D L McCormick

Summary

Affiliation: IIT Research Institute
Country: USA

Publications

  1. ncbi Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever rat
    D L McCormick
    Experimental Toxicology and Carcinogenesis Division, IIT Research Institute, Chicago, Ill 60616, USA
    Eur Urol 35:464-7. 1999
  2. ncbi Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice
    William D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 25:219-28. 2006
  3. ncbi Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone
    David L McCormick
    Life Sciences Group, IIT Research Institute Chicago, IL 60616, USA
    Carcinogenesis 28:398-403. 2007
  4. ncbi Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in B6C3F1 mice
    D L McCormick
    Illinois Institute of Toxicology Research Institute, Chicago 60616 3799, USA
    Toxicol Pathol 27:279-85. 1999
  5. ncbi Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate
    David L McCormick
    Life Sciences Research, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:381-92. 2010
  6. ncbi Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors
    David L McCormick
    IIT Research Institute, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:73-81. 2010
  7. ncbi Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Nutr Cancer 57:184-93. 2007
  8. ncbi Animal models for the study of childhood leukemia: considerations for model identification and optimization to identify potential risk factors
    David L McCormick
    IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 23:149-61. 2004
  9. ncbi Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Nutr Cancer 57:194-200. 2007
  10. ncbi Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
    W D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Food Chem Toxicol 49:3319-27. 2011

Collaborators

Detail Information

Publications21

  1. ncbi Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever rat
    D L McCormick
    Experimental Toxicology and Carcinogenesis Division, IIT Research Institute, Chicago, Ill 60616, USA
    Eur Urol 35:464-7. 1999
    ..Chemoprevention efficacy evaluations in the WU rat will support the identification of agents that merit study for prostate cancer chemoprevention in humans...
  2. ncbi Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice
    William D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 25:219-28. 2006
    ..By contrast, the positive-control article, p-cresidine, induced urinary bladder cancers in both studies. Neither PTI G-2535 nor BBIC demonstrates any evidence of oncogenicity in the p53((+/-)) mouse model...
  3. ncbi Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone
    David L McCormick
    Life Sciences Group, IIT Research Institute Chicago, IL 60616, USA
    Carcinogenesis 28:398-403. 2007
    ..The chemopreventive activity of a non-androgenic DHEA analog suggests that at least a portion of the chemopreventive activity of DHEA in the rat prostate is unrelated to hormonal effects...
  4. ncbi Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in B6C3F1 mice
    D L McCormick
    Illinois Institute of Toxicology Research Institute, Chicago 60616 3799, USA
    Toxicol Pathol 27:279-85. 1999
    ..These data do not support the hypothesis that chronic exposure to pure, linearly polarized 60 Hz magnetic fields is a significant risk factor for neoplastic development in mice...
  5. ncbi Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate
    David L McCormick
    Life Sciences Research, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:381-92. 2010
    ....
  6. ncbi Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors
    David L McCormick
    IIT Research Institute, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:73-81. 2010
    ..The chemopreventive activity of COX inhibitors may be linked to overexpression of their enzymatic target in incipient oral neoplasms...
  7. ncbi Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Nutr Cancer 57:184-93. 2007
    ....
  8. ncbi Animal models for the study of childhood leukemia: considerations for model identification and optimization to identify potential risk factors
    David L McCormick
    IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 23:149-61. 2004
    ....
  9. ncbi Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Nutr Cancer 57:194-200. 2007
    ..Reducing mean body weight by up to 25% through chronic dietary restriction has no effect on the induction of prostate cancers in the Wistar-Unilever rat model...
  10. ncbi Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
    W D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Food Chem Toxicol 49:3319-27. 2011
    ..The apparent cardioprotective activity of resveratrol in rats demonstrates that its potentially beneficial activities may extend beyond efficacy in cancer prevention...
  11. ncbi Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention
    W D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Food Chem Toxicol 46:1068-78. 2008
    ..5mg/kg/day. Based on alterations in hematology parameters and liver morphology in male dogs in all dose groups, the NOAEL for MSC in dogs is <0.15 mg/kg/day...
  12. ncbi Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice
    T L Horn
    Life Sciences Group, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Food Chem Toxicol 45:55-63. 2007
    ..By contrast, the positive control article, p-cresidine, induced urinary bladder cancer in both sexes. When administered to p53(+/-) mice at its maximum tolerated dose, resveratrol demonstrates no evidence of oncogenicity...
  13. ncbi Exposure to 60 Hz magnetic fields and risk of lymphoma in PIM transgenic and TSG-p53 (p53 knockout) mice
    D L McCormick
    Life Sciences Department, IIT Research Institute, Chicago, IL 60616, USA
    Carcinogenesis 19:1649-53. 1998
    ..These data do not support the hypothesis that exposure to magnetic fields is a significant risk factor for lymphoid neoplasia in mice with a genetic predisposition to the disease...
  14. ncbi Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: a comprehensive review
    Rajendra G Mehta
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Curr Med Chem 15:2785-825. 2008
    ..The structure-activity relationships for many chemopreventive agents evaluated in the MMOC model have been discussed...
  15. ncbi Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials
    Rajesh Naithani
    Drug Discovery Division, IIT Research Institute, 10 W 35th Street Chicago, IL 60616, USA
    Curr Med Chem 15:1044-71. 2008
    ..The experimental carcinogenesis studies in different biological models, in addition to the contribution from our laboratory are summarized...
  16. ncbi 60 Hz magnetic fields do not enhance cell killing by genotoxic chemicals in Ataxia telangiectasia and normal lymphoblastoid cells
    L I Loberg
    Experimental Toxicology and Carcinogenesis Division, IIT Research Institute, Chicago, Illinois 60616, USA
    Radiat Res 153:685-9. 2000
    ..These results do not support the hypothesis that MFs interact with genotoxic agents to induce adverse biological effects in either normal or genetically susceptible human cells...
  17. ncbi Reproductive toxicity assessment of chronic dietary exposure to soy isoflavones in male rats
    Ali S Faqi
    IIT Research Institute, Chicago, IL 60616, USA
    Reprod Toxicol 18:605-11. 2004
    ..The results of this study conducted in adult male rats differ from the significant alterations in reproductive parameters that have been reported in female rats receiving prenatal or juvenile exposure to isoflavones...
  18. ncbi Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist
    Thomas L Horn
    IIT Research Institute, Chicago, IL 60616, USA
    Toxicology 248:8-17. 2008
    ..The hepatic and renal toxicities seen in rats exposed to Antalarmin identify those tissues as the most likely targets for Antalarmin toxicity in humans...
  19. ncbi Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats
    Thomas L Horn
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Toxicol Sci 99:612-27. 2007
    ..Differential expression of genes involved in drug and lipid metabolism may underlie the observed effects of BEX on cholesterol and triglyceride levels and its effects on liver histology...
  20. ncbi Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol
    Thomas L Horn
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Chem Biol Interact 152:79-99. 2005
    ..It is concluded that non-toxic or minimally toxic doses of farnesol could alter the metabolism, efficacy, and/or toxicity of drugs with which it is co-administered...
  21. ncbi Chemoprevention strategies for prostate cancer
    Maarten C Bosland
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Eur J Cancer Prev 11:S18-27. 2002
    ..Such trials are an essential step in the development of antiprostate cancer chemoprevention agents...