Research TopicsGenomes and GenesSpecies | P KilgannonSummaryAffiliation: ICOS Corporation Country: USA Publications
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Publications
Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2P Kilgannon
ICOS Corporation, Bothell, Washington, 98021, USA
Genomics 54:328-30. 1998..This analysis has confirmed the unique expression pattern of this ICAM in human. In addition, we report the mapping of the human ICAM-5 gene to an 80-kb region on chromosome 19p13.2 that also contains ICAM-1 and ICAM-3...
The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functionsJ S Hayflick
ICOS Corp, Bothell, WA 98021, USA
Immunol Res 17:313-27. 1998..This information has led to the design of novel therapeutic agents that may prove effective in a variety of disease states...
Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18L Tian
Department of Biosciences, University of Helskinki, Finland
Eur J Immunol 30:810-8. 2000..This binding was blocked by monoclonal antibodies against CD11a/CD18 and ICAM-5. Thus ICAM-5 may act as a major adhesion molecule for leukocyte binding to neurons in the central nervous system...
Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesionL Tian
Department of Biosciences, Division of Biochemistry, Viikinkaari 5, University of Helsinki, Helsinki 00014, Finland
J Cell Biol 150:243-52. 2000..Thus, ICAM-5 displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes...
Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expressionA O Stewart
Abbott Laboratories, Pharmaceutical Products Division, Metabolic Diseases Research, Department 04MJ, Building AP10, 100 Abbott Park Road, Abbott Park, Illinois 60064-3500, USA
J Med Chem 44:988-1002. 2001..The relative position of the nitrogen atom in the thienopyridine isomer was shown to be critical for activity, as was a small amide 2-substituent...
