Pratip Bhattacharya

Summary

Affiliation: Huntington Medical Research Institutes
Country: USA

Publications

  1. pmc Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice
    Pratip Bhattacharya
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    NMR Biomed 24:1023-8. 2011
  2. doi request reprint Cardiovascular applications of hyperpolarized contrast media and metabolic tracers
    Pratip Bhattacharya
    Enhanced MR Laboratory, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105
    Exp Biol Med (Maywood) 234:1395-416. 2009
  3. pmc Quality assurance of PASADENA hyperpolarization for 13C biomolecules
    Jan Bernd Hövener
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    MAGMA 22:123-34. 2009
  4. pmc Hyperpolarized (1)H NMR employing low gamma nucleus for spin polarization storage
    Eduard Y Chekmenev
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, California 91105, USA
    J Am Chem Soc 131:3164-5. 2009
  5. pmc PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy
    Eduard Y Chekmenev
    A A Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 130:4212-3. 2008
  6. pmc Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model
    Mark D Lingwood
    Department of Chemistry, University of California, Santa Barbara, Mesa Road, Santa Barbara, CA 93106, USA
    Radiology 265:418-25. 2012
  7. pmc PASADENA hyperpolarization of 13C biomolecules: equipment design and installation
    Jan Bernd Hövener
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    MAGMA 22:111-21. 2009
  8. pmc Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate
    Niki M Zacharias
    Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, California, USA
    J Am Chem Soc 134:934-43. 2012
  9. pmc Fluorine-19 NMR chemical shift probes molecular binding to lipid membranes
    Eduard Y Chekmenev
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    J Phys Chem B 112:6285-7. 2008
  10. ncbi request reprint Clinical experience with 13C MRS in vivo
    Brian Ross
    Huntington Medical Research Institutes, 660 S Fair Oaks Avenue, Pasadena, CA 91105, USA
    NMR Biomed 16:358-69. 2003

Collaborators

  • William H Perman
  • Napapon Sailasuta
  • Shawn Wagner
  • Brian Ross
  • Thao T Tran
  • Eduard Y Chekmenev
  • Jan Bernd Hövener
  • Daniel P Weitekamp
  • Kent Harris
  • Mark D Lingwood
  • Henry R Chan
  • Niki M Zacharias
  • Kent C Harris
  • Valerie A Norton
  • Ting Ann Siaw
  • SongI Han
  • Osama A Abulseoud
  • Larry W Robertson
  • Lynne S Batchelder
  • Daniel Tofan
  • Jan Hovener
  • Siu Kei Chow
  • Willis Wong
  • Alexander Lin

Detail Information

Publications13

  1. pmc Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice
    Pratip Bhattacharya
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    NMR Biomed 24:1023-8. 2011
    ..TFPP therefore has the potential to act as an in vivo molecular probe for atheromatous plaque imaging and may serve as a model of receptor-targeted bio-imaging with enhanced MR sensitivity...
  2. doi request reprint Cardiovascular applications of hyperpolarized contrast media and metabolic tracers
    Pratip Bhattacharya
    Enhanced MR Laboratory, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105
    Exp Biol Med (Maywood) 234:1395-416. 2009
    ..These facts and considerations will help in the interpretation of the in vivo recorded hyperpolarization signals of metabolic tracers and contrast media...
  3. pmc Quality assurance of PASADENA hyperpolarization for 13C biomolecules
    Jan Bernd Hövener
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    MAGMA 22:123-34. 2009
    ..Define MR quality assurance procedures for maximal PASADENA hyperpolarization of a biological (13)C molecular imaging reagent...
  4. pmc Hyperpolarized (1)H NMR employing low gamma nucleus for spin polarization storage
    Eduard Y Chekmenev
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, California 91105, USA
    J Am Chem Soc 131:3164-5. 2009
    ..9 and 6.5, respectively. The low gamma nuclei exemplified here by (13)C with a T(1) of tens of seconds acts as an efficient spin polarization storage, while J-coupled protons are better for NMR detection...
  5. pmc PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy
    Eduard Y Chekmenev
    A A Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 130:4212-3. 2008
    ..7 T is measured as 27 s in H2O and 56 s in D2O. Together with known rates of succinate uptake in kidneys, this allows an estimate of the prospects for the molecular spectroscopy of metabolism...
  6. pmc Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model
    Mark D Lingwood
    Department of Chemistry, University of California, Santa Barbara, Mesa Road, Santa Barbara, CA 93106, USA
    Radiology 265:418-25. 2012
    ..To assess the feasibility of a perfusion magnetic resonance (MR) imaging technique that uses Overhauser dynamic nuclear polarization (DNP) to provide contrast during the continuous delivery of hyperpolarized water in rats...
  7. pmc PASADENA hyperpolarization of 13C biomolecules: equipment design and installation
    Jan Bernd Hövener
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    MAGMA 22:111-21. 2009
    ..The present paper describes equipment designed for rapid production of six to eight liquid samples per hour with high reproducibility of hyperpolarization...
  8. pmc Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate
    Niki M Zacharias
    Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, California, USA
    J Am Chem Soc 134:934-43. 2012
    ....
  9. pmc Fluorine-19 NMR chemical shift probes molecular binding to lipid membranes
    Eduard Y Chekmenev
    Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    J Phys Chem B 112:6285-7. 2008
    ..The potential in vitro and in vivo biomedical applications are outlined. The presented method is applicable with the conventional NMR equipment, magnetic fields of several Tesla, stationary samples, and natural abundance isotopes...
  10. ncbi request reprint Clinical experience with 13C MRS in vivo
    Brian Ross
    Huntington Medical Research Institutes, 660 S Fair Oaks Avenue, Pasadena, CA 91105, USA
    NMR Biomed 16:358-69. 2003
    ..Despite low inherent signal-to-noise, natural abundance (13)C MRS showed diagnostic promise. (13)C MRS is feasible in a clinical setting, at reasonable cost in neonates, children, adults and elderly patients...
  11. pmc Towards hyperpolarized (13)C-succinate imaging of brain cancer
    Pratip Bhattacharya
    MR Unit, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    J Magn Reson 186:150-5. 2007
    ..These ex vivo results indicate that hyperpolarized (13)C sodium succinate may become a useful tool for rapid in vivo identification of brain tumors, providing novel biomarkers in (13)C MR spectral-spatial images...
  12. ncbi request reprint Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia
    Kent Harris
    Magnetic Resonance Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Adv Exp Med Biol 576:263-73; discussion 361-3. 2006
  13. ncbi request reprint Application of NMR spectroscopy in medicinal chemistry and drug discovery
    Brian Ross
    Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Curr Top Med Chem 11:93-114. 2011
    ..Finally, recognizing that a known feature of MR is the lack of sensitivity, we describe new efforts to harness hyperpolarization, with its 50,000 signal amplification, to conventional MRS...