DAVID BASILE

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi Pathophysiology of acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Compr Physiol 2:1303-53. 2012
  2. pmc Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 83:242-50. 2013
  3. pmc Low proliferative potential and impaired angiogenesis of cultured rat kidney endothelial cells
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University, Indianapolis 46202, USA
    Microcirculation 19:598-609. 2012
  4. pmc Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F1494-502. 2012
  5. pmc Distinct effects on long-term function of injured and contralateral kidneys following unilateral renal ischemia-reperfusion
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F625-35. 2012
  6. doi Challenges of targeting vascular stability in acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 74:257-8. 2008
  7. ncbi The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function
    D P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 72:151-6. 2007
  8. pmc Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana Center for Biological Microscopy, Indiana University, Indianapolis, Indiana
    Am J Physiol Renal Physiol 300:F721-33. 2011
  9. doi A GAP in our knowledge of vascular signaling in acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 80:233-5. 2011
  10. ncbi Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1770-6. 2005

Research Grants

  1. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
  2. Long term effects of acute renal failure
    David P Basile; Fiscal Year: 2010
  3. Long term effects of acute renal failure
    DAVID BASILE; Fiscal Year: 2009
  4. Long-term effects of acute renal failure
    DAVID BASILE; Fiscal Year: 2006
  5. Long term effects of acute renal failure
    DAVID BASILE; Fiscal Year: 2009

Collaborators

Detail Information

Publications27

  1. doi Pathophysiology of acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Compr Physiol 2:1303-53. 2012
    ..Finally, earlier diagnosis of AKI represents an important area in treating patients with AKI that has spawned increased awareness of the potential that biomarkers of AKI may play in the future...
  2. pmc Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 83:242-50. 2013
    ..Thus, natural variants of these alleles or yet-to-be identified alleles on these chromosomes provide protection against AKI. These alleles may be potential modulators of AKI in susceptible patient populations...
  3. pmc Low proliferative potential and impaired angiogenesis of cultured rat kidney endothelial cells
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University, Indianapolis 46202, USA
    Microcirculation 19:598-609. 2012
    ..Surprisingly, peritubular capillaries have little repair capacity. We sought to establish long-term cultures of rat kidney endothelial cells to investigate their growth regulatory properties...
  4. pmc Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F1494-502. 2012
    ....
  5. pmc Distinct effects on long-term function of injured and contralateral kidneys following unilateral renal ischemia-reperfusion
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F625-35. 2012
    ..However, prior direct injury to the kidney is required to elicit the full manifestation of CKD induced by elevated sodium intake...
  6. doi Challenges of targeting vascular stability in acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 74:257-8. 2008
    ....
  7. ncbi The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function
    D P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 72:151-6. 2007
    ....
  8. pmc Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana Center for Biological Microscopy, Indiana University, Indianapolis, Indiana
    Am J Physiol Renal Physiol 300:F721-33. 2011
    ..Taken together, these data indicate that vascular dropout post-AKI results from endothelial phenotypic transition combined with an impaired regenerative capacity, which may contribute to progressive chronic kidney disease...
  9. doi A GAP in our knowledge of vascular signaling in acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 80:233-5. 2011
    ..The report by Siedlecki et al. highlights the important roles of RGS4, a GTPase-accelerating protein (GAP), in the regulation of vascular tone in the setting of acute kidney injury...
  10. ncbi Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1770-6. 2005
    ..Although the mechanisms of this altered responsiveness are unclear, such changes may relate, in part, to cardiovascular complications in patients with ARF and/or after renal transplant...
  11. ncbi Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
    ..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF...
  12. doi Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 294:F928-36. 2008
    ..However, the studies do suggest an overall inhibition of the VEGF pathway during the early injury and repair phase of renal ischemia that may contribute to an overall reduction in renal microvascular density...
  13. ncbi Transforming growth factor-beta in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
    Kimberly R Spurgeon
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 288:F568-77. 2005
    ..In contrast, the activation of this system may play an important role in the long-term structure of the postischemic kidney by influencing microvascular structure and interstitial cellularity...
  14. pmc Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1358-63. 2009
    ..The present data indicate that the pressure-natriuretic-diuretic response in I/R rats is blunted because of a decrease in GFR and RBF and the depressed pressure-dependent increase in medullary blood flow and interstitial pressure...
  15. pmc VEGF-121 preserves renal microvessel structure and ameliorates secondary renal disease following acute kidney injury
    Ellen C Leonard
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Dr MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 295:F1648-57. 2008
    ..These data suggest that early, but not delayed, treatment with VEGF-121 can preserve vascular structure after ischemia and influence chronic renal function in response to elevated sodium intake...
  16. ncbi Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 284:F338-48. 2003
    ..These data suggest that a reduction in the peritubular capillary density after ARF results in a persistent reduction in renal Po(2) and that hypoxia may play an important role in progression of chronic renal disease after ARF...
  17. doi Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
    ..The present data indicate that infiltrating immune cells mediate or participate in the development of sodium-sensitive hypertension and renal damage in rats apparently recovered from renal I/R injury...
  18. ncbi Transcriptome analysis and kidney research: toward systems biology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 67:2114-22. 2005
    ....
  19. ncbi Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy
    David P Basile
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Curr Opin Nephrol Hypertens 13:1-7. 2004
    ..The nature of the susceptibility that is conveyed to grafts following ischemic injury is not well understood...
  20. ncbi Leptin regulates gallbladder genes related to absorption and secretion
    Deborah A Swartz-Basile
    Department of Surgery, Indiana University School of Medicine, 535 Barnhill Drive, RT 130D, Indianapolis, IN 46202, USA
    Am J Physiol Gastrointest Liver Physiol 293:G84-90. 2007
    ....
  21. ncbi Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium
    Kimberly R Spurgeon-Pechman
    Dept of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Renal Physiol 293:F269-78. 2007
    ..These data suggest that the recovery from acute I/R injury is not complete, compromises Na homeostasis, and predisposes hypertension and secondary renal disease...
  22. ncbi Angiostatin and matrix metalloprotease expression following ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 286:F893-902. 2004
    ..Renal angiostatin generation following ARF may modulate renal capillary density postischemia and thereby influence chronic renal function...
  23. ncbi Resistance to ischemic acute renal failure in the Brown Norway rat: a new model to study cytoprotection
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 65:2201-11. 2004
    ....
  24. pmc Increased ANG II sensitivity following recovery from acute kidney injury: role of oxidant stress in skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physical Therapy, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1682-91. 2010
    ..Taken together, this study demonstrates that AKI alters peripheral vascular responses by increasing oxidant stress, likely in the endothelium, via an undefined mechanism...
  25. ncbi Angiostatin does not contribute to skeletal muscle microvascular rarefaction with low nitric oxide bioavailability
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Microcirculation 14:145-53. 2007
    ....
  26. ncbi Novel approaches in the investigation of acute kidney injury
    David P Basile
    J Am Soc Nephrol 18:7-9. 2007
  27. doi An expanding role of Toll-like receptors in sepsis-induced acute kidney injury
    Pierre C Dagher
    Am J Physiol Renal Physiol 294:F1048-9. 2008

Research Grants14

  1. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  2. Long term effects of acute renal failure
    David P Basile; Fiscal Year: 2010
    ..The acquisition of this information is required to design effective strategies for this increasingly apparent health problem. ..
  3. Long term effects of acute renal failure
    DAVID BASILE; Fiscal Year: 2009
    ..The acquisition of this information is required to design effective strategies for this increasingly apparent health problem. ..
  4. Long-term effects of acute renal failure
    DAVID BASILE; Fiscal Year: 2006
    ..The second aspect of this aim is geared toward deciphering the role and regulation of angiostatin using different strains of knockout mice or newly acquired metalloprotease inhibitors. ..
  5. Long term effects of acute renal failure
    DAVID BASILE; Fiscal Year: 2009
    ..The acquisition of this information is required to design effective strategies for this increasingly apparent health problem. ..