W J Hrushesky

Summary

Country: USA

Publications

  1. ncbi request reprint Seasonal modulation of post-resection breast cancer metastasis
    Eun Young Oh
    Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, USA
    Breast Cancer Res Treat 111:219-28. 2008
  2. pmc Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients
    Michael Retsky
    Department of Surgical Research, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Breast Cancer Res 6:R372-4. 2004
  3. pmc Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour
    Romano Demicheli
    Istituto Nazionale Tumori, Milano, Italy
    Breast Cancer Res 6:R689-96. 2004
  4. pmc Hypothesis: primary antiangiogenic method proposed to treat early stage breast cancer
    Michael W Retsky
    Department of Vascular Biology, Children s Hospital and Harvard Medical School, Boston 02115, MA, USA
    BMC Cancer 9:7. 2009
  5. ncbi request reprint Season, sun, sex, and cervical cancer
    William J M Hrushesky
    Department of Epidemiology and Biostatistics, Norman J Arnold of Public Health, University of South Carolina, Columbia, SC 29209, USA
    Cancer Epidemiol Biomarkers Prev 14:1940-7. 2005
  6. ncbi request reprint The temporal organization of life: the impact of multi-frequency non-linear biologic time structure upon the host-cancer balance
    W J Hrushesky
    WJB Dorn Veterans Affairs Medical Center and University of South Carolina School of Medicine, Columbia 29209, USA
    Jpn J Clin Oncol 30:529-33. 2000
  7. ncbi request reprint Tumor chronobiology
    W J Hrushesky
    WJB Dorn VA Medical Center, and the School of Medicine and Norman J Arnold School of Public Health of the University of South Carolina, Columbia, 29209, USA
    J Control Release 74:27-30. 2001
  8. doi request reprint Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm
    Xiaoming Yang
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Breast Cancer Res Treat 117:423-31. 2009
  9. doi request reprint The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day
    Xiaoming Yang
    Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, South Carolina 29209, USA
    Chronobiol Int 26:1323-39. 2009
  10. doi request reprint Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice
    Xiaoming Yang
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, University of South Carolina, Columbia, SC, USA
    J Biochem 145:289-97. 2009

Research Grants

  1. CORE--PATHOLOGY
    William Hrushesky; Fiscal Year: 2002

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Seasonal modulation of post-resection breast cancer metastasis
    Eun Young Oh
    Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, USA
    Breast Cancer Res Treat 111:219-28. 2008
    ..In order to better understand this seasonal cancer biology, we investigated the circannual pattern of post-resection breast cancer metastasis, under genetically and environmentally controlled conditions...
  2. pmc Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients
    Michael Retsky
    Department of Surgical Research, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Breast Cancer Res 6:R372-4. 2004
    ..We could imagine that it also plays a role in adjuvant chemotherapy effectiveness since, perhaps not coincidentally, this is most beneficial for premenopausal node-positive patients...
  3. pmc Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour
    Romano Demicheli
    Istituto Nazionale Tumori, Milano, Italy
    Breast Cancer Res 6:R689-96. 2004
    ..Information on the metastasis process in breast cancer patients undergoing primary tumour removal may be extracted from an analysis of the timing of clinical recurrence...
  4. pmc Hypothesis: primary antiangiogenic method proposed to treat early stage breast cancer
    Michael W Retsky
    Department of Vascular Biology, Children s Hospital and Harvard Medical School, Boston 02115, MA, USA
    BMC Cancer 9:7. 2009
    ..If that is so, it seems possible that we could suggest a primary antiangiogenic therapy but the problem then arises that starting a therapy before surgery would interfere with wound healing...
  5. ncbi request reprint Season, sun, sex, and cervical cancer
    William J M Hrushesky
    Department of Epidemiology and Biostatistics, Norman J Arnold of Public Health, University of South Carolina, Columbia, SC 29209, USA
    Cancer Epidemiol Biomarkers Prev 14:1940-7. 2005
    ..We now investigate whether premalignant and malignant cervical epithelial changes are also seasonal and related to seasonal sunlight fluency...
  6. ncbi request reprint The temporal organization of life: the impact of multi-frequency non-linear biologic time structure upon the host-cancer balance
    W J Hrushesky
    WJB Dorn Veterans Affairs Medical Center and University of South Carolina School of Medicine, Columbia 29209, USA
    Jpn J Clin Oncol 30:529-33. 2000
    ..Examples of the kinds of thinking and experiments necessary to exploit this new paradigm are provided...
  7. ncbi request reprint Tumor chronobiology
    W J Hrushesky
    WJB Dorn VA Medical Center, and the School of Medicine and Norman J Arnold School of Public Health of the University of South Carolina, Columbia, 29209, USA
    J Control Release 74:27-30. 2001
    ..They are predictable resonating dynamic systems, which require different amounts of drug at predictably different times within the circadian cycle in order to maximize desired and minimize undesired drug effects...
  8. doi request reprint Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm
    Xiaoming Yang
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Breast Cancer Res Treat 117:423-31. 2009
    ..Therefore, Per2 and perhaps other clock genes represent a new class of potential therapeutic targets whose manipulation will modulate cancer growth and cancer cell proliferation...
  9. doi request reprint The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day
    Xiaoming Yang
    Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, South Carolina 29209, USA
    Chronobiol Int 26:1323-39. 2009
    ..The data of the study suggest Per1 has tumor-suppressor function that diminishes cancer proliferation and tumor growth, but only at specific times of day...
  10. doi request reprint Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice
    Xiaoming Yang
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, University of South Carolina, Columbia, SC, USA
    J Biochem 145:289-97. 2009
    ..These findings suggest that disruption of the peripheral intestinal circadian clock may be intimately involved in beta-catenin induced intestinal epithelial neoplastic transformation in both mouse and man...
  11. ncbi request reprint Circadian coordination of cancer growth and metastatic spread
    W J Hrushesky
    Stratton VAMC 111 C, Albany, NY, USA
    Int J Cancer 83:365-73. 1999
    ..Similar to the fibrosarcoma data, the daily sleep/wake boundary was the time of day associated with the greatest resistance to metastatic spread...
  12. ncbi request reprint Fertility maintenance and 5-fluorouracil timing within the mammalian fertility cycle
    W J Hrushesky
    Department of Medicine, Albany Medical College, Stratton VA Medical Center, NY 12208, USA
    Reprod Toxicol 13:413-20. 1999
    ..It is concluded that optimizing the fertility cycle timing of 5-FU (e.g., during the periovulatory, proestrous stage) diminishes the frequency and severity of long-term reproductive damage...
  13. doi request reprint Period 2 mutation accelerates ApcMin/+ tumorigenesis
    Patricia A Wood
    Medical Chronobiology Laboratory, Dorn Research Institute, Columbia, South Carolina, USA
    Mol Cancer Res 6:1786-93. 2008
    ....
  14. ncbi request reprint Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index
    Patricia A Wood
    William Jennings Bryan Dorn Veterans Affairs Medical Center, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, 29209, USA
    Mol Cancer Ther 5:2023-33. 2006
    ....
  15. doi request reprint Clock genes and cancer
    Patricia A Wood
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Integr Cancer Ther 8:303-8. 2009
    ..PERIOD proteins may offer new targets for cancer prevention and control...
  16. ncbi request reprint Sun exposure, sexual behavior and uterine cervical human papilloma virus
    William J M Hrushesky
    Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina School of Medicine, Columbia, SC, USA
    Int J Biometeorol 50:167-73. 2006
    ..Confirming this relationship elsewhere may be important, because whatever the risk conferred by sunlight is, in principle, behaviorally avoidable...
  17. ncbi request reprint Daily coordination of cancer growth and circadian clock gene expression
    Shaojin You
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center and the School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Breast Cancer Res Treat 91:47-60. 2005
    ..These same genes are also rhythmically expressed each day within each peripheral tissue...
  18. doi request reprint Circadian time-dependent tumor suppressor function of period genes
    Xiaoming Yang
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, Columbia, SC, USA
    Integr Cancer Ther 8:309-16. 2009
    ..These data suggest that the therapeutic efficacy of antiproliferation agents depends on the time of day of drug delivery. The optimal times of day may be shifted in tumors that have mutant Period genes...
  19. pmc Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice
    Shaojin You
    Center for Colon Cancer Research, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center 151, Columbia, SC 29209, USA
    Int J Exp Pathol 87:227-36. 2006
    ....
  20. pmc Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control
    Xiaoming Yang
    Medical Chronobiology Laboratory, Wm Jennings Bryan Dorn Veterans Affairs Medical Center, Columbia, SC 29209, USA
    J Biol Chem 285:3030-4. 2010
    ..TIM is, thereby, a potential novel anticancer drug target whose inhibition may enhance the therapeutic cytotoxicity of agents that activate DNA damage pathways as part of their mechanism...
  21. doi request reprint Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms
    William J M Hrushesky
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, Columbia, SC 29209, USA
    Integr Cancer Ther 8:387-97. 2009
    ..These drugs and strategies can, in turn, be used to make cancer patients with advanced disease feel and function more normally...
  22. doi request reprint Global breast cancer seasonality
    Eun Young Oh
    Medical Chronobiological Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, School of Medicine and School of Public Health, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Breast Cancer Res Treat 123:233-43. 2010
    ..Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration...
  23. ncbi request reprint Circadian chemotherapy for gynecological and genitourinary cancers
    Minoru Kobayashi
    WJB Dorn VA Medical Center Department of Developmental Biology and Anatomy, The University of South Carolina School of Medicine, Columbia 29209, USA
    Chronobiol Int 19:237-51. 2002
    ..In summary, the timing of anthracycline, platinum, and fluoropyrimidine-based drug therapies during the 24h is relevant to the toxic therapeutic ratio of these agents in the treatment of gynecologic and genitourinary cancers...
  24. ncbi request reprint Sex cycle modulates cancer growth
    Patricia A Wood
    WJB Dorn VA Medical Center, and the University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 20209, USA
    Breast Cancer Res Treat 91:95-102. 2005
    ..There is strong support for the former in large retrospective studies of surgical resection timing within the menstrual cycle and the following experiments were conducted to critically evaluate the latter...
  25. ncbi request reprint Allometric scaling law questions the traditional mechanical model for axillary lymph node involvement in breast cancer
    Romano Demicheli
    Department of Medical Oncology, Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 24:4391-6. 2006
    ..To find a quantitative relationship between tumor size and frequency of axillary lymph node involvement...
  26. ncbi request reprint Screening and breast cancer
    Michael W Retsky
    N Engl J Med 354:767-9; author reply 767-9. 2006
  27. ncbi request reprint Menopausal status dependence of early mortality reduction due to diagnosis of smaller breast cancers (T1 v T2-T3): relevance to screening
    Romano Demicheli
    Istituto Nazionale Tumori, Department of Medical Oncology, Via Venezian 1, 20137 Milan, Italy
    J Clin Oncol 22:102-7. 2004
    ..To provide data relevant to the paradoxical mortality excess for women age 40 to 49 years observed during the first 6 to 8 years in the invited group in all mammography screening studies...
  28. ncbi request reprint Comment to Anderson WF, Jatoi I, Devesa SS: distinct breast cancer incidence and prognostic patterns in the NCI'S SEER program: suggesting a possible link between etiology and outcome. Breast Cancer Res Treat 90:127-137, 2005
    Romano Demicheli
    Breast Cancer Res Treat 97:341-3. 2006

Research Grants2

  1. CORE--PATHOLOGY
    William Hrushesky; Fiscal Year: 2002
    ..core abstract not provided ..