Syed Z Imam

Summary

Country: USA

Publications

  1. ncbi request reprint The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicity
    Syed Z Imam
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 993:350; discussion 387-93. 2003
  2. ncbi request reprint Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study
    Bobby Gough
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 965:410-20. 2002
  3. ncbi request reprint Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice
    Syed Z Imam
    South Texas Veteran Health Care System and Department of Medicine of UT Health Science, San Antonio, Texas, USA
    FASEB J 19:1441-50. 2005
  4. ncbi request reprint Cocaine induces a differential dose-dependent alteration in the expression profile of immediate early genes, transcription factors, and caspases in PC12 cells: a possible mechanism of neurotoxic damage in cocaine addiction
    Syed Z Imam
    South Texas Veterans Health Care System and Department of Medicine, University of Texas, Health Science Center, San Antonio, Texas 78229, USA
    Ann N Y Acad Sci 1053:482-90. 2005
  5. pmc Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
    Syed Z Imam
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 31:157-63. 2011
  6. pmc Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model
    Syed Z Imam
    Division of Neurotoxicology, US FDA National Center for Toxicological Research, Jefferson, Arkansas, United States of America
    PLoS ONE 8:e65129. 2013
  7. pmc Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease
    Kc Biju
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Ther 18:1536-44. 2010
  8. ncbi request reprint Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 281:15099-109. 2006
  9. ncbi request reprint Molecular mechanisms of dopaminergic neurodegeneration: genetic and environmental basis
    Syed Z Imam
    Division of Neurotoxicology, US FDA NCTR, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 993:377; discussion 387-93. 2003
  10. ncbi request reprint Role of peroxynitrite in methamphetamine-induced dopaminergic neurodegeneration and neuroprotection by antioxidants and selective NOS inhibitors
    Syed F Ali
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 1053:97-8. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicity
    Syed Z Imam
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 993:350; discussion 387-93. 2003
  2. ncbi request reprint Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study
    Bobby Gough
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 965:410-20. 2002
    ..5 or 5 mg/kg. All dose levels of PMA significantly decreased 5-HIAA (50 to 70%). These data suggest that PMA, like MDMA and METH, is capable of producing dopaminergic and serotonergic neurotoxicity...
  3. ncbi request reprint Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice
    Syed Z Imam
    South Texas Veteran Health Care System and Department of Medicine of UT Health Science, San Antonio, Texas, USA
    FASEB J 19:1441-50. 2005
    ....
  4. ncbi request reprint Cocaine induces a differential dose-dependent alteration in the expression profile of immediate early genes, transcription factors, and caspases in PC12 cells: a possible mechanism of neurotoxic damage in cocaine addiction
    Syed Z Imam
    South Texas Veterans Health Care System and Department of Medicine, University of Texas, Health Science Center, San Antonio, Texas 78229, USA
    Ann N Y Acad Sci 1053:482-90. 2005
    ....
  5. pmc Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
    Syed Z Imam
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 31:157-63. 2011
    ..Moreover, inhibition of c-Abl offers new therapeutic opportunities for blocking PD progression...
  6. pmc Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model
    Syed Z Imam
    Division of Neurotoxicology, US FDA National Center for Toxicological Research, Jefferson, Arkansas, United States of America
    PLoS ONE 8:e65129. 2013
    ..We propose that compounds of the INNO-406 class of Abl inhibitors will be useful new neuroprotective drugs for the treatment of PD-like pathology in preclinical systems that should be easily translated to the clinic...
  7. pmc Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease
    Kc Biju
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Ther 18:1536-44. 2010
    ..These results indicate that macrophage-mediated GDNF delivery is a promising strategy for developing a neuroprotective therapy for PD...
  8. ncbi request reprint Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 281:15099-109. 2006
    ..Atorvastatin inhibits IL-18-mediated aortic SMC migration and has therapeutic potential for attenuating the progression of atherosclerosis and restenosis...
  9. ncbi request reprint Molecular mechanisms of dopaminergic neurodegeneration: genetic and environmental basis
    Syed Z Imam
    Division of Neurotoxicology, US FDA NCTR, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 993:377; discussion 387-93. 2003
  10. ncbi request reprint Role of peroxynitrite in methamphetamine-induced dopaminergic neurodegeneration and neuroprotection by antioxidants and selective NOS inhibitors
    Syed F Ali
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 1053:97-8. 2005
  11. ncbi request reprint Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells
    Syed Z Imam
    Division of Neurotoxicology, US FDA NCTR, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 993:362; discussion 387-93. 2003
  12. ncbi request reprint Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner
    Syed Z Imam
    Laboratory of Molecular Gerontology, National Institute on Aging, Gerontology Research Center, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 27:1129-36. 2006
    ..Manipulation of DNA repair mechanisms may provide a strategy to prevent neuronal loss during age-dependent neurodegenerative disorders...
  13. ncbi request reprint Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta
    Meltem Muftuoglu
    Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland, USA
    Cancer Res 66:113-24. 2006
    ..Potential roles of TRF2 in cooperation with BER proteins for DNA repair pathways at telomeres, as well as other genomic regions, are discussed...
  14. ncbi request reprint Lack of hydroxyl radical generation upon central administration of methamphetamine in rat caudate nucleus: a microdialysis study
    Frederico C Pereira
    Neurochemistry Laboratory, Division of Neurotoxicology, HFT 132, NCTR FDA, Jefferson, AR 72079, USA
    Neurotox Res 6:149-52. 2004
    ..p.). No significant correlation was found between changes in extracellular DA levels and *OH generation when perfusing METH locally; however, both increased after systemic METH administration...
  15. doi request reprint alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease
    Kohichi Kawahara
    Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92039 0624, USA
    J Biol Chem 283:6979-87. 2008
    ..These studies provide a new perspective on the potential nature of pathogenic alpha-synuclein and parkin interactions in Parkinson disease...
  16. ncbi request reprint Role of nitric oxide in rotenone-induced nigro-striatal injury
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 86:1338-45. 2003
    ..Our data suggest that chronic rotenone administration can lead to significant injury to the nigro-striatal system, mediated by increased generation of nitric oxide...
  17. ncbi request reprint Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cells
    Syed Z Imam
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Resarch US FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 965:204-13. 2002
    ..The current study supports the hypothesis that METH acts at the dopaminergic nerve terminals and produces dopaminergic damage by the production of free radical peroxynitrite...