Georges Natsoulis

Summary

Affiliation: Iconix Pharmaceuticals
Country: USA

Publications

  1. pmc Classification of a large microarray data set: algorithm comparison and analysis of drug signatures
    Georges Natsoulis
    Iconix Pharmaceuticals, Mountain View, CA 94043, USA
    Genome Res 15:724-36. 2005
  2. ncbi request reprint Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
    Brigitte Ganter
    Iconix Pharmaceuticals, 325 E Middlefield Road, Mountain View, CA 94043, USA
    J Biotechnol 119:219-44. 2005
  3. ncbi request reprint A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity
    Mark R Fielden
    Iconix Pharmaceuticals, Inc, 325 East Middlefield Road, Mountain View, California 94043, USA
    Toxicol Pathol 33:675-83. 2005
  4. pmc Molecular basis for fungal selectivity of novel antimitotic compounds
    Thomas Lila
    Essential Therapeutics, Mountain View, California 94043, USA
    Antimicrob Agents Chemother 47:2273-82. 2003
  5. pmc The liver pharmacological and xenobiotic gene response repertoire
    Georges Natsoulis
    Iconix Biosciences now Entelos, Foster City, CA, USA
    Mol Syst Biol 4:175. 2008

Collaborators

Detail Information

Publications5

  1. pmc Classification of a large microarray data set: algorithm comparison and analysis of drug signatures
    Georges Natsoulis
    Iconix Pharmaceuticals, Mountain View, CA 94043, USA
    Genome Res 15:724-36. 2005
    ..Multiple signatures with no genes in common can be generated for the same classification end-point. Comparison of these gene lists identifies biological processes characteristic of a given class...
  2. ncbi request reprint Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
    Brigitte Ganter
    Iconix Pharmaceuticals, 325 E Middlefield Road, Mountain View, CA 94043, USA
    J Biotechnol 119:219-44. 2005
    ..We will demonstrate that gene expression events monitored in the liver can be used to predict pathological events occurring in that tissue as well as in hematopoietic tissues...
  3. ncbi request reprint A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity
    Mark R Fielden
    Iconix Pharmaceuticals, Inc, 325 East Middlefield Road, Mountain View, California 94043, USA
    Toxicol Pathol 33:675-83. 2005
    ..This study demonstrates that genomic data can be more sensitive than traditional methods for the early prediction of compound-induced pathology in the kidney...
  4. pmc Molecular basis for fungal selectivity of novel antimitotic compounds
    Thomas Lila
    Essential Therapeutics, Mountain View, California 94043, USA
    Antimicrob Agents Chemother 47:2273-82. 2003
    ..Features of the proposed binding site explain the observed fungal tubulin specificity of the series and are consistent with structure-activity relationships among a library of related compounds...
  5. pmc The liver pharmacological and xenobiotic gene response repertoire
    Georges Natsoulis
    Iconix Biosciences now Entelos, Foster City, CA, USA
    Mol Syst Biol 4:175. 2008
    ..Our approach using the whole genome and a diverse set of compounds allows a comprehensive view of most pharmacological and toxicological questions and is applicable to other situations such as disease and development...