T S Griffith
Affiliation: Immunex Corporation
- Intracellular regulation of TRAIL-induced apoptosis in human melanoma cellsT S Griffith
Department of Immunobiology, Immunex Corp, Seattle, WA 98101, USA
J Immunol 161:2833-40. 1998..Collectively, our results indicate that TRAIL-induced apoptosis occurs through a caspase signaling cascade and that resistance is controlled by intracellular regulators of apoptosis...
- TRAIL: a molecule with multiple receptors and control mechanismsT S Griffith
Department of Immunobiology, Immunex Corporation, 51 University Street, Seattle, WA 98101 2936, USA
Curr Opin Immunol 10:559-63. 1998..Currently, these molecules are of major interest due to their potential roles and application in cancer therapy...
- Functional analysis of TRAIL receptors using monoclonal antibodiesT S Griffith
Departments ofImmunobiology, Protein Chemistry, Biochemistry, Molecular Biology, and Hybridoma, Immunex Corporation, Seattle, WA 98101, USA
J Immunol 162:2597-605. 1999..In contrast, the expression of TRAIL-R3 or TRAIL-R4 did not appear to be a significant factor in determining the resistance or sensitivity of these tumor target cells to the effects of TRAIL...
- Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivoH Walczak
Immunex Corporation, Seattle, Washington 98101, USA
Nat Med 5:157-63. 1999..17 (SCID) mice, and histologic examination of tumors from SCID mice treated with LZ-huTRAIL demonstrated clear areas of apoptotic necrosis within 9-12 hours of injection...