Sudha Sharma

Summary

Affiliation: Howard University
Country: USA

Publications

  1. pmc Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks
    Swetha Parvathaneni
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, United States of America
    PLoS ONE 8:e62481. 2013
  2. pmc Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases
    Sudha Sharma
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Suite 3424A, Washington, DC 20059, USA
    J Nucleic Acids 2011:724215. 2011
  3. pmc RECQ1 plays a distinct role in cellular response to oxidative DNA damage
    Sudha Sharma
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA
    DNA Repair (Amst) 11:537-49. 2012
  4. ncbi request reprint Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1
    Sudha Sharma
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:28072-84. 2005
  5. ncbi request reprint Stimulation of flap endonuclease-1 by the Bloom's syndrome protein
    Sudha Sharma
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, DHHS, Baltimore, Maryland 21224 6825, USA
    J Biol Chem 279:9847-56. 2004
  6. ncbi request reprint RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination
    Kevin M Doherty
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:28085-94. 2005
  7. pmc Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D
    Xing Lu
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA
    Mol Cancer 12:29. 2013
  8. pmc Unique and important consequences of RECQ1 deficiency in mammalian cells
    Sudha Sharma
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Cell Cycle 7:989-1000. 2008
  9. ncbi request reprint Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer
    Rigu Gupta
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:25450-60. 2005
  10. pmc WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork
    Sudha Sharma
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Biol Cell 15:734-50. 2004

Collaborators

Detail Information

Publications11

  1. pmc Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks
    Swetha Parvathaneni
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, United States of America
    PLoS ONE 8:e62481. 2013
    ..Collectively, these results provide the first evidence for an interaction of RECQ1 with Ku70/80 and a role of the human RecQ helicase in double-strand break repair through nonhomologous end-joining...
  2. pmc Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases
    Sudha Sharma
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Suite 3424A, Washington, DC 20059, USA
    J Nucleic Acids 2011:724215. 2011
    ..In future, RecQ helicases are anticipated to be additional molecular targets for cancer chemotherapeutics...
  3. pmc RECQ1 plays a distinct role in cellular response to oxidative DNA damage
    Sudha Sharma
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA
    DNA Repair (Amst) 11:537-49. 2012
    ..As other RecQ helicases are known to interact with PARP-1, this study provides a paradigm to delineate specialized and redundant functions of RecQ homologs in repair of oxidative DNA damage...
  4. ncbi request reprint Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1
    Sudha Sharma
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:28072-84. 2005
    ..The enzymatic properties of the RECQ1 helicase and strand annealing activities are discussed in the context of proposed cellular DNA metabolic pathways that are important in the maintenance of genomic stability...
  5. ncbi request reprint Stimulation of flap endonuclease-1 by the Bloom's syndrome protein
    Sudha Sharma
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, DHHS, Baltimore, Maryland 21224 6825, USA
    J Biol Chem 279:9847-56. 2004
    ..We suggest that functional interactions between RecQ helicases and Rad2 family nucleases serve to process DNA substrates that are intermediates in DNA replication and repair...
  6. ncbi request reprint RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination
    Kevin M Doherty
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:28085-94. 2005
    ..Regulation of genetic recombination, a proposed role for RecQ helicases, is supported by the identified RECQ1 protein interactions and is discussed...
  7. pmc Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D
    Xing Lu
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA
    Mol Cancer 12:29. 2013
    ..We previously determined that RECQ1 helicase preferentially binds and unwinds substrates that mimic DNA replication/repair intermediates, and interacts with proteins involved in DNA replication restart mechanisms...
  8. pmc Unique and important consequences of RECQ1 deficiency in mammalian cells
    Sudha Sharma
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Cell Cycle 7:989-1000. 2008
    ..Collectively, these studies provide the first evidence for an important role of RECQ1 to confer chromosomal stability that is unique from that of other RecQ helicases and suggest its potential involvement in tumorigenesis...
  9. ncbi request reprint Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer
    Rigu Gupta
    Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:25450-60. 2005
    ....
  10. pmc WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork
    Sudha Sharma
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Biol Cell 15:734-50. 2004
    ..These results provide evidence for an interaction between WRN and FEN-1 in vivo and suggest that these proteins function together to process DNA structures associated with the replication fork...