Napapon Sailasuta

Summary

Affiliation: Huntington Medical Research Institutes
Country: USA

Publications

  1. doi request reprint Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, USA
    NMR Biomed 22:326-31. 2009
  2. pmc Swift Acetate Glial Assay (SAGA): an accelerated human ¹³C MRS brain exam for clinical diagnostic use
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, United States
    J Magn Reson 207:352-5. 2010
  3. pmc Glial dysfunction in abstinent methamphetamine abusers
    Napapon Sailasuta
    Clinical Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, California 91105, USA
    J Cereb Blood Flow Metab 30:950-60. 2010
  4. pmc Clinical NOE 13C MRS for neuropsychiatric disorders of the frontal lobe
    Napapon Sailasuta
    Huntington Medical Research Institutes, Clinical MRS Unit, 10 Pico Street, Pasadena, CA, USA
    J Magn Reson 195:219-25. 2008
  5. pmc Regional variations and the effects of age and gender on glutamate concentrations in the human brain
    Napapon Sailasuta
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Magn Reson Imaging 26:667-75. 2008
  6. doi request reprint Impact of fasting on human brain acid-base homeostasis using natural abundance (13) C and (31) P MRS
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, California, USA
    J Magn Reson Imaging 39:398-401. 2014
  7. pmc Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter
    Kalpana J Kallianpur
    Department of Medicine, Hawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA
    Neurology 80:1792-9. 2013
  8. pmc Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model
    Mark D Lingwood
    Department of Chemistry, University of California, Santa Barbara, Mesa Road, Santa Barbara, CA 93106, USA
    Radiology 265:418-25. 2012
  9. pmc Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate
    Niki M Zacharias
    Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, California, USA
    J Am Chem Soc 134:934-43. 2012
  10. doi request reprint MR spectroscopy in diagnosis and neurological decision-making
    Victor Xu
    Clinical Magnetic Resonance Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
    Semin Neurol 28:407-22. 2008

Collaborators

Detail Information

Publications20

  1. doi request reprint Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, USA
    NMR Biomed 22:326-31. 2009
    ..Our findings suggest that Glu neurotransmission is abnormal and may be a key target for early interventions to reduce the later incidence of neurocognitive impairment and dementia among HIV-seropositive patients...
  2. pmc Swift Acetate Glial Assay (SAGA): an accelerated human ¹³C MRS brain exam for clinical diagnostic use
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, United States
    J Magn Reson 207:352-5. 2010
    ..6 min. Results obtained from the new short method (SAGA) were comparable to those achieved in a conventional, long method and effective for determination of glial metabolic rate in posterior-parietal and frontal brain regions...
  3. pmc Glial dysfunction in abstinent methamphetamine abusers
    Napapon Sailasuta
    Clinical Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, California 91105, USA
    J Cereb Blood Flow Metab 30:950-60. 2010
    ....
  4. pmc Clinical NOE 13C MRS for neuropsychiatric disorders of the frontal lobe
    Napapon Sailasuta
    Huntington Medical Research Institutes, Clinical MRS Unit, 10 Pico Street, Pasadena, CA, USA
    J Magn Reson 195:219-25. 2008
    ..5 T. We predict these will be clinically useful biomarkers in many human neuropsychiatric and genetic conditions...
  5. pmc Regional variations and the effects of age and gender on glutamate concentrations in the human brain
    Napapon Sailasuta
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Magn Reson Imaging 26:667-75. 2008
    ..Our results also highlight the importance of brain region, age and gender matching in clinical studies...
  6. doi request reprint Impact of fasting on human brain acid-base homeostasis using natural abundance (13) C and (31) P MRS
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, California, USA
    J Magn Reson Imaging 39:398-401. 2014
    ..To use (13) C magnetic resonance spectroscopy (MRS) and (31) P MRS to develop a direct assay for regional [HCO3-] in the human brain and to define brain pH and physiological response of [HCO3-] to fasting...
  7. pmc Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter
    Kalpana J Kallianpur
    Department of Medicine, Hawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA
    Neurology 80:1792-9. 2013
    ..We evaluated regional brain volumes and cerebral metabolite levels as correlates of HIV DNA in peripheral blood mononuclear cells (PBMCs)...
  8. pmc Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model
    Mark D Lingwood
    Department of Chemistry, University of California, Santa Barbara, Mesa Road, Santa Barbara, CA 93106, USA
    Radiology 265:418-25. 2012
    ..To assess the feasibility of a perfusion magnetic resonance (MR) imaging technique that uses Overhauser dynamic nuclear polarization (DNP) to provide contrast during the continuous delivery of hyperpolarized water in rats...
  9. pmc Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate
    Niki M Zacharias
    Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, California, USA
    J Am Chem Soc 134:934-43. 2012
    ....
  10. doi request reprint MR spectroscopy in diagnosis and neurological decision-making
    Victor Xu
    Clinical Magnetic Resonance Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
    Semin Neurol 28:407-22. 2008
    ..In this review, the authors explain the technical and neurochemical aspects of MRS and critically discuss its clinical neuroimaging applications...
  11. ncbi request reprint Application of NMR spectroscopy in medicinal chemistry and drug discovery
    Brian Ross
    Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Curr Top Med Chem 11:93-114. 2011
    ..Finally, recognizing that a known feature of MR is the lack of sensitivity, we describe new efforts to harness hyperpolarization, with its 50,000 signal amplification, to conventional MRS...
  12. pmc Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, USA
    PLoS ONE 7:e49272. 2012
    ..We used MRS to measure brain changes during the first weeks following HIV infection and in response to antiretroviral therapy (ART)...
  13. pmc Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study
    Napapon Sailasuta
    Clinical MR Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Neuropsychiatr Dis Treat 7:495-9. 2011
    ..The value of (13)C MRS as an early, noninvasive biomarker may lie in the conduct of cost-effective clinical trials...
  14. ncbi request reprint Reproducibility of GABA measurements using 2D J-resolved magnetic resonance spectroscopy
    Katherine Lymer
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, UK
    Magn Reson Imaging 25:634-40. 2007
    ..In vivo, the CV for GABA measurement was 26%, suggesting that 2D J-resolved MRS would be suitable for detecting physiological changes in GABA, similar to those reported using other methods...
  15. ncbi request reprint Measurement of brain glutamate using TE-averaged PRESS at 3T
    Ralph Hurd
    GE Medical Systems, Menlo Park, California, USA
    Magn Reson Med 51:435-40. 2004
    ..A repeatibility error of <5%, and a coefficient of variation (CV) of <10% were observed for brain Glu levels in a study of six normal volunteers...
  16. ncbi request reprint A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain
    Radhika Srinivasan
    Magnetic Resonance Science Center, University of California, AC109, Box 1290, San Francisco, CA 94143, USA
    Magn Reson Imaging 22:523-8. 2004
    ..Using data from normal controls and the LCmodel quantification procedure, we found that the quantification precision, reproducibility and detection sensitivity of myo-inositol is significantly better at 3 T relative to 1.5 T...
  17. ncbi request reprint Design of symmetric-sweep spectral-spatial RF pulses for spectral editing
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 52:147-53. 2004
    ..5 T and 3 T. The spectral and spatial spin-echo profiles of the new pulses were measured experimentally. Spectra acquired in phantom experiments showed a well-resolved, edited lactate doublet, with 91% to 93% editing efficiency...
  18. ncbi request reprint Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
    Radhika Srinivasan
    Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
    Brain 128:1016-25. 2005
    ..001) myo-inositol levels in acute lesions compared with control white matter. These in vivo results support the hypothesis that altered glutamate metabolism is present in brains of multiple sclerosis patients...
  19. ncbi request reprint 1H MR spectroscopy using TE averaged PRESS: a more sensitive technique to detect neurodegeneration associated with Alzheimer's disease
    Ileana Hancu
    GE Global Research Center, One Research Circle, K1 NMR138, Niskayuna, NY 12309, USA
    Magn Reson Med 53:777-82. 2005
    ..This increased sensitivity enables new MR applications and, among other benefits, allows for smaller group sizes in drug trials, which can significantly reduce the cost of such trials...
  20. ncbi request reprint Detection of myoglobin desaturation in Mirounga angustirostris during apnea
    Paul J Ponganis
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093 0204, California, USA
    Am J Physiol Regul Integr Comp Physiol 282:R267-72. 2002
    ..The study establishes a firm methodological basis for using NMR to investigate the metabolic responses during sleep apnea of the elephant seal and to secure insights into oxygen regulation in diving mammals...

Research Grants2

  1. MR Spectroscopy to Study Brain Glutamate in HIV/AIDS and Methamphetamine Users
    Napapon Sailasuta; Fiscal Year: 2007
    ..Findings from the proposed research will guide me in my future research direction. ..