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Genomes and Genes | Steven D BillingsSummaryAffiliation: Indiana University Country: USA Publications
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Publications
Loss of heterozygosity analysis identifies genetic abnormalities in mycosis fungoides and specific loci associated with disease progressionTerrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 31:1552-6. 2007..Further, in this series, several loci associated with the tumor suppressor gene PTEN on chromosome 10 appear to be associated with progression from plaque to tumor stage...- Langerhans cell histiocytosis associated with myelodysplastic syndrome in adultsSteven D Billings
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Cutan Pathol 33:171-4. 2006..Langerhans cell histiocytosis (LCH) is primarily a pediatric disease, and rarely LCH has been described in association with pediatric MDS. We are aware of only a single case report of LCH associated with MDS in an adult... - Spindle cell lipoma of the oral cavitySteven D Billings
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Dermatopathol 28:28-31. 2006..The combination of the histologic features and the immunoreactivity for CD34 confirmed the diagnosis. Spindle cell lipoma should be considered in the differential diagnosis of oral cavity mesenchymal tumors... - Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 casesSteven D Billings
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 28:781-8. 2004..The median interval to death was 33.5 months. All 4 patients with disease have documented metastasis. CPRASB differs from Stewart-Treves AS by its shorter latency period and lack of association with lymphedema... - Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanomaTerrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 31:1029-37. 2007.... 
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinomaBriana C Gleason
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Cutan Pathol 36:543-7. 2009..p63 reactivity argues against the diagnosis of AFX and is therefore a useful addition to the standard immunohistochemical panel for cutaneous spindle cell neoplasms...- Malignant cutaneous glomus tumor presenting as a rapidly growing leg mass in a pregnant womanThomas L Cibull
Department of Pathology, University of Arkansas Medical Center, Little Rock, AR, USA
J Cutan Pathol 35:765-9. 2008..Although our case was superficially located, the nuclear atypia and mitotic rate, as well as the large size, fulfilled the criteria for a malignant glomus tumor... - Expression of androgen receptor by fibroepithelioma of Pinkus: evidence supporting classification as a basal cell carcinoma variant?Terrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Dermatopathol 29:7-12. 2007..In small, partial biopsy specimens, coexpression of androgen receptor and cytokeratin 20 may aid in the diagnosis of fibroepithelioma of Pinkus... - Clonal relationships between epidermotropic metastatic melanomas and their primary lesions: a loss of heterozygosity and X-chromosome inactivation-based analysisSoon Bahrami
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Mod Pathol 20:821-7. 2007..Our data also indicated that some cases diagnosed as epidermotropic metastatic melanoma might be divergent clones or new primaries rather than metastatic disease... - Expression of MiTF may be helpful in differentiating cellular neurothekeoma from plexiform fibrohistiocytic tumor (histiocytoid predominant) in a partial biopsy specimenMelanie D Fox
Department of Pathology, NorthShore University Healthsystem, Evanston, IL 60201, USA
Am J Dermatopathol 34:157-60. 2012..Some have suggested that CNT and PFHT are related entities. No prior study has demonstrated a reliable immunohistochemical panel to differentiate these entities... - Leiomyosarcoma of the penis presenting as a cutaneous lesionThomas L Cibull
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
J Cutan Pathol 35:585-7. 2008..This is an important diagnosis in the differential diagnosis of cutaneous spindle cell neoplasms of the male genital tract... - Spindle cell hemangioma: report of a case presenting in the oral cavityMichael Sheehan
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
J Cutan Pathol 34:797-800. 2007..Spindle cell hemangioma, formerly termed spindle cell hemangioendothelioma, is an uncommon benign vascular tumor. Presentation in the oral cavity is rare with only two previously reported cases... - Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma?Terrence M Katona
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46259, USA
J Cutan Pathol 35:174-9. 2008..We investigated whether AR and CK20 immunostains may distinguish between mBCC and DTE... - FUS rearrangements are rare in 'pure' sclerosing epithelioid fibrosarcomaWei Lien Wang
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mod Pathol 25:846-53. 2012.... - Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26Jerad M Gardner
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Am J Surg Pathol 36:1047-51. 2012..The low incidence of MDM2 gene amplification in our series indicates that most superficial PLs are unrelated to WDL/DL. PL likely evolves by way of more than 1 molecular pathway... - Myeloid leukemia cutis: a histologic and immunohistochemical reviewThomas L Cibull
Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
J Cutan Pathol 35:180-5. 2008..The histologic diagnosis of myeloid leukemia cutis (LC) can be difficult, requiring confirmatory immunohistochemical stains... - Cutaneous malignant ossifying fibromyxoid tumorThomas L Cibull
Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5126, USA
Am J Dermatopathol 29:156-9. 2007..Given the histologic features, this tumor was considered a malignant OFMT. The patient had a wide excision. The patient died secondary to unrelated comorbidities without evidence of recurrence or metastasis... - FUS (16p11) gene rearrangement as detected by fluorescence in-situ hybridization in cutaneous low-grade fibromyxoid sarcoma: a potential diagnostic toolRajiv M Patel
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Am J Dermatopathol 33:140-3. 2011..When applied to suspicious superficial myxoid or fibromyxoid neoplasms, the FUS FISH probe in formalin-fixed paraffin-embedded tissue can be a useful ancillary technique for diagnosis of this uncommon and deceptively bland tumor... - Epithelioid sarcoma-like hemangioendotheliomaSteven D Billings
Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
Am J Surg Pathol 27:48-57. 2003..Its distinction from other epithelioid vascular lesions is discussed. We think this tumor fits best into the family of "hemangioendothelioma" or vascular lesions of intermediate malignancy... - Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentationMary F Varsegi
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
J Cutan Pathol 35:591-3. 2008..To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma... - Cellular neurothekeoma with fascicular growth features mimicking cellular dermatofibromaBeenu Thakral
Department of Pathology, NorthShore University Healthsystem, Evanston, IL 60201, USA
Am J Dermatopathol 33:281-4. 2011..Most demonstrate a lobulated to micronodular architecture. Rarely, CNT demonstrates a predominantly fascicular growth pattern, without prominent sclerosis and thus can mimic cellular dermatofibroma (DF)... - Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experienceMunir R Tanas
Department of Pathology, Cleveland Clinic, Ohio, USA
Arch Pathol Lab Med 134:1797-803. 2010..Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH)... - Sebaceous carcinoma of the nippleThomas L Cibull
IUMC Clarian Pathology Laboratory 350 West 11th Street, Indianapolis, IN 46202, USA
J Cutan Pathol 35:608-10. 2008..We report a case of an 83-year-old woman with SC of the nipple. To our knowledge, this is the first report of SC arising in the nipple... - Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an updateSteven D Billings
Department of Pathology, Indiana University, Indianapolis, IN, USA
Am J Dermatopathol 26:141-55. 2004..The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed... 
Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infectionStanley M Spinola
Departments of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
Infect Immun 71:6658-63. 2003..There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model...- Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyiTricia L Humphreys
Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
Infect Immun 73:3896-902. 2005..Soler, T. L. Humphreys, S. M. Spinola, and J. J. Campbell, Blood 101:1677-1683, 2003), these studies led us to propose a model of memory T-cell trafficking to skin in response to experimental H. ducreyi infection... - Cutaneous malignant peripheral nerve sheath tumorsCrystal Thomas
Department of Pathology and Laboratory Medicine, Beth Israel Medical Center, Continuum Hospitals of New York, New York, NY, USA
J Cutan Pathol 36:896-900. 2009..Increase in size of pre-existing neurofibromas is an indication for biopsy. Recognition of the cellular atypia, increased cellularity and mitotic activity is key to the diagnosis... - Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literatureAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Am J Surg Pathol 28:1-30. 2004..Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO... - Expression of OCT4 transcription factor in cutaneous neoplasiaTerrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
Appl Immunohistochem Mol Morphol 15:359-62. 2007..In contrast to previous studies, our data indicate that the OCT4 expression is not retained in cutaneous neoplasms derived from basal epidermis or related adnexal neoplasms, including lesions of the scalp... - GMS is superior to PAS for diagnosis of onychomycosisZandra D'Hue
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
J Cutan Pathol 35:745-7. 2008..We performed a retrospective study comparing the use of PAS and Gomori methenamine silver (GMS) stains for histopathologic diagnosis of onychomycosis... - Abdominal plaque in a 10-day-old boyErnest Lee
Indiana University School of Medicine, Indianapolis, USA
Arch Dermatol 142:641-6. 2006 - Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric populationSteven D Billings
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Surg Pathol 29:204-10. 2005..Superficial LGFMS is more common than previously recognized and may affect children at a higher rate (7 of 19, 37%) than that for deep LGFMS. The prognosis is good and appears to be better than that for deep LGFMS... - CD4+ CD56+ hematodermic neoplasmThomas L Cibull
Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
Am J Dermatopathol 29:59-61. 2007..CD4+CD56+ hematodermic neoplasms are rare and commonly present as cutaneous lesions. This is an important diagnosis in the differential diagnosis of cutaneous hematologic malignancies because of the extremely poor prognosis... - Recalcitrant papulopustular rosacea in an immunocompetent patient responding to combination therapy with oral ivermectin and topical permethrinKattie J Allen
Indiana University School of Medicine, Indianapolis 46202, USA
Cutis 80:149-51. 2007..If infestation is demonstrated in these patients, oral ivermectin in combination with topical permethrin is a safe and effective therapeutic option... - Aberrant expression of tight junction-related proteins ZO-1, claudin-1 and occludin in synovial sarcoma: an immunohistochemical study with ultrastructural correlationSteven D Billings
Department of Pathology, Indiana University, Indianapolis, IN, USA
Mod Pathol 17:141-9. 2004..In contrast, the spindled cells of all synovial sarcomas show significant abnormalities in the expression and localization of tight junction proteins, suggesting partial and/or aberrant epithelial differentiation... - Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptorQiwei Zhang
Department of Dermatology, H B Wells Center for Pedoatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Invest 115:2855-61. 2005..These findings show a novel mechanism by which staphylococcal infections can inhibit Th1 reactions and thus worsen Th2 skin diseases, such as atopic dermatitis... - Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthomaSteven D Billings
Departments of Pathology and Laboratory Medicine and Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Pathol 163:2451-8. 2003..The HaCaT-NIE cells formed thin tumors resembling conventional SCC. The HaCaT-AR cells formed rapidly growing tumors with AR expression similar to KA. HaCaT-AR cells may represent a new system for the further evaluation of KA... - Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermisRaymond L Konger
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Invest Dermatol 124:965-70. 2005..In cultured primary human keratinocytes, we also verified the presence of functional EP(1) receptor coupled to intracellular calcium mobilization and EP(2) receptor coupled to cAMP production... - Histological evaluation of acute mucocutaneous graft-versus-host disease in nonmyeloablative hematologic stem cell transplants with an observation predicting an increased risk of progression to chronic graft-versus-host diseaseAndrew T Bridge
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Dermatopathol 29:1-6. 2007..Patients with composite skin GVHD may benefit from an earlier, more aggressive immunosuppressive interventional strategy... - Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testisKevin M Kernek
Departments of Pathology and Laboratory Medicine and Urology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Pathol 163:2477-84. 2003..Our data support the common clonal origin of mature teratoma with other components of malignant mixed germ cell tumors of the testis... - Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous diseaseW Scott Goebel
Department of Pediatrics Hematology Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Invest Dermatol 125:705-10. 2005.... - The enterobacterial common antigen-like gene cluster of Haemophilus ducreyi contributes to virulence in humansKeith E Banks
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
J Infect Dis 197:1531-6. 2008..3%-70.0%) of 15 parent-strain sites and at 8.3% (95% CI, 0.01%-23.6%) of 12 mutant-strain sites (P = .013). Thus, the expression of wecA contributes to the ability of H. ducreyi to cause pustules in humans... - Metastatic esophageal carcinoma masquerading as inflammatory breast carcinomaChristy L Nebesio
Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Int J Dermatol 46:303-5. 2007..The tumor nuclei were positive for CDX-2 but negative for both steroid receptors (Fig. 3), confirming the diagnosis of metastatic esophageal adenocarcinoma... - Molecular evidence supporting the neoplastic nature of some epidermoid cysts of the testisCheryl Younger
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Arch Pathol Lab Med 127:858-60. 2003..Our findings support that some examples of epidermoid cysts are neoplastic, although their low frequency of LOH also supports that they are genetically different from malignant germ cell tumors... - Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damageGopal K Marathe
Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
J Biol Chem 280:35448-57. 2005..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses... - Fungating forehead plaque: angiosarcomaBenjamin N Lockshin
Case Western Reserve School of Medicine, Silver Spring, MD, USA
Arch Dermatol 142:1059-64. 2006 - Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variantsSteven D Billings
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Dermatopathol 29:437-42. 2007..CD34 was diffusely positive (10/11). A high index of suspicion based on clinical context and identification of other typical features of SCL are key features to the diagnosis of low-fat and fat-free SCL... - Subungual pleomorphic fibromaYa-Ju Hsieh
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan
J Cutan Pathol 30:569-71. 2003..This is only the second case reported of a subungual pleomorphic fibroma. Pleomorphic fibroma should be considered in the differential diagnosis of pleomorphic subungual tumors... - Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?Torsten Ehrig
Dermatopathology Laboratory of New England, Meriden, CT 06450, USA
Ann Diagn Pathol 11:153-9. 2007..0 years). Cutaneous PN/ES is a superficial round cell tumor in older women, with better prognosis than deep PN/ES. These may have a hitherto unrecognized variant genetic abnormality... - Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimicsAndrew L Folpe
H 175 Department of Pathology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Am J Surg Pathol 26:1620-6. 2002..In particular, claudin-1 is often a more robust marker than EMA in a given perineurioma. Claudin-1 is not expressed within the lesional cells of the mesenchymal tumors that enter into the differential diagnosis of perineurioma...