Rajiv Agarwal

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi request reprint Thiazide diuretics in advanced chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Am Soc Hypertens 6:299-308. 2012
  2. doi request reprint Blood pressure response with fixed-dose combination therapy: comparing hydrochlorothiazide with amlodipine through individual-level meta-analysis
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Hypertens 31:1692-701. 2013
  3. doi request reprint Treated hypertension and the white coat phenomenon: Office readings are inadequate measures of efficacy
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    J Am Soc Hypertens 7:236-43. 2013
  4. doi request reprint How can we prevent intradialytic hypotension?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 21:593-9. 2012
  5. pmc Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 27:3908-14. 2012
  6. pmc The controversies of diagnosing and treating hypertension among hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Semin Dial 25:370-6. 2012
  7. ncbi request reprint Prognostic significance of between-arm blood pressure differences
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Hypertension 51:657-62. 2008
  8. doi request reprint Diagnostic utility of blood volume monitoring in hemodialysis patients
    Rajiv Agarwal
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Kidney Dis 51:242-54. 2008
  9. ncbi request reprint Competing risk factor analysis of end-stage renal disease and mortality in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Am J Nephrol 28:569-75. 2008
  10. pmc Diagnosing hypertension by intradialytic blood pressure recordings
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 3:1364-72. 2008

Research Grants

  1. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2003
  2. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2004
  3. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2005
  4. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2006
  5. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
  6. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
  7. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
  8. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010

Detail Information

Publications127 found, 100 shown here

  1. doi request reprint Thiazide diuretics in advanced chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Am Soc Hypertens 6:299-308. 2012
    ..Our review suggests that adequately powered randomized trials are needed before the use of thiazide diuretics can be firmly recommended in those with advanced CKD...
  2. doi request reprint Blood pressure response with fixed-dose combination therapy: comparing hydrochlorothiazide with amlodipine through individual-level meta-analysis
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Hypertens 31:1692-701. 2013
    ..Furthermore, we hypothesized that response to ARB along with HCTZ or ARB along with CCB may be heterogeneous depending on clinical characteristics...
  3. doi request reprint Treated hypertension and the white coat phenomenon: Office readings are inadequate measures of efficacy
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    J Am Soc Hypertens 7:236-43. 2013
    ..Thus, out-of-office BP monitoring especially among treated hypertensive patients with type 2 diabetes is necessary to provide better assessment of overall BP and response to treatment...
  4. doi request reprint How can we prevent intradialytic hypotension?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 21:593-9. 2012
    ..Intradialytic hypotension (IDH) produces uncomfortable symptoms for the patient and reduces the efficiency of dialysis...
  5. pmc Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 27:3908-14. 2012
    ..The prevalence, determinants and prognosis of pulmonary hypertension among long-term hemodialysis patients in the USA are poorly understood...
  6. pmc The controversies of diagnosing and treating hypertension among hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Semin Dial 25:370-6. 2012
    ..Evaluating home BP in every dialysis patient, evaluating volume status on a regular basis, and treating hypertension predominantly with nonpharmacological strategies are worthwhile...
  7. ncbi request reprint Prognostic significance of between-arm blood pressure differences
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Hypertension 51:657-62. 2008
    ..01 to 1.52) after adjusting for average systolic BP and chronic kidney disease. BP differences between arms are reproducible and carry prognostic information. Patients should have evaluation of BP in both arms at the screening visit...
  8. doi request reprint Diagnostic utility of blood volume monitoring in hemodialysis patients
    Rajiv Agarwal
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Kidney Dis 51:242-54. 2008
    ..Assessment of volume state is difficult in hemodialysis patients. Whether continuous blood volume monitoring can improve the assessment of volume state is unclear...
  9. ncbi request reprint Competing risk factor analysis of end-stage renal disease and mortality in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Am J Nephrol 28:569-75. 2008
    ..The purpose of our study was to evaluate the competing risk of ESRD versus mortality and to evaluate the risk factors associated with these two outcomes...
  10. pmc Diagnosing hypertension by intradialytic blood pressure recordings
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 3:1364-72. 2008
    ..The use of intradialytic BP measurements to diagnose hypertension is unknown...
  11. doi request reprint The challenge of discovering patient-level cardiovascular risk factors in chronic kidney disease
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 73:1340-2. 2008
    ..Nontraditional risk factors such as albuminuria can then be tested to evaluate the predictive value of these markers over and above traditional risk factors for patient-level decision making...
  12. pmc Assessment of iothalamate plasma clearance: duration of study affects quality of GFR
    Rajiv Agarwal
    Indiana University and Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 4:77-85. 2009
    ..The purpose of this study was to evaluate whether the duration of plasma sampling influences precision and estimation of GFR...
  13. ncbi request reprint Temperature sensitivity and fluorescence detection
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Sep Sci 31:128-32. 2008
    ..These results have implications for other applications utilizing fluorescence detectors...
  14. pmc On the importance of pedal edema in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 3:153-8. 2008
    ..Volume control is a key component of treatment of hemodialysis patients. The role of pedal edema as a marker of volume is unknown. The objective of this study was to determine factors that are associated with edema...
  15. pmc Serum albumin is strongly associated with erythropoietin sensitivity in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and the Richard L RoudebushVA Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 3:98-104. 2008
    ..We tested the hypothesis that the variability in hemoglobin (Hgb) response (epo sensitivity) is determined by key nutritional, inflammation, and oxidative stress markers...
  16. ncbi request reprint Prognostic importance of clinic and home blood pressure recordings in patients with chronic kidney disease
    R Agarwal
    Indiana University School of Medicine, Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Kidney Int 69:406-11. 2006
    ..In patients with CKD, BPs obtained at home are a stronger predictor of ESRD or death compared to BPs obtained in the clinic. Systolic home BP is an independent predictor for ESRD...
  17. ncbi request reprint Effects of statins on renal function
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Cardiol 97:748-55. 2006
    ..Several large trials are currently under way to examine the safety and efficacy of statins in renally compromised patients at high risk for cardiovascular disease...
  18. ncbi request reprint Home blood pressure monitoring improves the diagnosis of hypertension in hemodialysis patients
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, VAMC 111N, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 69:900-6. 2006
    ..Home BP monitoring is similar to standardized recording of BP in hemodialysis patients. A systolic BP threshold of 150 mmHg at home averaged over 1 week serves as a useful predictor of hypertension diagnosed by ambulatory BP monitoring...
  19. ncbi request reprint Blood pressure recordings within and outside the clinic and cardiovascular events in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Nephrol 26:503-10. 2006
    ..To assess the role of out-of-clinic BP recordings in predicting cardiovascular events in patients with chronic kidney disease (CKD), a prospective cohort study was conducted in 217 veterans with CKD...
  20. ncbi request reprint Reproducibility of renal function measurements in adult men with diabetic nephropathy: research and clinical implications
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 27:92-100. 2007
    ..The goal of this study was to describe the variability in these measurements and to calculate minimum sample size estimates over varying time frames for clinical trials...
  21. ncbi request reprint Antihypertensive agents and arterial stiffness: relevance to reducing cardiovascular risk in the chronic kidney disease patient
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 16:409-15. 2007
    ....
  22. ncbi request reprint Nonhematological benefits of iron
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Am J Nephrol 27:565-71. 2007
    ....
  23. pmc Location not quantity of blood pressure measurements predicts mortality in hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 28:210-7. 2008
    ..Whether it is the greater number of measurements made outside the dialysis unit that correlates with prognosis or whether BPs outside dialysis units are ecologically more valid is unknown...
  24. pmc Dry-weight reduction in hypertensive hemodialysis patients (DRIP): a randomized, controlled trial
    Rajiv Agarwal
    Division of Nephrology and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Hypertension 53:500-7. 2009
    ..The reduction of dry weight is a simple, efficacious, and well-tolerated maneuver to improve BP control in hypertensive hemodialysis patients. Long-term control of BP will depend on continued assessment and maintenance of dry weight...
  25. pmc Home blood pressure measurements for managing hypertension in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Ind, USA
    Am J Nephrol 30:126-34. 2009
    ..These data provide support for the use of home BP monitoring for the management of hypertension in hemodialysis patients...
  26. doi request reprint Nocturia, nocturnal activity, and nondipping
    Rajiv Agarwal
    Indiana University and Veterans Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Hypertension 54:646-51. 2009
    ..Whether nocturia itself or the resulting nondipping associated with nocturia is of prognostic importance for cardiorenal events in patients with chronic kidney disease should be tested in future studies...
  27. pmc Body mass index-mortality paradox in hemodialysis: can it be explained by blood pressure?
    Rajiv Agarwal
    Indiana University and VAMC, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Hypertension 58:1014-20. 2011
    ..Leaner patients have an accelerated mortality rate in the first 2 years; this is not completely explained by BP, LVMI, or other cardiovascular or dialysis-specific risk factors...
  28. pmc Epidemiology of interdialytic ambulatory hypertension and the role of volume excess
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Am J Nephrol 34:381-90. 2011
    ..The epidemiology of hypertension among hemodialysis (HD) patients is difficult to describe accurately because of difficulties in the assessment of blood pressure (BP)...
  29. pmc Toward a definition of masked hypertension and white-coat hypertension among hemodialysis patients
    Rajiv Agarwal
    Professor of Medicine, Indiana University and Veterans Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:2003-8. 2011
    ..In part, this is because it can detect white-coat hypertension and masked hypertension. Whether the same is true for hemodialysis patients is not known...
  30. pmc Patterns and prognostic value of total and differential leukocyte count in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:1393-9. 2011
    ..The purpose of this study was to evaluate the levels and patterns of total and differential leukocyte counts and their prognostic importance in a cohort of people with and without chronic kidney disease (CKD)...
  31. pmc Probing dry-weight improves left ventricular mass index
    Rajiv Agarwal
    Division of Nephrology, Indianapolis, IN, USA
    Am J Nephrol 33:373-80. 2011
    ..Although probing dry-weight improves blood pressure control, its effect on echocardiographic left ventricular mass index (LVMI) is unknown...
  32. doi request reprint Blood pressure goal in chronic kidney disease: what is the evidence?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 20:229-32. 2011
    ..Most guidelines recommend that seated clinic blood pressure (BP) be targeted to less than 130/80 mmHg in patients with chronic kidney disease (CKD). The evidence underlying these recommendations is the subject of this review...
  33. pmc Inferior vena cava diameter and left atrial diameter measure volume but not dry weight
    Rajiv Agarwal
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 6:1066-72. 2011
    ..Hypervolemia is an important and modifiable cause of hypertension. Hypertension improves with probing dry weight, but its effect on echocardiographic measures of volume is unknown...
  34. pmc Interdialytic hypertension-an update
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Adv Chronic Kidney Dis 18:11-6. 2011
    ..Beta blockers, dihydropyridine calcium blockers, and agents that block the renin-angiotensin system appear to be effective in lowering BP in these patients...
  35. doi request reprint Role of home blood pressure monitoring in overcoming therapeutic inertia and improving hypertension control: a systematic review and meta-analysis
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Ind 46202, USA
    Hypertension 57:29-38. 2011
    ..Hypertension control with home BP monitoring can be enhanced further when accompanied by plans to monitor and treat elevated BP such as through telemonitoring...
  36. pmc Determinants and prognostic significance of electrocardiographic left ventricular hypertrophy criteria in chronic kidney disease
    Rajiv Agarwal
    Indiana University and Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:528-36. 2011
    ..However, among those with chronic kidney disease (CKD), the determinants of electrocardiographic (EKG) LVH and its prognostic value are not clear...
  37. doi request reprint Diagnosing obesity by body mass index in chronic kidney disease: an explanation for the "obesity paradox?"
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hypertension 56:893-900. 2010
    ..Skinfold thickness measurements may be a better test to classify obesity among those with CKD. Given the low negative predictive value of BMI for obesity, our study may provide an explanation of the "obesity paradox."..
  38. pmc Hypervolemia is associated with increased mortality among hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Veterans Administration Medical Center, 1481 West 10th St, Indianapolis, IN 46202, USA
    Hypertension 56:512-7. 2010
    ..Its use to assess excess volume-related morbidity among chronic hemodialysis patients should be tested in randomized, controlled trials...
  39. ncbi request reprint Are vitamin D receptor agonists like angiotensin-converting enzyme inhibitors without side effects?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 77:943-5. 2010
    ..Whether VDRAs will accomplish this goal among proteinuric patients with chronic kidney disease needs to be tested in randomized controlled trials...
  40. pmc The effect of measuring ambulatory blood pressure on nighttime sleep and daytime activity--implications for dipping
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 5:281-5. 2010
    ..The effect of BP monitoring itself on the level of physical activity and sleep remains unknown. If BP monitoring affects these parameters, then monitoring itself may influence the circadian BP pattern...
  41. pmc Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 6:114-21. 2011
    ..This study examined differences in proteinuria between two intravenous iron preparations after multiple doses...
  42. ncbi request reprint Home and ambulatory blood pressure monitoring in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 18:507-12. 2009
    ..The purpose of this review is to discuss the recent advances in out-of-office BP recordings in the management of patients with CKD including those on hemodialysis...
  43. pmc Regulation of circadian blood pressure: from mice to astronauts
    Rajiv Agarwal
    Division of Nephrology, Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 19:51-8. 2010
    ..The purpose of this review is to examine the physiology of circadian BP variation and propose a tripartite model that explains the regulation of circadian BP...
  44. ncbi request reprint Antiproteinuric effect of oral paricalcitol in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Kidney Int 68:2823-8. 2005
    ..While active vitamin D and its analogs have been shown to have renal protective effects in animals, these hormones have not been shown to reduce proteinuria in CKD patients...
  45. ncbi request reprint Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United States
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and RLR VA Medical Center, Indianapolis 46202, USA
    Am J Med 115:291-7. 2003
    ..Hypertension is common in chronic hemodialysis patients, yet there are limited data on the epidemiology of hypertension in these patients in the United States...
  46. ncbi request reprint Rapid, fluorimetric-liquid chromatographic determination of malondialdehyde in biological samples
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 775:121-6. 2002
    ..MDA degrades at room temperature at a rate of 10% per hour. It is therefore, suggested that the total assay time be limited to 1 h beginning with sample preparation...
  47. ncbi request reprint On the nature of proteinuria with acute renal injury in patients with chronic kidney disease
    Rajiv Agarwal
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Renal Physiol 288:F265-71. 2005
    ..Measurement of total intact albumin may better quantify acute renal injury...
  48. ncbi request reprint A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 68:285-92. 2005
    ..We hypothesized that PPAR-gamma-based antidiabetic therapy would result in greater reduction in proteinuria compared to sulfonylurea-based therapy...
  49. ncbi request reprint Rapid microplate method for PAH estimation
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 283:F236-41. 2002
    ..The microplate method is a reliable alternative to a reference HPLC method and can be performed for a fraction of the cost, time, and reagents...
  50. ncbi request reprint Role of home blood pressure monitoring in hemodialysis patients
    R Agarwal
    Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA
    Am J Kidney Dis 33:682-7. 1999
    ..Home BP monitoring should be used as a cost-effective means to diagnose occult hypertension in chronic hemodialysis patients...
  51. ncbi request reprint Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 284:F863-9. 2003
    ..The significant association of the change in urinary MCP-1 with a reduction in oxidative stress supports the role of the redox state in the kidney with renal fibrosis and progressive kidney damage...
  52. ncbi request reprint Hypertension and survival in chronic hemodialysis patients--past lessons and future opportunities
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 67:1-13. 2005
    ....
  53. ncbi request reprint Issues related to iron replacement in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Semin Nephrol 22:479-87. 2002
    ..The current data suggest that the overall risk-benefit ratio favors use of IV iron when compared with untreated or partially treated iron-deficiency anemia...
  54. ncbi request reprint Transferrin saturation with intravenous irons: an in vitro study
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine, and VA Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 66:1139-44. 2004
    ..Drugs that may lead to rapid transferrin saturation may lead to greater efficacy but also increased toxicity if transferring-mediated uptake of iron is the basis of this toxicity...
  55. ncbi request reprint Liquid chromatography for iothalamate in biological samples
    Rajiv Agarwal
    Indiana University and VAMC, 1481 West 10th Street, Indianapolis, IN 46202, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 785:345-52. 2003
    ..There was excellent thermal and pH stability of iothalamate. No interference was found with para-amino hippuric acid (PAH) or N-acetyl PAH, which can be simultaneously assayed, if desired...
  56. ncbi request reprint Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, 46202, USA
    Kidney Int 65:2279-89. 2004
    ..The relationship of oxidative stress and renal injury in patients with CKD is unknown. Whether renal injury can occur at a time point when transferrin is incompletely saturated is also unclear...
  57. ncbi request reprint Evaluation of kidney function in patients with acute renal failure using high-performance liquid chromatography: a case report
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pharmacotherapy 24:145-9. 2004
    ..This and other methods for more accurate measurement of GFR in patients with acute renal failure may provide the foundation for clinical studies that assess the severity and management of acute renal failure...
  58. ncbi request reprint Dipstick proteinuria: can it guide hypertension management?
    Rajiv Agarwal
    Indiana University and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 39:1190-5. 2002
    ..These results suggest that patients with 3+ or greater proteinuria should not only trigger appropriate evaluation of proteinuria, but also have mean arterial pressures targeted to less than 92 mm Hg...
  59. ncbi request reprint Add-on angiotensin receptor blockade with maximized ACE inhibition
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and RLR VA Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 59:2282-9. 2001
    ..d.) will result in additional Ang II antagonism in patients with proteinuric chronic renal failure with hypertension...
  60. ncbi request reprint Monitoring interposition graft venous pressures at higher blood-flow rates improves sensitivity in predicting graft failure
    R Agarwal
    Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA
    Am J Kidney Dis 34:212-7. 1999
    ..There is a substantial variability in venous pressures in the same patient that reduces with increasing Qbs. Venous pressure monitoring at greater Qbs provides a more sensitive method for predicting access failure...
  61. ncbi request reprint The role of statins in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Am J Med Sci 330:69-81. 2005
    ....
  62. pmc Smoking, oxidative stress and inflammation: impact on resting energy expenditure in diabetic nephropathy
    Rajiv Agarwal
    Department of Medicine, Indiana University, RLR VA Medical Center, Indianapolis, Indiana, USA
    BMC Nephrol 6:13. 2005
    ..Smoking is a common mechanism for generating oxidative stress and inflammation. Whether smokers have increased REE and if so, whether it is accounted for by the pro-oxidant and inflammatory state is not known...
  63. ncbi request reprint Hypertension in chronic kidney disease and dialysis: pathophysiology and management
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Emerson Hall Room 520, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street 111 N, Indianapolis, IN 46202, USA
    Cardiol Clin 23:237-48. 2005
    ..It has long been recognized that kidney function affects and is affected by hypertension. This article discusses the pathophysiology and management of hypertension in patients with CKD...
  64. ncbi request reprint Supervised atenolol therapy in the management of hemodialysis hypertension
    R Agarwal
    Department of Medicine, Indiana University and RLR VA Medical Center, Indianapolis, USA
    Kidney Int 55:1528-35. 1999
    ..Atenolol, a water soluble beta-blocker has a prolonged half-life in renal failure and may serve as a useful antihypertensive agent in these patients...
  65. ncbi request reprint Prediction of hypertension in chronic hemodialysis patients
    R Agarwal
    Department of Medicine, Indiana University and VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 60:1982-9. 2001
    ..We sought to determine the clinical performance of predialysis and postdialysis systolic and diastolic blood pressure values (BPs) in diagnosing hypertension or assessing its control...
  66. ncbi request reprint Lisinopril therapy for hemodialysis hypertension: hemodynamic and endocrine responses
    R Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 38:1245-50. 2001
    ..In conclusion, supervised lisinopril therapy is effective in controlling hypertension in chronic HD patients. This may be related to blockade of angiotensin II generation by kidneys despite the loss of excretory function...
  67. ncbi request reprint Correlates of systolic hypertension in patients with chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA
    Hypertension 46:514-20. 2005
    ....
  68. ncbi request reprint Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile?
    R Agarwal
    Indiana University and Roudebush VA Medical Center, Indianapolis 46202, USA
    Clin Nephrol 57:167-70. 2002
    ....
  69. pmc Chronobiology of arterial hypertension in hemodialysis patients: implications for home blood pressure monitoring
    Rajiv Agarwal
    Division of Nephrology, Richard L Roudebush VA Medical Center, Indianapolis, IN, USA
    Am J Kidney Dis 54:693-701. 2009
    ..This study sought to determine the optimal time to perform home BP monitoring in hemodialysis patients to improve the strength of prediction of 44-hour interdialytic ambulatory BP...
  70. ncbi request reprint Sodium ferric gluconate causes oxidative stress but not acute renal injury in patients with chronic kidney disease: a pilot study
    David J Leehey
    Division of Nephrology, Department of Medicine, Loyola University School of Medicine and Edward Hines Jr VA Medical Center, Hines, IL 60141, USA
    Nephrol Dial Transplant 20:135-40. 2005
    ..Intravenous (i.v) iron is widely used to treat anaemia in patients with chronic kidney disease (CKD). Although beneficial and usually well tolerated, concerns have been raised about its ability to cause oxidative stress and renal injury...
  71. pmc Relative plasma volume monitoring during hemodialysis AIDS the assessment of dry weight
    Arjun D Sinha
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Hypertension 55:305-11. 2010
    ..We conclude that RPV slope monitoring is a valid method to assess dry weight among hypertensive hemodialysis patients...
  72. ncbi request reprint Trended cosinor change model for analyzing hemodynamic rhythm patterns in hemodialysis patients
    Ken Kelley
    Inquiry Methodology Program, Indiana University, Bloomington, IN, USA
    Hypertension 50:143-50. 2007
    ..Antihypertensive drugs, though associated with higher average BP, are associated with blunted rate of change in BP over time...
  73. pmc Masked hypertension and white-coat hypertension in chronic kidney disease: a meta-analysis
    Farhan Bangash
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 4:656-64. 2009
    ..The goal of this meta-analysis was to estimate the prevalence and determinants of white-coat and masked hypertension in the adult CKD population...
  74. ncbi request reprint Acute injury with intravenous iron and concerns regarding long-term safety
    Kalkidan Bishu
    Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 1:S19-23. 2006
    ..Although the long-term dangers of intravenous iron are unproved, these data call for examination of effects of intravenous iron on the potential for long-term harm in patients with chronic kidney disease...
  75. pmc Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients
    Sangeetha Satyan
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 50:1009-19. 2007
    ..The objective of this study is to determine factors associated with NT-pro-BNP and cTnT and determine whether these levels are associated with mortality...
  76. ncbi request reprint Effects of statins on renal function
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush corrected VA Medical Center, 1481 W Tenth St 111N, Indianapolis, IN 46202, USA
    Mayo Clin Proc 82:1381-90. 2007
    ..Several ongoing studies are evaluating the effect of statins on cardiovascular end points in patients with CKD and may provide data needed to support adjunctive use of these agents in this high-risk population...
  77. ncbi request reprint Selection of initial antihypertensive therapy, regimen design, and goal blood pressure
    Rajiv Agarwal
    Indiana University, Indianapolis, Indiana 46202, USA
    Cardiol Rev 11:197-205. 2003
  78. ncbi request reprint Safety and efficacy of sodium ferric gluconate complex in patients with chronic kidney disease
    Atinder Panesar
    Richard L Roudebush Veterans Affairs Medical Center, and Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 40:924-31. 2002
    ..We hypothesized that intravenous iron will improve hemoglobin (Hgb) concentrations in anemic patients with chronic kidney disease (CKD), and the response would be greater if the underlying erythropoietin deficiency also was treated...
  79. ncbi request reprint Home blood pressure monitoring in CKD
    Martin J Andersen
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 45:994-1001. 2005
    ....
  80. ncbi request reprint Improving outcomes in CKD and ESRD patients: carrying the torch from training to practice
    Allen R Nissenson
    Department of Medicine, Division of Nephrology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    Semin Dial 17:380-97. 2004
    ..If nephrologists are to take their appropriate place as leaders of the care delivery team, nephrology fellowships must be restructured with appropriate emphasis placed on the comprehensive care of ESRD and CKD patients...
  81. ncbi request reprint A longitudinal study of kidney structure and function in adults
    Shathabish S Kariyanna
    Division of Nephrology, Indiana University, Indianapolis, IN, USA
    Nephrol Dial Transplant 25:1120-6. 2010
    ..We conducted this longitudinal study to better understand the relationship between kidney size and function...
  82. ncbi request reprint Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and RLR Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 39:486-92. 2002
    ..We speculate that dual blockade with losartan and an ACE inhibitor may provide additional renoprotection by decreasing renal production of TGF-beta1...
  83. doi request reprint Prognostic value of circadian blood pressure variation in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Indianapolis, Ind, USA
    Am J Nephrol 30:547-53. 2009
    ..Reduced circadian variation in blood pressure (BP) has been associated with cardiovascular morbidity, mortality and accelerated progression of kidney disease, but its independent prognostic value remains unknown...
  84. ncbi request reprint Physical activity is a determinant of circadian blood pressure variation in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 31:15-23. 2010
    ..The causes of this blunted circadian variation remain incompletely understood...
  85. pmc Intradialytic hypertension is a marker of volume excess
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 25:3355-61. 2010
    ..Intradialytic blood pressure (BP) profiles have been associated with all-cause mortality, but its pathophysiology remains unknown. We tested the hypothesis that intradialytic changes in BP reflect excess volume...
  86. doi request reprint Relationship between glycosylated hemoglobin and blood glucose during progression of chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Nephrol 34:32-41. 2011
    ..The value of measurement of glycosylated hemoglobin (HgbA(1C)) in determining the degree of glycemic control in patients with chronic kidney disease (CKD) is unclear...
  87. pmc Dry-weight: a concept revisited in an effort to avoid medication-directed approaches for blood pressure control in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street, 111N, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 5:1255-60. 2010
    ..Achieving and maintaining dry-weight appears to be an effective but forgotten strategy in controlling and maintaining normotension among hypertensive patients on hemodialysis...
  88. pmc Blood pressure and mortality among hemodialysis patients
    Rajiv Agarwal
    Indiana University, Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Hypertension 55:762-8. 2010
    ..Therefore, the management of hypertension among these patients should focus on blood pressure recordings outside the dialysis unit...
  89. doi request reprint Developing a self-administered CKD symptom assessment instrument
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 25:160-6. 2010
    ..This purpose of this report is to describe the development of an instrument to measure the presence and severity of a wide range of symptoms commonly attributable to CKD...
  90. ncbi request reprint Pre- and postdialysis blood pressures are imprecise estimates of interdialytic ambulatory blood pressure
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 1:389-98. 2006
    ..1 to -36.3 mmHg) and diastolic BP (19.3 to -23.9 mmHg). Dialysis unit BP measurements are imprecise estimates of ABP. Better methods are needed for the assessment of BP in hemodialysis patients for clinical decision making...
  91. ncbi request reprint Strategies for successful patient oriented research: why did I (not) get funded?
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, Ind, USA
    Clin J Am Soc Nephrol 1:340-3. 2006
    ....
  92. ncbi request reprint Dialysis dose and the diagnosis of hypertension in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Blood Press Monit 12:281-7. 2007
    ..Evidence for effect modification was tested for several plausible demographic, clinical and laboratory factors...
  93. ncbi request reprint How should hypertension be assessed and managed in hemodialysis patients? Home BP, not dialysis unit BP, should be used for managing hypertension
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Semin Dial 20:402-5. 2007
  94. ncbi request reprint Home blood pressures are of greater prognostic value than hemodialysis unit recordings
    Pooneh Alborzi
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 2:1228-34. 2007
    ..Home BP agree well with ambulatory BP, but the prognostic significance of home BP recordings is unknown in hemodialysis patients. This study ascertained the role of home BP in predicting all-cause and cardiovascular mortality...
  95. ncbi request reprint Arterial stiffness and interdialytic weight gain influence ambulatory blood pressure patterns in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush Department of Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 294:F303-8. 2008
    ....
  96. ncbi request reprint Oxidative stress in hypertension and chronic kidney disease: role of angiotensin II
    Rajiv Agarwal
    Indian University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Semin Nephrol 24:101-14. 2004
    ....
  97. ncbi request reprint Out-of-office blood pressure monitoring in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Blood Press Monit 14:2-11. 2009
    ..Out-of-office BP monitoring is recommended for the management of hypertension in all stages of CKD...
  98. ncbi request reprint Relationship between circadian blood pressure variation and circadian protein excretion in CKD
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 293:F655-9. 2007
    ..Pulse pressure is related to proteinuria independent of the awake-sleep state. Reducing mean arterial pressure during the day and pulse pressure during the day or night may be effective antiproteinuric strategies...
  99. pmc Volume-associated ambulatory blood pressure patterns in hemodialysis patients
    Rajiv Agarwal
    Veterans Affairs Medical Center, 111N, 1481 West 10th St, Indianapolis, IN 46202, USA
    Hypertension 54:241-7. 2009
    ....
  100. ncbi request reprint Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy
    Rajiv Agarwal
    Indiana University School of Medicine, and Veterans Affairs Medical Center, 111N, 1481 West 10th St, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 290:F600-5. 2006
    ..This surrogate end point needs to be confirmed in trials designed to demonstrate cardiovascular protection...

Research Grants9

  1. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2003
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  2. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2004
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  3. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2005
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  4. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2006
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  5. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  6. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  7. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  8. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..