Chris Downing

Summary

Affiliation: Idaho State University
Country: USA

Publications

  1. pmc Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure
    Chris Downing
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, USA
    Alcohol Clin Exp Res 36:1519-29. 2012
  2. doi request reprint Quantitative trait locus mapping for ethanol teratogenesis in BXD recombinant inbred mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Alcohol Clin Exp Res 36:1340-54. 2012
  3. pmc Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Alcohol 45:65-71. 2011
  4. pmc The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    Pharmacogenet Genomics 20:553-64. 2010
  5. pmc Genetic and maternal effects on valproic acid teratogenesis in C57BL/6J and DBA/2J mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Toxicol Sci 116:632-9. 2010
  6. pmc No effect of prenatal alcohol exposure on activity in three inbred strains of mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    Alcohol Alcohol 44:25-33. 2009
  7. pmc Ethanol teratogenesis in five inbred strains of mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Colorado, USA
    Alcohol Clin Exp Res 33:1238-45. 2009
  8. ncbi request reprint Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel
    Beth Bennett
    Institute for Behavioral Genetics, Colorado 80309 0447, USA
    Alcohol Clin Exp Res 31:200-8. 2007
  9. pmc DNA microarray and proteomic strategies for understanding alcohol action
    James M Sikela
    University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA
    Alcohol Clin Exp Res 30:700-8. 2006
  10. ncbi request reprint QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    Alcohol Clin Exp Res 30:1111-20. 2006

Detail Information

Publications12

  1. pmc Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure
    Chris Downing
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, USA
    Alcohol Clin Exp Res 36:1519-29. 2012
    ..B6 fetuses are susceptible to morphological malformations following prenatal alcohol exposure while D2 are relatively resistant...
  2. doi request reprint Quantitative trait locus mapping for ethanol teratogenesis in BXD recombinant inbred mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Alcohol Clin Exp Res 36:1340-54. 2012
    ..Here, we present the results of quantitative trait locus (QTL) mapping for EtOH teratogenesis in recombinant inbred strains derived from a cross between B6 and D2 (BXD RIs)...
  3. pmc Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Alcohol 45:65-71. 2011
    ..Thus, although prenatal alcohol had only small effects on DNA methylation at the Igf2 locus, placing dams on a methyl-supplemented diet partially ameliorated ethanol teratogenesis...
  4. pmc The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    Pharmacogenet Genomics 20:553-64. 2010
    ..This study investigated the metabotropic glutamate receptor subtype 5 (mGluR5) as a candidate gene underlying Lore7, a QTL mediating differential LORE sensitivity...
  5. pmc Genetic and maternal effects on valproic acid teratogenesis in C57BL/6J and DBA/2J mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Toxicol Sci 116:632-9. 2010
    ..Lines of mice derived from B6 and D2 will be a useful model for elucidating the genetic architecture underlying susceptibility to VPA teratogenesis...
  6. pmc No effect of prenatal alcohol exposure on activity in three inbred strains of mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    Alcohol Alcohol 44:25-33. 2009
    ..The present study investigated the effects of prenatal ethanol exposure on activity in mice from three inbred strains: C57BL/6 (B6), Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS)...
  7. pmc Ethanol teratogenesis in five inbred strains of mice
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Colorado, USA
    Alcohol Clin Exp Res 33:1238-45. 2009
    ..Many factors, including genetic differences, have been shown to play a role in susceptibility and resistance, but few studies have investigated the range of genetic variation in rodent models...
  8. ncbi request reprint Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel
    Beth Bennett
    Institute for Behavioral Genetics, Colorado 80309 0447, USA
    Alcohol Clin Exp Res 31:200-8. 2007
    ..We report replication of QTL regions reported by earlier studies of AFT and preliminary application of a coarse single nucleotide polymorphism map analysis to limit QTL intervals for subsequent candidate gene hypotheses...
  9. pmc DNA microarray and proteomic strategies for understanding alcohol action
    James M Sikela
    University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA
    Alcohol Clin Exp Res 30:700-8. 2006
    ..Kerns; and (4) Quantitative Proteomic Analysis of AC7-Modified Mice, by Kathleen J. Grant...
  10. ncbi request reprint QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    Alcohol Clin Exp Res 30:1111-20. 2006
    ..The LXS RI panel has additional genetic variation, and greater power due to a larger number of strains, compared with other RI panels and strain crosses...
  11. ncbi request reprint Mouse genetic models in alcohol research
    Beth Bennett
    Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309 0447, USA
    Trends Genet 22:367-74. 2006
    ..Many of the underlying genes should be identified in the near future...
  12. ncbi request reprint Mapping quantitative trait loci mediating sensitivity to etomidate
    Chris Downing
    Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, Colorado 80309 0447, USA
    Mamm Genome 14:367-75. 2003
    ..These QTL regions need to be further narrowed before the testing of candidate genes is feasible...