Michael Harrington

Summary

Affiliation: Huntington Medical Research Institutes
Country: USA

Publications

  1. pmc Prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101, USA
    Dis Markers 22:73-81. 2006
  2. pmc Executive function changes before memory in preclinical Alzheimer's pathology: a prospective, cross-sectional, case control study
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, California, United States of America
    PLoS ONE 8:e79378. 2013
  3. pmc Blood serum alpha fetoprotein enhancer binding protein, a tumor suppressor, decreases in chronic HBV hepatitis patients as hepatocellular cancer appears
    James N Riggins
    Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Dis Markers 28:125-35. 2010
  4. pmc Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case-control study
    Alfred N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 N El Molino Ave, Pasadena, CA 91101, USA
    J Headache Pain 14:60. 2013
  5. pmc Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat
    Xianghong Arakaki
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 N, El Molino Avenue, Pasadena, CA, 91101, USA
    Fluids Barriers CNS 10:14. 2013
  6. pmc Sodium MRI in a rat migraine model and a NEURON simulation study support a role for sodium in migraine
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101, USA
    Cephalalgia 31:1254-65. 2011
  7. pmc Cerebrospinal fluid sodium rhythms
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, 91101, USA
    Cerebrospinal Fluid Res 7:3. 2010
  8. pmc The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid
    Michael G Harrington
    Molecular Neurology, Huntington Medical Research Institutes, Pasadena, CA, 91101 USA
    Cerebrospinal Fluid Res 6:10. 2009
  9. pmc Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods
    Alfred N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Dis Markers 22:39-64. 2006
  10. doi request reprint Modulation of neuronal activity and plasma membrane properties with low-power millimeter waves in organotypic cortical slices
    Victor Pikov
    Neural Engineering Program, Huntington Medial Research Institutes, Pasadena, CA, USA
    J Neural Eng 7:045003. 2010

Research Grants

  1. Clinical and molecular pathophysiology of headache
    Michael Harrington; Fiscal Year: 2003
  2. Clinical and molecular pathophysiology of headache
    Michael Harrington; Fiscal Year: 2006

Collaborators

  • Alfred N Fonteh
  • Victor Pikov
  • Xianghong Arakaki
  • James N Riggins
  • Elizabeth Loder
  • Andreas F Huhmer
  • Dan Levy
  • Jiarong Chiang
  • Matthew Techy
  • Paige McCleary
  • Brian Armstrong
  • Linus Kuo
  • William Corey
  • Michael Cutrer
  • Heidi Amato
  • Peter Sandor
  • Roger G Biringer
  • Boukje de Vries

Detail Information

Publications14

  1. pmc Prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101, USA
    Dis Markers 22:73-81. 2006
    ..It is concluded that qualitative and quantitative fluctuations of cerebrospinal fluid PTGDS isoforms reflect both major and subtle brain pathophysiology...
  2. pmc Executive function changes before memory in preclinical Alzheimer's pathology: a prospective, cross-sectional, case control study
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, California, United States of America
    PLoS ONE 8:e79378. 2013
    ..Our hypothesis is that neuropsychological changes within the normal range will help to predict preclinical disease and locate early pathology...
  3. pmc Blood serum alpha fetoprotein enhancer binding protein, a tumor suppressor, decreases in chronic HBV hepatitis patients as hepatocellular cancer appears
    James N Riggins
    Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Dis Markers 28:125-35. 2010
    ..These data suggest that rising AFPebp levels in chronic HBV hepatitis may be protective, while falling levels may contribute to HCC development...
  4. pmc Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case-control study
    Alfred N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 N El Molino Ave, Pasadena, CA 91101, USA
    J Headache Pain 14:60. 2013
    ..Here, we examined whether PC-PLC activity from a larger group of well-state migraineurs is related to the number of their migraine comorbidities...
  5. pmc Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat
    Xianghong Arakaki
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 N, El Molino Avenue, Pasadena, CA, 91101, USA
    Fluids Barriers CNS 10:14. 2013
    ..Since Na,K-ATPase isoforms have different locations and physiological roles, our objective was to establish which alpha isoforms are present at sites where sodium homeostasis is disrupted...
  6. pmc Sodium MRI in a rat migraine model and a NEURON simulation study support a role for sodium in migraine
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101, USA
    Cephalalgia 31:1254-65. 2011
    ..We used ultra-high field MRI to investigate cranial sodium in a rat migraine model, and simulated the effects of extracellular sodium on neuronal excitability...
  7. pmc Cerebrospinal fluid sodium rhythms
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, 91101, USA
    Cerebrospinal Fluid Res 7:3. 2010
    ..The physiological importance of sodium in the nervous system suggests that these rhythms may have additional repercussions on ultradian functions...
  8. pmc The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid
    Michael G Harrington
    Molecular Neurology, Huntington Medical Research Institutes, Pasadena, CA, 91101 USA
    Cerebrospinal Fluid Res 6:10. 2009
    ..However, synthesis and transport mechanisms for such signaling are not defined. The purpose of this study was to investigate whether human CSF contains discrete structures that may enable the regulation of humoral transmission...
  9. pmc Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods
    Alfred N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Dis Markers 22:39-64. 2006
    ..Combining lipidomics and proteomics will enhance existing knowledge of disease pathology and increase the likelihood of discovering specific markers and biochemical mechanisms of brain diseases...
  10. doi request reprint Modulation of neuronal activity and plasma membrane properties with low-power millimeter waves in organotypic cortical slices
    Victor Pikov
    Neural Engineering Program, Huntington Medial Research Institutes, Pasadena, CA, USA
    J Neural Eng 7:045003. 2010
    ..Implication of these findings for the therapeutic modulation of neuronal excitability is discussed...
  11. ncbi request reprint Cerebrospinal profiling of proteins, lipids, small molecules, and elements: application to the study of migraine pathophysiology
    Michael G Harrington
    Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101, USA
    Headache 46:S9-12. 2006
    ....
  12. ncbi request reprint Cerebrospinal fluid biomarkers in primary headache disorders
    Michael G Harrington
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101, USA
    Headache 46:1075-87. 2006
    ..The object of this review is to examine the published literature for cerebrospinal fluid laboratory measures of primary headache disorders to identify biomarkers and provide recommendations for future biomarker discovery...
  13. ncbi request reprint Selected confirmed, probable, and exploratory migraine biomarkers
    Elizabeth Loder
    Harvard Medical School and the John R Graham Headache Centre, Department of Neurology, Brigham and Women s Faulkner Hospital, Boston, MA, USA
    Headache 46:1108-27. 2006
  14. pmc Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challenges
    Andreas F Huhmer
    Proteomics, Finnigan Mass Spectrometry, Thermo Electron, San Jose, CA 95134, USA
    Dis Markers 22:3-26. 2006
    ..We also discuss necessary development in methodology in order to have the highest impact on the study of the molecular composition of CSF proteins...

Research Grants4

  1. Clinical and molecular pathophysiology of headache
    Michael Harrington; Fiscal Year: 2003
    ..Delineation of these compositional differences should extend our pathophysiological understanding beyond the current theories, yield useful biomarkers and lead to more knowledge-based remedies or interventions. ..
  2. Clinical and molecular pathophysiology of headache
    Michael Harrington; Fiscal Year: 2006
    ..Delineation of these compositional differences should extend our pathophysiological understanding beyond the current theories, yield useful biomarkers and lead to more knowledge-based remedies or interventions. ..