Research Topics
Species | Kebreten F ManayeSummaryAffiliation: Howard University Country: USA Publications
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Detail Information
Publications
Age-related loss of noradrenergic neurons in the brains of triple transgenic miceKebreten F Manaye
Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W St NW, Washington, DC 20059, USA
Age (Dordr) 35:139-47. 2013..Understanding the neurobiology of this apparent neuroprotection could lead to an improved understanding of age-related cognitive function in general, and the development of novel strategies for the therapeutic management of AD patients...
Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistryKebreten F Manaye
Department of Physiology and Biophysics, Howard University College of Medicine, 520 W Street, NW, Suite 2305, Adams Bldg, Washington, DC, 20059, USA
Age (Dordr) 29:87-96. 2007....
Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorderKebreten F Manaye
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA
J Neuropathol Exp Neurol 64:224-9. 2005..This selective neuronal loss in the PVN appears to identify an important neurobiologic substrate for the behavioral manifestations of depression...
17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 miceKebreten F Manaye
Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA
J Alzheimers Dis 23:629-39. 2011..These findings support the view that 17αE2, which may act through non-genomic mechanisms independent of traditional estrogen receptors, could prevent or delay the progression of AD in older men and women...
Comparative anatomy of the locus coeruleus in humans and nonhuman primatesYukti Sharma
Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA
J Comp Neurol 518:963-71. 2010....
Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY ratsYousef Tizabi
Dept of Pharmacology, College of Medicine, Howard Univ Washington, DC 20059, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:62-9. 2010..These findings further validate the use of WKY rats as an animal model of human depression and signify the importance of inherent genetic differences in final behavioral outcome of nicotine...
Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 micePeter R Mouton
Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, United States
J Chem Neuroanat 34:102-7. 2007..These findings support the use of murine models of Abeta deposition to develop novel strategies for the therapeutic management of patients afflicted with AD...
Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1ΔE9 double transgenic miceSara Kalifa
Department of Physiology and Biophysics, Howard University, Washington, DC 20059, USA
Brain Res 1376:94-100. 2011..Furthermore, the study suggests a decreased CB1 receptor expression may result in diminished anti-inflammatory processes, exacerbating the neuropathology associated with Alzheimer's disease...
Orexin stimulates breathing via medullary and spinal pathwaysJohn K Young
Dept of Anatomy, Howard Univ College of Medicine, 520 W St, NW, Washington, DC 20059, USA
J Appl Physiol 98:1387-95. 2005..05) increase in diaphragm electromyographic activity. These data indicate that orexin regulates respiratory activity and may have a role in the pathophysiology of sleep-related respiratory disorders...
Nicotine inhibits ethanol-induced toxicity in cultured cerebral cortical cellsYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, Division of Internal Medicine, Howard University Hospital, 520 W Street NW, Washington, DC 20059, USA
Neurotox Res 6:311-6. 2004..The neuroprotective effect of nicotine against ethanol-induced toxicity may be a contributing factor to the high incidence of smoking among alcoholics...
Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cellsYousef Tizabi
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Neurotox Res 5:315-21. 2003..The neuroprotective effect of nicotine against ethanol-induced toxicity in cerebellar neurons may be a contributing factor to the high incidence of smoking among alcoholics...
Nicotine promotes survival of cells expressing amyloid precursor protein and presenilin: Implication for Alzheimer's diseaseDwayne Brown
Department of Pharmacology, College of Medicine, Howard University, Washington, DC, United States
Neurosci Lett 535:57-61. 2013..These results suggest differential sensitivity of cell lines representing AD pathology to the protective effects of nicotine and provide further support of therapeutic potential of nicotinic agonists in at least a subtype of AD patients...
Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strainKatrice D Long
Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
Brain Res Bull 69:626-30. 2006..The results could be relevant to the development of glycinergic interventions for the treatment of neuropsychiatric disorders...
Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cellsYousef Tizabi
Department of Pharmacology, Howard University, Washington, DC 20059, USA
Neurotox Res 7:319-22. 2005..Anti-apoptotic effects of nicotine in this model may be suggestive of potential use of nicotinic agonists in neurotoxic insults and/or neurodegenerative disorders...
Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonismBruce A Rasmussen
Department of Pharmacology and Physiology, George Washington University, Washington DC, USA
Neurotox Res 13:151-61. 2008..The results suggest a sustainable model of PPI impairment and possible role of nicotinic receptors in selective brain regions in this behavior...
Long-term effects of developmental PCP administration on sensorimotor gating in male and female ratsBruce A Rasmussen
Department of Pharmacology and Physiology, George Washington School of Medicine, Washington DC, USA
Psychopharmacology (Berl) 190:43-9. 2007..Aspects of acute NMDA receptor antagonism limit the applications of these models...
