Research Topics
Genomes and Genes
| D CosmanSummaryAffiliation: Immunex Corporation Country: USA Publications
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Detail Information
Publications
ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptorD Cosman
Department of Molecular Biology, Immunex Corporation, 51 University Street, Seattle, WA 98101
Immunity 14:123-33. 2001..Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system...- The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamilyL Galibert
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 273:34120-7. 1998.... - The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytesN A Fanger
Immunex Corporation, Seattle, Washington 98101, USA
Eur J Immunol 28:3423-34. 1998..These findings suggest that LIR-1 and LIR-2 function as unique MHC class I receptors involved in the inhibition or down-modulation of monocyte activation signals, particularly those mediated through the receptors for IgG, IgE and IgA... - The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functionsC L Sutherland
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
Immunol Rev 181:185-92. 2001..The possible roles of ULBPs in mediating immune responses to viruses and tumors and the potential mechanisms by which UL16 may allow HCMV to evade immune detection are areas of active investigation... - A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I moleculesL Borges
Immunex Corp, Seattle, WA 98101, USA
J Immunol 159:5192-6. 1997..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation... - Human cytomegalovirus, MHC class I and inhibitory signalling receptors: more questions than answersD Cosman
Immunex Corporation, Seattle, Washington 98110, USA
Immunol Rev 168:177-85. 1999..Evidence for and against a role of UL18 as an inhibitor of NK-cell function is discussed, as are possible functional outcomes of UL18-LIR-1 interactions in monocytic cells... 
RANK is essential for osteoclast and lymph node developmentW C Dougall
Immunex Corporation, Seattle, Washington 98101 USA
Genes Dev 13:2412-24. 1999..These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation...- A novel immunoglobulin superfamily receptor for cellular and viral MHC class I moleculesD Cosman
Immunex Corporation, Seattle, Washington 98101, USA
Immunity 7:273-82. 1997..Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function... - The R27080 glycoprotein is abundantly secreted from human cytomegalovirus-infected fibroblastsJ Mullberg
Immunex Corporation, Seattle, WA 98101, USA
J Gen Virol 80:437-40. 1999..Proteolytic cleavage of R27080 by a furin-like enzyme was analysed in transfected COS-7 cells. R27080 is the first identified viral protein secreted from HCMV-infected cells... - Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptorJ G Giri
Immunex Research and Development Corporation, Seattle, WA 98101, USA
EMBO J 14:3654-63. 1995..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2... - The leukocyte immunoglobulin-like receptors (LIRs): a new family of immune regulatorsN A Fanger
Immunex Corporation, Seattle, Washington 98101, USA
J Leukoc Biol 66:231-6. 1999..This review summarizes the expression, distribution, and signaling capacities of the LIRs and discusses possible roles of the LIRs in both inhibition and activation of the cellular responses... - Further evidence for a common mechanism for shedding of cell surface proteinsJ Mullberg
Immunex Corporation, Seattle, WA 98101, USA
FEBS Lett 401:235-8. 1997.... - LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cellsL Borges
Immunex Corporation, 51 University Street, Seattle WA 98101, USA
Cytokine Growth Factor Rev 11:209-17. 2000..This review summarizes our current knowledge on the LIRs, their ligands, and biological functions... - IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2J G Giri
Immunex Research and Development Corporation, Seattle, WA 98101, USA
J Leukoc Biol 57:763-6. 1995..Differences in the expression pattern of IL-15 and its receptor compared to the IL-2 system suggest unique in vivo roles for IL-15... - IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expressionL M Sedger
Department of Molecular Immunology, Immunex Corporation, Seattle, WA 98101, USA
J Immunol 163:920-6. 1999..The regulation of TRAIL and TRAIL-R expression may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis... - A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionD M Anderson
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
Nature 390:175-9. 1997..Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells... - ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cellsM Kubin
Department of Immunobiology, Immunex Corporation, Seattle 98101, USA
Eur J Immunol 31:1428-37. 2001..Addition of soluble recombinant UL16 protein inhibited the biological activities mediated by ULBP, suggesting the existence of a novel mechanism utilized by CMV to evade elimination by the host immune system... - Interleukin 15D Cosman
Immunex Corporation, Seattle, WA 98101, USA
Biochem Soc Trans 25:371-4. 1997 - Interleukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cellsS Kumaki
Department of Molecular Biology, Immunex Research and Development Corporation, WA 98101, USA
Eur J Immunol 26:1235-9. 1996..These results suggest a mechanism by which IL-15, a product of activated macrophages, may cooperate with IL-2 at the initiation of an immune response and enhance subsequent IL-2 responsiveness during T cell expansion... - Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15J G Giri
Immunex Research and Development Corporation, Seattle, WA 98101
EMBO J 13:2822-30. 1994..The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component... - Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble formsD M Anderson
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
Cell 63:235-43. 1990..The soluble protein promotes the proliferation of MGF-responsive cell lines and, in the presence of erythropoietin, stimulates the formation of macroscopic [corrected] erythroid and multilineage hematopoietic colonies... - The hematopoietin receptor superfamilyD Cosman
Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, WA 98101
Cytokine 5:95-106. 1993.... - Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130D P Gearing
Immunex Corporation, Seattle, WA 98101
EMBO J 10:2839-48. 1991..Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence... - Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complexL S Park
Immunex Research and Development Corporation, Seattle, WA 98101
Proc Natl Acad Sci U S A 89:4295-9. 1992..These studies show that clone 71 and AIC2B are capable of forming an alpha beta complex capable of binding murine GM-CSF with high affinity, while AIC2A appears not to be a component of the murine GM-CSF receptor... - Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24D M Anderson
Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, Washington 98101
Cell Growth Differ 2:373-8. 1991..Chromosomal in situ hybridization localized the gene to 12q22-q24 in the region predicted by the comparative mapping of the murine Mgf/Sl locus... - A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell typesC J McMahan
Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, WA 98101
EMBO J 10:2821-32. 1991..Like the type I receptor, the human type II IL-1 receptor can bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1ra). Vaccinia virus contains an open reading frame bearing strong resemblance to the type II IL-1 receptor... - A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteinsC A Smith
Immunex Corporation, Seattle, WA 98101
Science 248:1019-23. 1990.... - Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single geneD P Cerretti
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
Mol Immunol 25:761-70. 1988..However, when the membrane spanning region was present in the three M-CSF cDNAs, cell surface associated forms of M-CSF could be readily detected... - Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cellsR G Goodwin
Immunex Corporation, Seattle, WA 98101
Proc Natl Acad Sci U S A 86:302-6. 1989..Analysis of RNA by blot hybridization demonstrated the presence of two size classes of interleukin 7 mRNA in human splenic and thymic tissue... - Retention of ligand binding activity by the extracellular domain of the IL-1 receptorS K Dower
Immunex Corporation, Seattle, WA 98101
J Immunol 142:4314-20. 1989..Gel filtration chromatography experiments show that a complex can be formed between a single truncated receptor molecule and a single IL-1 alpha molecule... - Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsivenessL S Park
Department of Biochemistry, Immunex Corporation, Seattle, WA 98101
Blood 74:56-65. 1989..These results provide new insights into the complex role that CSFs may play in ANL... - Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamilyR G Goodwin
Immunex Corporation, Seattle, Washington 98101
Cell 60:941-51. 1990..Analysis of the sequence of the IL-7 receptor revealed significant homology in the extracellular domain to several recently cloned cytokine receptors, demonstrating that the IL-7 receptor is a member of a new receptor superfamily... - Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3D L Urdal
Immunex Corporation, Seattle, Washington 98101
Ann N Y Acad Sci 554:167-76. 1989 - cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamilyJ E Sims
Immunex Corporation, Seattle, WA 98101
Science 241:585-9. 1988..The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long... - Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activationB Mosley
Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 271:32635-43. 1996.... - Bovine GM-CSF: molecular cloning and biological activity of the recombinant proteinC R Maliszewski
Immunex Corporation, Seattle, WA 98101
Mol Immunol 25:843-50. 1988..In contrast, human GM-CSF was weakly active on bovine but not murine mouse bone marrow cells and mouse GM-CSF was only active on murine bone marrow cells... - Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAsC R Maliszewski
Immunex Corporation, Seattle, WA 98101
Mol Immunol 25:429-37. 1988..Both IL-1 alpha and IL-1 beta exist as single genomic copies. In addition, bovine IL-1 beta mRNA is approx. 10-fold more abundant than IL-1 alpha mRNA in stimulated alveolar macrophages... - Allelic and interlocus comparison of the PERB11 multigene family in the MHCS Gaudieri
Centre for Molecular Immunology and Instrumentation, The University of Western Australia GPO BOX F298, Perth, Western Australia 6001
Immunogenetics 45:209-16. 1997..The most divergent domain is the transmembrane region when PERB11.1 and PERB11.2 are compared. The results suggest that these two molecules may have different functions... - Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel allelesN G Copeland
Mammalian Genetics Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
Cell 63:175-83. 1990..Furthermore, we show that Mgf maps near Sl in the distal region of mouse chromosome 10 and is deleted in a number of Sl alleles. These findings strongly support the notion that Sl encodes the mast cell growth factor... - Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growthI Vigon
INSERM U363, ICGM, Hopital Cochin, Paris, France
Oncogene 8:2607-15. 1993..This demonstrated that the cytoplasmic Mpl domain is most probably implicated in proliferative signal transduction... - cMpl ligand is a humoral regulator of megakaryocytopoiesisF Wendling
INSERM U362, Institut Gustave Roussy, Villejuif, France
Nature 369:571-4. 1994..Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule... - Cloning, sequence, and expression of bovine interleukin 2D P Cerretti
Proc Natl Acad Sci U S A 83:3223-7. 1986..Bovine IL-2 is unique among IL-2 homologs in that it has a single N-linked glycosylation site. Biologically active bovine IL-2 was synthesized in an Escherichia coli expression system... - The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7M A Pritchard
Department of Cytogenetics and Molecular Genetics, Adelaide Children s Hospital, Australia
Genomics 10:801-6. 1991..Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas... - Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptorD P Gearing
Cell 66:9-10. 1991 - High level stable expression of human interleukin-2 receptors in mouse cells generates only low affinity interleukin-2 binding sitesD Cosman
Mol Immunol 23:935-41. 1986..However, all of these receptors bound IL-2 with low affinity... - Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiencyS Kumaki
Department of Pediatric Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Blood 93:607-12. 1999..The result shows that IL-4- and/or IL-7-induced signaling through the gammac chain is critical for T-cell development and plays an important role in the development of the X-SCID phenotype... - Cloning, sequence, and expression of bovine interferon-gammaD P Cerretti
J Immunol 136:4561-4. 1986..w. of 16,858. It has an amino acid homology of 63% with human IFN-gamma, and 47% with murine IFN-gamma. Biologically active bovine IFN-gamma was synthesized in an Escherichia coli expression system... - Cloning, sequence and expression of human interleukin-2 receptorD Cosman
Nature 312:768-71. 1984..The insert was flanked by an 8-bp direct repeat reminiscent of a transposable element, and appeared to code for a region of marked structural homology to the NH2-terminal region of the receptor molecule...