T S Griffith

Summary

Affiliation: Immunex Corporation
Country: USA

Publications

  1. ncbi Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
    T S Griffith
    Department of Immunobiology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 161:2833-40. 1998
  2. ncbi TRAIL: a molecule with multiple receptors and control mechanisms
    T S Griffith
    Department of Immunobiology, Immunex Corporation, 51 University Street, Seattle, WA 98101 2936, USA
    Curr Opin Immunol 10:559-63. 1998
  3. ncbi Functional analysis of TRAIL receptors using monoclonal antibodies
    T S Griffith
    Departments ofImmunobiology, Protein Chemistry, Biochemistry, Molecular Biology, and Hybridoma, Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 162:2597-605. 1999
  4. ncbi Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    H Walczak
    Immunex Corporation, Seattle, Washington 98101, USA
    Nat Med 5:157-63. 1999

Detail Information

Publications4

  1. ncbi Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
    T S Griffith
    Department of Immunobiology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 161:2833-40. 1998
    ..Collectively, our results indicate that TRAIL-induced apoptosis occurs through a caspase signaling cascade and that resistance is controlled by intracellular regulators of apoptosis...
  2. ncbi TRAIL: a molecule with multiple receptors and control mechanisms
    T S Griffith
    Department of Immunobiology, Immunex Corporation, 51 University Street, Seattle, WA 98101 2936, USA
    Curr Opin Immunol 10:559-63. 1998
    ..Currently, these molecules are of major interest due to their potential roles and application in cancer therapy...
  3. ncbi Functional analysis of TRAIL receptors using monoclonal antibodies
    T S Griffith
    Departments ofImmunobiology, Protein Chemistry, Biochemistry, Molecular Biology, and Hybridoma, Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 162:2597-605. 1999
    ..In contrast, the expression of TRAIL-R3 or TRAIL-R4 did not appear to be a significant factor in determining the resistance or sensitivity of these tumor target cells to the effects of TRAIL...
  4. ncbi Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    H Walczak
    Immunex Corporation, Seattle, Washington 98101, USA
    Nat Med 5:157-63. 1999
    ..17 (SCID) mice, and histologic examination of tumors from SCID mice treated with LZ-huTRAIL demonstrated clear areas of apoptotic necrosis within 9-12 hours of injection...