J J Peschon

Summary

Affiliation: Immunex Corporation
Country: USA

Publications

  1. ncbi request reprint An essential role for ectodomain shedding in mammalian development
    J J Peschon
    Immunex Corporation, Seattle, WA 98101, USA
    Science 282:1281-4. 1998
  2. ncbi request reprint TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
  3. ncbi request reprint Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
  4. ncbi request reprint Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice
    E Maraskovsky
    Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Cell 89:1011-9. 1997
  5. ncbi request reprint Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
    P Reddy
    Department of Cell Sciences, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 275:14608-14. 2000
  6. ncbi request reprint A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    R A Black
    Immunex Corporation, Seattle, Washington 98101, USA
    Nature 385:729-33. 1997
  7. ncbi request reprint Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
    M B Glaccum
    Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 159:3364-71. 1997
  8. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
  9. ncbi request reprint Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor
    Y Yamada
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
    Hepatology 28:959-70. 1998
  10. ncbi request reprint Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeruginosa
    S J Skerrett
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108, USA
    Am J Physiol 276:L715-27. 1999

Collaborators

Detail Information

Publications32

  1. ncbi request reprint An essential role for ectodomain shedding in mammalian development
    J J Peschon
    Immunex Corporation, Seattle, WA 98101, USA
    Science 282:1281-4. 1998
    ..The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo...
  2. ncbi request reprint TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo...
  3. ncbi request reprint Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
    ..We conclude that flt3L has an important role in the expansion of early hematopoietic progenitors and in the generation of mature peripheral leukocytes...
  4. ncbi request reprint Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice
    E Maraskovsky
    Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Cell 89:1011-9. 1997
    ..These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2...
  5. ncbi request reprint Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
    P Reddy
    Department of Cell Sciences, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 275:14608-14. 2000
    ..IL-1R-II shedding required the cysteine-rich domain of TACE as well as the catalytic domain, whereas TNF and p75 TNFR shedding required only the tethered TACE catalytic domain...
  6. ncbi request reprint A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    R A Black
    Immunex Corporation, Seattle, Washington 98101, USA
    Nature 385:729-33. 1997
    ..Our results should facilitate the development of therapeutically useful inhibitors of TNF-alpha release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins...
  7. ncbi request reprint Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
    M B Glaccum
    Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 159:3364-71. 1997
    ..Interestingly, ICE-/-/type I IL-1R-/- double mutant mice are resistant to high dose LPS. Type I IL-1R-/- mice backcrossed to the C57BL/6 background were as equally resistant as wild-type mice to Listeria monocytogenes...
  8. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
  9. ncbi request reprint Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor
    Y Yamada
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
    Hepatology 28:959-70. 1998
    ..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication...
  10. ncbi request reprint Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeruginosa
    S J Skerrett
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108, USA
    Am J Physiol 276:L715-27. 1999
    ..In contrast, TNFR1 attenuates lung inflammation in response to live bacteria but does not contribute to increased lung permeability and is not required for the elimination of P. aeruginosa...
  11. pmc RANK is essential for osteoclast and lymph node development
    W C Dougall
    Immunex Corporation, Seattle, Washington 98101 USA
    Genes Dev 13:2412-24. 1999
    ..These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation...
  12. ncbi request reprint IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression
    L M Sedger
    Department of Molecular Immunology, Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 163:920-6. 1999
    ..The regulation of TRAIL and TRAIL-R expression may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis...
  13. ncbi request reprint Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells
    E Maraskovsky
    Department of Cellular Immunology, Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 157:5315-23. 1996
    ..We propose that an absence of IL-7R signaling not only affects T cell development in the thymus, but also results in the accumulation of functionally inactive T cells in the periphery...
  14. ncbi request reprint Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55
    S A Schreyer
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:26174-8. 1996
    ..Our results support the concept that increased scavenger receptor activity contributes to excessive fatty streak formation. We conclude that TNF p55 receptors protect against atherosclerotic lesion development in the mouse...
  15. ncbi request reprint Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    M A DeBenedette
    Department of Immunology, University of Toronto, Ontario, Canada
    J Immunol 163:4833-41. 1999
    ..These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo...
  16. ncbi request reprint Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice
    R Sadhukhan
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 274:10511-6. 1999
    ..We demonstrate that soluble ACE-secretase from both sources failed to cleave its substrate in solution, suggesting a requirement for anchoring to the membrane...
  17. ncbi request reprint Roles of tumor necrosis factor receptor signaling during murine Escherichia coli pneumonia
    J P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 22:85-91. 2000
    ..During acute E. coli pneumonia, the absence of TNFR signaling compromised bacterial killing, but did not prevent inflammation, as measured by the accumulation of edema fluid and neutrophils...
  18. ncbi request reprint Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice
    L A Ortiz
    Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Section of Endocrinology, Tulane University Medical Center, New Orleans, Louisiana, USA
    Am J Respir Cell Mol Biol 20:825-33. 1999
    ..This study supports the concept that TNF is a central mediator of interstitial pulmonary fibrosis...
  19. ncbi request reprint Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice
    L A Ortiz
    Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112 2699, USA
    Exp Lung Res 24:721-43. 1998
    ..These results provide further support for a role of macrophages and TNF in the induction of lung inflammation...
  20. ncbi request reprint Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
    J D Buxbaum
    Departments of Psychiatry and Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 273:27765-7. 1998
    ..Furthermore, we show that inhibiting this enzyme affects both APP secretion and Abeta formation in cultured cells...
  21. ncbi request reprint TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection
    D M Page
    Department of Biology and the Cancer Center, University of California San Diego, La Jolla 92093 0687, USA
    J Immunol 160:120-33. 1998
    ..Current models of negative selection and the role of TNFR family members in this process are discussed in light of these results...
  22. ncbi request reprint Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice
    S Candeias
    SAIC, NCI FCRDC, Frederick, MD 21702 1201, USA
    Immunol Lett 57:9-14. 1997
    ..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus...
  23. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor...
  24. ncbi request reprint Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
    M Matsumoto
    Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 271:1289-91. 1996
    ..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow...
  25. ncbi request reprint Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, California, 90033, USA
    Dev Biol 232:204-18. 2001
    ....
  26. ncbi request reprint Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton
    M Shi
    Departments of. Biochemistry and Orthopedic Surgery, Section of Biochemistry and Molecular Biology, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
    J Immunol 167:123-31. 2001
    ..We conclude that the CD44 sheddase and TACE are distinct enzymes, and that Ab- and phorbol ester-enhanced cleavage of CD44 is controlled in a cell type-dependent fashion by Rho GTPases through the cytoskeleton...
  27. pmc Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction
    K M Kurrelmeyer
    Winters Center for Heart Failure Research, Cardiology Section, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:5456-61. 2000
    ..These data suggest that TNF signaling gives rise to one or more cytoprotective signals that prevent and/or delay the development of cardiac myocyte apoptosis after acute ischemic injury...
  28. pmc Spermatid-specific expression of protamine 1 in transgenic mice
    J J Peschon
    Proc Natl Acad Sci U S A 84:5316-9. 1987
    ..The cis-acting sequences required for tissue-specific protamine expression reside on a 2.4-kilobase restriction fragment. Prospects for using transgenic mice to address fundamental questions of male germ-cell development are discussed...
  29. ncbi request reprint An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state
    K Fujihashi
    Department of Oral Biology, University of Alabama at Birmingham, Medical Center 35294 2170, USA
    Eur J Immunol 27:2133-8. 1997
    ..The direct comparison of IL-7-/- and IL-7R-/- mice clearly supports the hypothesis that both IL-7 and another IL-7R binding molecule can influence the development of gamma delta T cells in the intestinal epithelium...
  30. pmc Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    J J Peschon
    Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 180:1955-60. 1994
    ..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7...
  31. ncbi request reprint Sequence homologies in the mouse protamine 1 and 2 genes
    P A Johnson
    Department of Biology, Tufts University, Medford, MA 02155
    Biochim Biophys Acta 950:45-53. 1988
    ..An additional shared sequence is present in the 3' untranslated region surrounding the poly(A) addition signal in both genes...
  32. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...