Scott M Sternson

Summary

Affiliation: Howard Hughes Medical Institute
Country: USA

Publications

  1. ncbi request reprint Chemogenetic tools to interrogate brain functions
    Scott M Sternson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147 email
    Annu Rev Neurosci 37:387-407. 2014
  2. pmc AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    Yexica Aponte
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Neurosci 14:351-5. 2011
  3. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
  4. pmc Neural circuits and motivational processes for hunger
    Scott M Sternson
    Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Curr Opin Neurobiol 23:353-60. 2013
  5. doi request reprint Hypothalamic survival circuits: blueprints for purposive behaviors
    Scott M Sternson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 77:810-24. 2013
  6. ncbi request reprint Neuron transplantation partially reverses an obesity disorder in mice
    Scott M Sternson
    Janelia Farm Research Campus, HHMI, Ashburn, VA 20147, USA
    Cell Metab 15:133-4. 2012
  7. ncbi request reprint Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior
    Tevye J Stachniak
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 82:797-808. 2014
  8. pmc Chemical and genetic engineering of selective ion channel-ligand interactions
    Christopher J Magnus
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Science 333:1292-6. 2011
  9. pmc A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 28:7025-30. 2008
  10. pmc Parallel, redundant circuit organization for homeostatic control of feeding behavior
    J Nicholas Betley
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 155:1337-50. 2013

Collaborators

  • Loren L Looger
  • Anirvan Ghosh
  • Luke D Lavis
  • Lin Tian
  • Deniz Atasoy
  • J Nicholas Betley
  • Helen H Su
  • Yexica Aponte
  • Tevye J Stachniak
  • Yunlei Yang
  • Christopher J Magnus
  • Leopoldo Petreanu
  • KIMBERLY D RITOLA
  • Zhen Fang Huang Cao
  • Peter H Lee
  • Tianyi Mao
  • Karel Svoboda
  • Helen Hong Su

Detail Information

Publications14

  1. ncbi request reprint Chemogenetic tools to interrogate brain functions
    Scott M Sternson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147 email
    Annu Rev Neurosci 37:387-407. 2014
    ..These tools have revealed remarkably specific behavioral physiological influences for molecularly defined cell types that are often intermingled with populations having different or even opposite functions. ..
  2. pmc AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    Yexica Aponte
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Neurosci 14:351-5. 2011
    ..Furthermore, feeding was evoked selectively over drinking without training or prior photostimulus exposure, which suggests that AGRP neurons serve a dedicated role coordinating this complex behavior...
  3. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
    ..These experiments reveal a new neural circuit that regulates hunger state and pathways associated with overeating disorders...
  4. pmc Neural circuits and motivational processes for hunger
    Scott M Sternson
    Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Curr Opin Neurobiol 23:353-60. 2013
    ..We also consider research into the motivational processes that are thought to underlie hunger in order to outline considerations for bridging the gap between homeostatic and motivational neural circuits...
  5. doi request reprint Hypothalamic survival circuits: blueprints for purposive behaviors
    Scott M Sternson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 77:810-24. 2013
    ..These new tools have the potential to bridge the gaps between neurobiological and psychological thinking about the mechanisms of complex motivated behavior...
  6. ncbi request reprint Neuron transplantation partially reverses an obesity disorder in mice
    Scott M Sternson
    Janelia Farm Research Campus, HHMI, Ashburn, VA 20147, USA
    Cell Metab 15:133-4. 2012
    ..Transplantation of leptin receptor-expressing hypothalamic progenitor neurons into the brains of leptin receptor deficient mice led to integration into neural circuits, reduced obesity, and normalized circulating glucose levels...
  7. ncbi request reprint Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior
    Tevye J Stachniak
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 82:797-808. 2014
    ..This synaptic silencing approach is broadly applicable for cell-type-specific and axon projection-selective functional analysis of diverse neural circuits...
  8. pmc Chemical and genetic engineering of selective ion channel-ligand interactions
    Christopher J Magnus
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Science 333:1292-6. 2011
    ....
  9. pmc A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 28:7025-30. 2008
  10. pmc Parallel, redundant circuit organization for homeostatic control of feeding behavior
    J Nicholas Betley
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 155:1337-50. 2013
    ..The concerted anatomical and functional analysis of AGRP neuron projection populations reveals a constellation of core forebrain nodes, which are part of an extended circuit that mediates feeding behavior. ..
  11. pmc Adeno-associated viral vectors for mapping, monitoring, and manipulating neural circuits
    J Nicholas Betley
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
    Hum Gene Ther 22:669-77. 2011
    ..Here, we highlight these developments and discuss areas for improvement that could further expand capabilities for neural circuit analysis...
  12. pmc Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    Yunlei Yang
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 146:992-1003. 2011
    ..Based on these experiments, we propose a memory storage device for physiological state constructed from bistable synapses that are flipped between two sustained activity states by transient exposure to hormones signaling energy levels...
  13. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
    ..Our experiments reveal high specificity in the subcellular organization of excitatory circuits...
  14. pmc Selective esterase-ester pair for targeting small molecules with cellular specificity
    Lin Tian
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Proc Natl Acad Sci U S A 109:4756-61. 2012
    ..We expect this approach to have general utility for the specific delivery of many small molecules to defined cellular populations...