Rajendra Mehta

Summary

Affiliation: IIT Research Institute
Country: USA

Publications

  1. ncbi Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: a comprehensive review
    Rajendra G Mehta
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Curr Med Chem 15:2785-825. 2008
  2. pmc Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells
    Fatouma Alimirah
    Division of Cancer Biology, IIT Research Institute, Illinois Institute of Technology, Chicago, Illinois, United States of America
    PLoS ONE 6:e16024. 2011
  3. pmc Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells
    Rajeshwari Mehta
    Cancer Biology and Analytical Chemistry Divisions, IIT Research Institute, Chicago, Illinois, United States of America
    PLoS ONE 8:e65113. 2013
  4. doi PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance
    Rajendra G Mehta
    IIT Research Institute, Chicago, IL 60616, USA
    Mol Cell Biochem 372:249-56. 2013
  5. ncbi Cancer chemoprevention by natural products: how far have we come?
    Rajendra G Mehta
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, Illinois 60616, USA
    Pharm Res 27:950-61. 2010
  6. ncbi Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells
    Xinjian Peng
    IIT Research Institute, Chicago, Illinois 60616, USA
    J Cell Biochem 110:1324-33. 2010
  7. ncbi Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials
    Rajesh Naithani
    Drug Discovery Division, IIT Research Institute, 10 W 35th Street Chicago, IL 60616, USA
    Curr Med Chem 15:1044-71. 2008
  8. ncbi Discovery of cancer preventive agents from natural products: from plants to prevention
    Rajendra G Mehta
    Department of Medicinal Chemistry and Pharmacognosy MC 877, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Oncol Rep 4:478-86. 2002
  9. pmc 25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture
    Xinjian Peng
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Breast Cancer Res Treat 113:31-41. 2009
  10. ncbi Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1alpha-hydroxyvitamin D5
    Erum A Hussain-Hakimjee
    Department of Surgical Oncology and Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Carcinogenesis 27:551-9. 2006

Collaborators

Detail Information

Publications40

  1. ncbi Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: a comprehensive review
    Rajendra G Mehta
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Curr Med Chem 15:2785-825. 2008
    ..The structure-activity relationships for many chemopreventive agents evaluated in the MMOC model have been discussed...
  2. pmc Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells
    Fatouma Alimirah
    Division of Cancer Biology, IIT Research Institute, Illinois Institute of Technology, Chicago, Illinois, United States of America
    PLoS ONE 6:e16024. 2011
    ..The functional significance of the VDR FokI polymorphism in vitamin D action is undefined...
  3. pmc Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells
    Rajeshwari Mehta
    Cancer Biology and Analytical Chemistry Divisions, IIT Research Institute, Chicago, Illinois, United States of America
    PLoS ONE 8:e65113. 2013
    ..In this report we evaluated efficacy and mechanism of action of Deguelin in triple negative breast cancer cell lines...
  4. doi PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance
    Rajendra G Mehta
    IIT Research Institute, Chicago, IL 60616, USA
    Mol Cell Biochem 372:249-56. 2013
    ..The induction of ERα by GW9662, including newer analogs, may permit use of anti-ER strategies to inhibit breast cancer in ER- patients...
  5. ncbi Cancer chemoprevention by natural products: how far have we come?
    Rajendra G Mehta
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, Illinois 60616, USA
    Pharm Res 27:950-61. 2010
    ..Novel technologies, such as nanotechnology, along with a better understanding of cancer stem cells, are certain to continue the advancement of the field of cancer chemoprevention in years to come...
  6. ncbi Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells
    Xinjian Peng
    IIT Research Institute, Chicago, Illinois 60616, USA
    J Cell Biochem 110:1324-33. 2010
    ..These data suggest that there is a significant protective role for 25(OH)D(3) against cellular stress in the breast epithelial cells and these effects may be mediated by altered miRNA expression...
  7. ncbi Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials
    Rajesh Naithani
    Drug Discovery Division, IIT Research Institute, 10 W 35th Street Chicago, IL 60616, USA
    Curr Med Chem 15:1044-71. 2008
    ..The experimental carcinogenesis studies in different biological models, in addition to the contribution from our laboratory are summarized...
  8. ncbi Discovery of cancer preventive agents from natural products: from plants to prevention
    Rajendra G Mehta
    Department of Medicinal Chemistry and Pharmacognosy MC 877, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Oncol Rep 4:478-86. 2002
    ..Alternatively, some natural products may be administered as dietary supplements (eg, resveratrol). In either case, chemoprevention offers great hope in reducing the morbidity and mortality associated with cancer...
  9. pmc 25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture
    Xinjian Peng
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Breast Cancer Res Treat 113:31-41. 2009
    ..We conclude that 25(OH)D(3) could serve as a non-toxic natural chemopreventive agent for further development for breast cancer prevention...
  10. ncbi Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1alpha-hydroxyvitamin D5
    Erum A Hussain-Hakimjee
    Department of Surgical Oncology and Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Carcinogenesis 27:551-9. 2006
    ..These results indicate that the growth inhibitory effect of 1alpha(OH)D5 was achieved in both carcinogen-transformed MCF-12F and breast cancer cells at a dose that was non-inhibitory in normal-like breast epithelial cells...
  11. ncbi Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses
    Lorna Whyte
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, Chicago, Illinois 60616, USA
    Cancer Res 67:12007-17. 2007
    ..Resveratrol is a potent inhibitor of A549 lung cancer cell growth, and our results suggest that resveratrol may be a promising chemopreventive or chemotherapeutic agent for lung cancer...
  12. ncbi Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems
    Stefan Gafner
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Phytochemistry 65:2849-59. 2004
    ..Most potent effects were at concentrations between 1 and 5 microM for 10, 13 and 21, and at 10 microM for curcumin. These data demonstrate the substitution pattern on the aromatic moiety is especially crucial for activity...
  13. ncbi Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria
    Dae Sik Jang
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 66:1166-70. 2003
    ..Selected compounds were tested in a mouse mammary organ culture assay to evaluate the inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesions...
  14. ncbi Regulation of steroid receptor expression by 1alpha-hydroxyvitamin D5 in hormone-responsive breast cancer cells
    Erum A Hussain-Hakimjee
    Department of Surgical Oncology, University of Illinois at Chicago, Chicago, IL, USA
    Anticancer Res 29:3555-61. 2009
    ..The present study assessed 1alpha(OH)D5-mediated regulation of VDR, and its potential anti-estrogenic activity in BT-474 cells...
  15. ncbi Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro
    Robert T Chatterton
    Department of Obstetrics Gynecology, Northwestern University Medical School, 333 East Superior Street, Chicago, IL 60611, USA
    Cancer Lett 188:47-52. 2002
    ..We conclude that in the absence of PR, epithelial structures are resistant to the carcinogenic action of DMBA...
  16. ncbi Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2
    Dae Sik Jang
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    Phytochemistry 61:867-72. 2002
    ..All isolates were tested for their inhibitory effects against both cyclooxygenases-1 and -2, and selected compounds were evaluated in a mouse mammary organ culture assay...
  17. ncbi Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway
    Genoveva Murillo
    Division of Carcinogenesis and Chemoprevention, IIT Research Institute, Chicago, Illinois 60616, USA
    Cancer Prev Res (Phila) 2:942-50. 2009
    ..These studies support the antiproliferative effects of deguelin in human breast cancer cells and, perhaps more importantly, illustrate novel actions by deguelin in the Wnt signaling pathway...
  18. ncbi Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice
    Genoveva Murillo
    Department of Surgical Oncology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Int J Cancer 104:7-11. 2003
    ..Greatest inhibition was observed when deguelin was administered during the promotional stage (73.3%, p < 0.001). These results demonstrate that deguelin is an efficacious chemopreventive agent against colon carcinogenesis...
  19. ncbi Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5
    Genoveva Murillo
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    J Steroid Biochem Mol Biol 97:129-36. 2005
    ..Cumulatively, these studies support the chemopreventive properties of 1alpha(OH)D(5) against the development of breast and colon cancers...
  20. ncbi Stage-specific inhibition of mammary carcinogenesis by 1alpha-hydroxyvitamin D5
    Rajendra G Mehta
    Department of Surgical Oncology, College of Medicine, University of Illinois, 840 S Wood Street M C 820, Chicago, IL 60612, USA
    Eur J Cancer 40:2331-7. 2004
    ..These results clearly show, for the first time, that the effects of vitamin D may be mediated selectively during the promotion or progression phases of carcinogenesis...
  21. ncbi Bioactive constituents of the seeds of Brucea javanica
    Bao Ning Su
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Planta Med 68:730-3. 2002
    ....
  22. ncbi Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity
    Jian Qiao Gu
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 65:532-6. 2002
    ..0% at 10 microg/mL) lesion formation in the mouse mammary organ culture assay. The chemical structures of 1-3 were elucidated by spectroscopic analysis. The absolute configurations of 1 and 2 were determined by Mosher ester methodology...
  23. ncbi Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis
    Genoveva Murillo
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, Chicago, IL 60616, USA
    Nutr Cancer 57:28-37. 2007
    ..The present study is the first to report the potent anticancer activity of zapotin and suggests a role for zapotin both as a chemopreventive and a chemotherapeutic agent against colon cancer...
  24. pmc Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancer
    Genoveva Murillo
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    J Steroid Biochem Mol Biol 103:763-7. 2007
    ..The increased expression of 1alpha(OH)ase in colon cancer cells treated with the pro-hormone and its anti-proliferative effects, suggest that 25(OH)D(3) may offer possible therapeutic and chemopreventive option in colon cancer...
  25. pmc Differential expression of prohibitin is correlated with dual action of Vitamin D as a proliferative and antiproliferative hormone in breast epithelial cells
    Xinjian Peng
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    J Steroid Biochem Mol Biol 103:446-50. 2007
    ..These results demonstrated that Vitamin D mediated antiproliferative activity in unstressed condition and growth maintaining activity under stressed condition involve differential expression of prohibitin...
  26. ncbi Identification of novel RARbeta2 transcript variants with short 5'-UTRs in normal and cancerous breast epithelial cells
    Xinjian Peng
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, M C 820, Chicago, IL 60612, USA
    Oncogene 24:1296-301. 2005
    ..Our data suggest that the RARbeta2 transcript variants with short 5'-UTR may serve as major transcripts for RARbeta2 protein translation as well as potential targets for retinoids in breast cancer prevention and therapy studies...
  27. ncbi Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon
    Damien Matusiak
    Department of Medicine, University of Illinois at Chicago, 840 South Wood Street M C 716, Chicago, IL 60612, USA
    Cancer Epidemiol Biomarkers Prev 14:2370-6. 2005
    ..Overall, these data support using 25(OH)D3 for colorectal cancer chemoprevention but suggest that pro-vitamin D is less likely to be useful for colorectal cancer chemotherapy...
  28. ncbi Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells
    Xinjian Peng
    Illinois Institute of Technology Research Institute, Chicago, Illinois 60616, USA
    Cancer Res 66:7361-9. 2006
    ..This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, which is involved in the antiproliferative action of vitamin D without affecting CYP24 transactivation in breast cancer cells...
  29. ncbi Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling
    Xiao Zhang
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Carcinogenesis 28:143-50. 2007
    ....
  30. ncbi Efficacy and mechanism of action of 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha[OH]D5) in breast cancer prevention and therapy
    Erum A Hussain
    Department of Surgical Oncology, University of Illinois at Chicago, 840 S Wood Street, Chicago, IL 60612, USA
    Recent Results Cancer Res 164:393-411. 2003
    ..This implies a differential effect of 1alpha(OH)D5 on ER+ vs. ER- cells. Additionally, comparison between the effects of 1alpha(OH)D5 on normal vs. transformed cells indicated that 1alpha(OH)D5 does not suppress cell prolifera-..
  31. ncbi Advanced rat mammary cancers are growth hormone dependent
    Qi Shen
    Department of Medicinal Chemistry and Pharmacognosy, 833 South Wood Street MC 781, University of Illinois at Chicago, Chicago, IL 60612, USA
    Endocrinology 148:4536-44. 2007
    ..Furthermore, advanced rat mammary cancers are dependent on GH and/or IGF-I for their survival. Therefore, therapeutics that target either GH or IGF-I may be effective at treating even advanced mammary cancers...
  32. ncbi Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase
    Dae Sik Jang
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, and Center for Pharmaceutical Biotechnology, College of Pharmacy, Chicago, Illinois 60612, USA
    J Agric Food Chem 50:6330-4. 2002
    ..Isolates 1-5 were evaluated for their potential cancer chemopreventive properties utilizing an in vitro assay to determine quinone reductase induction and a mouse mammary organ culture assay...
  33. ncbi Chemoprevention of mammary carcinogenesis by 1alpha-hydroxyvitamin D5, a synthetic analog of Vitamin D
    Rajendra G Mehta
    Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, 840 South Wood Street M C 820, Chicago, IL 60612, USA
    Mutat Res 523:253-64. 2003
    ....
  34. ncbi Chemical and biological investigation of the fungus Pulveroboletus ravenelii
    Christine J G Duncan
    Department of Pharmacognosy, Thad Cochran National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 66:103-7. 2003
    ..The isolates were evaluated for antimicrobial activity as well as their potential to inhibit cyclooxygenase (COX) activity and carcinogen-induced preneoplastic lesion formation with mouse mammary organ culture (MMOC)...
  35. ncbi Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean)
    Dae Sik Jang
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612, USA
    J Nat Prod 66:583-7. 2003
    ..Selected compounds (3-5) were evaluated in a mouse mammary organ culture assay, with isoliquiritigenin (3) found to exhibit 76% inhibition at a dose of 10 microg/mL...
  36. ncbi Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model
    Dae Sik Jang
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, U S A
    Arch Pharm Res 26:585-90. 2003
    ..3, 75.0, and 66.7% inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions, respectively, at a dose of 10 microg/mL...
  37. ncbi Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells
    Juliana K Choi
    Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, IL, USA
    FEBS J 273:5714-23. 2006
    ..Furthermore, immunocytochemistry demonstrated increased concentrations of mucin 3 in IxoA-treated SW480 cells. These findings suggest that chemicals present in tomatillos (e.g. IxoA) may have cancer chemopreventive properties...
  38. ncbi Designing a randomized phase I/II prostate cancer chemoprevention trial using 1alpha-hydroxy-24-ethyl-cholecalciferol, an analogue of vitamin D3
    S Packianathan
    Department of Radiation Oncology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California, USA
    Cancer J 10:357-67. 2004
    ....
  39. ncbi Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)
    Hyun Ah Jung
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 54:2077-82. 2006
    ..Alpha-mangostin (10) inhibited 7,12-dimethylbenz[alpha]anthracene-induced preneoplastic lesions in a mouse mammary organ culture assay with an IC50 of 1.0 microg/mL (2.44 microM)...
  40. ncbi Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity
    Bao Ning Su
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA
    J Nat Prod 65:163-9. 2002
    ..Isolates were evaluated for their inhibitory effects against both cyclooxygenase-1 (COX-1) and -2 (COX-2) and in a mouse mammary organ culture assay...

Research Grants11

  1. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra Mehta; Fiscal Year: 2009
    ..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
  2. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra Mehta; Fiscal Year: 2007
    ..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
  3. Vitamin D5 in Prevention of Mammary Carcinogenesis
    Rajendra Mehta; Fiscal Year: 2006
    ..Whether prohibitin plays a role in cell transformation and chemopreventive efficacy in these cells? 3. How is 1alpha(OH)D5 metabolized in normal and neoplastic mammary epithelial cells and tissues? ..
  4. Vitamin D5 in Prevention of Mammary Carcinogenesis
    Rajendra Mehta; Fiscal Year: 2005
    ..Whether prohibitin plays a role in cell transformation and chemopreventive efficacy in these cells? 3. How is 1alpha(OH)D5 metabolized in normal and neoplastic mammary epithelial cells and tissues? ..
  5. Vitamin D5 in Prevention of Mammary Carcinogenesis
    Rajendra Mehta; Fiscal Year: 2004
    ..Whether prohibitin plays a role in cell transformation and chemopreventive efficacy in these cells? 3. How is 1alpha(OH)D5 metabolized in normal and neoplastic mammary epithelial cells and tissues? ..
  6. Vitamin D5 in Prevention of Mammary Carcinogenesis
    Rajendra Mehta; Fiscal Year: 2003
    ..Whether prohibitin plays a role in cell transformation and chemopreventive efficacy in these cells? 3. How is 1alpha(OH)D5 metabolized in normal and neoplastic mammary epithelial cells and tissues? ..
  7. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..