Research Grants

  1. Cytokine Enhancement of Myeloid Progenitor Cell Survival
    Hal Broxmeyer; Fiscal Year: 2007
  2. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal Broxmeyer; Fiscal Year: 2007
  3. Indiana University Initiative for Maximizing Graduate Student Diversity
    Hal Broxmeyer; Fiscal Year: 2007
  4. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
  5. BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASES
    Hal Broxmeyer; Fiscal Year: 2007
  6. Bridges to the Doctorate at IU School of Medicine
    Hal Broxmeyer; Fiscal Year: 2007
  7. Cytokine Enhancement of Myeloid Progenitor Cell Survival
    Hal Broxmeyer; Fiscal Year: 2009
  8. REGULATION OF HEMATOPOIETIC CELL PRODUCTION
    Hal Broxmeyer; Fiscal Year: 2007
  9. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2000
  10. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal Broxmeyer; Fiscal Year: 1999

Detail Information

Publications125 found, 100 shown here

  1. ncbi Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Stem Cells Dev 22:998-1006. 2013
    ....
  2. ncbi Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Exp Med 210:205-8. 2013
    ....
  3. ncbi Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Nat Med 18:1786-96. 2012
    ..DPP4 inhibition enhanced engraftment in mice without compromising HSC function, suggesting the potential clinical utility of this approach...
  4. ncbi Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Stem Cells Dev 21:1597-603. 2012
    ..These findings underscore the complex interplay of cell cycle regulators in HPC, and demonstrate that loss of one can sometimes be compensated by loss of another CDKI in both, a pro- or anti-proliferative context...
  5. ncbi CD1d expression on and regulation of murine hematopoietic stem and progenitor cells
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood 119:5731-41. 2012
    ..Pretreatment of normal BM cells with CD1d Abs greatly enhanced their engraftment of HSCs. The results of the present study implicate CD1d in a previously unrecognized regulatory role of normal and stressed hematopoiesis...
  6. ncbi DEK regulates hematopoietic stem engraftment and progenitor cell proliferation
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Stem Cells Dev 21:1449-54. 2012
    ..This demonstrates that DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest...
  7. ncbi Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood Cells Mol Dis 48:25-9. 2012
    ..Thus, among ANGPTL family members, ANGPTL-2 and -3 had enhancing activities on human HPC survival and replating activity, effects requiring the CC domain of the ANGPTL molecules. This information is of relevance to hu HPC regulation...
  8. ncbi Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses
    C H Kim
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Exp Med 190:681-90. 1999
    ..However, expression of some chemokine receptors (CCR1, CCR2, CCR3, and CXCR2) was significantly enhanced in me(v)/me(v) T cells. Our results implicate SHP-1 involvement in a number of different chemokine-induced biological activities...
  9. ncbi Identification of a massive reserve of hematopoietic progenitors in mice
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:105-10. 2005
    ....
  10. ncbi Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities
    H E Broxmeyer
    Department of Microbiology Immunology, Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis 46202 5254, USA
    Exp Hematol 27:1113-23. 1999
    ....
  11. ncbi Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:199-203. 2005
    ..Thus, SDF-1/CXCL12 differentially and selectively regulates suppression of HPC proliferation by chemokines. These effects may counter myelosuppressive effects of certain chemokines in vivo, where proliferation of HPCs must be sustained...
  12. ncbi Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with Ara-C
    Hal E Broxmeyer
    Departments of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Exp Hematol 34:1069-77. 2006
    ..We also evaluated three chemokines in vivo for myeloprotection against Ara-C-induced decreases in HPCs...
  13. ncbi Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins
    Hal E Broxmeyer
    Departments of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, IN 46202 5181, USA
    Exp Hematol 34:1078-84. 2006
    ....
  14. ncbi Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors
    H E Broxmeyer
    Department of Microbiology, Indiana University School of Medicine, Indianapolis 46202, USA
    Ann N Y Acad Sci 872:142-62; discussion 163. 1999
    ..It was also found that SDF-1-induced chemotaxis of progenitors can occur in the presence of fibronectin (FN) and extracellular matrix components and that FN effects involve activation of beta 1-, and possibly alpha 4-, integrins...
  15. ncbi Dominant myelopoietic effector functions mediated by chemokine receptor CCR1
    H E Broxmeyer
    Department of Microbiology Immunology, The Department of Medicine, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Exp Med 189:1987-92. 1999
    ..CCR1 is not a dominant receptor for MIP-1alpha suppression of MPC proliferation, but it does negatively impact G-CSF-induced MPC mobilization...
  16. ncbi Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Exp Med 201:1307-18. 2005
    ..These results support the hypothesis that the CXCL12-CXCR4 axis is involved in marrow retention of HSCs and HPCs, and demonstrate the clinical potential of AMD3100 for HSC mobilization...
  17. ncbi Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells
    Hal E Broxmeyer
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Leukoc Biol 73:630-8. 2003
    ..These results extend information on the survival effects mediated through the SDF-1/CXCL12-CXCR4 axis and may be of relevance for ex vivo expansion and gene-transduction procedures...
  18. ncbi High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 1044 West Walnut Street, R4 302, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 100:645-50. 2003
    ....
  19. ncbi Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo
    Hal E Broxmeyer
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 170:421-9. 2003
    ..These results substantiate survival effects of SDF-1/CXCL12, now extended to progenitors engineered to endogenously produce low levels of this cytokine, and demonstrate activity in vivo for SDF-1/CXCL12 in addition to cell trafficking...
  20. ncbi Regulation of hematopoiesis by chemokine family members
    H E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis 46202 5254, USA
    Int J Hematol 74:9-17. 2001
    ..This article reviews the field of chemokine regulation of hematopoiesis at the level of myeloid progenitor cells...
  21. ncbi AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 1106:1-19. 2007
    ..These results demonstrate the means to increase the mobilization of HPCs, the engrafting capability of HSCs, and responsiveness of HPCs to the survival-enhancing activity of SDF-1/CXCL12, effects that may be of practical value...
  22. ncbi Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31
    Hal E Broxmeyer
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Exp Hematol 35:78-86. 2007
    ..Because OSM-Rbeta-deficient animals have reduced hematopoietic progenitor cells (HPC) and OSM has effects on and is involved in homeostasis of HPC, we studied whether IL-31 and IL-31R play a role in hematopoiesis...
  23. ncbi A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus
    Hal E Broxmeyer
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, IN 46202, USA
    Exp Hematol 35:87-93. 2007
    ..We hypothesized that CD1d and NKT cells are involved in protection of the hematopoietic modulating effects of CMV, and that adoptive transfer of NKT cells would protect against these infection-induced effects...
  24. ncbi Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 117:4773-7. 2011
    ....
  25. ncbi Umbilical cord transplantation: epilogue
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Semin Hematol 47:97-103. 2010
    ..Rigorous investigations and close interactions between scientific and clinical investigators are required to translate human in vitro and animal in vivo findings into clinical utility...
  26. ncbi Will iPS cells enhance therapeutic applicability of cord blood cells and banking?
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Stem Cell 6:21-4. 2010
    ....
  27. ncbi Mechanism unknown: prostaglandin E2 may improve HSC therapies
    Hal E Broxmeyer
    Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, R2 302, Indianapolis, IN 46202 5181, USA
    Cell Stem Cell 1:135-6. 2007
    ..This work may have practical therapeutic value, but much remains to be determined before this possibility is realized...
  28. ncbi Experimental basis of cord blood transplantation
    H E Broxmeyer
    Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Bone Marrow Transplant 44:627-33. 2009
    ....
  29. ncbi Chemokines in hematopoiesis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, and Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN 46202, USA
    Curr Opin Hematol 15:49-58. 2008
    ..This article summarizes recent progress in understanding the production and actions of chemokines and chemokine receptors, with an emphasis on the SDF-1/CXCL12-CXCR4 axis...
  30. ncbi SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells
    Hal E Broxmeyer
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 16:589-96. 2007
    ..However, the results suggest that SDF-1/CXCL12 enhances in vitro replating/self-renewal of HPCs, which may contribute to myelopoiesis in vivo. This information may be of value to ex vivo expansion of HPCs/HSCs...
  31. ncbi Chemokine regulation of hematopoiesis and the involvement of pertussis toxin-sensitive G alpha i proteins
    H E Broxmeyer
    Departments of Microbiology and Immunology, and Medicine Hematology Oncology, The Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 938:117-27; discussion 127-8. 2001
    ..These results suggest that not all chemokine-mediated effects on MPCs are necessarily mediated through pertussis toxin-sensitive G alpha i proteins...
  32. ncbi Cloning and characterization of exodus, a novel beta-chemokine
    R Hromas
    Department of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
    Blood 89:3315-22. 1997
    ..Exodus also stimulated chemotaxis of peripheral blood mononuclear cells. The sequence homology, expression, and biological activity indicate that Exodus represents a novel divergent beta-chemokine...
  33. ncbi Polymerization of murine macrophage inflammatory protein 1 alpha inactivates its myelosuppressive effects in vitro: the active form is a monomer
    C Mantel
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    Proc Natl Acad Sci U S A 90:2232-6. 1993
    ..v) Suppression is initiated during the DNA-synthesis phase of the cell cycle. We conclude that polymerization of MIP-1 alpha might be a control mechanism that limits the myelosuppressive effects of monomeric MIP-1 alpha...
  34. ncbi Extensive proliferative capacity of single isolated CD34 human cord blood cells in suspension culture
    M Xiao
    Department of Medicine, Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    Blood Cells 20:455-66; discussion 466-7. 1994
    ..These results demonstrate the expansion capacity of single CD34 cord blood cells and demonstrate that factors in addition to SLF, IL-1 alpha, and IL-3 are necessary for optimal expansion of progenitors from single isolated CD34 cells...
  35. ncbi CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells
    C H Kim
    Department of Microbiology Immunology, The Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 160:2418-24. 1998
    ....
  36. ncbi Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue
    H E Broxmeyer
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Exp Med 184:1825-32. 1996
    ..This provides strong support for a negative myeloid regulatory role played by the mIL-8Rh in vivo, whose active ligand may be MIP-2...
  37. ncbi Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity
    B S Youn
    Department of Microbiology and Immunology, Department of Medicine, Walther Oncology Center, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana, 46202, USA
    Biochem Biophys Res Commun 247:217-22. 1998
    ..This data suggests that the LMC gene is located at human chromosome 17q which encompasses a human CC chemokine gene cluster...
  38. ncbi Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3
    B S Youn
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 159:5201-5. 1997
    ..Hence, we have isolated and characterized a human C6 beta-chemokine that is a potent agonist at CCR1 and CCR3 and shows broad biologic activities, including leukocyte chemoattraction...
  39. ncbi A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors
    B S Youn
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 155:2661-7. 1995
    ....
  40. ncbi SDF-1alpha/CXCL12 enhances retroviral-mediated gene transfer into immature subsets of human and murine hematopoietic progenitor cells
    W Tao
    Department of Microbiology and Immunology, The Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA
    Gene Ther 11:61-9. 2004
    ..These results may be of clinical relevance...
  41. ncbi Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1
    B S Youn
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 91:3118-26. 1998
    ..To our knowledge, this is the first example that an alternative splicing produces two active beta-chemokines from a single gene...
  42. ncbi Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells
    C H Kim
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 161:2580-5. 1998
    ....
  43. ncbi Suppression of p53-mediated growth factor withdrawal-induced apoptosis in the myeloid compartment by hematopoietic cytokines: an overview of hematopoiesis and apoptosis with a presentation of thrombopoietin and the M07E cell line as a model system
    A Ritchie
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, USA
    Crit Rev Oncol Hematol 31:169-91. 1999
    ..Further studies that investigate the interface between cytokine signaling transduction cascades and the subsystem(s) regulating the redox state of p53 are critical to advancing this field...
  44. ncbi A positive effect of p21cip1/waf1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer
    S E Braun
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood Cells Mol Dis 24:138-48. 1998
    ..These results document the positive effect of p21cip1/waf1 in the proliferation and/or differentiation of the murine myeloid progenitor cells that lead to colony formation...
  45. ncbi The kit receptor and its ligand, steel factor, as regulators of hemopoiesis
    H E Broxmeyer
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    Cancer Cells 3:480-7. 1991
    ..We also discuss present knowledge of the molecules involved in SLF-triggered signal transduction, and speculate on potential therapeutic applications for SLF in human disease...
  46. ncbi Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension
    R Hromas
    Hematology Oncology, Biochemistry Molecular Biology, and the Walther Oncology Center, Indiana University Medical Center, 1044 W Walnut St, Indianapolis, Indiana, 46202, USA
    Biochem Biophys Res Commun 258:737-40. 1999
    ..It is expressed preferentially in testis, heart, and liver, which is atypical for CC chemokines...
  47. ncbi Modulation of integrin function in hematopoietic progenitor cells by CD43 engagement: possible involvement of protein tyrosine kinase and phospholipase C-gamma
    N Anzai
    Departments of Microbiology Immunology, Medicine, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 93:3317-26. 1999
    ..These results indicate that signals mediated through CD43 may increase integrin affinity to fibronectin via a pathway dependent on protein tyrosine kinase and PLC-gamma activation in hematopoietic progenitors...
  48. ncbi Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
    R Hromas
    Department of Hematology and Oncology, Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut Street, Indianapolis, Indiana, 46202
    Biochem Biophys Res Commun 255:703-6. 1999
    ..BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31...
  49. ncbi p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells
    C Mantel
    Department of Microbiology Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5121, USA
    Blood 93:1390-8. 1999
    ..A centrosome duplication checkpoint could be a new target for novel chemotherapy strategies...
  50. ncbi p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells
    S Zhang
    Departments of Microbiology Immunology and Medicine and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA
    Biochem Biophys Res Commun 254:440-5. 1999
    ..In THP-1 cells, p85 associates inducibly with tyrosine phosphorylated SHIP, p100 and p120. These results indicate that p85 does not bind human Flt3, but forms a complex with SHP-2, SHIP, p100 and p120 in hematopoietic cells...
  51. ncbi Measurement of interleukin 3 and other hematopoietic cytokines, such as GM-CSF, G-CSF, M-CSF, erythropoietin, steel factor, and Flt-3 ligand
    S H Cooper
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Curr Protoc Immunol . 2001
    ....
  52. ncbi Myeloid progenitor cell proliferation and mobilization effects of BB10010, a genetically engineered variant of human macrophage inflammatory protein-1alpha, in a phase I clinical trial in patients with relapsed/refractory breast cancer
    H E Broxmeyer
    Department of Microbiology Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 24:14-30. 1998
    ..The above effects of BB10010 were similar at the four different dosage levels assessed. These results demonstrate in humans the suppressive and mobilizing effects of MIP-1alpha and BB10010 previously noted in vivo in mice...
  53. ncbi Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension
    R Hromas
    Department of Medicine, Indiana University Medical Center, Indianapolis 46202, USA
    J Immunol 159:2554-8. 1997
    ..The combination of these characteristics may be a functional correlate for the unique carboxyl-terminal structure of Exodus-2...
  54. ncbi Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2
    M D Krathwohl
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 94:9875-80. 1997
    ..The significance of hematopoietic progenitor cell inhibition in viral pathogenesis is uncertain...
  55. ncbi Altered responsiveness to chemokines due to targeted disruption of SHIP
    C H Kim
    Departments of Microbiology Immunology and Medicine and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 104:1751-9. 1999
    ....
  56. ncbi Co-transduction of cDNAs for c-kit and steel factor into single CD34+ cord blood cells further enhances the growth of erythroid and multipotential progenitors
    L Lu
    Department of Microbiology and Immunology, Indiana University School of Medicine, 1044 West Walnut Street, Room 302, Indianapolis, IN 46202 5254, USA
    J Hematother Stem Cell Res 9:813-25. 2000
    ..These results demonstrate the enhancement of the proliferation of growth factor responsive HPC that express transduced c-kit and SLF genes...
  57. ncbi The interphase microtubule damage checkpoint defines an S-phase commitment point and does not require p21(waf-1)
    C R Mantel
    Department of Microbiology Immunology, Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, IN 46202 5121, USA
    Blood 97:1505-7. 2001
    ..The G(1)MTC is also present in a human myeloid cell line deficient in p21(waf-1) gene expression. The p21-independent G(1)MTC may be important in cellular responses to MTD such as those induced by drugs used to treat cancer...
  58. ncbi The exodus subfamily of CC chemokines inhibits the proliferation of chronic myelogenous leukemia progenitors
    R Hromas
    Hematology Oncology, Biochemistry Molecular Biology, Microbiology Immunology, and the Walther Oncology Center, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Blood 95:1506-8. 2000
    ..This demonstration of consistent inhibition of CML progenitor proliferation makes the 3 Exodus chemokines unique among chemokines. (Blood. 2000;95:1506-1508)..
  59. ncbi The CC chemokine CK beta-11/MIP-3 beta/ELC/Exodus 3 mediates tumor rejection of murine breast cancer cells through NK cells
    S E Braun
    Departments ofMicrobiology Immunology and Medicine Hematology Oncology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 164:4025-31. 2000
    ..Furthermore, CK beta-11-transduced tumor cells generate long-term antitumor immunity that requires CD4+ cells. These studies demonstrate the potential role of CK beta-11 as an adjuvant in stimulating antitumor responses...
  60. ncbi Steel factor regulates cell cycle asymmetry
    C Mantel
    Department of Microbiology, Walther Oncology Center, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202 5121, USA
    Stem Cells 19:483-91. 2001
    ..The factor-dependent MO7e/SCF- synergy/asymmetry model described here may therefore be useful for studies of the effects of various cytokines on cell cycle asymmetry...
  61. ncbi Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation
    B G Thomson
    Stem Cell Transplantation Program, Department of Pediatric Hematology Oncology, Indiana University School of Medicine, Indianapolis, USA
    Blood 96:2703-11. 2000
    ..4%), respectively. This series of 30 UCB transplants suggests that although CD8 cell recovery is delayed, the pattern of immune reconstitution with UCB is similar to that reported for other stem cell sources. (Blood. 2000;96:2703-2711)..
  62. ncbi Blocking of c-FLIP(L)--independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction
    B S Youn
    Department of Microbiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 98:925-33. 2001
    ..It also suggests the existence of a novel pathway leading to CHX-induced apoptosis independently of c-FLIP(L). (Blood. 2001;98:925-933)..
  63. ncbi Development of a transgenic mouse that overexpresses a novel product of the growth hormone-releasing hormone gene
    S Fang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Endocrinology 141:1377-83. 2000
    ....
  64. ncbi Biology of cord blood cells and future prospects for enhanced clinical benefit
    H E Broxmeyer
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana univrsity School of Medicine, Indianapolis, IN 46202, USA
    Cytotherapy 7:209-18. 2005
    ..The presence and biology of these non-HSC/HPC may open up future possibilities for additional clinical benefit of CB, a product considered mainly for discard before its clinical transplantation potential was realized in the late 1980s...
  65. ncbi Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production
    T Starnes
    Department of Medicine and Biochemistry, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA
    J Immunol 167:4137-40. 2001
    ..However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1...
  66. ncbi TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor
    B S Youn
    Department of Microbiology, Walther Oncology Center, Indianapolis, IN, USA
    Blood 94:2533-6. 1999
    ..Our data suggest that TECK/CCR9 interaction may play a pivotal role in T-cell migration in the thymus...
  67. ncbi Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway
    T Tauchi
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    J Exp Med 179:167-75. 1994
    ..Shc may not be required for Grb2-c-kit interaction, because it fails to bind strongly to c-kit...
  68. ncbi Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice
    L S Haneline
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 91:4092-8. 1998
    ..Together these data suggest a role of Fac in affecting the signaling of multiple cytokine pathways and support cytokine-mediated apoptosis as a major mechanism responsible for BM failure observed in FA patients...
  69. ncbi Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways
    T Tauchi
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    J Biol Chem 270:5631-5. 1995
    ..These results suggest that Syp may be an important signaling component downstream of the EpoR and may regulate the proliferation and differentiation of hematopoietic cells...
  70. ncbi Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1
    Jizhong Zhang
    Department of Microbiology and Immunology, Division of Infectious Diseases, Walther Oncology Center, Walther Oncology Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 174:7995-8002. 2005
    ..These results provide one potential mechanism through which GC infection increases HIV replication in patients infected with both GC and HIV...
  71. ncbi The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
    T Tauchi
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    J Biol Chem 269:25206-11. 1994
    ..These results suggest that Syp may be an important signaling component downstream of the c-kit receptor and involved in activation of the Ras signaling pathway in hematopoietic cells...
  72. ncbi Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells
    C K Qu
    Departments of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5254, USA
    Mol Cell Biol 18:6075-82. 1998
    ..More importantly, the requirement for Shp-2 is more stringent in hematopoiesis than in other systems...
  73. ncbi Synergistic activation of RSK correlates with c-fos induction in MO7e cells stimulated with GM-CSF plus Steel factor
    Y Lee
    Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biochem Biophys Res Commun 281:897-901. 2001
    ..Taken together, synergistic activation of RSK may contribute, at least in part, to the synergistic induction of c-fos after combined stimulation with GM-CSF plus SLF...
  74. ncbi Interleukin-11 enhancement of VLA-5 mediated adhesion of CD34+ cells from cord blood to fibronectin is associated with the PI-3 kinase pathway
    L S Wang
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202 5254, USA
    In Vivo 14:331-7. 2000
    ..The results suggest that this enhanced adhesion is associated with the PI-3 kinase pathway, an inside-out signaling pathway...
  75. ncbi Efficacy of recombinant human macrophage colony-stimulating factor in combination with whole-body hyperthermia in the treatment of mice infected with the polycythemia-inducing strain of the Friend virus complex
    L Lu
    Department of Medicine, Indiana University School of Medicine, Indianapolis
    Exp Hematol 19:804-9. 1991
    ..These results suggest the possibility that M-CSF may have a therapeutic effect in combination with WBH in the in vivo treatment of certain hematologic malignancies and/or retroviral infections...
  76. ncbi Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
    S Zhang
    Department of Microbiology Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202 5254, USA
    J Leukoc Biol 65:372-80. 1999
    ....
  77. ncbi Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice
    M Tian
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Exp Med 185:1517-22. 1997
    ..Taken together, these results suggest a novel role of the mu opioid receptor in hematopoiesis and reproductive physiology, in addition to its known involvement in pain relief...
  78. ncbi Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells
    Y J Kim
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Hematother Stem Cell Res 10:441-9. 2001
    ..In this review, we discuss the importance of 4-1BB for development or survival of functionally active effector CD8(+) T cells against tumors, virus infection, and allogeneic immune responses and for potential therapeutic application...
  79. ncbi Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not
    Wen Tao
    Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Room 302, Indianapolis, IN 46202, USA
    Stem Cells 25:670-8. 2007
    ..Therefore, EGFP has no detectable deteriorative effects on HSCs, and is nearly an ideal long-term expression tracer for hematopoietic cells; however, DsRed-Express fluorescent protein is not suitable for these cells...
  80. ncbi Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte-derived dendritic cells to CCL19 and CXCL12
    Geling Li
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN 46202, USA
    Blood 109:3173-6. 2007
    ..These findings may have potential relevance to better understanding DC function in CB transplantation...
  81. ncbi A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities
    Jeffrey D Altenburg
    Department of Microbiology and Immunology, Indiana University School of Medicine, 635 Barnhill Drive, Room 420, Indianapolis, IN 46202, USA
    J Virol 81:8140-8. 2007
    ....
  82. ncbi Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice
    Hal E Broxmeyer
    Department of Microbiology and Immunology and the Walther Oncology Center, 950 W Walnut St R2 302, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cell Biol 27:5275-85. 2007
    ..Since both BAZF- and BCL-6-deficient mice have defects in CD8 T-cell differentiation, we hypothesize that both BCL-6 and BAZF regulate HPC homeostasis by an indirect pathway involving CD8 T cells...
  83. ncbi Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist
    W Conrad Liles
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Transfusion 45:295-300. 2005
    ..CONCLUSION: These findings indicate that AMD3100 can be used alone or as an adjunct to G-CSF to mobilize cells for HPC transplantation...
  84. ncbi TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors
    Geling Li
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood 110:2872-9. 2007
    ..TGF-M-DCs appear unique among culture-generated DCs in their capability for silencing immunity while promoting expansion of myeloid progenitors, events that may be of therapeutic value...
  85. ncbi Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice
    Timothy B Campbell
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Stem Cells Dev 16:347-54. 2007
    ..These results suggest that inhibition of CD26 may be one way to enhance engraftment of limiting numbers of stem cells during CB transplantation...
  86. ncbi Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4
    Yong-Hao Hou
    Cancer Research and Treatment Center, University of New Mexico Health Science Center, 900 Camino de Salud, Albuquerque, NM 87131, USA
    Blood 105:3488-92. 2005
    ..These data define a novel B-cell/myeloid common progenitor (termed the BMP) and imply a less restrictive pathway of myeloid versus lymphoid development than previously postulated...
  87. ncbi Sirt1, notch and stem cell "age asymmetry"
    Charlie R Mantel
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Cell Cycle 7:2821-5. 2008
    ..Here, we discuss the potential relationships between SIRT1 and the surface receptor protein, Notch, with stem cell self-renewal, asymmetric cell division, signaling and stem cell aging...
  88. ncbi Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells
    Ying Liu
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:947-56. 2008
    ..To optimize culture and transduction conditions, we compared various lengths of time for prestimulation before transduction, transduction duration, and posttransduction cell culture...
  89. ncbi AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice
    Anna C Pulliam
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Exp Hematol 36:1084-90. 2008
    ....
  90. ncbi Src kinase, but not the src kinase family member p56lck, mediates stromal cell-derived factor 1alpha/CXCL12-induced chemotaxis of a T cell line
    Seiichi Okabe
    Department of Microbiology/Immunology and Medicine, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202-5254, USA
    J Hematother Stem Cell Res 11:923-8. 2002
    ....
  91. ncbi 4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells
    Young June Kim
    Department of Microbiology and Immunology, Indiana University School of Medicine 2 Walther Oncology Center, Indianapolis, IN 46202 5181, USA
    Blood 111:1378-86. 2008
    ..Co-expression of NKG2D and 4-1BB may represent an important biomarker for defining competency of tumor infiltrating CD8(+) T cells...
  92. ncbi CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation
    Timothy B Campbell
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Front Biosci 13:1795-805. 2008
    ..CD26 inhibition may, therefore, represent a novel approach to increasing the efficacy and success of HSC/HPC transplantation, especially under conditions of limiting donor cell yield...
  93. ncbi Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin
    Ying Guo
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Stem Cells 26:30-4. 2008
    ..Our results suggest that Oct-4 is essential for antiapoptosis of ES cells in response to stress, effects that may be mediated through the STAT3/Survivin pathway...
  94. ncbi Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells
    Sunanda Basu
    Department of Microbiology and Immunology, Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, IN 46202, USA
    J Immunol 179:3075-85. 2007
    ..CD34(+) CB cells pretreated with OA showed impaired ability to repopulate NOD-SCID mice in vivo, suggesting physiological relevance of these observations...
  95. ncbi Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide
    Wen Tao
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Ind 46202 5254, USA
    Exp Hematol 31:251-60. 2003
    ..Here we sought to systematically evaluate the basic molecular components and main pathways that govern and mediate cellular response initiated within human CD34(+) cells to etoposide-induced apoptosis...
  96. ncbi Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells
    Shigeki Ito
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1923-30. 2007
    ..These results suggest that Mad2 is involved in synergistic growth of immature hematopoietic progenitor cells in response to SCF plus GM-CSF, effects that may be mediated via physical association of Mad2 with c-Kit...
  97. ncbi CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice
    Kent W Christopherson
    Department of Microbiology Immunology and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, Ind 46202 5254, USA
    Exp Hematol 31:1126-34. 2003
    ..We set out to establish whether CD26 was an essential component of normal G-CSF-induced mobilization of HSC/HPC...
  98. ncbi Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution
    Laura S Haneline
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN, USA
    Blood 101:1299-307. 2003
    ..These studies also reveal potential detrimental effects of ex vivo manipulation for untransduced Fancc(-/-) HSCs...
  99. ncbi Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
    W Conrad Liles
    Department of Medicine, University of Washington, HSB AA 522, Box 356422, Seattle, WA 98195
    Blood 102:2728-30. 2003
    ..AMD3100 was well tolerated and caused only mild, transient toxicity. These findings suggest potential clinical application of AMD3100 for CD34+ cell mobilization and collection for hematopoietic stem cell transplantation...
  100. ncbi Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20
    Ling Liu
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Blood 102:3206-9. 2003
    ..This is the first cytokine with such specificity identified...
  101. ncbi Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
    Brian Freie
    Cancer Research Institute, 1044 W Walnut St, R4 408, Indianapolis, IN 46202, USA
    Blood 102:4146-52. 2003
    ..Collectively, these data demonstrate that p53 and Fancc interact functionally to regulate apoptosis and tumorigenesis in Fancc-deficient cells...

Research Grants40

  1. Cytokine Enhancement of Myeloid Progenitor Cell Survival
    Hal Broxmeyer; Fiscal Year: 2007
    ..These studies should enhance our knowledge of factors enhancing survival and self-renewal of stem cells, information that may be of clinical utility. ..
  2. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal Broxmeyer; Fiscal Year: 2007
    ..3. Elucidate the role of MSAC in proliferation of HSC and MPC, and in self-renewal of HSC, and link these effects to cytokine actions on these functions. ..
  3. Indiana University Initiative for Maximizing Graduate Student Diversity
    Hal Broxmeyer; Fiscal Year: 2007
    ..D. degrees and pursue careers as independent academic biomedical research scientists/faculty members. ..
  4. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  5. BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASES
    Hal Broxmeyer; Fiscal Year: 2007
    ..abstract_text> ..
  6. Bridges to the Doctorate at IU School of Medicine
    Hal Broxmeyer; Fiscal Year: 2007
    ....
  7. Cytokine Enhancement of Myeloid Progenitor Cell Survival
    Hal Broxmeyer; Fiscal Year: 2009
    ..These studies should enhance our knowledge of factors enhancing survival and self-renewal of stem cells, information that may be of clinical utility. ..
  8. REGULATION OF HEMATOPOIETIC CELL PRODUCTION
    Hal Broxmeyer; Fiscal Year: 2007
    ..cancer center, an NIH-designated National Gene Vector Laboratory, an NIDDK Center of Excellence in Molecular Hematology, and state-of-the-art infrastructure, and frequent contacts with active investigators at IU and throughout the world ..
  9. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2000
    ..These studies should help improve our understanding of stem/progenitor cell migration, homing and mobilization, information of importance to stem and progenitor cell behavior and transplantation. ..
  10. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal Broxmeyer; Fiscal Year: 1999
    ..4) Evaluate roles for the protein tyrosine phosphatases Syp and PRP-1C in synergistically-induced stimulation of cell proliferation and its suppression by chemokine family members. ..
  11. Cytokine Ehancement of Myeloid Progenitor Cell Survival
    Hal Broxmeyer; Fiscal Year: 2004
    ..Use MPC from mice functionally-deleted in proposed intracellular signaling molecules to determine dominant effects of these intracellular molecules in survival/anti-apoptotic events. ..
  12. Cytokine Enhancement of Myeloid Progenitor Cell Survival
    Hal Broxmeyer; Fiscal Year: 2003
    ..These studies should increase current understanding of the cytokines/receptors involved in survival of HES and their hematopoietic cell progeny. ..
  13. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal Broxmeyer; Fiscal Year: 2003
    ..abstract_text> ..
  14. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal E Broxmeyer; Fiscal Year: 2010
    ....