Ao Yuan

Summary

Affiliation: Howard University
Country: USA

Publications

  1. pmc A novel approach for the simultaneous analysis of common and rare variants in complex traits
    Ao Yuan
    National Human Genome Center, Howard University, Washington DC, USA
    Bioinform Biol Insights 6:1-9. 2012
  2. ncbi request reprint Two new recursive likelihood calculation methods for genetic analysis
    Ao Yuan
    National Human Genome Center, Howard University, Statistical Genetics and Bioinformatics Unit, Washington DC, USA
    Hum Hered 54:82-98. 2002
  3. ncbi request reprint An extension of the weighted dissimilarity test to association study in families
    Ao Yuan
    National Human Genome Center, Department of Community Health and Family Medicine, Howard University, Washington, DC 20059, USA
    Hum Genet 122:83-94. 2007
  4. ncbi request reprint Detecting disease gene in DNA haplotype sequences by nonparametric dissimilarity test
    Ao Yuan
    National Human Genome Center, Department of Community Health and Family Medicine, Howard University, Washington, DC, USA
    Hum Genet 120:253-61. 2006
  5. ncbi request reprint Variance components model with disequilibria
    Ao Yuan
    National Human Genome Center, Howard University, Washington DC 20059, USA
    Eur J Hum Genet 14:941-52. 2006
  6. pmc A study of genetic association with electrophysiological measures related to alcoholism: GAW14 data
    Ao Yuan
    National Human Genome Center, Howard University, Washington, DC, USA
    BMC Genet 6:S126. 2005
  7. ncbi request reprint A statistical framework for haplotype block inference
    Ao Yuan
    Statistical Genetics and Bioinformatics Unit, Howard University, Washington, DC 20059, USA
    J Bioinform Comput Biol 3:1021-38. 2005
  8. pmc Identifying the susceptibility gene(s) in a set of trait-linked genes using genotype data
    Ao Yuan
    Statistical Genetics and Bioinformatics Unit, National Human Genome Center, Howard University, Washington, DC 20059, USA
    Genetics 167:1445-59. 2004
  9. ncbi request reprint Genetic network analysis by quasi-bayesian method
    Ao Yuan
    National Human Genome Center, Howard University, 2216 Sixth Street, N W, Suite 206, Washington, DC 20059, USA
    J Bioinform Comput Biol 7:175-92. 2009
  10. pmc Bayes factor based on the trend test incorporating Hardy-Weinberg disequilibrium: more power to detect genetic association
    Jinfeng Xu
    Department of Statistics and Applied Probability, National University of Singapore, Singapore
    Ann Hum Genet 76:301-11. 2012

Detail Information

Publications17

  1. pmc A novel approach for the simultaneous analysis of common and rare variants in complex traits
    Ao Yuan
    National Human Genome Center, Howard University, Washington DC, USA
    Bioinform Biol Insights 6:1-9. 2012
    ..We found common and rare variants associated with both traits, consistent with published results...
  2. ncbi request reprint Two new recursive likelihood calculation methods for genetic analysis
    Ao Yuan
    National Human Genome Center, Howard University, Statistical Genetics and Bioinformatics Unit, Washington DC, USA
    Hum Hered 54:82-98. 2002
    ..These methods can also be used in other model-based analyses. These methods are implemented in G.E.M.S., the genetic epidemiology models software...
  3. ncbi request reprint An extension of the weighted dissimilarity test to association study in families
    Ao Yuan
    National Human Genome Center, Department of Community Health and Family Medicine, Howard University, Washington, DC 20059, USA
    Hum Genet 122:83-94. 2007
    ..001 or lower) for association with alcoholism. Our work can serve as a guide in the design of association studies in families...
  4. ncbi request reprint Detecting disease gene in DNA haplotype sequences by nonparametric dissimilarity test
    Ao Yuan
    National Human Genome Center, Department of Community Health and Family Medicine, Howard University, Washington, DC, USA
    Hum Genet 120:253-61. 2006
    ..Simulation studies indicate that our test statistic overcomes the weakness of the existing ones and is robust and powerful as well...
  5. ncbi request reprint Variance components model with disequilibria
    Ao Yuan
    National Human Genome Center, Howard University, Washington DC 20059, USA
    Eur J Hum Genet 14:941-52. 2006
    ..Simulation studies suggest that this extended model improves inference significantly over the existing models when deviations of these disequilibria are present...
  6. pmc A study of genetic association with electrophysiological measures related to alcoholism: GAW14 data
    Ao Yuan
    National Human Genome Center, Howard University, Washington, DC, USA
    BMC Genet 6:S126. 2005
    ..86, respectively. These results show that the partial answer to our starting question for this brief analysis is that the NTTH phenotypes are not jointly genetically controlled. The component ntth1 displays marked genetic linkage...
  7. ncbi request reprint A statistical framework for haplotype block inference
    Ao Yuan
    Statistical Genetics and Bioinformatics Unit, Howard University, Washington, DC 20059, USA
    J Bioinform Comput Biol 3:1021-38. 2005
    ..The algorithm is linear in the number of loci, instead of NP-hard for many such algorithms. We illustrate the applications of our method to both simulated and real data sets...
  8. pmc Identifying the susceptibility gene(s) in a set of trait-linked genes using genotype data
    Ao Yuan
    Statistical Genetics and Bioinformatics Unit, National Human Genome Center, Howard University, Washington, DC 20059, USA
    Genetics 167:1445-59. 2004
    ..This method can be used for singleton data, relative pair data, or general pedigree data. We have applied the method to simulated data as well as a real data set; it gives satisfactory results...
  9. ncbi request reprint Genetic network analysis by quasi-bayesian method
    Ao Yuan
    National Human Genome Center, Howard University, 2216 Sixth Street, N W, Suite 206, Washington, DC 20059, USA
    J Bioinform Comput Biol 7:175-92. 2009
    ..This method is simple to use, permits information updating, is flexible to incorporate desired features, and has closed-form solution. Simulation studies show that the model fits the data quite well...
  10. pmc Bayes factor based on the trend test incorporating Hardy-Weinberg disequilibrium: more power to detect genetic association
    Jinfeng Xu
    Department of Statistics and Applied Probability, National University of Singapore, Singapore
    Ann Hum Genet 76:301-11. 2012
    ..We discuss how to use each of them and how to specify priors. Simulation studies and applications to three GWAS are provided to illustrate their usefulness to detect nonadditive gene susceptibility in practice...
  11. pmc Genome scan linkage analysis comparing microsatellites and single-nucleotide polymorphisms markers for two measures of alcoholism in chromosomes 1, 4, and 7
    Guanjie Chen
    National Human Genome Center, College of Medicine, Howard University, Washington, DC, USA
    BMC Genet 6:S4. 2005
    ..Finally, results of all SNP analyses were compared with those obtained using microsatellite markers...
  12. ncbi request reprint Exact test of Hardy-Weinberg equilibrium by Markov chain Monte Carlo
    Ao Yuan
    Statistical Genetics and Bioinformatics Unit, National Human Genome Center, Howard University, Washington, DC 20059, USA
    Math Med Biol 20:327-40. 2003
    ..To expand the family of test statistics, we consider a class of divergence measures for the departure of HWE. Examples are given as illustrations...
  13. doi request reprint Detecting case-control expression quantitative trait loci using locally most powerful or maximin robust rank tests
    Ao Yuan
    National Human Genome Center, Howard University, 2216 Sixth Street NW, Washington, DC 20059, USA
    Stat Med 31:887-900. 2012
    ..We conduct simulation studies to assess their performance and use an application to real data for illustration...
  14. ncbi request reprint Semiparametric clustering method for microarray data analysis
    Ao Yuan
    National Human Genome Center, Department of Community Health and Family Medicine, Howard University, Washington, DC, USA
    J Bioinform Comput Biol 6:261-82. 2008
    ..The results show that the proposed method yields reasonable partition of the data. As an illustration, the proposed method is applied to a real microarray data set to cluster genes...
  15. pmc On coalescence analysis using genealogy rooted trees
    Ao Yuan
    Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, DC 20057, USA
    Comput Math Methods Med 2014:194202. 2014
    ..Then we study a relatively simple computation method for this analysis and illustrate how to use it. ..
  16. ncbi request reprint Summary of contributions to GAW15 Group 13: candidate gene association studies
    Mariza de Andrade
    Division of Biostatistics, Department of Health Science Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Genet Epidemiol 31:S110-7. 2007
    ....