Rajiv Agarwal

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi request reprint Thiazide diuretics in advanced chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Am Soc Hypertens 6:299-308. 2012
  2. ncbi request reprint A randomized controlled trial of oral versus intravenous iron in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Am J Nephrol 26:445-54. 2006
  3. ncbi request reprint Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and RLR Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 39:486-92. 2002
  4. doi request reprint Prognostic value of circadian blood pressure variation in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Indianapolis, Ind, USA
    Am J Nephrol 30:547-53. 2009
  5. ncbi request reprint Long-term retinal, renal and cardiovascular outcomes in diabetic chronic kidney disease without proteinuria
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Richard L Roudebush Veterans Administration Medical Center, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 27:310-7. 2012
  6. ncbi request reprint Buzz in the axilla: a new physical sign in hemodialysis forearm graft evaluation
    R Agarwal
    Indiana University School of Medicine, and Roudebush VA MedicalCenter, 1481 West 10th St, Indianapolis, IN 46202, USA
    Am J Kidney Dis 38:853-7. 2001
  7. doi request reprint GFR, proteinuria and circadian blood pressure
    Rajiv Agarwal
    1Division of Nephrology, Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, IN, USA
    Nephrol Dial Transplant 24:2400-6. 2009
  8. ncbi request reprint Strategies for successful patient oriented research: why did I (not) get funded?
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, Ind, USA
    Clin J Am Soc Nephrol 1:340-3. 2006
  9. ncbi request reprint Iron sucrose causes greater proteinuria than ferric gluconate in non-dialysis chronic kidney disease
    R Agarwal
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 72:638-42. 2007
  10. ncbi request reprint Oxidative stress in hypertension and chronic kidney disease: role of angiotensin II
    Rajiv Agarwal
    Indian University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Semin Nephrol 24:101-14. 2004

Research Grants

  1. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2003
  2. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2004
  3. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2005
  4. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2006
  5. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
  6. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
  7. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2008
  8. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
  9. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010

Detail Information

Publications138 found, 100 shown here

  1. doi request reprint Thiazide diuretics in advanced chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Am Soc Hypertens 6:299-308. 2012
    ..Our review suggests that adequately powered randomized trials are needed before the use of thiazide diuretics can be firmly recommended in those with advanced CKD...
  2. ncbi request reprint A randomized controlled trial of oral versus intravenous iron in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Am J Nephrol 26:445-54. 2006
    ..We conducted a randomized multicenter controlled trial in adult anemic, iron-deficient non-dialysis CKD (ND-CKD) patients (>or=stage 3) not receiving erythropoiesis-stimulating agents (ESAs)...
  3. ncbi request reprint Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and RLR Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 39:486-92. 2002
    ..We speculate that dual blockade with losartan and an ACE inhibitor may provide additional renoprotection by decreasing renal production of TGF-beta1...
  4. doi request reprint Prognostic value of circadian blood pressure variation in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Indianapolis, Ind, USA
    Am J Nephrol 30:547-53. 2009
    ..Reduced circadian variation in blood pressure (BP) has been associated with cardiovascular morbidity, mortality and accelerated progression of kidney disease, but its independent prognostic value remains unknown...
  5. ncbi request reprint Long-term retinal, renal and cardiovascular outcomes in diabetic chronic kidney disease without proteinuria
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Richard L Roudebush Veterans Administration Medical Center, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 27:310-7. 2012
    ..Patients with diabetes mellitus (DM) with chronic kidney disease (CKD) often have no proteinuria...
  6. ncbi request reprint Buzz in the axilla: a new physical sign in hemodialysis forearm graft evaluation
    R Agarwal
    Indiana University School of Medicine, and Roudebush VA MedicalCenter, 1481 West 10th St, Indianapolis, IN 46202, USA
    Am J Kidney Dis 38:853-7. 2001
    ..This single physical sign also correlated with subsequent graft failure and should be incorporated into physical examinations of all dialysis grafts...
  7. doi request reprint GFR, proteinuria and circadian blood pressure
    Rajiv Agarwal
    1Division of Nephrology, Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, IN, USA
    Nephrol Dial Transplant 24:2400-6. 2009
    ..Emerging evidence suggests that consideration of excretory function together with proteinuria may provide a more holistic assessment of the extent of derangement in renal function...
  8. ncbi request reprint Strategies for successful patient oriented research: why did I (not) get funded?
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, Ind, USA
    Clin J Am Soc Nephrol 1:340-3. 2006
    ....
  9. ncbi request reprint Iron sucrose causes greater proteinuria than ferric gluconate in non-dialysis chronic kidney disease
    R Agarwal
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 72:638-42. 2007
    ..Although our study showed that acutely, iron sucrose increased proteinuria, the long-term effects of repeated i.v. non-dextran iron on kidney function requires further study...
  10. ncbi request reprint Oxidative stress in hypertension and chronic kidney disease: role of angiotensin II
    Rajiv Agarwal
    Indian University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Semin Nephrol 24:101-14. 2004
    ....
  11. doi request reprint Resistant hypertension and the neglected antihypertensive: sodium restriction
    Rajiv Agarwal
    Correspondence and offprint requests to Rajiv Agarwal E mail
    Nephrol Dial Transplant 27:4041-5. 2012
    ..Sodium restriction is therefore a valuable but a neglected antihypertensive...
  12. doi request reprint Multiple comparisons, interaction effects, and statistical inference: lessons from chronic kidney disease progression among blacks
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 81:516-9. 2012
    ..Tests of statistical interaction are then applied and interpreted to understand effect modification (or lack thereof) in the context of this trial...
  13. ncbi request reprint How should hypertension be assessed and managed in hemodialysis patients? Home BP, not dialysis unit BP, should be used for managing hypertension
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Semin Dial 20:402-5. 2007
  14. ncbi request reprint Vitamin D, proteinuria, diabetic nephropathy, and progression of CKD
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 4:1523-8. 2009
    ..To demonstrate the putative benefits of native vitamin D and VDRA among patients with CKD, randomized, controlled trials are needed...
  15. doi request reprint Developing a self-administered CKD symptom assessment instrument
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 25:160-6. 2010
    ..This purpose of this report is to describe the development of an instrument to measure the presence and severity of a wide range of symptoms commonly attributable to CKD...
  16. pmc Intradialytic hypertension is a marker of volume excess
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 25:3355-61. 2010
    ..Intradialytic blood pressure (BP) profiles have been associated with all-cause mortality, but its pathophysiology remains unknown. We tested the hypothesis that intradialytic changes in BP reflect excess volume...
  17. pmc Blood pressure components and the risk for end-stage renal disease and death in chronic kidney disease
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 4:830-7. 2009
    ..I examined the unique contributions of systolic (SBP) and diastolic BP (DBP) on the risk for ESRD and death in patients with chronic kidney disease (CKD)...
  18. doi request reprint Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 80:1073-9. 2011
    ..Thus, short-term vitamin D receptor activation increases creatinine generation and serum creatinine, but it does not influence the glomerular filtration rate...
  19. ncbi request reprint Prognostic importance of ambulatory blood pressure recordings in patients with chronic kidney disease
    R Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 69:1175-80. 2006
    ..Systolic ambulatory BP and nondipping are independent predictors for ESRD after adjusting for clinic BP. However, adjustment for other risk factors for CKD progression removes the independent prognostic value of ambulatory BP...
  20. ncbi request reprint Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy
    Rajiv Agarwal
    Indiana University School of Medicine, and Veterans Affairs Medical Center, 111N, 1481 West 10th St, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 290:F600-5. 2006
    ..This surrogate end point needs to be confirmed in trials designed to demonstrate cardiovascular protection...
  21. ncbi request reprint Relationship between circadian blood pressure variation and circadian protein excretion in CKD
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 293:F655-9. 2007
    ..Pulse pressure is related to proteinuria independent of the awake-sleep state. Reducing mean arterial pressure during the day and pulse pressure during the day or night may be effective antiproteinuric strategies...
  22. pmc Cardiovascular protection with antihypertensive drugs in dialysis patients: systematic review and meta-analysis
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Hypertension 53:860-6. 2009
    ..Randomized trials suggested a benefit of antihypertensive therapy among hemodialysis patients. Adequately powered randomized trials are required to confirm these observations, especially among those with hypertension...
  23. ncbi request reprint Pre- and postdialysis blood pressures are imprecise estimates of interdialytic ambulatory blood pressure
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 1:389-98. 2006
    ..1 to -36.3 mmHg) and diastolic BP (19.3 to -23.9 mmHg). Dialysis unit BP measurements are imprecise estimates of ABP. Better methods are needed for the assessment of BP in hemodialysis patients for clinical decision making...
  24. ncbi request reprint Chronic kidney disease is associated with oxidative stress independent of hypertension
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and RLR VA Medical Center, Indianapolis, IN 46202, USA
    Clin Nephrol 61:377-83. 2004
    ..Oxidative stress is implicated in the pathogenesis of chronic kidney disease (CKD) and essential hypertension (EHTN). However, the role of hypertension in causing increased oxidative stress in patients with CKD is unknown...
  25. ncbi request reprint Dialysis dose and the diagnosis of hypertension in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Blood Press Monit 12:281-7. 2007
    ..Evidence for effect modification was tested for several plausible demographic, clinical and laboratory factors...
  26. ncbi request reprint Hypertension diagnosis and prognosis in chronic kidney disease with out-of-office blood pressure monitoring
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 15:309-13. 2006
    ..This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and outcomes...
  27. pmc Ambulatory blood pressure and cardiovascular events in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Semin Nephrol 27:538-43. 2007
    ..Ambulatory BP monitoring can refine cardiovascular and renal risk assessment in all stages of CKD. The independent prognostic role of nondipping is unclear...
  28. ncbi request reprint Proinflammatory effects of iron sucrose in chronic kidney disease
    R Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 69:1259-63. 2006
    ..These results may have implications for the progression of CKD with parenteral iron...
  29. ncbi request reprint Arterial stiffness and interdialytic weight gain influence ambulatory blood pressure patterns in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush Department of Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 294:F303-8. 2008
    ....
  30. pmc Sleep and activity in chronic kidney disease: a longitudinal study
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:1258-65. 2011
    ..Commonly sleep is disrupted and physical activity is restricted among patients with CKD and those on long-term dialysis. However, few studies have assessed patients longitudinally...
  31. pmc Dry-weight: a concept revisited in an effort to avoid medication-directed approaches for blood pressure control in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street, 111N, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 5:1255-60. 2010
    ..Achieving and maintaining dry-weight appears to be an effective but forgotten strategy in controlling and maintaining normotension among hypertensive patients on hemodialysis...
  32. doi request reprint Individualizing decision-making--resurrecting the doctor-patient relationship in the anemia debate
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street, 111N, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 5:1340-6. 2010
    ..Above all, clinical decision-making should incorporate patient preference...
  33. doi request reprint Debate from the 2012 ASH Annual Scientific Sessions: should blood pressure be reduced in hemodialysis patients? Pro position
    Rajiv L Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA
    J Am Soc Hypertens 6:439-42. 2012
    ..Adequately designed and powered randomized trials are needed to examine the notion that blood pressure lowering and, if so, to what level of blood pressure will improve clinically meaningful outcomes among chronic dialysis patients...
  34. pmc Median intradialytic blood pressure can track changes evoked by probing dry-weight
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 5:897-904. 2010
    ..Median BP obtained over a single dialysis treatment can diagnose hypertension among hemodialysis patients. Whether median BP is as useful to track change in BP is unknown...
  35. pmc Blood pressure and mortality among hemodialysis patients
    Rajiv Agarwal
    Indiana University, Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Hypertension 55:762-8. 2010
    ..Therefore, the management of hypertension among these patients should focus on blood pressure recordings outside the dialysis unit...
  36. doi request reprint Relationship between glycosylated hemoglobin and blood glucose during progression of chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Nephrol 34:32-41. 2011
    ..The value of measurement of glycosylated hemoglobin (HgbA(1C)) in determining the degree of glycemic control in patients with chronic kidney disease (CKD) is unclear...
  37. doi request reprint Circadian blood pressure classification scheme and the health of patients with chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 30:536-46. 2009
    ..Circadian rhythms in systolic BP are often described by the dichotomous dipper classification but may not be adequate to fully characterize derangements in cyclical variation in BP...
  38. ncbi request reprint How to diagnose hypertension in hemodialysis patients?
    R Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis 46202, USA
    Minerva Urol Nefrol 54:149-56. 2002
    ..Improving the measurement technique in the dialysis unit, averaging multiple BP, using a 20 min postdialysis reading, or home BP monitoring can improve BP determination when interdialytic BP monitoring is not possible...
  39. pmc Volume-associated ambulatory blood pressure patterns in hemodialysis patients
    Rajiv Agarwal
    Veterans Affairs Medical Center, 111N, 1481 West 10th St, Indianapolis, IN 46202, USA
    Hypertension 54:241-7. 2009
    ....
  40. ncbi request reprint Management of hypertension in hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Hemodial Int 10:241-8. 2006
    ..Whether control of hypertension translates into better outcomes is not known, but collective evidence suggests that hypertension should be controlled in hemodialysis patients...
  41. ncbi request reprint Ambulatory GFR measurement with cold iothalamate in adults with chronic kidney disease
    Rajiv Agarwal
    Indiana University and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 41:752-9. 2003
    ....
  42. pmc Physical activity and hemodynamic reactivity in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 3:1660-8. 2008
    ..This study was designed to understand better the presence and strength of the relationship between physical activity and BP and to explore determinants of hemodynamic reactivity...
  43. doi request reprint Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial
    Pooneh Alborzi
    Indiana University and VAMC, 1481 W 10th St, Indianapolis, IN 46202, USA
    Hypertension 52:249-55. 2008
    ..Long-term randomized, controlled trials are required to confirm these benefits of vitamin D analogs...
  44. pmc Assessment and management of hypertension in patients on dialysis
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana
    J Am Soc Nephrol 25:1630-46. 2014
    ..Future clinical trials designed to clarify the controversial results discussed here should lead to the implementation of diagnostic and therapeutic techniques that improve long-term cardiovascular outcomes in patients with ESRD. ..
  45. ncbi request reprint Physical activity is a determinant of circadian blood pressure variation in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 31:15-23. 2010
    ..The causes of this blunted circadian variation remain incompletely understood...
  46. ncbi request reprint Out-of-hemodialysis-unit blood pressure is a superior determinant of left ventricular hypertrophy
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hypertension 47:62-8. 2006
    ..Routine and standardized measurements of BP were similarly weak correlates of LVH. Systolic BP outside the dialysis unit was a stronger correlate of LVH compared with dialysis unit BP...
  47. doi request reprint Blood pressure response with fixed-dose combination therapy: comparing hydrochlorothiazide with amlodipine through individual-level meta-analysis
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    J Hypertens 31:1692-701. 2013
    ..Furthermore, we hypothesized that response to ARB along with HCTZ or ARB along with CCB may be heterogeneous depending on clinical characteristics...
  48. doi request reprint Treated hypertension and the white coat phenomenon: Office readings are inadequate measures of efficacy
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    J Am Soc Hypertens 7:236-43. 2013
    ..Thus, out-of-office BP monitoring especially among treated hypertensive patients with type 2 diabetes is necessary to provide better assessment of overall BP and response to treatment...
  49. doi request reprint How can we prevent intradialytic hypotension?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 21:593-9. 2012
    ..Intradialytic hypotension (IDH) produces uncomfortable symptoms for the patient and reduces the efficiency of dialysis...
  50. pmc Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 27:3908-14. 2012
    ..The prevalence, determinants and prognosis of pulmonary hypertension among long-term hemodialysis patients in the USA are poorly understood...
  51. pmc The controversies of diagnosing and treating hypertension among hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Semin Dial 25:370-6. 2012
    ..Evaluating home BP in every dialysis patient, evaluating volume status on a regular basis, and treating hypertension predominantly with nonpharmacological strategies are worthwhile...
  52. ncbi request reprint Monitoring interposition graft venous pressures at higher blood-flow rates improves sensitivity in predicting graft failure
    R Agarwal
    Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA
    Am J Kidney Dis 34:212-7. 1999
    ..There is a substantial variability in venous pressures in the same patient that reduces with increasing Qbs. Venous pressure monitoring at greater Qbs provides a more sensitive method for predicting access failure...
  53. ncbi request reprint Dipstick proteinuria: can it guide hypertension management?
    Rajiv Agarwal
    Indiana University and Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 39:1190-5. 2002
    ..These results suggest that patients with 3+ or greater proteinuria should not only trigger appropriate evaluation of proteinuria, but also have mean arterial pressures targeted to less than 92 mm Hg...
  54. pmc Dry-weight reduction in hypertensive hemodialysis patients (DRIP): a randomized, controlled trial
    Rajiv Agarwal
    Division of Nephrology and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Hypertension 53:500-7. 2009
    ..The reduction of dry weight is a simple, efficacious, and well-tolerated maneuver to improve BP control in hypertensive hemodialysis patients. Long-term control of BP will depend on continued assessment and maintenance of dry weight...
  55. ncbi request reprint Rapid, fluorimetric-liquid chromatographic determination of malondialdehyde in biological samples
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 775:121-6. 2002
    ..MDA degrades at room temperature at a rate of 10% per hour. It is therefore, suggested that the total assay time be limited to 1 h beginning with sample preparation...
  56. pmc Toward a definition of masked hypertension and white-coat hypertension among hemodialysis patients
    Rajiv Agarwal
    Professor of Medicine, Indiana University and Veterans Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:2003-8. 2011
    ..In part, this is because it can detect white-coat hypertension and masked hypertension. Whether the same is true for hemodialysis patients is not known...
  57. ncbi request reprint Home and ambulatory blood pressure monitoring in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 18:507-12. 2009
    ..The purpose of this review is to discuss the recent advances in out-of-office BP recordings in the management of patients with CKD including those on hemodialysis...
  58. doi request reprint Nocturia, nocturnal activity, and nondipping
    Rajiv Agarwal
    Indiana University and Veterans Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Hypertension 54:646-51. 2009
    ..Whether nocturia itself or the resulting nondipping associated with nocturia is of prognostic importance for cardiorenal events in patients with chronic kidney disease should be tested in future studies...
  59. ncbi request reprint Issues related to iron replacement in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Semin Nephrol 22:479-87. 2002
    ..The current data suggest that the overall risk-benefit ratio favors use of IV iron when compared with untreated or partially treated iron-deficiency anemia...
  60. ncbi request reprint Supervised atenolol therapy in the management of hemodialysis hypertension
    R Agarwal
    Department of Medicine, Indiana University and RLR VA Medical Center, Indianapolis, USA
    Kidney Int 55:1528-35. 1999
    ..Atenolol, a water soluble beta-blocker has a prolonged half-life in renal failure and may serve as a useful antihypertensive agent in these patients...
  61. pmc Body mass index-mortality paradox in hemodialysis: can it be explained by blood pressure?
    Rajiv Agarwal
    Indiana University and VAMC, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Hypertension 58:1014-20. 2011
    ..Leaner patients have an accelerated mortality rate in the first 2 years; this is not completely explained by BP, LVMI, or other cardiovascular or dialysis-specific risk factors...
  62. ncbi request reprint Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 284:F863-9. 2003
    ..The significant association of the change in urinary MCP-1 with a reduction in oxidative stress supports the role of the redox state in the kidney with renal fibrosis and progressive kidney damage...
  63. ncbi request reprint Liquid chromatography for iothalamate in biological samples
    Rajiv Agarwal
    Indiana University and VAMC, 1481 West 10th Street, Indianapolis, IN 46202, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 785:345-52. 2003
    ..There was excellent thermal and pH stability of iothalamate. No interference was found with para-amino hippuric acid (PAH) or N-acetyl PAH, which can be simultaneously assayed, if desired...
  64. pmc Home blood pressure measurements for managing hypertension in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Ind, USA
    Am J Nephrol 30:126-34. 2009
    ..These data provide support for the use of home BP monitoring for the management of hypertension in hemodialysis patients...
  65. pmc Patterns and prognostic value of total and differential leukocyte count in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:1393-9. 2011
    ..The purpose of this study was to evaluate the levels and patterns of total and differential leukocyte counts and their prognostic importance in a cohort of people with and without chronic kidney disease (CKD)...
  66. doi request reprint Role of home blood pressure monitoring in overcoming therapeutic inertia and improving hypertension control: a systematic review and meta-analysis
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Ind 46202, USA
    Hypertension 57:29-38. 2011
    ..Hypertension control with home BP monitoring can be enhanced further when accompanied by plans to monitor and treat elevated BP such as through telemonitoring...
  67. pmc Determinants and prognostic significance of electrocardiographic left ventricular hypertrophy criteria in chronic kidney disease
    Rajiv Agarwal
    Indiana University and Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:528-36. 2011
    ..However, among those with chronic kidney disease (CKD), the determinants of electrocardiographic (EKG) LVH and its prognostic value are not clear...
  68. pmc Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 6:114-21. 2011
    ..This study examined differences in proteinuria between two intravenous iron preparations after multiple doses...
  69. doi request reprint Diagnosing obesity by body mass index in chronic kidney disease: an explanation for the "obesity paradox?"
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hypertension 56:893-900. 2010
    ..Skinfold thickness measurements may be a better test to classify obesity among those with CKD. Given the low negative predictive value of BMI for obesity, our study may provide an explanation of the "obesity paradox."..
  70. pmc Hypervolemia is associated with increased mortality among hemodialysis patients
    Rajiv Agarwal
    Indiana University School of Medicine and Veterans Administration Medical Center, 1481 West 10th St, Indianapolis, IN 46202, USA
    Hypertension 56:512-7. 2010
    ..Its use to assess excess volume-related morbidity among chronic hemodialysis patients should be tested in randomized, controlled trials...
  71. ncbi request reprint Add-on angiotensin receptor blockade with maximized ACE inhibition
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and RLR VA Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 59:2282-9. 2001
    ..d.) will result in additional Ang II antagonism in patients with proteinuric chronic renal failure with hypertension...
  72. ncbi request reprint Are vitamin D receptor agonists like angiotensin-converting enzyme inhibitors without side effects?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 77:943-5. 2010
    ..Whether VDRAs will accomplish this goal among proteinuric patients with chronic kidney disease needs to be tested in randomized controlled trials...
  73. pmc Inferior vena cava diameter and left atrial diameter measure volume but not dry weight
    Rajiv Agarwal
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 6:1066-72. 2011
    ..Hypervolemia is an important and modifiable cause of hypertension. Hypertension improves with probing dry weight, but its effect on echocardiographic measures of volume is unknown...
  74. ncbi request reprint Prediction of hypertension in chronic hemodialysis patients
    R Agarwal
    Department of Medicine, Indiana University and VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 60:1982-9. 2001
    ..We sought to determine the clinical performance of predialysis and postdialysis systolic and diastolic blood pressure values (BPs) in diagnosing hypertension or assessing its control...
  75. ncbi request reprint Lisinopril therapy for hemodialysis hypertension: hemodynamic and endocrine responses
    R Agarwal
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 38:1245-50. 2001
    ..In conclusion, supervised lisinopril therapy is effective in controlling hypertension in chronic HD patients. This may be related to blockade of angiotensin II generation by kidneys despite the loss of excretory function...
  76. ncbi request reprint Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile?
    R Agarwal
    Indiana University and Roudebush VA Medical Center, Indianapolis 46202, USA
    Clin Nephrol 57:167-70. 2002
    ....
  77. doi request reprint Blood pressure goal in chronic kidney disease: what is the evidence?
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 20:229-32. 2011
    ..Most guidelines recommend that seated clinic blood pressure (BP) be targeted to less than 130/80 mmHg in patients with chronic kidney disease (CKD). The evidence underlying these recommendations is the subject of this review...
  78. pmc The effect of measuring ambulatory blood pressure on nighttime sleep and daytime activity--implications for dipping
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 5:281-5. 2010
    ..The effect of BP monitoring itself on the level of physical activity and sleep remains unknown. If BP monitoring affects these parameters, then monitoring itself may influence the circadian BP pattern...
  79. ncbi request reprint Rapid microplate method for PAH estimation
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 283:F236-41. 2002
    ..The microplate method is a reliable alternative to a reference HPLC method and can be performed for a fraction of the cost, time, and reagents...
  80. pmc Regulation of circadian blood pressure: from mice to astronauts
    Rajiv Agarwal
    Division of Nephrology, Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 19:51-8. 2010
    ..The purpose of this review is to examine the physiology of circadian BP variation and propose a tripartite model that explains the regulation of circadian BP...
  81. pmc Interdialytic hypertension-an update
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Adv Chronic Kidney Dis 18:11-6. 2011
    ..Beta blockers, dihydropyridine calcium blockers, and agents that block the renin-angiotensin system appear to be effective in lowering BP in these patients...
  82. pmc Assessment of iothalamate plasma clearance: duration of study affects quality of GFR
    Rajiv Agarwal
    Indiana University and Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 4:77-85. 2009
    ..The purpose of this study was to evaluate whether the duration of plasma sampling influences precision and estimation of GFR...
  83. pmc On the importance of pedal edema in hemodialysis patients
    Rajiv Agarwal
    Division of Nephrology, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 3:153-8. 2008
    ..Volume control is a key component of treatment of hemodialysis patients. The role of pedal edema as a marker of volume is unknown. The objective of this study was to determine factors that are associated with edema...
  84. ncbi request reprint Antihypertensive agents and arterial stiffness: relevance to reducing cardiovascular risk in the chronic kidney disease patient
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Curr Opin Nephrol Hypertens 16:409-15. 2007
    ....
  85. ncbi request reprint Hypertension and survival in chronic hemodialysis patients--past lessons and future opportunities
    Rajiv Agarwal
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 67:1-13. 2005
    ....
  86. ncbi request reprint A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 68:285-92. 2005
    ..We hypothesized that PPAR-gamma-based antidiabetic therapy would result in greater reduction in proteinuria compared to sulfonylurea-based therapy...
  87. pmc Epidemiology of interdialytic ambulatory hypertension and the role of volume excess
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Am J Nephrol 34:381-90. 2011
    ..The epidemiology of hypertension among hemodialysis (HD) patients is difficult to describe accurately because of difficulties in the assessment of blood pressure (BP)...
  88. ncbi request reprint Reproducibility of renal function measurements in adult men with diabetic nephropathy: research and clinical implications
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 27:92-100. 2007
    ..The goal of this study was to describe the variability in these measurements and to calculate minimum sample size estimates over varying time frames for clinical trials...
  89. ncbi request reprint Blood pressure recordings within and outside the clinic and cardiovascular events in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Nephrol 26:503-10. 2006
    ..To assess the role of out-of-clinic BP recordings in predicting cardiovascular events in patients with chronic kidney disease (CKD), a prospective cohort study was conducted in 217 veterans with CKD...
  90. pmc Probing dry-weight improves left ventricular mass index
    Rajiv Agarwal
    Division of Nephrology, Indianapolis, IN, USA
    Am J Nephrol 33:373-80. 2011
    ..Although probing dry-weight improves blood pressure control, its effect on echocardiographic left ventricular mass index (LVMI) is unknown...
  91. ncbi request reprint Hypertension in chronic kidney disease and dialysis: pathophysiology and management
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Emerson Hall Room 520, Indiana University School of Medicine, and Roudebush VA Medical Center, 1481 West 10th Street 111 N, Indianapolis, IN 46202, USA
    Cardiol Clin 23:237-48. 2005
    ..It has long been recognized that kidney function affects and is affected by hypertension. This article discusses the pathophysiology and management of hypertension in patients with CKD...
  92. ncbi request reprint Correlates of systolic hypertension in patients with chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine, Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA
    Hypertension 46:514-20. 2005
    ....
  93. ncbi request reprint The role of statins in chronic kidney disease
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Am J Med Sci 330:69-81. 2005
    ....
  94. ncbi request reprint Home blood pressure monitoring improves the diagnosis of hypertension in hemodialysis patients
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, VAMC 111N, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 69:900-6. 2006
    ..Home BP monitoring is similar to standardized recording of BP in hemodialysis patients. A systolic BP threshold of 150 mmHg at home averaged over 1 week serves as a useful predictor of hypertension diagnosed by ambulatory BP monitoring...
  95. ncbi request reprint Effects of statins on renal function
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Cardiol 97:748-55. 2006
    ..Several large trials are currently under way to examine the safety and efficacy of statins in renally compromised patients at high risk for cardiovascular disease...
  96. pmc Smoking, oxidative stress and inflammation: impact on resting energy expenditure in diabetic nephropathy
    Rajiv Agarwal
    Department of Medicine, Indiana University, RLR VA Medical Center, Indianapolis, Indiana, USA
    BMC Nephrol 6:13. 2005
    ..Smoking is a common mechanism for generating oxidative stress and inflammation. Whether smokers have increased REE and if so, whether it is accounted for by the pro-oxidant and inflammatory state is not known...
  97. ncbi request reprint Prognostic importance of clinic and home blood pressure recordings in patients with chronic kidney disease
    R Agarwal
    Indiana University School of Medicine, Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Kidney Int 69:406-11. 2006
    ..In patients with CKD, BPs obtained at home are a stronger predictor of ESRD or death compared to BPs obtained in the clinic. Systolic home BP is an independent predictor for ESRD...
  98. ncbi request reprint On the nature of proteinuria with acute renal injury in patients with chronic kidney disease
    Rajiv Agarwal
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Renal Physiol 288:F265-71. 2005
    ..Measurement of total intact albumin may better quantify acute renal injury...
  99. ncbi request reprint Nonhematological benefits of iron
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and Richard L Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Am J Nephrol 27:565-71. 2007
    ....
  100. ncbi request reprint The challenge of discovering patient-level cardiovascular risk factors in chronic kidney disease
    R Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 73:1340-2. 2008
    ..Nontraditional risk factors such as albuminuria can then be tested to evaluate the predictive value of these markers over and above traditional risk factors for patient-level decision making...

Research Grants9

  1. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2003
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  2. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2004
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  3. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2005
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  4. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2006
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  5. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  6. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  7. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2008
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  8. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  9. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..