Research Topics
| Napapon SailasutaSummaryAffiliation: Huntington Medical Research Institutes Country: USA Publications
Research Grants
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Detail Information
Publications
Swift Acetate Glial Assay (SAGA): an accelerated human ¹³C MRS brain exam for clinical diagnostic useNapapon Sailasuta
Huntington Medical Research Institutes, Pasadena, CA, United States
J Magn Reson 207:352-5. 2010..6 min. Results obtained from the new short method (SAGA) were comparable to those achieved in a conventional, long method and effective for determination of glial metabolic rate in posterior-parietal and frontal brain regions...- Glial dysfunction in abstinent methamphetamine abusersNapapon Sailasuta
Clinical Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, California 91105, USA
J Cereb Blood Flow Metab 30:950-60. 2010.... 
Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patientsNapapon Sailasuta
Huntington Medical Research Institutes, Pasadena, CA, USA
NMR Biomed 22:326-31. 2009..Our findings suggest that Glu neurotransmission is abnormal and may be a key target for early interventions to reduce the later incidence of neurocognitive impairment and dementia among HIV-seropositive patients...- Regional variations and the effects of age and gender on glutamate concentrations in the human brainNapapon Sailasuta
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Magn Reson Imaging 26:667-75. 2008..Our results also highlight the importance of brain region, age and gender matching in clinical studies... - Clinical NOE 13C MRS for neuropsychiatric disorders of the frontal lobeNapapon Sailasuta
Huntington Medical Research Institutes, Clinical MRS Unit, 10 Pico Street, Pasadena, CA, USA
J Magn Reson 195:219-25. 2008..5 T. We predict these will be clinically useful biomarkers in many human neuropsychiatric and genetic conditions... - Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat modelMark D Lingwood
Department of Chemistry, University of California, Santa Barbara, Mesa Road, Santa Barbara, CA 93106, USA
Radiology 265:418-25. 2012..To assess the feasibility of a perfusion magnetic resonance (MR) imaging technique that uses Overhauser dynamic nuclear polarization (DNP) to provide contrast during the continuous delivery of hyperpolarized water in rats... - Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinateNiki M Zacharias
Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, California, USA
J Am Chem Soc 134:934-43. 2012.... - MR spectroscopy in diagnosis and neurological decision-makingVictor Xu
Clinical Magnetic Resonance Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
Semin Neurol 28:407-22. 2008..In this review, the authors explain the technical and neurochemical aspects of MRS and critically discuss its clinical neuroimaging applications... 
Application of NMR spectroscopy in medicinal chemistry and drug discoveryBrian Ross
Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
Curr Top Med Chem 11:93-114. 2011..Finally, recognizing that a known feature of MR is the lack of sensitivity, we describe new efforts to harness hyperpolarization, with its 50,000 signal amplification, to conventional MRS...- Change in brain magnetic resonance spectroscopy after treatment during acute HIV infectionNapapon Sailasuta
Huntington Medical Research Institutes, Pasadena, CA, USA
PLoS ONE 7:e49272. 2012..We used MRS to measure brain changes during the first weeks following HIV infection and in response to antiretroviral therapy (ART)... - Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary studyNapapon Sailasuta
Clinical MR Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
Neuropsychiatr Dis Treat 7:495-9. 2011..The value of (13)C MRS as an early, noninvasive biomarker may lie in the conduct of cost-effective clinical trials... - Reproducibility of GABA measurements using 2D J-resolved magnetic resonance spectroscopyKatherine Lymer
Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, UK
Magn Reson Imaging 25:634-40. 2007..In vivo, the CV for GABA measurement was 26%, suggesting that 2D J-resolved MRS would be suitable for detecting physiological changes in GABA, similar to those reported using other methods... - 1H MR spectroscopy using TE averaged PRESS: a more sensitive technique to detect neurodegeneration associated with Alzheimer's diseaseIleana Hancu
GE Global Research Center, One Research Circle, K1 NMR138, Niskayuna, NY 12309, USA
Magn Reson Med 53:777-82. 2005..This increased sensitivity enables new MR applications and, among other benefits, allows for smaller group sizes in drug trials, which can significantly reduce the cost of such trials... - Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 TRadhika Srinivasan
Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
Brain 128:1016-25. 2005..001) myo-inositol levels in acute lesions compared with control white matter. These in vivo results support the hypothesis that altered glutamate metabolism is present in brains of multiple sclerosis patients... - Design of symmetric-sweep spectral-spatial RF pulses for spectral editingCharles H Cunningham
Department of Electrical Engineering, Stanford University, Stanford, California, USA
Magn Reson Med 52:147-53. 2004..5 T and 3 T. The spectral and spatial spin-echo profiles of the new pulses were measured experimentally. Spectra acquired in phantom experiments showed a well-resolved, edited lactate doublet, with 91% to 93% editing efficiency... - A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brainRadhika Srinivasan
Magnetic Resonance Science Center, University of California, AC109, Box 1290, San Francisco, CA 94143, USA
Magn Reson Imaging 22:523-8. 2004..Using data from normal controls and the LCmodel quantification procedure, we found that the quantification precision, reproducibility and detection sensitivity of myo-inositol is significantly better at 3 T relative to 1.5 T... - Measurement of brain glutamate using TE-averaged PRESS at 3TRalph Hurd
GE Medical Systems, Menlo Park, California, USA
Magn Reson Med 51:435-40. 2004..A repeatibility error of <5%, and a coefficient of variation (CV) of <10% were observed for brain Glu levels in a study of six normal volunteers... - Detection of myoglobin desaturation in Mirounga angustirostris during apneaPaul J Ponganis
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093-0204, California, USA
Am J Physiol Regul Integr Comp Physiol 282:R267-72. 2002..The study establishes a firm methodological basis for using NMR to investigate the metabolic responses during sleep apnea of the elephant seal and to secure insights into oxygen regulation in diving mammals...
Research Grants
- MR Spectroscopy to Study Brain Glutamate in HIV/AIDS and Methamphetamine UsersNapapon Sailasuta; Fiscal Year: 2007..Findings from the proposed research will guide me in my future research direction. ..