Matthew R Allen

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Variability of in vivo reference point indentation in skeletally mature inbred rats
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, MS 5035, Indianapolis, IN 635 Barnhill, United States Electronic address
    J Biomech 47:2504-7. 2014
  2. pmc Absence of exposed bone following dental extraction in beagle dogs treated with 9 months of high-dose zoledronic acid combined with dexamethasone
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 71:1017-26. 2013
  3. pmc Skeletal effects of zoledronic acid in an animal model of chronic kidney disease
    M R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Osteoporos Int 24:1471-81. 2013
  4. pmc Lack of correlation between duration of osteonecrosis of the jaw and sequestra tissue morphology: what it tells us about the condition and what it means for future studies
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 68:2730-4. 2010
  5. ncbi request reprint Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs
    M R Allen
    Dept of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Osteoporos Int 19:95-9. 2008
  6. ncbi request reprint Animal models of osteonecrosis of the jaw
    M R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 7:358-60. 2007
  7. ncbi request reprint Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra
    M R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Osteoporos Int 19:329-37. 2008
  8. pmc Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Calcif Tissue Int 82:354-60. 2008
  9. pmc Bisphosphonates and osteonecrosis of the jaw: moving from the bedside to the bench
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Cells Tissues Organs 189:289-94. 2009
  10. ncbi request reprint Skeletal accumulation of bisphosphonates: implications for osteoporosis treatment
    Matthew R Allen
    Indiana University School of Medicine, Department of Anatomy and Cell Biology, 635 Barnhill Drive, MS 5035, IN 46202, Indianapolis, USA
    Expert Opin Drug Metab Toxicol 4:1371-8. 2008

Collaborators

Detail Information

Publications69

  1. pmc Variability of in vivo reference point indentation in skeletally mature inbred rats
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, MS 5035, Indianapolis, IN 635 Barnhill, United States Electronic address
    J Biomech 47:2504-7. 2014
    ..These results provide important data on RPI variability (intra- and inter-animal) in rats that can be used to properly power future experiments using this technique. ..
  2. pmc Absence of exposed bone following dental extraction in beagle dogs treated with 9 months of high-dose zoledronic acid combined with dexamethasone
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 71:1017-26. 2013
    ..The goal of this study was to assess the combination of these 2 drugs in a large animal model previously shown to be susceptible to exposed bone in the oral cavity when treated with bisphosphonates...
  3. pmc Skeletal effects of zoledronic acid in an animal model of chronic kidney disease
    M R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Osteoporos Int 24:1471-81. 2013
    ..Bisphosphonates reduce skeletal loss and fracture risk, but their use has been limited in patients with chronic kidney disease. This study shows skeletal benefits of zoledronic acid in an animal model of chronic kidney disease...
  4. pmc Lack of correlation between duration of osteonecrosis of the jaw and sequestra tissue morphology: what it tells us about the condition and what it means for future studies
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 68:2730-4. 2010
    ..The goal of this study was to determine if properties, specifically bone morphology assessed by microcomputed tomography, were influenced by the duration of ONJ...
  5. ncbi request reprint Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs
    M R Allen
    Dept of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Osteoporos Int 19:95-9. 2008
    ..Our results show that at equivalent bone densities, vertebrae from beagles treated with bisphosphonate have equivalent bone strength and reduced bone energy absorption compared to those from untreated animals...
  6. ncbi request reprint Animal models of osteonecrosis of the jaw
    M R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 7:358-60. 2007
  7. ncbi request reprint Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra
    M R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Osteoporos Int 19:329-37. 2008
    ..These results show that pharmacological suppression of turnover alters the organic matrix component of bone...
  8. pmc Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Calcif Tissue Int 82:354-60. 2008
    ....
  9. pmc Bisphosphonates and osteonecrosis of the jaw: moving from the bedside to the bench
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Cells Tissues Organs 189:289-94. 2009
    ....
  10. ncbi request reprint Skeletal accumulation of bisphosphonates: implications for osteoporosis treatment
    Matthew R Allen
    Indiana University School of Medicine, Department of Anatomy and Cell Biology, 635 Barnhill Drive, MS 5035, IN 46202, Indianapolis, USA
    Expert Opin Drug Metab Toxicol 4:1371-8. 2008
    ..This skeletal accumulation has important physiological implications that are not completely understood...
  11. doi request reprint The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 67:61-70. 2009
    ....
  12. doi request reprint Higher bone matrix density exists in only a subset of patients with bisphosphonate-related osteonecrosis of the jaw
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 67:1373-7. 2009
    ..The aim of this study was to quantify bone matrix density of tissue from patients with BRONJ...
  13. doi request reprint The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Odontology 99:8-17. 2011
    ..This review focuses on recent work describing how bisphosphonates affect bone remodeling, tissue properties, and postsurgical healing in the oral cavity...
  14. doi request reprint Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don't know
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Bone 49:56-65. 2011
    ..This paper reviews the literature on these topics, and identifies gaps in knowledge that can be addressed with further research...
  15. pmc Morphological assessment of basic multicellular unit resorption parameters in dogs shows additional mechanisms of bisphosphonate effects on bone
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Calcif Tissue Int 86:67-71. 2010
    ....
  16. pmc Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs
    M R Allen
    Department of Anatomy and Cell Biology, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Osteoporos Int 22:693-702. 2011
    ..Our results, showing significantly compromised osseous healing within the socket as well as presence of exposed bone and development of a sequestrum in one animal, provide a building block toward understanding osteonecrosis of the jaw...
  17. doi request reprint Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Bone 49:128-32. 2011
    ....
  18. ncbi request reprint Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment
    Matthew R Allen
    Department of Anatomy, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Bone Miner Res 22:1759-65. 2007
    ..This suggests microdamage accumulation peaks during the early period of bisphosphonate treatment and does not continue to accumulate with longer periods of treatment...
  19. ncbi request reprint Raloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone
    Matthew R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Endocrinology 148:3908-13. 2007
    ..This may help explain how raloxifene reduces osteoporotic fractures despite modest changes in bone mass...
  20. ncbi request reprint Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035 Indianapolis, IN 46202, USA
    Bone 36:311-6. 2005
    ....
  21. pmc Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 25:98-105. 2010
    ..These results document nearly complete intracortical remodeling suppression resulting from monthly intravenous zoledronic acid dosing, with changes being most dramatic at the mandible...
  22. ncbi request reprint Raloxifene enhances vertebral mechanical properties independent of bone density
    Matthew R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Bone 39:1130-5. 2006
    ..015). Based on these data, we conclude that raloxifene produces improvements in bone mechanical properties in ways that do not involve increases in BMD...
  23. ncbi request reprint Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate
    Matthew R Allen
    Department of Anatomy and Cell Biology, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Bone 39:872-9. 2006
    ....
  24. ncbi request reprint Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib
    M R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Calcif Tissue Int 79:255-61. 2006
    ....
  25. pmc Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 66:987-94. 2008
    ..An increasing number of reports have implicated bisphosphonates as contributing to osteonecrosis of the jaw. The goal of this study was to evaluate mandible necrosis in beagle dogs treated for 3 years with oral alendronate (ALN)...
  26. ncbi request reprint Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats
    M R Allen
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77840, USA
    J Musculoskelet Neuronal Interact 6:217-25. 2006
    ....
  27. ncbi request reprint Periosteum: biology, regulation, and response to osteoporosis therapies
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 35:1003-12. 2004
    ..Improving our understanding of mechanisms controlling periosteal expansion will likely provide insights necessary to enhance current and develop novel interventions to further reduce the risk of osteoporotic fractures...
  28. pmc Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation
    Nicoletta Bivi
    Department Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    J Bone Miner Res 27:374-89. 2012
    ..Thus, Cx43 is essential in a cell-autonomous fashion in vivo and in vitro for osteocyte survival and for controlling the expression of osteocytic genes that affect osteoclast and osteoblast function...
  29. doi request reprint Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading
    Anthony Feher
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202, USA
    Bone 46:203-7. 2010
    ....
  30. pmc PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
    Yumie Rhee
    Department of Anatomy and Cell Biology, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 26:1035-46. 2011
    ..These findings demonstrate that PTH receptor signaling influences cortical bone through actions on osteocytes and defines the role of Wnt signaling in PTH receptor action...
  31. pmc Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
    Xiaolin Tu
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 50:209-17. 2012
    ..Thus, downregulation of Sost/sclerostin in osteocytes is an obligatory step in the mechanotransduction cascade that activates Wnt signaling and directs osteogenesis to where bone is structurally needed...
  32. pmc In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs
    Mohammad Aref
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 56:449-53. 2013
    ..These data build on previous work that has documented positive effects of raloxifene on material properties by showing that these changes exist after 6 months...
  33. pmc Short-courses of dexamethasone abolish bisphosphonate-induced reductions in bone toughness
    Tianyi D Luo
    Department of Anatomy and Cell Biology, Indiana University School of Medicine Indianapolis, Indianapolis, IN, USA
    Bone 56:199-203. 2013
    ..Understanding the mechanism for this tissue-level effect could lead to novel approaches for reducing the risk of atypical femoral fractures...
  34. pmc Circulating αKlotho influences phosphate handling by controlling FGF23 production
    Rosamund C Smith
    Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Clin Invest 122:4710-5. 2012
    ..These findings have important implications for the regulation of αKL and FGF23 in disorders of phosphate handling and biomineralization...
  35. pmc Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk
    David B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS259, Indianapolis, Indiana 46202, USA
    J Orthop Res 27:1288-92. 2009
    ....
  36. ncbi request reprint Partial weight bearing does not prevent musculoskeletal losses associated with disuse
    Joshua M Swift
    1Department of Health and Kinesiology, Texas A and M University, College Station, TX 2Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 3Department of Biomedical Engineering, Texas A and M University, College Station, TX 4Department of Mechanical Engineering, Texas A and M University, College Station, TX and 5Department of Nutrition and Food Science, Texas A and M University, College Station, TX
    Med Sci Sports Exerc 45:2052-60. 2013
    ....
  37. pmc Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing
    Maxime A Gallant
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS 5035, Indianapolis, IN 46202, USA
    Bone 53:301-5. 2013
    ..Collectively these results provide a starting point for understanding how RPI relates to traditional mechanical testing results...
  38. pmc A Comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD
    Sharon M Moe
    Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA Richard L Roduebush Veterans Affairs Medical Center, Indianapolis, IN, USA
    J Bone Miner Res 29:902-10. 2014
    ..Calcium effectively reduces PTH and benefits both cortical and trabecular bone yet increases the degree of extra skeletal calcification. © 2014 American Society for Bone and Mineral Research. ..
  39. doi request reprint Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits
    John Turek
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA
    Calcif Tissue Int 90:202-10. 2012
    ..These data, from an animal model that undergoes intracortical remodeling similar to humans, demonstrate that the affinity of bisphosphonates for the bone determines the reach of the drugs in both cortical and cancellous bone...
  40. pmc High bone mass in mice lacking Cx37 because of defective osteoclast differentiation
    Rafael Pacheco-Costa
    From the Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
    J Biol Chem 289:8508-20. 2014
    ..These findings demonstrate a previously unrecognized role of Cx37 in bone homeostasis that is not compensated for by Cx43 in vivo. ..
  41. ncbi request reprint Neonatal Iron Deficiency Causes Abnormal Phosphate Metabolism by Elevating FGF23 in Normal and ADHR Mice
    Erica L Clinkenbeard
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 29:361-9. 2014
    ..Therefore, disturbed iron and oxygen metabolism in neonatal life may have important effects on skeletal function and structure through FGF23 activity on phosphate regulation. © 2014 American Society for Bone and Mineral Research. ..
  42. pmc Bisphosphonate-induced reductions in rat femoral bone energy absorption and toughness are testing rate-dependent
    Eric R Smith
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis 46202, Indiana, USA
    J Orthop Res 31:1317-22. 2013
    ..05). These data document that bisphosphonate-induced reductions in energy absorption and toughness can be quantified in rats yet they are highly dependent on testing rate...
  43. pmc Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease
    Christopher L Newman
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 9:e99262. 2014
    ....
  44. pmc Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties
    Maxime A Gallant
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS 5035, Indianapolis, IN 46202, USA
    Bone 61:191-200. 2014
    ....
  45. ncbi request reprint Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats
    Matthew R Allen
    Department of Health and Kinesiology, Texas A and M University, College Station 77843 4243, USA
    J Appl Physiol 94:642-50. 2003
    ..These results suggest that cortical bone, rather than cancellous bone, is more prominently affected by unloading in skeletally mature retired breeder female rats...
  46. doi request reprint Methodological assessment of acid-etching for visualizing the osteocyte lacunar-canalicular networks using scanning electron microscopy
    Daniel J Kubek
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Microsc Res Tech 73:182-6. 2010
    ..Our findings show acid etchingwith a 9% phosphoric acid solution for 20 s provided the most favorable visualization of the osteocyte lacunar-canalicular network...
  47. ncbi request reprint Strontium ranelate does not stimulate bone formation in ovariectomized rats
    R K Fuchs
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Osteoporos Int 19:1331-41. 2008
    ..We evaluated the effects of SrR on the skeleton in ovariectomized (OVX) rats and evaluated the influence of dietary calcium...
  48. pmc Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra
    T Diab
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Osteoporos Int 20:647-52. 2009
    ..Alendronate treatment resulted in similar levels of turnover in both sites, suggesting that a lower limit of bone turnover suppression with alendronate may exist...
  49. pmc Mandibular necrosis in beagle dogs treated with bisphosphonates
    D B Burr
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Orthod Craniofac Res 12:221-8. 2009
    ..The development of an animal model that mimics important aspects of BP-related osteonecrosis of the jaw is important to understanding the pathogenesis of osteonecrosis...
  50. pmc Parathyroid Hormone Receptor Signaling Induces Bone Resorption in the Adult Skeleton by Directly Regulating the RANKL Gene in Osteocytes
    Abdullah N Ben-Awadh
    Departments of Anatomy and Cell Biology A N B, J D C, X T, K K, M R A, L I P, T B and Medicine T B, Division of Endocrinology, Indiana University School of Medicine, and Roudebush Veterans Administration Medical Center J D C, L I P, T B, Indianapolis, Indiana 46202
    Endocrinology 155:2797-809. 2014
    ..Thus, PTH upregulates Rankl expression in osteocytes in vitro, ex vivo and in vivo, and resorption induced by PTH receptor signaling in the adult skeleton requires direct regulation of the Rankl gene in osteocytes. ..
  51. ncbi request reprint Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
    ....
  52. pmc Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:E1146-55. 2011
    ....
  53. ncbi request reprint Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats
    S A Bloomfield
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Bone 31:149-57. 2002
    ..Given the sharp decline in BFR for midshaft cortical bone, it appears likely that deficits in BMD, area, or mechanical properties would develop with longer duration unloading...
  54. pmc Adverse Mandibular Bone Effects Associated with Kidney Disease Are Only Partially Corrected with Bisphosphonate and/or Calcium Treatment
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Ind, USA
    Am J Nephrol 38:458-64. 2013
    ..2013 S. Karger AG, Basel. ..
  55. pmc Dietary phosphate restriction normalizes biochemical and skeletal abnormalities in a murine model of tumoral calcinosis
    Shoji Ichikawa
    Department of Medicine, Division of Endocrinology and Metabolism, Indiana University School of Medicine, 541 North Clinical Drive, CL 459, Indianapolis, Indiana 46202, USA
    Endocrinology 152:4504-13. 2011
    ..In conclusion, dietary phosphate restriction normalizes biochemical and skeletal phenotypes of Galnt3 knockout mice and, thus, can be an effective therapy for tumoral calcinosis...
  56. ncbi request reprint A novel approach to evaluate the effect of medicaments used in endodontic regeneration on root canal surface indentation
    Ghaeth H Yassen
    Department of Restorative Dentistry, Division of Dental Biomaterials, Indiana University School of Dentistry, 1121W Michigan St, Indianapolis, IN, 46202, USA
    Clin Oral Investig 18:1569-75. 2014
    ....
  57. pmc Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD)
    Neal X Chen
    Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e64558. 2013
    ..The decreased levels in the circulation may reflect decreased vascular release but more studies are needed to confirm this relationship...
  58. doi request reprint Orthodontic mini-implant diameter does not affect in-situ linear microcrack generation in the mandible or the maxilla
    Sean Shih Yao Liu
    Department of Orthodontics and Oral Facial Genetics, School of Dentistry, Indiana University, Indianapolis, USA
    Am J Orthod Dentofacial Orthop 142:768-73. 2012
    ..The objective of this study was to investigate whether the diameter of mini-implants affects linear microcrack generation and whether this differs between the mandible and the maxilla because of their contrasting cortical thicknesses...
  59. ncbi request reprint Effects of eccentric exercise training on cortical bone and muscle strength in the estrogen-deficient mouse
    M J Hubal
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    J Appl Physiol 98:1674-81. 2005
    ..These data indicate that eccentric exercise training in adult mice can significantly increase bone stiffness, despite the absence of ovarian hormones...
  60. ncbi request reprint The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific
    Joseph M Wallace
    Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109 2099, and Henry Ford Hospital, Bone and Joint Center, Detroit, MI 48202, USA
    Bone 39:106-16. 2006
    ....
  61. ncbi request reprint Biglycan deficiency interferes with ovariectomy-induced bone loss
    Karina L Nielsen
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 18:2152-8. 2003
    ....
  62. pmc A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover
    Senthil K Eswaran
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech 40:3424-31. 2007
    ....
  63. pmc Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis
    Yasuo Miura
    Department of Physiology, University of Maryland School of Medicine, Rockville, MD 20855, USA
    Proc Natl Acad Sci U S A 102:14022-7. 2005
    ..Altogether, this work demonstrates that CD18 functions critically in the osteogenesis of BMSSCs, and thus lack of CD18 expression in the leukocyte adhesion deficiency patients may predispose them to osteoporosis...
  64. ncbi request reprint Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089)
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Bone 35:134-43. 2004
    ....
  65. pmc Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific
    Joseph M Wallace
    The University of Michigan, Department of Biomedical Engineering, Ann Arbor, MI, USA
    Bone 40:1120-7. 2007
    ..Exercise also influenced the quality of this forming bone, significantly impacting structural and tissue-level mechanical properties...
  66. ncbi request reprint Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats
    Rhonda D Prisby
    Division of Exercise Physiology, Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Bone Miner Res 22:1280-8. 2007
    ..Femoral perfusion was lower in old animals, as well as endothelium-dependent vasodilation and NO bioavailability. These effects could contribute to old age-related bone loss and the increased risk of fracture...
  67. pmc A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, MD 20892, USA
    J Clin Invest 114:1704-13. 2004
    ..This study demonstrates that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-beta/Smad2 pathway and cell cycle progression...
  68. ncbi request reprint Low bone turnover and microdamage? How and where to assess it?
    David B Burr
    J Bone Miner Res 23:1150-1; author reply 1152-3. 2008
  69. doi request reprint Failure of mineralized collagen fibrils: modeling the role of collagen cross-linking
    Thomas Siegmund
    School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA
    J Biomech 41:1427-35. 2008
    ..As a consequence the toughness of bone that has more non-enzymatically mediated collagen cross-links will be drastically reduced...