Darron Brown

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Expression of cytokeratin 16 in human papillomavirus type 11-infected genital epithelium
    Tracy L McClowry
    Department of Biology and Microbiology, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, USA
    J Med Virol 66:96-101. 2002
  2. pmc A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women
    Darron R Brown
    Division of Infectious Diseases, Indiana University School of Medicine, 545 Barnhill Dr, Emerson Hall, Rm 435, Indianapolis, IN 46202, USA
    J Infect Dis 191:182-92. 2005
  3. pmc Detection of multiple human papillomavirus types in Condylomata acuminata lesions from otherwise healthy and immunosuppressed patients
    D R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5124, USA
    J Clin Microbiol 37:3316-22. 1999
  4. ncbi request reprint The humoral response to Gardasil over four years as defined by total IgG and competitive Luminex immunoassay
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Vaccin 7:230-8. 2011
  5. ncbi request reprint Human papillomavirus infection and its association with cervical dysplasia in Ecuadorian women attending a private cancer screening clinic
    C R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Braz J Med Biol Res 42:629-36. 2009
  6. ncbi request reprint Intracellular expression patterns of the human papillomavirus type 59 E1/E4 protein in COS cells, keratinocytes, and genital epithelium
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Intervirology 47:321-7. 2004
  7. ncbi request reprint Early assessment of the efficacy of a human papillomavirus type 16 L1 virus-like particle vaccine
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Emerson Hall Room 435, 545 Barnhill Drive, Indianapolis 46022, USA
    Vaccine 22:2936-42. 2004
  8. ncbi request reprint Distribution of human papillomavirus types in cervicovaginal washings from women evaluated in a sexually transmitted diseases clinic
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Sex Transm Dis 29:763-8. 2002
  9. ncbi request reprint Abnormalities of cornified cell envelopes isolated from human papillomavirus type 11-infected genital epithelium
    D R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Virology 271:65-70. 2000
  10. ncbi request reprint Neutralization of human papillomavirus type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: correlation with competitive radioimmunoassay titer
    D R Brown
    Indiana University School of Medicine and Roudebush Veterans Administration Hospital, 545 Barnhill Dr, Indianapolis, IN 46202, USA
    J Infect Dis 184:1183-6. 2001

Research Grants

  1. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
  2. HPV in Adolescent Women
    Darron R Brown; Fiscal Year: 2010

Detail Information

Publications30

  1. ncbi request reprint Expression of cytokeratin 16 in human papillomavirus type 11-infected genital epithelium
    Tracy L McClowry
    Department of Biology and Microbiology, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, USA
    J Med Virol 66:96-101. 2002
    ..Determining the mechanisms of K16 transcriptional induction could lead to therapies with the ability to reduce cell proliferation within infected tissue...
  2. pmc A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women
    Darron R Brown
    Division of Infectious Diseases, Indiana University School of Medicine, 545 Barnhill Dr, Emerson Hall, Rm 435, Indianapolis, IN 46202, USA
    J Infect Dis 191:182-92. 2005
    ..We performed a study to better characterize the natural history of genital human papillomavirus (HPV) infection in a cohort of closely followed adolescent women...
  3. pmc Detection of multiple human papillomavirus types in Condylomata acuminata lesions from otherwise healthy and immunosuppressed patients
    D R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5124, USA
    J Clin Microbiol 37:3316-22. 1999
    ..Further studies are needed to determine the influence these additional HPV types have on the epidemiology of genital tract HPV infections and the natural history of condylomata acuminata, especially in immunosuppressed patients...
  4. ncbi request reprint The humoral response to Gardasil over four years as defined by total IgG and competitive Luminex immunoassay
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Vaccin 7:230-8. 2011
    ..Differences in seropositivity status are attributed to the measurement parameters and sensitivity of the individual immunoassays and do not indicate reduced anti-HPV18 protective antibodies...
  5. ncbi request reprint Human papillomavirus infection and its association with cervical dysplasia in Ecuadorian women attending a private cancer screening clinic
    C R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Braz J Med Biol Res 42:629-36. 2009
    ....
  6. ncbi request reprint Intracellular expression patterns of the human papillomavirus type 59 E1/E4 protein in COS cells, keratinocytes, and genital epithelium
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Intervirology 47:321-7. 2004
    ..To compare and contrast the intracellular distribution pattern of the human papillomavirus type 59 (HPV 59) E1/E4 protein in COS cells, human keratinocytes, and naturally infected genital epithelium...
  7. ncbi request reprint Early assessment of the efficacy of a human papillomavirus type 16 L1 virus-like particle vaccine
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Emerson Hall Room 435, 545 Barnhill Drive, Indianapolis 46022, USA
    Vaccine 22:2936-42. 2004
    ..These results support the institution of larger efficacy trials for HPV L1 VLP vaccines...
  8. ncbi request reprint Distribution of human papillomavirus types in cervicovaginal washings from women evaluated in a sexually transmitted diseases clinic
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Sex Transm Dis 29:763-8. 2002
    ..Women evaluated for sexually transmitted diseases (STDs) may be at increased risk for human papillomavirus (HPV) infection, a condition associated with cervical dysplasia. The distribution of HPV types in such a population is unknown...
  9. ncbi request reprint Abnormalities of cornified cell envelopes isolated from human papillomavirus type 11-infected genital epithelium
    D R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Virology 271:65-70. 2000
    ..We conclude that in addition to the previously described epithelial abnormalities induced by HPV, the CCE is also affected by infection in ways that may facilitate transmission of virus from person to person...
  10. ncbi request reprint Neutralization of human papillomavirus type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: correlation with competitive radioimmunoassay titer
    D R Brown
    Indiana University School of Medicine and Roudebush Veterans Administration Hospital, 545 Barnhill Dr, Indianapolis, IN 46202, USA
    J Infect Dis 184:1183-6. 2001
    ..Immunization with HPV VLPs elicits a vigorous serum immune response in a high percentage of women. The HPV-11 cRIA titer appears to be a surrogate marker for neutralization...
  11. doi request reprint Natural history of multiple human papillomavirus infections in female adolescents with prolonged follow-up
    Bree Weaver
    Department of Medicine, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    J Adolesc Health 48:473-80. 2011
    ..The aim of the study was to better characterize the natural history of human papillomavirus (HPV) infections in female adolescents...
  12. pmc Reduction of HPV infections through vaccination among at-risk urban adolescents
    Teresa Cummings
    Department of Pediatrics, Indiana University School of Medicine, 410 West 10th Street, HS 1001, Indianapolis, IN 46202, USA
    Vaccine 30:5496-9. 2012
    ..This study examines the impact of HPV vaccination on subsequent HPV detection and sexual behaviors among urban adolescents in a clinical setting...
  13. ncbi request reprint Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3
    Elizabeth Lehr
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    J Med Virol 72:478-83. 2004
    ..Expression of individual SPRs differed between these types and these alterations may play a role in fragility of CCEs in HPV infection...
  14. ncbi request reprint Infection with the oncogenic human papillomavirus type 59 alters protein components of the cornified cell envelope
    Elizabeth Lehr
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Virology 309:53-60. 2003
    ..Because loricrin is the major CCE protein, a reduction in this component could alter the physical properties of the CCE, thus facilitating virion release...
  15. pmc Prevalence and persistence of cervical human papillomavirus infection in HIV-positive women initiating highly active antiretroviral therapy
    Kenneth H Fife
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5124, USA
    J Acquir Immune Defic Syndr 51:274-82. 2009
    ....
  16. doi request reprint The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16-26 years
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Infect Dis 199:926-35. 2009
    ..Here, its impact on CIN1-3/AIS associated with nonvaccine oncogenic HPV types was evaluated...
  17. ncbi request reprint The human papillomavirus type 11 E1--E4 protein is a transglutaminase 3 substrate and induces abnormalities of the cornified cell envelope
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46077, USA
    Virology 345:290-8. 2006
    ..We conclude from these in vitro experiments that the E1--E4 protein is cross-linked by transglutaminase 3, and that E1--E4 expression in differentiated keratinocytes induces morphologic abnormalities of the cornified cell envelope...
  18. ncbi request reprint Poor sensitivity of polymerase chain reaction assays of genital skin swabs and urine to detect HPV 6 and 11 DNA in men
    Kenneth H Fife
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Sex Transm Dis 30:246-8. 2003
    ..A possible reason for the failure to detect human papillomavirus (HPV) DNA in asymptomatic men who are likely to be infected is the sensitivity of the detection methods...
  19. ncbi request reprint Human papillomavirus type 59 immortalized keratinocytes express late viral proteins and infectious virus after calcium stimulation
    Elizabeth E Lehr
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Virology 314:562-71. 2003
    ..Thus, the complete viral growth cycle, including production on infectious virus, was demonstrated in the HPV 59 immortalized cells grown in a simple culture system...
  20. ncbi request reprint Dose-ranging studies of the safety and immunogenicity of human papillomavirus Type 11 and Type 16 virus-like particle candidate vaccines in young healthy women
    Kenneth H Fife
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Vaccine 22:2943-52. 2004
    ..Antibody to HPV11 and 16 was still present at Month 36 in 96.8 and 93.5% of vaccinees, respectively. Both vaccines were well tolerated and were associated with only mild to moderate injection-site reactions...
  21. ncbi request reprint Progression from productive infection to integration and oncogenic transformation in human papillomavirus type 59-immortalized foreskin keratinocytes
    Helena Spartz
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Virology 336:11-25. 2005
    ..We conclude that ERIN 59 cells are a valuable cell line representing a model of progression from HPV 59 episomal infection and virus production to HPV 59 integration and associated oncogenic transformation on the same host background...
  22. ncbi request reprint Association of condom use, sexual behaviors, and sexually transmitted infections with the duration of genital human papillomavirus infection among adolescent women
    Marcia L Shew
    Division of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Arch Pediatr Adolesc Med 160:151-6. 2006
    ..To examine the association of potentially modifiable factors such as condom use, sexual behaviors, and concurrent sexually transmitted infections with duration of genital human papillomavirus (HPV) infections among adolescent women...
  23. ncbi request reprint Human papillomavirus type 11 alters the transcription and expression of loricrin, the major cell envelope protein
    Elizabeth Lehr
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Virology 298:240-7. 2002
    ..Further studies will examine the effects of specific HPV gene products on transcription of loricrin and other CCE components, as it is likely that viral egress from the infected keratinocyte depends on these effects...
  24. ncbi request reprint A controlled trial of a human papillomavirus type 16 vaccine
    Laura A Koutsky
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 347:1645-51. 2002
    ..Although most infections are benign, some progress to anogenital cancer. A vaccine that reduces the incidence of HPV-16 infection may provide important public health benefits...
  25. ncbi request reprint Antibodies from women immunized with Gardasil cross-neutralize HPV 45 pseudovirions
    Judith F Smith
    Vaccine and Biologics Research, MRL, Merck and Co, Inc, West Point, Pennsylvania, USA
    Hum Vaccin 3:109-15. 2007
    ..These data demonstrate that Gardasil(r) immunization induces antibodies capable of neutralizing HPV 18 PsV and HPV 45 PsV in vitro...
  26. ncbi request reprint Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:5571-83. 2006
    ..Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported...
  27. ncbi request reprint Efficacy of human papillomavirus-16 vaccine to prevent cervical intraepithelial neoplasia: a randomized controlled trial
    Constance Mao
    Department of Obstetrics and Gynecology and Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    Obstet Gynecol 107:18-27. 2006
    ..Whether protection lasts longer than 18 months and, thus, impacts rates of cervical intraepithelial neoplasia (CIN) 2-3 has not yet been established. We present results from an HPV16 L1 VLP vaccine trial through 48 months...
  28. ncbi request reprint Detection of specific human papillomavirus types in paraffin-embedded sections of cervical carcinomas
    Janine T Bryan
    Merck Research Laboratories, West Point, Pennsylvania, USA
    J Med Virol 78:117-24. 2006
    ..We conclude that HPV typing from formalin-fixed, paraffin-embedded sections of cervical carcinomas is possible, with a sensitivity that is similar to that found in studies using fresh tissue...
  29. ncbi request reprint Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Lancet Oncol 6:271-8. 2005
    ....
  30. ncbi request reprint Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?
    Joakim Dillner
    Division of Laboratory Medicine, Department of Medical Microbiology, University Hospital at Malmö, Lund University, S 20502 Malmo, Sweden
    Expert Rev Mol Med 6:1-21. 2004
    ..It then summarises studies examining the use of vaccines to prevent HPV infection in animals and humans, and, finally, discusses some of the unanswered issues surrounding vaccine development against HPV infection and cervical cancer...

Research Grants7

  1. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..abstract_text> ..
  2. HPV in Adolescent Women
    Darron R Brown; Fiscal Year: 2010
    ..This information is important in determining why some, but not all women with HPV infection develop cancer. ..