Research Topics
| Y TizabiSummaryAffiliation: Howard University Country: USA Publications
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Publications
Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's diseaseRobert L Copeland
Department of Pharmacology and Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA
Neurotox Res 8:289-93. 2005..It is suggested that selective nicotinic agonists may be of therapeutic potential in at least a subpopulation of Parkinsonian patients...
Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar-Kyoto ratsY Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Neuroscience 213:72-80. 2012..These findings suggest potential therapeutic benefit in simultaneous reduction of central NMDA and elevation of AMPA receptor function in treatment of depression...- Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shellYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Alcohol Alcohol 42:413-6. 2007..Moreover, to also investigate whether nicotinic receptors may be mediating these effects of alcohol and nicotine, the effects of mecamylamine, a nicotinic receptor antagonist was also evaluated... - Nicotine inhibits ethanol-induced toxicity in cultured cerebral cortical cellsYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, Division of Internal Medicine, Howard University Hospital, 520 W Street NW, Washington, DC 20059, USA
Neurotox Res 6:311-6. 2004..The neuroprotective effect of nicotine against ethanol-induced toxicity may be a contributing factor to the high incidence of smoking among alcoholics... - Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholismYousef Tizabi
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059, United States
Prog Neuropsychopharmacol Biol Psychiatry 33:398-402. 2009..Thus, nicotinic receptors could be suitable targets for the development of novel pharmacotherapy for treatment of depression and possibly alcoholism... - Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cellsYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Neurotox Res 5:315-21. 2003..The neuroprotective effect of nicotine against ethanol-induced toxicity in cerebellar neurons may be a contributing factor to the high incidence of smoking among alcoholics... - Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cellsYousef Tizabi
Department of Pharmacology, Howard University, Washington, DC 20059, USA
Neurotox Res 7:319-22. 2005..Anti-apoptotic effects of nicotine in this model may be suggestive of potential use of nicotinic agonists in neurotoxic insults and/or neurodegenerative disorders... - Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbensYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Alcohol Clin Exp Res 26:394-9. 2002.... - Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY ratsYousef Tizabi
Dept of Pharmacology, College of Medicine, Howard Univ Washington, DC 20059, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:62-9. 2010..These findings further validate the use of WKY rats as an animal model of human depression and signify the importance of inherent genetic differences in final behavioral outcome of nicotine... - Nicotine attenuates DOI-induced head-twitch response in mice: implications for Tourette syndromeY Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Prog Neuropsychopharmacol Biol Psychiatry 25:1445-57. 2001..Indeed, at higher doses, mecamylamine also reduced the DOI-induced HTR. The data suggest that both nicotine and mecamylamine may be of therapeutic potential in the treatment of some symptoms of TS... - Prenatal nicotine exposure is associated with an increase in [125I]epibatidine binding in discrete cortical regions in ratsY Tizabi
Department of Pharmacology, College of Medicine, Howard University, 520 W Street N W, Washington, DC 20059, USA
Pharmacol Biochem Behav 67:319-23. 2000..These neurochemical effects may be responsible for some of the behavioral abnormalities seen in such offspring... - Nicotine blocks quinpirole-induced behavior in rats: psychiatric implicationsY Tizabi
Department of Pharmacology, College of Medicine, Howard University, 520W Street N W, Washington, DC 20059, USA
Psychopharmacology (Berl) 145:433-41. 1999..0 mg/kg/day), for the first 3 weeks from birth. This priming process replicated previous findings of behavioral sensitization, manifested as hyperlocomotion, increased paw treading with jumping, and increased yawning... - Antidepressant effects of nicotine in an animal model of depressionY Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Psychopharmacology (Berl) 142:193-9. 1999..These data strongly implicate the involvement of central nicotinic receptors in the depressive characteristics of the FSL rats, and suggest that nicotinic agonists may have therapeutic benefits in depressive disorders... - Nicotine and nicotinic system in hypoglutamatergic models of schizophreniaYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Neurotox Res 12:233-46. 2007..Moreover, it is evident that various experimental paradigms or models of schizophrenia symptoms need to be combined to provide a wider spectrum of the behavioral phenotype, as each model has its inherent limitations... - Alcohol preference: association with reduced striatal nicotinic receptorsY Tizabi
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Alcohol Alcohol 36:318-22. 2001..Only the striatum of P rats had a reduction in the number of binding sites for both ligands, compared to NP rats. The data suggest a link between striatal nicotinic receptors and alcohol preference... - Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strainsBruk Getachew
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Pharmacol Biochem Behav 91:97-103. 2008..It may be suggested that prophylactic treatment of alcoholics with an antidepressant prior to detoxification may improve treatment outcome for alcoholism... 
Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cellsJharna R Das
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Neurotox Res 16:194-204. 2009..The findings suggest a therapeutic potential for the combination of donepezil and nicotine in PD...- Hyperactivity induced by prenatal nicotine exposure is associated with an increase in cortical nicotinic receptorsY Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Pharmacol Biochem Behav 58:141-6. 1997..These results suggest that hyperactive male offspring of nicotine-exposed dams are also susceptible to neurochemical effects of intrauterine nicotine exposure... - Stereological analysis of the hypothalamic hypocretin/orexin neurons in an animal model of depressionJoanne S Allard
Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Neuropeptides 38:311-5. 2004..These findings support the view that reduced number or size of hypothalamic hypocretinergic neurons may underlie the disrupted sleep pattern associated with depressive characteristics in WKY rats... - Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorderKebreten F Manaye
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA
J Neuropathol Exp Neurol 64:224-9. 2005..This selective neuronal loss in the PVN appears to identify an important neurobiologic substrate for the behavioral manifestations of depression... - Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistryKebreten F Manaye
Department of Physiology and Biophysics, Howard University College of Medicine, 520 W Street, NW, Suite 2305, Adams Bldg, Washington, DC, 20059, USA
Age (Dordr) 29:87-96. 2007.... - Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reductionBruk Getachew
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Pharmacol Biochem Behav 96:395-401. 2010..Moreover, it is suggested that selective NE uptake inhibitors may be of particular therapeutic potential in co-morbid condition of alcoholism and depression... - Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depressionJoanne S Allard
Department of Physiology and Biophysics, Howard University, College of Medicine, 520 W Street NW, Washington, DC 20059, USA
Neuropeptides 41:329-37. 2007..Moreover, the findings do not support direct antidepressant-like activity for REMSD on hypothalamic Hcrt neurons in WKY rats... - Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndromeRenee L Hayslett
Department of Pharmacology, College of Medicine, Howard University, 520 W Street N.W, Washington, DC 20059, USA
Pharmacol Biochem Behav 76:409-15. 2003..These results suggest that donepezil may have therapeutic potential in treating motor tic symptoms of TS. Moreover, the action of donepezil and nicotine may be mediated through the same mechanism... - Effect of nicotine on quinpirole-induced checking behavior in rats: implications for obsessive-compulsive disorderYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Biol Psychiatry 51:164-71. 2002..CONCLUSIONS: Nicotine attenuates some symptoms of compulsive checking in a rat model of OCD; however, the mechanisms of this effect and therapeutic efficacy of nicotinic agonists in OCD require further study... - Antinociceptive effects of alcohol and nicotine: involvement of the opioid systemVera Combs Campbell
Howard University, College of Medicine, Department of Pharmacology, Numa P. Adams Suite 3408, 520 W Street North West, Washington, DC 20059, USA
Brain Res 1097:71-7. 2006..The analgesic effects induced by combination of alcohol and nicotine may be a contributory factor in their co-abuse... - Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 micePeter R Mouton
Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, United States
J Chem Neuroanat 34:102-7. 2007..These findings support the use of murine models of Abeta deposition to develop novel strategies for the therapeutic management of patients afflicted with AD... - Computational modeling study of human nicotinic acetylcholine receptor for developing new drugs in the treatment of alcoholismZeng Jian Hu
Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, USA
Interdiscip Sci 1:254-62. 2009..Since the nAChR ligand-binding site is a useful target for mutagenesis studies and the rational design of drugs against various diseases, these models provide useful information for future investigation... - Effects of nicotine on quinpirole- and dizocilpine (MK-801)-induced sensorimotor gating impairments in ratsAmy A Nespor
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA
Psychopharmacology (Berl) 200:403-11. 2008..Nicotine, on the other hand, may have beneficial effects on attentional/cognitive functions... - Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndromeRenee L Hayslett
Department of Pharmacology, Howard University College of Medicine, 520 W Street N.W, Washington, DC 20059, USA
Pharmacol Biochem Behav 81:879-86. 2005..Thus, further investigation of involvement of cortical 5-HT2A receptors in TS as well as evaluation of selective 5-HT2A receptor antagonists in this disorder is warranted... - Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicityRobert L Copeland
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Neurotox Res 12:61-9. 2007..Hence, nicotinic agonists in combination with other antiapoptotic agents may be of substantial benefit in at least a subpopulation of Parkinson patients... - Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonismBruce A Rasmussen
Department of Pharmacology and Physiology, George Washington University, Washington DC, USA
Neurotox Res 13:151-61. 2008..The results suggest a sustainable model of PPI impairment and possible role of nicotinic receptors in selective brain regions in this behavior... - Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:1030-40. 2008..In conclusion, the data suggest attentional impairments with clozapine alone and no modification of this effect with nicotine or dizocilpine. Moreover, cortical low affinity nicotinic receptors may have a role in attentional functions... - Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor bindingEdward D Levin
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Brain Res 1041:132-42. 2005..Chronic nicotine effects on receptor regulation are significantly affected by concurrent blockade of NMDA glutamate receptors... - Effects of selective opioid receptor antagonists on alcohol-induced and nicotine-induced antinociceptionVera Combs Campbell
Department of Pharmaceutical Sciences, Hampton University School of Pharmacy, Hampton, Virginia, USA
Alcohol Clin Exp Res 31:1435-40. 2007..The purpose of this study was to determine the role of selective opioid receptor subtypes (micro, delta, and kappa) in mediating the antinociceptive effects of alcohol, nicotine, and their combination... - Smoking comorbidity in alcoholism: neurobiological and neurocognitive consequencesDieter J Meyerhoff
Department of Radiology, University of California at San Francisco, San Francisco, California, USA
Alcohol Clin Exp Res 30:253-64. 2006.... - Long-term effects of developmental PCP administration on sensorimotor gating in male and female ratsBruce A Rasmussen
Department of Pharmacology and Physiology, George Washington School of Medicine, Washington DC, USA
Psychopharmacology (Berl) 190:43-9. 2007..Aspects of acute NMDA receptor antagonism limit the applications of these models...