Research Topics
| Rajendra MehtaSummaryAffiliation: IIT Research Institute Country: USA Publications
Research Grants
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Publications
PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significanceRajendra G Mehta
IIT Research Institute, Chicago, IL 60616, USA
Mol Cell Biochem 372:249-56. 2013..The induction of ERα by GW9662, including newer analogs, may permit use of anti-ER strategies to inhibit breast cancer in ER- patients...
Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: a comprehensive reviewRajendra G Mehta
IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
Curr Med Chem 15:2785-825. 2008..The structure-activity relationships for many chemopreventive agents evaluated in the MMOC model have been discussed...- Cancer chemoprevention by natural products: how far have we come?Rajendra G Mehta
Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, Illinois 60616, USA
Pharm Res 27:950-61. 2010..Novel technologies, such as nanotechnology, along with a better understanding of cancer stem cells, are certain to continue the advancement of the field of cancer chemoprevention in years to come... - Discovery of cancer preventive agents from natural products: from plants to preventionRajendra G Mehta
Department of Medicinal Chemistry and Pharmacognosy (MC 877, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Curr Oncol Rep 4:478-86. 2002..Alternatively, some natural products may be administered as dietary supplements (eg, resveratrol). In either case, chemoprevention offers great hope in reducing the morbidity and mortality associated with cancer... - Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trialsRajesh Naithani
Drug Discovery Division, IIT Research Institute, 10 W 35th Street Chicago, IL 60616, USA
Curr Med Chem 15:1044-71. 2008..The experimental carcinogenesis studies in different biological models, in addition to the contribution from our laboratory are summarized... - Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cellsXinjian Peng
IIT Research Institute, Chicago, Illinois 60616, USA
J Cell Biochem 110:1324-33. 2010..These data suggest that there is a significant protective role for 25(OH)D(3) against cellular stress in the breast epithelial cells and these effects may be mediated by altered miRNA expression... 
25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ cultureXinjian Peng
IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
Breast Cancer Res Treat 113:31-41. 2009..We conclude that 25(OH)D(3) could serve as a non-toxic natural chemopreventive agent for further development for breast cancer prevention...- Regulation of steroid receptor expression by 1alpha-hydroxyvitamin D5 in hormone-responsive breast cancer cellsErum A Hussain-Hakimjee
Department of Surgical Oncology, University of Illinois at Chicago, Chicago, IL, USA
Anticancer Res 29:3555-61. 2009..The present study assessed 1alpha(OH)D5-mediated regulation of VDR, and its potential anti-estrogenic activity in BT-474 cells... - Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathwayGenoveva Murillo
Division of Carcinogenesis and Chemoprevention, IIT Research Institute, Chicago, Illinois 60616, USA
Cancer Prev Res (Phila) 2:942-50. 2009..These studies support the antiproliferative effects of deguelin in human breast cancer cells and, perhaps more importantly, illustrate novel actions by deguelin in the Wnt signaling pathway... - Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analysesLorna Whyte
Carcinogenesis and Chemoprevention Division, IIT Research Institute, Chicago, Illinois 60616, USA
Cancer Res 67:12007-17. 2007..Resveratrol is a potent inhibitor of A549 lung cancer cell growth, and our results suggest that resveratrol may be a promising chemopreventive or chemotherapeutic agent for lung cancer... - Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1alpha-hydroxyvitamin D5Erum A Hussain-Hakimjee
Department of Surgical Oncology and Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
Carcinogenesis 27:551-9. 2006..These results indicate that the growth inhibitory effect of 1alpha(OH)D5 was achieved in both carcinogen-transformed MCF-12F and breast cancer cells at a dose that was non-inhibitory in normal-like breast epithelial cells... - Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systemsStefan Gafner
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Phytochemistry 65:2849-59. 2004..Most potent effects were at concentrations between 1 and 5 microM for 10, 13 and 21, and at 10 microM for curcumin. These data demonstrate the substitution pattern on the aromatic moiety is especially crucial for activity... - Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicariaDae Sik Jang
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Nat Prod 66:1166-70. 2003..Selected compounds were tested in a mouse mammary organ culture assay to evaluate the inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesions... - Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitroRobert T Chatterton
Department of Obstetrics Gynecology, Northwestern University Medical School, 333 East Superior Street, Chicago, IL 60611, USA
Cancer Lett 188:47-52. 2002..We conclude that in the absence of PR, epithelial structures are resistant to the carcinogenic action of DMBA... - Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2Dae Sik Jang
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
Phytochemistry 61:867-72. 2002..All isolates were tested for their inhibitory effects against both cyclooxygenases-1 and -2, and selected compounds were evaluated in a mouse mammary organ culture assay... - Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 miceGenoveva Murillo
Department of Surgical Oncology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Int J Cancer 104:7-11. 2003..Greatest inhibition was observed when deguelin was administered during the promotional stage (73.3%, p < 0.001). These results demonstrate that deguelin is an efficacious chemopreventive agent against colon carcinogenesis... - Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancerGenoveva Murillo
Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
J Steroid Biochem Mol Biol 103:763-7. 2007..The increased expression of 1alpha(OH)ase in colon cancer cells treated with the pro-hormone and its anti-proliferative effects, suggest that 25(OH)D(3) may offer possible therapeutic and chemopreventive option in colon cancer... - Bioactive constituents of the seeds of Brucea javanicaBao Ning Su
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Planta Med 68:730-3. 2002.... - Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5Genoveva Murillo
Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
J Steroid Biochem Mol Biol 97:129-36. 2005..Cumulatively, these studies support the chemopreventive properties of 1alpha(OH)D(5) against the development of breast and colon cancers... - Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activityJian-Qiao Gu
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Nat Prod 65:532-6. 2002..0% at 10 microg/mL) lesion formation in the mouse mammary organ culture assay. The chemical structures of 1-3 were elucidated by spectroscopic analysis. The absolute configurations of 1 and 2 were determined by Mosher ester methodology... - Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesisGenoveva Murillo
Carcinogenesis and Chemoprevention Division, IIT Research Institute, Chicago, IL 60616, USA
Nutr Cancer 57:28-37. 2007..The present study is the first to report the potent anticancer activity of zapotin and suggests a role for zapotin both as a chemopreventive and a chemotherapeutic agent against colon cancer... - Stage-specific inhibition of mammary carcinogenesis by 1alpha-hydroxyvitamin D5Rajendra G Mehta
Department of Surgical Oncology, College of Medicine, University of Illinois, 840 S Wood Street M C 820, Chicago, IL 60612, USA
Eur J Cancer 40:2331-7. 2004..These results clearly show, for the first time, that the effects of vitamin D may be mediated selectively during the promotion or progression phases of carcinogenesis... - Differential expression of prohibitin is correlated with dual action of Vitamin D as a proliferative and antiproliferative hormone in breast epithelial cellsXinjian Peng
IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
J Steroid Biochem Mol Biol 103:446-50. 2007..These results demonstrated that Vitamin D mediated antiproliferative activity in unstressed condition and growth maintaining activity under stressed condition involve differential expression of prohibitin... - Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signalingXiao Zhang
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
Carcinogenesis 28:143-50. 2007.... - Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cellsXinjian Peng
Illinois Institute of Technology Research Institute, Chicago, Illinois 60616, USA
Cancer Res 66:7361-9. 2006..This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, which is involved in the antiproliferative action of vitamin D without affecting CYP24 transactivation in breast cancer cells... - Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colonDamien Matusiak
Department of Medicine, University of Illinois at Chicago, 840 South Wood Street (M/C 716, Chicago, IL 60612, USA
Cancer Epidemiol Biomarkers Prev 14:2370-6. 2005..Overall, these data support using 25(OH)D3 for colorectal cancer chemoprevention but suggest that pro-vitamin D is less likely to be useful for colorectal cancer chemotherapy... - Identification of novel RARbeta2 transcript variants with short 5'-UTRs in normal and cancerous breast epithelial cellsXinjian Peng
Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, M C 820, Chicago, IL 60612, USA
Oncogene 24:1296-301. 2005..Our data suggest that the RARbeta2 transcript variants with short 5'-UTR may serve as major transcripts for RARbeta2 protein translation as well as potential targets for retinoids in breast cancer prevention and therapy studies... - Efficacy and mechanism of action of 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha[OH]D5) in breast cancer prevention and therapyErum A Hussain
Department of Surgical Oncology, University of Illinois at Chicago, 840 S. Wood Street, Chicago, IL 60612, USA
Recent Results Cancer Res 164:393-411. 2003..This implies a differential effect of 1alpha(OH)D5 on ER+ vs. ER- cells. Additionally, comparison between the effects of 1alpha(OH)D5 on normal vs. transformed cells indicated that 1alpha(OH)D5 does not suppress cell prolifera-.. - Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductaseDae Sik Jang
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, and Center for Pharmaceutical Biotechnology, College of Pharmacy, Chicago, Illinois 60612, USA
J Agric Food Chem 50:6330-4. 2002..Isolates 1-5 were evaluated for their potential cancer chemopreventive properties utilizing an in vitro assay to determine quinone reductase induction and a mouse mammary organ culture assay... - Advanced rat mammary cancers are growth hormone dependentQi Shen
Department of Medicinal Chemistry and Pharmacognosy, 833 South Wood Street MC 781, University of Illinois at Chicago, Chicago, IL 60612, USA
Endocrinology 148:4536-44. 2007..Furthermore, advanced rat mammary cancers are dependent on GH and/or IGF-I for their survival. Therefore, therapeutics that target either GH or IGF-I may be effective at treating even advanced mammary cancers... - Chemoprevention of mammary carcinogenesis by 1alpha-hydroxyvitamin D5, a synthetic analog of Vitamin DRajendra G Mehta
Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, 840 South Wood Street M C 820, Chicago, IL 60612, USA
Mutat Res 523:253-64. 2003.... - Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture modelDae Sik Jang
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, U.S.A
Arch Pharm Res 26:585-90. 2003..3, 75.0, and 66.7% inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions, respectively, at a dose of 10 microg/mL... - Chemical and biological investigation of the fungus Pulveroboletus raveneliiChristine J G Duncan
Department of Pharmacognosy, Thad Cochran National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
J Nat Prod 66:103-7. 2003..The isolates were evaluated for antimicrobial activity as well as their potential to inhibit cyclooxygenase (COX) activity and carcinogen-induced preneoplastic lesion formation with mouse mammary organ culture (MMOC)... - Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cellsJuliana K Choi
Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, IL, USA
FEBS J 273:5714-23. 2006..Furthermore, immunocytochemistry demonstrated increased concentrations of mucin 3 in IxoA-treated SW480 cells. These findings suggest that chemicals present in tomatillos (e.g. IxoA) may have cancer chemopreventive properties... - Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)Hyun Ah Jung
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 54:2077-82. 2006..Alpha-mangostin (10) inhibited 7,12-dimethylbenz[alpha]anthracene-induced preneoplastic lesions in a mouse mammary organ culture assay with an IC50 of 1.0 microg/mL (2.44 microM)... - Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean)Dae Sik Jang
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612, USA
J Nat Prod 66:583-7. 2003..Selected compounds (3-5) were evaluated in a mouse mammary organ culture assay, with isoliquiritigenin (3) found to exhibit 76% inhibition at a dose of 10 microg/mL... - Designing a randomized phase I/II prostate cancer chemoprevention trial using 1alpha-hydroxy-24-ethyl-cholecalciferol, an analogue of vitamin D3S Packianathan
Department of Radiation Oncology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California, USA
Cancer J 10:357-67. 2004.... - Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activityBao-Ning Su
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA
J Nat Prod 65:163-9. 2002..Isolates were evaluated for their inhibitory effects against both cyclooxygenase-1 (COX-1) and -2 (COX-2) and in a mouse mammary organ culture assay...
Research Grants
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra Mehta; Fiscal Year: 2009..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra Mehta; Fiscal Year: 2007..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
- Vitamin D5 in Prevention of Mammary CarcinogenesisRajendra Mehta; Fiscal Year: 2006..Whether prohibitin plays a role in cell transformation and chemopreventive efficacy in these cells? 3. How is 1alpha(OH)D5 metabolized in normal and neoplastic mammary epithelial cells and tissues? ..
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra G Mehta; Fiscal Year: 2010..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..