Affiliation: Iconix Pharmaceuticals
- Classification of a large microarray data set: algorithm comparison and analysis of drug signaturesGeorges Natsoulis
Iconix Pharmaceuticals, Mountain View, CA 94043, USA
Genome Res 15:724-36. 2005..Multiple signatures with no genes in common can be generated for the same classification end-point. Comparison of these gene lists identifies biological processes characteristic of a given class...
- Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and actionBrigitte Ganter
Iconix Pharmaceuticals, 325 E Middlefield Road, Mountain View, CA 94043, USA
J Biotechnol 119:219-44. 2005..We will demonstrate that gene expression events monitored in the liver can be used to predict pathological events occurring in that tissue as well as in hematopoietic tissues...
- A gene expression signature that predicts the future onset of drug-induced renal tubular toxicityMark R Fielden
Iconix Pharmaceuticals, Inc, 325 East Middlefield Road, Mountain View, California 94043, USA
Toxicol Pathol 33:675-83. 2005..This study demonstrates that genomic data can be more sensitive than traditional methods for the early prediction of compound-induced pathology in the kidney...
- Molecular basis for fungal selectivity of novel antimitotic compoundsThomas Lila
Essential Therapeutics, Mountain View, California 94043, USA
Antimicrob Agents Chemother 47:2273-82. 2003..Features of the proposed binding site explain the observed fungal tubulin specificity of the series and are consistent with structure-activity relationships among a library of related compounds...
- The liver pharmacological and xenobiotic gene response repertoireGeorges Natsoulis
Iconix Biosciences now Entelos, Foster City, CA, USA
Mol Syst Biol 4:175. 2008..Our approach using the whole genome and a diverse set of compounds allows a comprehensive view of most pharmacological and toxicological questions and is applicable to other situations such as disease and development...