William D Johnson

Summary

Affiliation: IIT Research Institute
Country: USA

Publications

  1. pmc Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
    W D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Food Chem Toxicol 49:3319-27. 2011
  2. pmc Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs
    William D Johnson
    Life Sciences Group, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Toxicology 289:141-50. 2011
  3. ncbi request reprint Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Nutr Cancer 57:184-93. 2007
  4. pmc Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate
    David L McCormick
    Life Sciences Research, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:381-92. 2010
  5. pmc Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs
    Miguel Muzzio
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    J Pharm Biomed Anal 59:201-8. 2012
  6. ncbi request reprint Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Nutr Cancer 57:194-200. 2007
  7. pmc Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS
    Miguel Muzzio
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    J Pharm Biomed Anal 56:809-14. 2011
  8. pmc Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors
    David L McCormick
    IIT Research Institute, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:73-81. 2010
  9. pmc Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist
    Thomas L Horn
    IIT Research Institute, Chicago, IL 60616, USA
    Toxicology 248:8-17. 2008
  10. ncbi request reprint Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice
    William D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 25:219-28. 2006

Collaborators

Detail Information

Publications12

  1. pmc Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
    W D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Food Chem Toxicol 49:3319-27. 2011
    ..The apparent cardioprotective activity of resveratrol in rats demonstrates that its potentially beneficial activities may extend beyond efficacy in cancer prevention...
  2. pmc Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs
    William D Johnson
    Life Sciences Group, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Toxicology 289:141-50. 2011
    ....
  3. ncbi request reprint Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Nutr Cancer 57:184-93. 2007
    ....
  4. pmc Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate
    David L McCormick
    Life Sciences Research, IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:381-92. 2010
    ....
  5. pmc Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs
    Miguel Muzzio
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    J Pharm Biomed Anal 59:201-8. 2012
    ..Mean molecular-weight adjusted ratios of resveratrol metabolites to resveratrol for AUC ranged from 1 to 9 for resveratrol glucuronide and from 2 to 11 for resveratrol sulfate...
  6. ncbi request reprint Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Nutr Cancer 57:194-200. 2007
    ..Reducing mean body weight by up to 25% through chronic dietary restriction has no effect on the induction of prostate cancers in the Wistar-Unilever rat model...
  7. pmc Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS
    Miguel Muzzio
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    J Pharm Biomed Anal 56:809-14. 2011
    ..The validated method was applied to preclinical toxicology studies in rats and dogs after oral administration of CP-31398...
  8. pmc Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors
    David L McCormick
    IIT Research Institute, Chicago, IL 60616, USA
    Cancer Prev Res (Phila) 3:73-81. 2010
    ..The chemopreventive activity of COX inhibitors may be linked to overexpression of their enzymatic target in incipient oral neoplasms...
  9. pmc Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist
    Thomas L Horn
    IIT Research Institute, Chicago, IL 60616, USA
    Toxicology 248:8-17. 2008
    ..The hepatic and renal toxicities seen in rats exposed to Antalarmin identify those tissues as the most likely targets for Antalarmin toxicity in humans...
  10. ncbi request reprint Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice
    William D Johnson
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Int J Toxicol 25:219-28. 2006
    ..By contrast, the positive-control article, p-cresidine, induced urinary bladder cancers in both studies. Neither PTI G-2535 nor BBIC demonstrates any evidence of oncogenicity in the p53((+/-)) mouse model...
  11. ncbi request reprint Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone
    David L McCormick
    Life Sciences Group, IIT Research Institute Chicago, IL 60616, USA
    Carcinogenesis 28:398-403. 2007
    ..The chemopreventive activity of a non-androgenic DHEA analog suggests that at least a portion of the chemopreventive activity of DHEA in the rat prostate is unrelated to hormonal effects...
  12. ncbi request reprint Reproductive toxicity assessment of chronic dietary exposure to soy isoflavones in male rats
    Ali S Faqi
    IIT Research Institute, Chicago, IL 60616, USA
    Reprod Toxicol 18:605-11. 2004
    ..The results of this study conducted in adult male rats differ from the significant alterations in reproductive parameters that have been reported in female rats receiving prenatal or juvenile exposure to isoflavones...