Scott M Sternson

Summary

Affiliation: Howard Hughes Medical Institute
Country: USA

Publications

  1. doi request reprint Neural circuits and motivational processes for hunger
    Scott M Sternson
    Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Curr Opin Neurobiol 23:353-60. 2013
  2. doi request reprint Hypothalamic survival circuits: blueprints for purposive behaviors
    Scott M Sternson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 77:810-24. 2013
  3. ncbi request reprint Neuron transplantation partially reverses an obesity disorder in mice
    Scott M Sternson
    Janelia Farm Research Campus, HHMI, Ashburn, VA 20147, USA
    Cell Metab 15:133-4. 2012
  4. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
  5. doi request reprint Parallel, redundant circuit organization for homeostatic control of feeding behavior
    J Nicholas Betley
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 155:1337-50. 2013
  6. pmc Chemical and genetic engineering of selective ion channel-ligand interactions
    Christopher J Magnus
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Science 333:1292-6. 2011
  7. pmc Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    Yunlei Yang
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 146:992-1003. 2011
  8. pmc AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    Yexica Aponte
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Neurosci 14:351-5. 2011
  9. pmc Selective esterase-ester pair for targeting small molecules with cellular specificity
    Lin Tian
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Proc Natl Acad Sci U S A 109:4756-61. 2012
  10. pmc Adeno-associated viral vectors for mapping, monitoring, and manipulating neural circuits
    J Nicholas Betley
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
    Hum Gene Ther 22:669-77. 2011

Collaborators

Detail Information

Publications10

  1. doi request reprint Neural circuits and motivational processes for hunger
    Scott M Sternson
    Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Curr Opin Neurobiol 23:353-60. 2013
    ..We also consider research into the motivational processes that are thought to underlie hunger in order to outline considerations for bridging the gap between homeostatic and motivational neural circuits...
  2. doi request reprint Hypothalamic survival circuits: blueprints for purposive behaviors
    Scott M Sternson
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 77:810-24. 2013
    ..These new tools have the potential to bridge the gaps between neurobiological and psychological thinking about the mechanisms of complex motivated behavior...
  3. ncbi request reprint Neuron transplantation partially reverses an obesity disorder in mice
    Scott M Sternson
    Janelia Farm Research Campus, HHMI, Ashburn, VA 20147, USA
    Cell Metab 15:133-4. 2012
    ..Transplantation of leptin receptor-expressing hypothalamic progenitor neurons into the brains of leptin receptor deficient mice led to integration into neural circuits, reduced obesity, and normalized circulating glucose levels...
  4. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
    ..These experiments reveal a new neural circuit that regulates hunger state and pathways associated with overeating disorders...
  5. doi request reprint Parallel, redundant circuit organization for homeostatic control of feeding behavior
    J Nicholas Betley
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 155:1337-50. 2013
    ..The concerted anatomical and functional analysis of AGRP neuron projection populations reveals a constellation of core forebrain nodes, which are part of an extended circuit that mediates feeding behavior. ..
  6. pmc Chemical and genetic engineering of selective ion channel-ligand interactions
    Christopher J Magnus
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Science 333:1292-6. 2011
    ....
  7. pmc Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    Yunlei Yang
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell 146:992-1003. 2011
    ..Based on these experiments, we propose a memory storage device for physiological state constructed from bistable synapses that are flipped between two sustained activity states by transient exposure to hormones signaling energy levels...
  8. pmc AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    Yexica Aponte
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Neurosci 14:351-5. 2011
    ..Furthermore, feeding was evoked selectively over drinking without training or prior photostimulus exposure, which suggests that AGRP neurons serve a dedicated role coordinating this complex behavior...
  9. pmc Selective esterase-ester pair for targeting small molecules with cellular specificity
    Lin Tian
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Proc Natl Acad Sci U S A 109:4756-61. 2012
    ..We expect this approach to have general utility for the specific delivery of many small molecules to defined cellular populations...
  10. pmc Adeno-associated viral vectors for mapping, monitoring, and manipulating neural circuits
    J Nicholas Betley
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
    Hum Gene Ther 22:669-77. 2011
    ..Here, we highlight these developments and discuss areas for improvement that could further expand capabilities for neural circuit analysis...