Research Topics
Genomes and Genes
| J J PeschonSummaryAffiliation: Immunex Corporation Country: USA Publications
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Detail Information
Publications
An essential role for ectodomain shedding in mammalian developmentJ J Peschon
Immunex Corporation, Seattle, WA 98101, USA
Science 282:1281-4. 1998..The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo...- TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammationJ J Peschon
Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
J Immunol 160:943-52. 1998..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo... - Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cellsH J McKenna
Immunex Corporation, Seattle, WA 98101, USA
Blood 95:3489-97. 2000..We conclude that flt3L has an important role in the expansion of early hematopoietic progenitors and in the generation of mature peripheral leukocytes... - Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- miceE Maraskovsky
Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
Cell 89:1011-9. 1997..These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2... - Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzymeP Reddy
Department of Cell Sciences, Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 275:14608-14. 2000..IL-1R-II shedding required the cysteine-rich domain of TACE as well as the catalytic domain, whereas TNF and p75 TNFR shedding required only the tethered TACE catalytic domain... - A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cellsR A Black
Immunex Corporation, Seattle, Washington 98101, USA
Nature 385:729-33. 1997..Our results should facilitate the development of therapeutically useful inhibitors of TNF-alpha release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins... - Phenotypic and functional characterization of mice that lack the type I receptor for IL-1M B Glaccum
Immunex Corporation, Seattle, WA 98101, USA
J Immunol 159:3364-71. 1997..Interestingly, ICE-/-/type I IL-1R-/- double mutant mice are resistant to high dose LPS. Type I IL-1R-/- mice backcrossed to the C57BL/6 background were as equally resistant as wild-type mice to Listeria monocytogenes... 
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceM K Kennedy
Immunex Corporation, Seattle, Washington 98101, USA
J Exp Med 191:771-80. 2000..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...- Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptorY Yamada
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
Hepatology 28:959-70. 1998..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication... - Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeruginosaS J Skerrett
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108, USA
Am J Physiol 276:L715-27. 1999..In contrast, TNFR1 attenuates lung inflammation in response to live bacteria but does not contribute to increased lung permeability and is not required for the elimination of P. aeruginosa... - RANK is essential for osteoclast and lymph node developmentW C Dougall
Immunex Corporation, Seattle, Washington 98101 USA
Genes Dev 13:2412-24. 1999..These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation... - IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expressionL M Sedger
Department of Molecular Immunology, Immunex Corporation, Seattle, WA 98101, USA
J Immunol 163:920-6. 1999..The regulation of TRAIL and TRAIL-R expression may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis... - Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cellsE Maraskovsky
Department of Cellular Immunology, Immunex Corporation, Seattle, WA 98101, USA
J Immunol 157:5315-23. 1996..We propose that an absence of IL-7R signaling not only affects T cell development in the thymus, but also results in the accumulation of functionally inactive T cells in the periphery... - Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55S A Schreyer
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 271:26174-8. 1996..Our results support the concept that increased scavenger receptor activity contributes to excessive fatty streak formation. We conclude that TNF p55 receptors protect against atherosclerotic lesion development in the mouse... - Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virusM A DeBenedette
Department of Immunology, University of Toronto, Ontario, Canada
J Immunol 163:4833-41. 1999..These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo... - Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient miceR Sadhukhan
Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 274:10511-6. 1999..We demonstrate that soluble ACE-secretase from both sources failed to cleave its substrate in solution, suggesting a requirement for anchoring to the membrane... - Roles of tumor necrosis factor receptor signaling during murine Escherichia coli pneumoniaJ P Mizgerd
Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Am J Respir Cell Mol Biol 22:85-91. 2000..During acute E. coli pneumonia, the absence of TNFR signaling compromised bacterial killing, but did not prevent inflammation, as measured by the accumulation of edema fluid and neutrophils... - Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout miceL A Ortiz
Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Section of Endocrinology, Tulane University Medical Center, New Orleans, Louisiana, USA
Am J Respir Cell Mol Biol 20:825-33. 1999..This study supports the concept that TNF is a central mediator of interstitial pulmonary fibrosis... - Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in miceL A Ortiz
Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112 2699, USA
Exp Lung Res 24:721-43. 1998..These results provide further support for a role of macrophages and TNF in the induction of lung inflammation... - Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursorJ D Buxbaum
Departments of Psychiatry and Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 273:27765-7. 1998..Furthermore, we show that inhibiting this enzyme affects both APP secretion and Abeta formation in cultured cells... - TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selectionD M Page
Department of Biology and the Cancer Center, University of California San Diego, La Jolla 92093 0687, USA
J Immunol 160:120-33. 1998..Current models of negative selection and the role of TNFR family members in this process are discussed in light of these results... - Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout miceS Candeias
SAIC, NCI FCRDC, Frederick, MD 21702 1201, USA
Immunol Lett 57:9-14. 1997..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus... - Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptorY Yamada
Department of Pathology, University of Washington, Seattle 98195, USA
Proc Natl Acad Sci U S A 94:1441-6. 1997..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor... - Role of lymphotoxin and the type I TNF receptor in the formation of germinal centersM Matsumoto
Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
Science 271:1289-91. 1996..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow... - Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesisJ Zhao
Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, California, 90033, USA
Dev Biol 232:204-18. 2001.... - Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeletonM Shi
Departments of. Biochemistry and Orthopedic Surgery, Section of Biochemistry and Molecular Biology, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
J Immunol 167:123-31. 2001..We conclude that the CD44 sheddase and TACE are distinct enzymes, and that Ab- and phorbol ester-enhanced cleavage of CD44 is controlled in a cell type-dependent fashion by Rho GTPases through the cytoskeleton... - Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarctionK M Kurrelmeyer
Winters Center for Heart Failure Research, Cardiology Section, Veterans Affairs Medical Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 97:5456-61. 2000..These data suggest that TNF signaling gives rise to one or more cytoprotective signals that prevent and/or delay the development of cardiac myocyte apoptosis after acute ischemic injury... - Spermatid-specific expression of protamine 1 in transgenic miceJ J Peschon
Proc Natl Acad Sci U S A 84:5316-9. 1987..The cis-acting sequences required for tissue-specific protamine expression reside on a 2.4-kilobase restriction fragment. Prospects for using transgenic mice to address fundamental questions of male germ-cell development are discussed... - An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient stateK Fujihashi
Department of Oral Biology, University of Alabama at Birmingham, Medical Center 35294 2170, USA
Eur J Immunol 27:2133-8. 1997..The direct comparison of IL-7-/- and IL-7R-/- mice clearly supports the hypothesis that both IL-7 and another IL-7R binding molecule can influence the development of gamma delta T cells in the intestinal epithelium... - Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient miceJ J Peschon
Immunex Research and Development Corporation, Seattle, Washington 98101
J Exp Med 180:1955-60. 1994..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7... - Sequence homologies in the mouse protamine 1 and 2 genesP A Johnson
Department of Biology, Tufts University, Medford, MA 02155
Biochim Biophys Acta 950:45-53. 1988..An additional shared sequence is present in the 3' untranslated region surrounding the poly(A) addition signal in both genes... - Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defenseP Ye
Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
J Exp Med 194:519-27. 2001..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...