Millie Hughes-Fulford

Summary

Country: USA

Publications

  1. ncbi Signal transduction and mechanical stress
    Millie Hughes-Fulford
    Laboratory of Cell Growth, Department of Medicine, Veterans Affairs Medical Center, University of California, and Northern California Institute for Research and Education, San Francisco, CA 94121, USA
    Sci STKE 2004:RE12. 2004
  2. ncbi Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells
    Millie Hughes-Fulford
    Laboratory of Cell Growth, Mail Code 151F, Department of Medicine, Northern California Institute for Research and Education and Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Carcinogenesis 26:1520-6. 2005
  3. ncbi Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer
    Millie Hughes-Fulford
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 91421, USA
    Cancer Res 66:1427-33. 2006
  4. ncbi Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
    Chai Fei Li
    Laboratory of Cell Growth, Northern California Institute for Research and Education, San Francisco, California, USA
    J Bone Miner Res 21:946-55. 2006
  5. ncbi The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization
    Millie Hughes-Fulford
    Department of Research, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Orthop Surg Res 6:8. 2011
  6. ncbi Lessons learned about spaceflight and cell biology experiments
    Millie Hughes-Fulford
    Northern California Institute for Research and Education, San Francisco, CA, USA
    J Gravit Physiol 11:105-9. 2004
  7. ncbi Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer
    June M Chan
    Department of Urology, University of California San Francisco, 1450 3rd Street, San Francisco, CA 94158 9001, USA
    Cancer Causes Control 22:141-50. 2011
  8. ncbi Polyunsaturated fatty acids and peripheral artery disease
    S Marlene Grenon
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94121, USA
    Vasc Med 17:51-63. 2012
  9. ncbi Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes
    Tammy T Chang
    Department of Surgery, University of California, San Francisco, San Francisco, California 94121, USA
    Tissue Eng Part A 15:559-67. 2009
  10. ncbi Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity
    Millie Hughes-Fulford
    Northern California Institute for Research and Education, San Francisco, California, USA
    J Cell Biochem 99:435-49. 2006

Collaborators

Detail Information

Publications14

  1. ncbi Signal transduction and mechanical stress
    Millie Hughes-Fulford
    Laboratory of Cell Growth, Department of Medicine, Veterans Affairs Medical Center, University of California, and Northern California Institute for Research and Education, San Francisco, CA 94121, USA
    Sci STKE 2004:RE12. 2004
    ..Here, we examine the various types of stress and the sequential response of transduction pathways that result in changes in gene expression and the ensuing proliferation of osteoblasts...
  2. ncbi Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells
    Millie Hughes-Fulford
    Laboratory of Cell Growth, Mail Code 151F, Department of Medicine, Northern California Institute for Research and Education and Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Carcinogenesis 26:1520-6. 2005
    ..Since cPLA2 is upstream in the eicosanoid pathway, it may be a good alternative for a pharmaceutical target for the treatment of cancer...
  3. ncbi Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer
    Millie Hughes-Fulford
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 91421, USA
    Cancer Res 66:1427-33. 2006
    ..Taken together, the data suggest that arachidonic acid via conversion to PGE(2) plays an important role in stimulation of growth-related genes and proliferation via PI3K signaling and NF-kappaB translocation to the nucleus...
  4. ncbi Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
    Chai Fei Li
    Laboratory of Cell Growth, Northern California Institute for Research and Education, San Francisco, California, USA
    J Bone Miner Res 21:946-55. 2006
    ..The induction of fgf-2 is mediated by PKA and ERK pathways...
  5. ncbi The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization
    Millie Hughes-Fulford
    Department of Research, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Orthop Surg Res 6:8. 2011
    ..Here we describe the sequential roles of FGF-2 in inducing gene expression, cell growth and BMP-2 in gene expression and mineralization of bone...
  6. ncbi Lessons learned about spaceflight and cell biology experiments
    Millie Hughes-Fulford
    Northern California Institute for Research and Education, San Francisco, CA, USA
    J Gravit Physiol 11:105-9. 2004
    ..Finally, spaceflight experiments are rewarding and worth your effort and patience...
  7. ncbi Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer
    June M Chan
    Department of Urology, University of California San Francisco, 1450 3rd Street, San Francisco, CA 94158 9001, USA
    Cancer Causes Control 22:141-50. 2011
    ....
  8. ncbi Polyunsaturated fatty acids and peripheral artery disease
    S Marlene Grenon
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94121, USA
    Vasc Med 17:51-63. 2012
    ..The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review...
  9. ncbi Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes
    Tammy T Chang
    Department of Surgery, University of California, San Francisco, San Francisco, California 94121, USA
    Tissue Eng Part A 15:559-67. 2009
    ..These findings illustrate the importance of physical environment on cellular organization and its effects on hepatocyte processes...
  10. ncbi Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity
    Millie Hughes-Fulford
    Northern California Institute for Research and Education, San Francisco, California, USA
    J Cell Biochem 99:435-49. 2006
    ..Life on this planet has evolved in a normal gravity field and these data suggest that gravity plays a significant role in regulation of osteoblast transcription...
  11. ncbi The role of signaling pathways in osteoblast gravity perception
    Millie Hughes-Fulford
    Lab of Cell Growth, Department of Veteran s Affairs Medical Center and University of California San Francisco, San Francisco, CA 94121, USA lab site www spacedu com
    J Gravit Physiol 9:P257-60. 2002
    ..The secondary signal may include growth factor related kinases such as ERK, p38 and JNK map kinase (MAPK) pathways. Experimental evidence suggests that normal osteoblast response to stress and sera requires normal earth gravity...
  12. ncbi Glycosylation regulates turnover of cyclooxygenase-2
    Mary B Sevigny
    Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA 94901, USA
    FEBS Lett 580:6533-6. 2006
    ..Thus, COX-2 turnover appears to depend upon glycosylation of the 72kDa glycoform...
  13. ncbi Physiological effects of microgravity on osteoblast morphology and cell biology
    Millie Hughes-Fulford
    U CA, San Francisco
    Adv Space Biol Med 8:129-57. 2002
  14. ncbi A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway
    Jason P Hatton
    U CA, San Francisco
    J Bone Miner Res 18:58-66. 2003
    ..001). These studies suggest that short periods of physiological mechanical stress induce immediate early gene expression and growth in MC3T3-E1 osteoblasts primarily through an ERK 1/2-mediated pathway...