R A Black

Summary

Affiliation: Immunex Corporation
Country: USA

Publications

  1. ncbi A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    R A Black
    Immunex Corporation, Seattle, Washington 98101, USA
    Nature 385:729-33. 1997
  2. ncbi The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries
    K Poindexter
    Immunex Corporation, Seattle, WA 98101, USA
    Gene 237:61-70. 1999
  3. ncbi Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
    P Reddy
    Department of Cell Sciences, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 275:14608-14. 2000
  4. ncbi Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression
    D P Cerretti
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Biochem Biophys Res Commun 263:810-5. 1999
  5. ncbi An essential role for ectodomain shedding in mammalian development
    J J Peschon
    Immunex Corporation, Seattle, WA 98101, USA
    Science 282:1281-4. 1998
  6. ncbi Expression and purification of correctly processed, active human TACE catalytic domain in Saccharomyces cerevisiae
    H R Clarke
    Immunex Corporation, Seattle, Washington 98101, USA
    Protein Expr Purif 13:104-10. 1998
  7. ncbi Further evidence for a common mechanism for shedding of cell surface proteins
    J Mullberg
    Immunex Corporation, Seattle, WA 98101, USA
    FEBS Lett 401:235-8. 1997
  8. ncbi Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25
    D P Cerretti
    Immunex Corporation, 51 University St, Seattle, WA, 98101, USA
    Cytokine 11:541-51. 1999
  9. ncbi Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme
    J R Doedens
    Department of Research Administration, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 275:14598-607. 2000
  10. ncbi Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor
    S R Kronheim
    Protein Chemistry Department, Immunex Corporation, Seattle, Washington 98101
    Arch Biochem Biophys 296:698-703. 1992

Collaborators

Detail Information

Publications23

  1. ncbi A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    R A Black
    Immunex Corporation, Seattle, Washington 98101, USA
    Nature 385:729-33. 1997
    ..Our results should facilitate the development of therapeutically useful inhibitors of TNF-alpha release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins...
  2. ncbi The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries
    K Poindexter
    Immunex Corporation, Seattle, WA 98101, USA
    Gene 237:61-70. 1999
    ..1, 8p23, and 14q24.1, respectively. An ancestral analysis of all known ADAMs indicates that the zinc-binding motif in the catalytic domain arose once in a common ancestor and was lost by those members lacking this motif...
  3. ncbi Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
    P Reddy
    Department of Cell Sciences, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 275:14608-14. 2000
    ..IL-1R-II shedding required the cysteine-rich domain of TACE as well as the catalytic domain, whereas TNF and p75 TNFR shedding required only the tethered TACE catalytic domain...
  4. ncbi Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression
    D P Cerretti
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Biochem Biophys Res Commun 263:810-5. 1999
    ..An ancestral analysis of all known mammalian ADAMs indicates that the zinc-binding motif in the catalytic domain arose once in a common ancestor and was subsequently lost by those members lacking this motif...
  5. ncbi An essential role for ectodomain shedding in mammalian development
    J J Peschon
    Immunex Corporation, Seattle, WA 98101, USA
    Science 282:1281-4. 1998
    ..The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo...
  6. ncbi Expression and purification of correctly processed, active human TACE catalytic domain in Saccharomyces cerevisiae
    H R Clarke
    Immunex Corporation, Seattle, Washington 98101, USA
    Protein Expr Purif 13:104-10. 1998
    ..Mass spectrometry of the purified catalytic domain showed that removal of both N-linked sites results in a homogeneous sized polypeptide lacking further posttranslational modifications...
  7. ncbi Further evidence for a common mechanism for shedding of cell surface proteins
    J Mullberg
    Immunex Corporation, Seattle, WA 98101, USA
    FEBS Lett 401:235-8. 1997
    ....
  8. ncbi Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25
    D P Cerretti
    Immunex Corporation, 51 University St, Seattle, WA, 98101, USA
    Cytokine 11:541-51. 1999
    ..The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25...
  9. ncbi Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme
    J R Doedens
    Department of Research Administration, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 275:14598-607. 2000
    ..Thus, PMA activates shedding and causes the down-regulation of a major "sheddase," suggesting that induced shedding may be regulated by a mechanism that decreases the amount of active TACE on the cell surface...
  10. ncbi Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor
    S R Kronheim
    Protein Chemistry Department, Immunex Corporation, Seattle, Washington 98101
    Arch Biochem Biophys 296:698-703. 1992
    ..An antiserum raised against a peptide based on the N-terminus was used to precipitate the protease, confirming our identification of the 22,000-Da protein as the IL-1 beta converting enzyme...
  11. ncbi Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice
    R Sadhukhan
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 274:10511-6. 1999
    ..We demonstrate that soluble ACE-secretase from both sources failed to cleave its substrate in solution, suggesting a requirement for anchoring to the membrane...
  12. ncbi A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
    C Brou
    Unité de Biologie Moléculaire de l Expression Génique, URA 1773 CNRS, Institut Pasteur, Paris, France
    Mol Cell 5:207-16. 2000
    ..Furthermore, experiments carried out on TACE-/- bone marrow-derived monocytic precursor cells suggest that this metalloprotease plays a prominent role in the activation of the Notch pathway...
  13. pmc Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase
    H Mizutani
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 174:821-5. 1991
    ..Mast cells lie in close apposition to blood vessels in dermis; therefore, chymase mediated conversion of 31 kD IL-1 beta might be expected to have a critical role in the initiation of the inflammatory response in skin...
  14. pmc Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme
    K Maskos
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 95:3408-12. 1998
    ....
  15. ncbi Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates
    J I Levin
    Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2799-803. 2003
    ....
  16. ncbi Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group
    J I Levin
    Wyeth Ayerst Research, 401N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 12:1199-202. 2002
    ..In particular, compound 4t bearing a butynyloxy P1' moiety has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1 and oral activity in an in vivo model of TNF-alpha production...
  17. ncbi Skeletal muscle cell hypertrophy induced by inhibitors of metalloproteases; myostatin as a potential mediator
    C Huet
    The Burnham Institute, La Jolla, California 92037, USA
    Am J Physiol Cell Physiol 281:C1624-34. 2001
    ....
  18. ncbi Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis
    Y Zhang
    Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 276:24565-73. 2001
    ..The implications of these findings with regard to GH signaling and GHR down-regulation are discussed...
  19. ncbi Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation
    Y Zhang
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Endocrinology 141:4342-8. 2000
    ..We conclude that TACE is an enzyme required for PMA-induced GHBP shedding and that PMA-induced down-regulation of GHR abundance may in significant measure be attributable to TACE-mediated GHR proteolysis...
  20. ncbi Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
    J D Buxbaum
    Departments of Psychiatry and Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 273:27765-7. 1998
    ..Furthermore, we show that inhibiting this enzyme affects both APP secretion and Abeta formation in cultured cells...
  21. ncbi Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
    C A Ray
    Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710
    Cell 69:597-604. 1992
    ..These viral countermeasures to host defenses against infection may contribute significantly to the pathology associated with poxvirus infections...
  22. ncbi Molecular cloning of the murine IL-1 beta converting enzyme cDNA
    M A Nett
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110
    J Immunol 149:3254-9. 1992
    ..These studies establish that the IL-1 beta convertase is an evolutionarily conserved, widely expressed enzyme that can be regulated at a pretranslational level...
  23. doi Complex patterns of genetic and phenotypic divergence in an island bird and the consequences for delimiting conservation units
    A B Phillimore
    Division of Biology, Imperial College London, Silwood Park, Ascot, Berkshire, SL5 7PY, UK
    Mol Ecol 17:2839-53. 2008
    ..A continuum of divergence and a degree of discordance between different characters are both to be expected under simple models of evolution, but they present problems in terms of delimiting conservation units...