Jon A Friesen

Summary

Affiliation: Illinois State University
Country: USA

Publications

  1. pmc Comparative kinetic analysis of glycerol 3-phosphate cytidylyltransferase from Enterococcus faecalis and Listeria monocytogenes
    Ashley N Mericl
    Department of Chemistry, Illinois State University, Normal, IL 61790 4160, USA
    Med Sci Monit 18:BR427-34. 2012
  2. pmc The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
    Jon A Friesen
    Department of Chemistry, Illinois State University, Normal, IL 61790 4160, USA
    Genome Biol 5:248. 2004
  3. pmc Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase
    Jason R Stephenson
    Department of Chemistry, Illinois State University, Normal, Illinois 61790 4160, USA
    Protein Sci 16:401-10. 2007
  4. pmc Methyl farnesoate synthesis in the lobster mandibular organ: the roles of HMG-CoA reductase and farnesoic acid O-methyltransferase
    Sheng Li
    Department of Biological Science, Illinois State University, Normal, IL 61790, USA
    Comp Biochem Physiol A Mol Integr Physiol 155:49-55. 2010
  5. ncbi request reprint Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster
    Beth Ann Helmink
    Department of Chemistry, Illinois State University, Normal, IL 61790, USA
    Biochim Biophys Acta 1683:78-88. 2004
  6. pmc The lobster mandibular organ produces soluble and membrane-bound forms of 3-hydroxy-3-methylglutaryl-CoA reductase
    Sheng Li
    Department of Biological Science, Illinois State University, Normal, IL 61790, USA
    Biochem J 381:831-40. 2004
  7. ncbi request reprint Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity
    Amy E Theivagt
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 45:14397-406. 2006
  8. doi request reprint Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase
    Dana M Tilley
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 47:11838-46. 2008
  9. ncbi request reprint Investigation of the catalytic and structural roles of conserved histidines of human coproporphyrinogen oxidase using site-directed mutagenesis
    Shani J Gitter
    Department of Chemistry, Illinois State University, Normal, IL, USA
    Med Sci Monit 13:BR1-10. 2007
  10. pmc Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase
    Jay D Braker
    Department of Chemistry, Illinois State University, Normal, IL 61790, USA
    Arch Biochem Biophys 492:10-6. 2009

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Comparative kinetic analysis of glycerol 3-phosphate cytidylyltransferase from Enterococcus faecalis and Listeria monocytogenes
    Ashley N Mericl
    Department of Chemistry, Illinois State University, Normal, IL 61790 4160, USA
    Med Sci Monit 18:BR427-34. 2012
    ..Catalysis by GCT from Enterococcus faecalis and Listeria monocytogenes has been investigated and catalytic properties compared...
  2. pmc The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
    Jon A Friesen
    Department of Chemistry, Illinois State University, Normal, IL 61790 4160, USA
    Genome Biol 5:248. 2004
    ..Probably because of its critical role in cellular cholesterol homeostasis, mammalian HMG-CoA reductase is extensively regulated at the transcriptional, translational, and post-translational levels...
  3. pmc Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase
    Jason R Stephenson
    Department of Chemistry, Illinois State University, Normal, Illinois 61790 4160, USA
    Protein Sci 16:401-10. 2007
    ..Possible roles for arginine 262 and 401 include coordination of carboxylate groups of coproporphyrinogen-III, while aspartate 400 may initiate deprotonation of substrate, resulting in an oxidative decarboxylation...
  4. pmc Methyl farnesoate synthesis in the lobster mandibular organ: the roles of HMG-CoA reductase and farnesoic acid O-methyltransferase
    Sheng Li
    Department of Biological Science, Illinois State University, Normal, IL 61790, USA
    Comp Biochem Physiol A Mol Integr Physiol 155:49-55. 2010
    ..Nevertheless, molecular modeling indicated that the catalytic mechanisms of lobster and mammalian HMGR were similar...
  5. ncbi request reprint Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster
    Beth Ann Helmink
    Department of Chemistry, Illinois State University, Normal, IL 61790, USA
    Biochim Biophys Acta 1683:78-88. 2004
    ....
  6. pmc The lobster mandibular organ produces soluble and membrane-bound forms of 3-hydroxy-3-methylglutaryl-CoA reductase
    Sheng Li
    Department of Biological Science, Illinois State University, Normal, IL 61790, USA
    Biochem J 381:831-40. 2004
    ..Other lobster tissues (i.e. midgut, brain and muscles) had low HMGR activities and mRNA levels. MO with higher HMGR activities had higher HMGR mRNA levels, implying that HMGR is regulated, in part, at the transcription level...
  7. ncbi request reprint Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity
    Amy E Theivagt
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 45:14397-406. 2006
    ....
  8. doi request reprint Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase
    Dana M Tilley
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 47:11838-46. 2008
    ..The cellular location of both CCT1 and CCT2 isoforms was elucidated by expressing green fluorescent fusion proteins in cultured D. melanogaster Schneider 2 cells. CCT1 was identified as the nuclear isoform, while CCT2 is cytoplasmic...
  9. ncbi request reprint Investigation of the catalytic and structural roles of conserved histidines of human coproporphyrinogen oxidase using site-directed mutagenesis
    Shani J Gitter
    Department of Chemistry, Illinois State University, Normal, IL, USA
    Med Sci Monit 13:BR1-10. 2007
    ..The catalytic contribution of four conserved histidines of human coproporphyrinogen oxidase (CPO) has been investigated using site-directed mutagenesis to change histidine (H) into alanine (A)...
  10. pmc Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase
    Jay D Braker
    Department of Chemistry, Illinois State University, Normal, IL 61790, USA
    Arch Biochem Biophys 492:10-6. 2009
    ..These results support a concerted mechanism of lipid activation that requires multiple residues on the hydrophobic face of the putative amphipathic alpha helix...
  11. ncbi request reprint 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk
    Sheng Li
    Department of Biological Science, Illinois State University, Normal, IL 61790, USA
    Gen Comp Endocrinol 134:147-55. 2003
    ..The regulation of crustacean HMGR by the SG suggests that the lobster MO is a useful model system for investigating the cellular regulation of HMGR activity...
  12. ncbi request reprint Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha
    Beth Ann Helmink
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 42:5043-51. 2003
    ....

Research Grants1

  1. Activation of CTP:phosphocholine cytidyltransferase
    JON FRIESEN; Fiscal Year: 2002
    ....