Robert Bigsby

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer
    Suresh Kumar
    Departments of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Pathol 163:2531-41. 2003
  2. ncbi Protective effects of estrogen in a rat model of age-related cataracts
    R M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46228, USA
    Proc Natl Acad Sci U S A 96:9328-32. 1999
  3. ncbi The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202 5121, USA
    Carcinogenesis 32:1162-6. 2011
  4. ncbi Estrogen induces a systemic growth factor through an estrogen receptor-alpha-dependent mechanism
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    Biol Reprod 70:178-83. 2004
  5. ncbi Control of growth and differentiation of the endometrium: the role of tissue interactions
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    Ann N Y Acad Sci 955:110-7; discussion 118, 396-406. 2002
  6. ncbi Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street IB360, Indianapolis, IN 46202, USA
    Cancer Lett 179:113-9. 2002
  7. ncbi Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase
    Minati Satpathy
    Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
    Cancer Res 67:7194-202. 2007
  8. ncbi The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging
    Susan Brutkiewicz
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Luminescence 22:221-8. 2007
  9. ncbi Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma
    Zane Hammoud
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street IB360, Indianapolis, Indiana 46202 5121, USA
    Endocr Relat Cancer 15:475-83. 2008
  10. ncbi The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells
    Meiyun Fan
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Mol Endocrinol 17:356-65. 2003

Research Grants

  1. TISSUE INTERACTIONS AND HORMONAL RESPONSES IN THE UTERUS
    Robert Bigsby; Fiscal Year: 2004
  2. Endocrine Regulation of Hepatocellular Carcinogenesis
    Robert Bigsby; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer
    Suresh Kumar
    Departments of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Pathol 163:2531-41. 2003
    ..Taken together, these results suggest that cancer cell-derived cytokines, such as IL-1 alpha, induce cachexia by affecting leptin-dependent metabolic pathways...
  2. ncbi Protective effects of estrogen in a rat model of age-related cataracts
    R M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46228, USA
    Proc Natl Acad Sci U S A 96:9328-32. 1999
    ..Thus, the MNU-treated, ovariectomized rat serves as a model for age-related cataractogenesis, and observation of a clear protective effect of estrogens in this system supports the implications of epidemiologic data...
  3. ncbi The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202 5121, USA
    Carcinogenesis 32:1162-6. 2011
    ..In addition, it can be concluded that sex differences in liver tumorigenesis cannot be explained by the sexually dimorphic pattern of GH secretion. The results also rule out PRL as the mediator of the protective effect of the ovaries...
  4. ncbi Estrogen induces a systemic growth factor through an estrogen receptor-alpha-dependent mechanism
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    Biol Reprod 70:178-83. 2004
    ....
  5. ncbi Control of growth and differentiation of the endometrium: the role of tissue interactions
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    Ann N Y Acad Sci 955:110-7; discussion 118, 396-406. 2002
    ..Tissue xenograft and tissue recombination studies offer a means of defining the role of specific growth factors in uterine physiology...
  6. ncbi Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer
    Robert M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street IB360, Indianapolis, IN 46202, USA
    Cancer Lett 179:113-9. 2002
    ..These results point to an important interaction between estrogens and progestins in promoting mammary tumorigenesis...
  7. ncbi Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase
    Minati Satpathy
    Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
    Cancer Res 67:7194-202. 2007
    ..Highly expressed in ovarian tumors, TG2 facilitates i.p. tumor dissemination by enhancing cell adhesion to the extracellular matrix and modulating beta(1) integrin subunit expression...
  8. ncbi The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging
    Susan Brutkiewicz
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Luminescence 22:221-8. 2007
    ..The observation that a high level of luciferase expression will inhibit tumour cell growth when an animal is subjected to serial in vivo bioluminescence imaging is potentially an important factor in designing these types of studies...
  9. ncbi Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma
    Zane Hammoud
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street IB360, Indianapolis, Indiana 46202 5121, USA
    Endocr Relat Cancer 15:475-83. 2008
    ..In conclusion, estrogen acts as a promoter for lung adenocarcinoma in a genetically defined lung cancer model; estrogen-induced cell proliferation in the oncogene-initiated cells is likely to play a role in this tumor promoter activity...
  10. ncbi The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells
    Meiyun Fan
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Mol Endocrinol 17:356-65. 2003
    ....
  11. ncbi Effect of estrogen on radiation-induced cataractogenesis
    Joseph R Dynlacht
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Radiat Res 165:9-15. 2006
    ..Taken together, our data suggest that estrogen accelerates progression of radiation-induced opacification...
  12. ncbi Use of the Leksell Gamma Knife for localized small field lens irradiation in rodents
    Colleen DesRosiers
    Departments of Radiation Oncology, Indiana University Schools of Medicine and Dentistry, Indianapolis, IN 46202, USA
    Technol Cancer Res Treat 2:449-54. 2003
    ..Our results validate the use of the Gamma Knife for cataract studies in rodents, and confirmed the precision and utility of the instrument as a small animal irradiator for translational radiobiology experiments...
  13. ncbi The activating enzyme of NEDD8 inhibits steroid receptor function
    Meiyun Fan
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Mol Endocrinol 16:315-30. 2002
    ..Understanding the mechanisms controlling hormone responsiveness of target tissues, such as the uterus and mammary gland, may lead to novel insights of therapeutic intervention...
  14. ncbi Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase
    Bailin Tan
    Department of Obstetrics and Gynecology University School of Medicine, Indianapolis, Indiana 46202, USA
    J Mol Endocrinol 40:199-210. 2008
    ..These observations suggest that an rSTRN3gamma-PP2A(C) complex is recruited to agonist-activated ERalpha, thereby leading to its dephosphorylation and inhibiting transcription...
  15. ncbi The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic
    Minerva Mercado-Feliciano
    Department of Pharmacology and Toxicology, University School of Medicine, 975 W Walnut St IB360, Indianapolis, IN 46202 5121 USA
    Environ Health Perspect 116:605-11. 2008
    ..Polybrominated diphenyl ethers (PBDEs) are widely found in the environment, and they may act as endocrine disruptors...
  16. ncbi Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms
    Xinghua Long
    Medical Sciences, Indiana University School of Medicine, 302 Jordan Hall, 1001 East 3rd Street, Bloomington, IN 47405 4401, USA
    Mol Cancer Ther 7:2096-108. 2008
    ..We conclude that apigenin, through its ability to target both ERalpha-dependent and ERalpha-independent pathways, holds promise as a new therapeutic agent against antiestrogen-resistant breast cancer...
  17. ncbi Hydroxylated metabolites of the polybrominated diphenyl ether mixture DE-71 are weak estrogen receptor-alpha ligands
    Minerva Mercado-Feliciano
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    Environ Health Perspect 116:1315-21. 2008
    ..Polybrominated diphenyl ethers (PBDEs) are widely found in the environment and are suspected endocrine disruptors. We previously identified six hydroxylated metabolites of PBDE (OH-PBDEs) in treated mice...
  18. ncbi A role for sulfation-desulfation in the uptake of bisphenol a into breast tumor cells
    Cheri L Stowell
    Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405, USA
    Chem Biol 13:891-7. 2006
    ..No BPAS is found inside the cells. These findings suggest a mechanism for the selective uptake of BPA into cells expressing estrone sulfatase. Therefore, sulfation may increase the estrogenic potential of xenobiotics...

Research Grants6

  1. TISSUE INTERACTIONS AND HORMONAL RESPONSES IN THE UTERUS
    Robert Bigsby; Fiscal Year: 2004
    ..If IGF-I proves critical for tissue interactions it will be the first paracrine factor to be definitively identified as a mediator of steroid action in the uterus. ..
  2. Endocrine Regulation of Hepatocellular Carcinogenesis
    Robert Bigsby; Fiscal Year: 2007
    ..Furthermore, the gene products identified may yield new biomarkers useful in predicting exposure to endocrine disrupter chemicals and other environmental chemicals that have deleterious effects in the liver. ..