Research Topics
Species | Lynn M RiddifordSummaryAffiliation: Howard Hughes Medical Institute Country: USA Publications
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Detail Information
Publications
Endocrine insights into the evolution of metamorphosis in insectsJames W Truman
Department of Zoology, University of Washington, Seattle, Washington 98195 1800, USA
Annu Rev Entomol 47:467-500. 2002..We discuss how complete metamorphosis may have influenced the molecular aspects of both ecdysone and JH signaling...- Size assessment and growth control: how adult size is determined in insectsChristen Kerry Mirth
Department of Biology, University of Washington, Seattle, WA 98195, USA
Bioessays 29:344-55. 2007..Thus, the mechanisms that control growth rates converge on those assessing size to ensure that the larvae attain the appropriate size at metamorphosis... 
How does juvenile hormone control insect metamorphosis and reproduction?Lynn M Riddiford
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
Gen Comp Endocrinol 179:477-84. 2012..Critical actions of JH and its receptor in the timing of maturation of the adult optic lobe and of female receptivity in Drosophila are also discussed...
Temporal patterns of broad isoform expression during the development of neuronal lineages in DrosophilaBaohua Zhou
Department of Biology, University of Washington, Seattle, 98195, USA
Neural Dev 4:39. 2009..These latter, 'secondary' neurons show a complex pattern of expression of broad, which encodes a transcription factor usually associated with metamorphosis, where it acts as a key regulator in the transitions from larva and pupa...- A role for juvenile hormone in the prepupal development of Drosophila melanogasterLynn M Riddiford
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
Development 137:1117-26. 2010..Thus, the lack of JH and its receptor Met causes a heterochronic shift in the development of the visual system that is likely to result from some cells 'misinterpreting' the ecdysteroid peaks that drive metamorphosis... - Juvenile hormone action: a 2007 perspectiveLynn M Riddiford
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
J Insect Physiol 54:895-901. 2008..This short review highlights the recent papers of the past year that lend new insight into the role of this hormone in the larva and the mechanisms whereby it achieves this role... - The ecdysone receptor controls the post-critical weight switch to nutrition-independent differentiation in Drosophila wing imaginal discsChristen K Mirth
Department of Biology, Box 351800, University of Washington, Seattle, WA 98195, USA
Development 136:2345-53. 2009..These results suggest that post-critical weight, EcR signaling switches wing discs to a nutrition-independent mode of development via derepression... - The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogasterChristen Mirth
Department of Biology, Box 351800, University of Washington, Seattle, Washington 98195, USA
Curr Biol 15:1796-807. 2005..We present evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved... - The pupal specifier broad directs progressive morphogenesis in a direct-developing insectDeniz F Erezyilmaz
Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
Proc Natl Acad Sci U S A 103:6925-30. 2006..After this shift in br expression, the progressive changes that occur within the nymphal series in basal insects became compressed to the one short period of morphogenesis seen in the larva-to-pupa transition of holometabolous insects... - Developmental expression and hormonal regulation of different isoforms of the transcription factor E75 in the tobacco hornworm Manduca sextaBela Keshan
Department of Biology, University of Washington, Box 351800, Seattle, WA 98195-1800, USA
Dev Biol 295:623-32. 2006..Neither E75A nor E75D mRNA was up-regulated by JH alone. Thus, E75C is primarily involved in adult differentiation whereas E75D has roles both during the molt and pupal commitment... - Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogasterChieka Minakuchi
Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
Mech Dev 125:91-105. 2008..We also show for the first time that the JH-mediated maintenance of br expression in this epidermis is patterned and that JH delays the fusion of the imaginal cells and the disappearance of Dpp in the dorsal midline... - The role of nutrition in creation of the eye imaginal disc and initiation of metamorphosis in Manduca sextaSteven G B MacWhinnie
Department of Biology, University of Southern Maine, 96 Falmouth Street, Portland, ME 04103-9300, USA
Dev Biol 285:285-97. 2005..Instead, creation of the late-forming imaginal discs in Manduca appears to be controlled by unidentified endocrine factors whose activation is regulated by the nutritional state of the animal... - Differential control of MHR3 promoter activity by isoforms of the ecdysone receptor and inhibitory effects of E75A and MHR3Kiyoshi Hiruma
Department of Biology, University of Washington, Seattle, WA 98195-1800, USA
Dev Biol 272:510-21. 2004..In addition, E75A, another ecdysone-induced transcription factor, and MHR3 itself suppressed MHR3 promoter activity by binding to the monomeric response element (MRE2). Therefore, MHR3 can be down-regulated both by itself and by E75A... - Overexpression of broad: a new insight into its role in the Drosophila prothoracic gland cellsXiaofeng Zhou
Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
J Exp Biol 207:1151-61. 2004..Overexpression of each of the BR isoforms caused degeneration of the PG cells but on different time courses, indicating that BR is a signal for the degeneration of the PG cells that normally occurs during the pupal-adult transition... - E74 exhibits stage-specific hormonal regulation in the epidermis of the tobacco hornworm, manduca sextaGeoffrey E Stilwell
Department of Biology, University of Washington, Box 351800, Seattle, WA 98195-1800, USA
Dev Biol 258:76-90. 2003..Thus, MsE74B appears to have a similar role at the onset of metamorphosis in Manduca as it does in Drosophila, whereas MsE74A is regulated differently at pupation in Manduca than at pupariation in Drosophila... - A novel gene in the takeout gene family is regulated by hormones and nutrients in Manduca larval epidermisJianguang Du
Department of Biology, 24 Kincaid Hall, University of Washington, Box 351800, Seattle, WA 98195-1800, USA
Insect Biochem Mol Biol 33:803-14. 2003..The role of Moling may be to stabilize JH in the epidermal cell during the final intermolt when the JH esterase activity increases... - Evolution of the Drosophila broad locus: the Manduca sexta broad Z4 isoform has biological activity in DrosophilaCynthia Bayer
Department of Biology, University of Central Florida, Orlando, FL 32816 2368, USA
Dev Genes Evol 213:471-6. 2003.... - Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosisMirka Uhlirova
Department of Molecular Biology, University of South Bohemia and Institute of Entomology, The Czech Academy of Sciences, Ceske Budejovice, 37005 Czech Republic
Proc Natl Acad Sci U S A 100:15607-12. 2003..We also demonstrate that the Sindbis virus is a useful vehicle for silencing of developmental genes in new insect models... - Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogasterLynn M Riddiford
Department of Biology, University of Washington, 24 Kincaid Hall, Box 351800, Seattle, WA 98195 1800, USA
Insect Biochem Mol Biol 33:1327-38. 2003..Premature expression of different Broad isoforms also is shown to cause precocious degeneration of the prothoracic glands as well as to prevent ecdysteroid release during its presence... - Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and ManducaXiaofeng Zhou
Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
Development 129:2259-69. 2002..Consequently, the 'status quo' action of JH on the pupal-adult transformation is mediated by the JH-induced re-expression of BR... - Heat-inducible transgenic expression in the silkmoth Bombyx moriMirka Uhlirova
University of South Bohemia, Branisovká 31, České Budějovice 370 05, Czech Republic
Dev Genes Evol 212:145-51. 2002..Immunostaining of epidermis using anti-BmFtz-F1 antibody showed a clear increase of nuclear signal 90 min after a heat shock... - Molecular cloning of the prothoracicotropic hormone from the tobacco hornworm, Manduca sextaMotoko Shionoya
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa 277-8562, Japan
Insect Biochem Mol Biol 33:795-801. 2003.... - rosy Function is required for juvenile hormone effects in Drosophila melanogasterXiaofeng Zhou
Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
Genetics 178:273-81. 2008.... - The role of Broad in the development of Tribolium castaneum: implications for the evolution of the holometabolous insect pupaYuichiro Suzuki
Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
Development 135:569-77. 2008..Our findings show that the br isoform functions are broadly conserved within the Holometabola and suggest that evolution of br isoform expression may have played an important role in the evolution of the pupa in holometabolous insects... - The control of metamorphosis in the kissing bugLynn M Riddiford
University of Washington, USA
J Exp Biol 210:3133-4. 2007 - The morphostatic actions of juvenile hormoneJames W Truman
Department of Biology, University of Washington, Seattle, WA 98195, USA
Insect Biochem Mol Biol 37:761-70. 2007..This suppression of embryonic patterning then results in embryonic fields that remain dormant as long as JH is present. These are the primordia that can transform into imaginal discs once JH disappears in preparation for metamorphosis... - Border of Notch activity establishes a boundary between the two dorsal appendage tube cell typesEllen J Ward
Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195 7350, USA
Dev Biol 297:461-70. 2006..Generating a boundary by the Notch pathway might constitute an evolutionarily conserved first step during organ formation in many tissues...