Research Topics
Species | Darron BrownSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
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Detail Information
Publications
Expression of cytokeratin 16 in human papillomavirus type 11-infected genital epitheliumTracy L McClowry
Department of Biology and Microbiology, University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA
J Med Virol 66:96-101. 2002..Determining the mechanisms of K16 transcriptional induction could lead to therapies with the ability to reduce cell proliferation within infected tissue...
A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent womenDarron R Brown
Division of Infectious Diseases, Indiana University School of Medicine, 545 Barnhill Dr, Emerson Hall, Rm 435, Indianapolis, IN 46202, USA
J Infect Dis 191:182-92. 2005..We performed a study to better characterize the natural history of genital human papillomavirus (HPV) infection in a cohort of closely followed adolescent women...- Detection of multiple human papillomavirus types in Condylomata acuminata lesions from otherwise healthy and immunosuppressed patientsD R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5124, USA
J Clin Microbiol 37:3316-22. 1999..Further studies are needed to determine the influence these additional HPV types have on the epidemiology of genital tract HPV infections and the natural history of condylomata acuminata, especially in immunosuppressed patients... - The humoral response to Gardasil over four years as defined by total IgG and competitive Luminex immunoassayDarron R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Hum Vaccin 7:230-8. 2011..Differences in seropositivity status are attributed to the measurement parameters and sensitivity of the individual immunoassays and do not indicate reduced anti-HPV18 protective antibodies... - Human papillomavirus infection and its association with cervical dysplasia in Ecuadorian women attending a private cancer screening clinicC R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Braz J Med Biol Res 42:629-36. 2009.... - Intracellular expression patterns of the human papillomavirus type 59 E1/E4 protein in COS cells, keratinocytes, and genital epitheliumDarron R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Intervirology 47:321-7. 2004..To compare and contrast the intracellular distribution pattern of the human papillomavirus type 59 (HPV 59) E1/E4 protein in COS cells, human keratinocytes, and naturally infected genital epithelium... - Early assessment of the efficacy of a human papillomavirus type 16 L1 virus-like particle vaccineDarron R Brown
Department of Medicine, Indiana University School of Medicine, Emerson Hall Room 435, 545 Barnhill Drive, Indianapolis 46022, USA
Vaccine 22:2936-42. 2004..These results support the institution of larger efficacy trials for HPV L1 VLP vaccines... - Distribution of human papillomavirus types in cervicovaginal washings from women evaluated in a sexually transmitted diseases clinicDarron R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Sex Transm Dis 29:763-8. 2002..Women evaluated for sexually transmitted diseases (STDs) may be at increased risk for human papillomavirus (HPV) infection, a condition associated with cervical dysplasia. The distribution of HPV types in such a population is unknown... - Abnormalities of cornified cell envelopes isolated from human papillomavirus type 11-infected genital epitheliumD R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Virology 271:65-70. 2000..We conclude that in addition to the previously described epithelial abnormalities induced by HPV, the CCE is also affected by infection in ways that may facilitate transmission of virus from person to person... - Neutralization of human papillomavirus type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: correlation with competitive radioimmunoassay titerD R Brown
Indiana University School of Medicine and Roudebush Veterans Administration Hospital, 545 Barnhill Dr, Indianapolis, IN 46202, USA
J Infect Dis 184:1183-6. 2001..Immunization with HPV VLPs elicits a vigorous serum immune response in a high percentage of women. The HPV-11 cRIA titer appears to be a surrogate marker for neutralization... 
Natural history of multiple human papillomavirus infections in female adolescents with prolonged follow-upBree Weaver
Department of Medicine, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
J Adolesc Health 48:473-80. 2011..The aim of the study was to better characterize the natural history of human papillomavirus (HPV) infections in female adolescents...- Reduction of HPV infections through vaccination among at-risk urban adolescentsTeresa Cummings
Department of Pediatrics, Indiana University School of Medicine, 410 West 10th Street, HS 1001, Indianapolis, IN 46202, USA
Vaccine 30:5496-9. 2012..This study examines the impact of HPV vaccination on subsequent HPV detection and sexual behaviors among urban adolescents in a clinical setting... - Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3Elizabeth Lehr
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
J Med Virol 72:478-83. 2004..Expression of individual SPRs differed between these types and these alterations may play a role in fragility of CCEs in HPV infection... - Infection with the oncogenic human papillomavirus type 59 alters protein components of the cornified cell envelopeElizabeth Lehr
Indiana University School of Medicine, Indianapolis, IN 46202, USA
Virology 309:53-60. 2003..Because loricrin is the major CCE protein, a reduction in this component could alter the physical properties of the CCE, thus facilitating virion release... - Prevalence and persistence of cervical human papillomavirus infection in HIV-positive women initiating highly active antiretroviral therapyKenneth H Fife
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5124, USA
J Acquir Immune Defic Syndr 51:274-82. 2009.... - The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16-26 yearsDarron R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Infect Dis 199:926-35. 2009..Here, its impact on CIN1-3/AIS associated with nonvaccine oncogenic HPV types was evaluated... - The human papillomavirus type 11 E1--E4 protein is a transglutaminase 3 substrate and induces abnormalities of the cornified cell envelopeDarron R Brown
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46077, USA
Virology 345:290-8. 2006..We conclude from these in vitro experiments that the E1--E4 protein is cross-linked by transglutaminase 3, and that E1--E4 expression in differentiated keratinocytes induces morphologic abnormalities of the cornified cell envelope... - Poor sensitivity of polymerase chain reaction assays of genital skin swabs and urine to detect HPV 6 and 11 DNA in menKenneth H Fife
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Sex Transm Dis 30:246-8. 2003..A possible reason for the failure to detect human papillomavirus (HPV) DNA in asymptomatic men who are likely to be infected is the sensitivity of the detection methods... - Human papillomavirus type 59 immortalized keratinocytes express late viral proteins and infectious virus after calcium stimulationElizabeth E Lehr
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Virology 314:562-71. 2003..Thus, the complete viral growth cycle, including production on infectious virus, was demonstrated in the HPV 59 immortalized cells grown in a simple culture system... - Dose-ranging studies of the safety and immunogenicity of human papillomavirus Type 11 and Type 16 virus-like particle candidate vaccines in young healthy womenKenneth H Fife
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
Vaccine 22:2943-52. 2004..Antibody to HPV11 and 16 was still present at Month 36 in 96.8 and 93.5% of vaccinees, respectively. Both vaccines were well tolerated and were associated with only mild to moderate injection-site reactions... - Progression from productive infection to integration and oncogenic transformation in human papillomavirus type 59-immortalized foreskin keratinocytesHelena Spartz
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Virology 336:11-25. 2005..We conclude that ERIN 59 cells are a valuable cell line representing a model of progression from HPV 59 episomal infection and virus production to HPV 59 integration and associated oncogenic transformation on the same host background... - Association of condom use, sexual behaviors, and sexually transmitted infections with the duration of genital human papillomavirus infection among adolescent womenMarcia L Shew
Division of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
Arch Pediatr Adolesc Med 160:151-6. 2006..30]). CONCLUSIONS: These findings support public health messages of reducing the number of sexual partners, promoting routine condom use, and frequent sexually transmitted infection screening that may be beneficial with HPV infections... - Human papillomavirus type 11 alters the transcription and expression of loricrin, the major cell envelope proteinElizabeth Lehr
Indiana University School of Medicine, Indianapolis, IN 46202, USA
Virology 298:240-7. 2002..Further studies will examine the effects of specific HPV gene products on transcription of loricrin and other CCE components, as it is likely that viral egress from the infected keratinocyte depends on these effects... - A controlled trial of a human papillomavirus type 16 vaccineLaura A Koutsky
Department of Epidemiology, University of Washington, Seattle, USA
N Engl J Med 347:1645-51. 2002..Although most infections are benign, some progress to anogenital cancer. A vaccine that reduces the incidence of HPV-16 infection may provide important public health benefits... - Antibodies from women immunized with Gardasil cross-neutralize HPV 45 pseudovirionsJudith F Smith
Vaccine and Biologics Research, MRL, Merck and Co, Inc, West Point, Pennsylvania, USA
Hum Vaccin 3:109-15. 2007..These data demonstrate that Gardasil(r) immunization induces antibodies capable of neutralizing HPV 18 PsV and HPV 45 PsV in vitro... - Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18Luisa L Villa
Department of Virology, Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, SP, Brazil
Vaccine 24:5571-83. 2006..Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported... - Efficacy of human papillomavirus-16 vaccine to prevent cervical intraepithelial neoplasia: a randomized controlled trialConstance Mao
Department of Obstetrics and Gynecology and Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
Obstet Gynecol 107:18-27. 2006..Whether protection lasts longer than 18 months and, thus, impacts rates of cervical intraepithelial neoplasia (CIN) 2-3 has not yet been established. We present results from an HPV16 L1 VLP vaccine trial through 48 months... - Detection of specific human papillomavirus types in paraffin-embedded sections of cervical carcinomasJanine T Bryan
Merck Research Laboratories, West Point, Pennsylvania, USA
J Med Virol 78:117-24. 2006..We conclude that HPV typing from formalin-fixed, paraffin-embedded sections of cervical carcinomas is possible, with a sensitivity that is similar to that found in studies using fresh tissue... - Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trialLuisa L Villa
Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
Lancet Oncol 6:271-8. 2005.... - Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?Joakim Dillner
Division of Laboratory Medicine, Department of Medical Microbiology, University Hospital at Malmö, Lund University, S 20502 Malmo, Sweden
Expert Rev Mol Med 6:1-21. 2004..It then summarises studies examining the use of vaccines to prevent HPV infection in animals and humans, and, finally, discusses some of the unanswered issues surrounding vaccine development against HPV infection and cervical cancer...
Research Grants
- Changes in the Cornified Cell Envelope in HPV InfectionDarron Brown; Fiscal Year: 2006..abstract_text> ..
- HPV in Adolescent WomenDarron R Brown; Fiscal Year: 2010..This information is important in determining why some, but not all women with HPV infection develop cancer. ..