INDIRA NONE POOLA

Summary

Affiliation: Howard University
Country: USA

Publications

  1. ncbi request reprint Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, USA
    Nat Med 11:481-3. 2005
  2. pmc The Cell Surface Estrogen Receptor, G Protein- Coupled Receptor 30 (GPR30), is Markedly Down Regulated During Breast Tumorigenesis
    Indira Poola
    Department of Surgery and Breast Center and
    Breast Cancer (Auckl) 1:65-78. 2008
  3. pmc Molecular constitution of breast but not other reproductive tissues is rich in growth promoting molecules: a possible link to highest incidence of tumor growths
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, United States
    FEBS Lett 583:3069-75. 2009
  4. doi request reprint Molecular risk assessment for breast cancer development in patients with ductal hyperplasias
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia 20059, USA
    Clin Cancer Res 14:1274-80. 2008
  5. pmc Estrogen receptor alpha (ER alpha) mRNA copy numbers in immunohistochemically ER alpha-positive-, and negative breast cancer tissues
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University School of Medicine, Washington, DC 20059, USA
    BMC Cancer 7:56. 2007
  6. ncbi request reprint Expression of carcinoembryonic antigen cell adhesion molecule 6 oncoprotein in atypical ductal hyperplastic tissues is associated with the development of invasive breast cancer
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, USA
    Clin Cancer Res 12:4773-83. 2006
  7. ncbi request reprint Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia 20059, USA
    Clin Cancer Res 11:7579-85. 2005
  8. ncbi request reprint Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization
    Indira Poola
    Department of Biochemistry, Howard University College of Medicine, Washington, DC 20059, USA
    Endocrine 27:227-38. 2005
  9. ncbi request reprint Molecular assays to profile 10 estrogen receptor beta isoform mRNA copy numbers in ovary, breast, uterus, and bone tissues
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University School of Medicine, 520 W Street NW, Washington, DC 20059, USA
    Endocrine 22:101-12. 2003
  10. ncbi request reprint Molecular assay to generate expression profile of eight estrogen receptor alpha isoform mRNA copy numbers in picogram amounts of total RNA from breast cancer tissues
    Indira Poola
    Department of Anatomy, Howard University School of Medicine, Washington, DC 20059, USA
    Anal Biochem 314:217-26. 2003

Detail Information

Publications15

  1. ncbi request reprint Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, USA
    Nat Med 11:481-3. 2005
    ..We identify MMP-1 as a candidate marker that may be useful for identification of breast lesions that can develop into cancer...
  2. pmc The Cell Surface Estrogen Receptor, G Protein- Coupled Receptor 30 (GPR30), is Markedly Down Regulated During Breast Tumorigenesis
    Indira Poola
    Department of Surgery and Breast Center and
    Breast Cancer (Auckl) 1:65-78. 2008
    ..Therefore, GPR30 could play a critical role in hormonal regulation of breast epithelial cell integrity. Deregulation of the events mediated by GPR30 could contribute to tumorigenesis...
  3. pmc Molecular constitution of breast but not other reproductive tissues is rich in growth promoting molecules: a possible link to highest incidence of tumor growths
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, United States
    FEBS Lett 583:3069-75. 2009
    ....
  4. doi request reprint Molecular risk assessment for breast cancer development in patients with ductal hyperplasias
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia 20059, USA
    Clin Cancer Res 14:1274-80. 2008
    ..The purpose of this study is to investigate whether expression of hyaluronoglucosaminidase 1 (HYAL1), a known tumor promoter, in hyperplastic tissues identifies a "true precancerous stage" and predicts subsequent IBC development...
  5. pmc Estrogen receptor alpha (ER alpha) mRNA copy numbers in immunohistochemically ER alpha-positive-, and negative breast cancer tissues
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University School of Medicine, Washington, DC 20059, USA
    BMC Cancer 7:56. 2007
    ..However, it is not known how the mRNA copy numbers correlate to IHC positive and negative status...
  6. ncbi request reprint Expression of carcinoembryonic antigen cell adhesion molecule 6 oncoprotein in atypical ductal hyperplastic tissues is associated with the development of invasive breast cancer
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, USA
    Clin Cancer Res 12:4773-83. 2006
    ..The purpose of this study is to investigate whether elevated expression of carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in ADH tissues is associated with the development of IBC...
  7. ncbi request reprint Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia 20059, USA
    Clin Cancer Res 11:7579-85. 2005
    ..These two transcription factors could be potential molecular targets for designing chemopreventive drugs to treat ERalpha-negative breast cancers...
  8. ncbi request reprint Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization
    Indira Poola
    Department of Biochemistry, Howard University College of Medicine, Washington, DC 20059, USA
    Endocrine 27:227-38. 2005
    ....
  9. ncbi request reprint Molecular assays to profile 10 estrogen receptor beta isoform mRNA copy numbers in ovary, breast, uterus, and bone tissues
    Indira Poola
    Department of Biochemistry and Molecular Biology, Howard University School of Medicine, 520 W Street NW, Washington, DC 20059, USA
    Endocrine 22:101-12. 2003
    ..In addition to the assay development, evidence is presented to demonstrate for the first time that ERbeta4 and ERbeta5 are full length receptors, contrary to previous reports that they are short receptors of exon 7-8...
  10. ncbi request reprint Molecular assay to generate expression profile of eight estrogen receptor alpha isoform mRNA copy numbers in picogram amounts of total RNA from breast cancer tissues
    Indira Poola
    Department of Anatomy, Howard University School of Medicine, Washington, DC 20059, USA
    Anal Biochem 314:217-26. 2003
    ..In addition, these methods could highly facilitate the design of tissue-specific selective estrogen receptor modulators to treat breast cancers and other estrogen-related abnormalities...
  11. ncbi request reprint Estrogen receptor beta splice variant mRNAs are differentially altered during breast carcinogenesis
    Indra Poola
    Department of Anatomy, Howard University School of Medicine, Washington, DC 20059, USA
    J Steroid Biochem Mol Biol 82:169-79. 2002
    ..03). Other variants were either expressed at very low frequency or not significantly altered...
  12. ncbi request reprint Identification of ten exon deleted ERbeta mRNAs in human ovary, breast, uterus and bone tissues: alternate splicing pattern of estrogen receptor beta mRNA is distinct from that of estrogen receptor alpha
    Indra Poola
    Department of Anatomy, Howard University College of Medicine, Washington, DC 20059, USA
    FEBS Lett 516:133-8. 2002
    ..The presence of a ERbeta variant profile together with other ER isoforms in a tissue may have functional implications in binding and response to a particular ligand...
  13. ncbi request reprint Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women
    Indra Poola
    Department of Anatomy, Howard University School of Medicine, Washington, DC 20059, USA
    Cancer 94:615-23. 2002
    ..The molecular factors responsible for these tumor characteristics are mostly unknown...
  14. ncbi request reprint Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues
    I Poola
    Department of Anatomy, Howard University School of Medicine, 520 W Street, NW, Washington, DC 20059, USA
    J Steroid Biochem Mol Biol 78:459-69. 2001
    ....
  15. pmc Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer
    Sidney W Fu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC, USA
    Breast Cancer Res 5:R82-7. 2003
    ..Here BP1 expression was examined in breast cancer, and the relationship between BP1 expression and clinicopathological data was determined...

Research Grants3

  1. Retrospective validation of putative breast cancer predictive molecular markers
    Indira Poola; Fiscal Year: 2007
    ..Detection at the precancerous stage and treatment could lead to fewer incidences of breast cancer and deaths from it. ..
  2. MOLECULAR ASSAY FOR ESTROGEN RECEPTORS IN BREAST TUMORS
    Indira Poola; Fiscal Year: 2002
    ..Such outcomes will be significant for the breast cancer patients who are resistant or acquire resistance to anti-estrogen therapies. ..