Kebreten F Manaye

Summary

Affiliation: Howard University
Country: USA

Publications

  1. pmc Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
    Katherine D Laclair
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA
    Mol Neurodegener 8:18. 2013
  2. pmc Age-related loss of noradrenergic neurons in the brains of triple transgenic mice
    Kebreten F Manaye
    Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W St NW, Washington, DC 20059, USA
    Age (Dordr) 35:139-47. 2013
  3. doi request reprint 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice
    Kebreten F Manaye
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA
    J Alzheimers Dis 23:629-39. 2011
  4. ncbi request reprint Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder
    Kebreten F Manaye
    Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA
    J Neuropathol Exp Neurol 64:224-9. 2005
  5. pmc Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry
    Kebreten F Manaye
    Department of Physiology and Biophysics, Howard University College of Medicine, 520 W Street, NW, Suite 2305, Adams Bldg, Washington, DC, 20059, USA
    Age (Dordr) 29:87-96. 2007
  6. ncbi request reprint Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice
    Jahn N O'Neil
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, United States
    J Chem Neuroanat 34:102-7. 2007
  7. pmc Comparative anatomy of the locus coeruleus in humans and nonhuman primates
    Yukti Sharma
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA
    J Comp Neurol 518:963-71. 2010
  8. pmc Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats
    Yousef Tizabi
    Dept of Pharmacology, College of Medicine, Howard Univ Washington, DC 20059, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:62-9. 2010
  9. doi request reprint Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1ΔE9 double transgenic mice
    Sara Kalifa
    Department of Physiology and Biophysics, Howard University, Washington, DC 20059, USA
    Brain Res 1376:94-100. 2011
  10. pmc Nicotine promotes survival of cells expressing amyloid precursor protein and presenilin: implication for Alzheimer's disease
    Dwayne Brown
    Department of Pharmacology, College of Medicine, Howard University, Washington, DC, United States
    Neurosci Lett 535:57-61. 2013

Collaborators

Detail Information

Publications17

  1. pmc Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
    Katherine D Laclair
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA
    Mol Neurodegener 8:18. 2013
    ..Although recent bexarotene studies failed to replicate the rapid clearance of Aβ from brains, behavioral and cognitive effects of this compound remain controversial...
  2. pmc Age-related loss of noradrenergic neurons in the brains of triple transgenic mice
    Kebreten F Manaye
    Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W St NW, Washington, DC 20059, USA
    Age (Dordr) 35:139-47. 2013
    ..Understanding the neurobiology of this apparent neuroprotection could lead to an improved understanding of age-related cognitive function in general, and the development of novel strategies for the therapeutic management of AD patients...
  3. doi request reprint 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice
    Kebreten F Manaye
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA
    J Alzheimers Dis 23:629-39. 2011
    ..These findings support the view that 17αE2, which may act through non-genomic mechanisms independent of traditional estrogen receptors, could prevent or delay the progression of AD in older men and women...
  4. ncbi request reprint Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder
    Kebreten F Manaye
    Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA
    J Neuropathol Exp Neurol 64:224-9. 2005
    ..This selective neuronal loss in the PVN appears to identify an important neurobiologic substrate for the behavioral manifestations of depression...
  5. pmc Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry
    Kebreten F Manaye
    Department of Physiology and Biophysics, Howard University College of Medicine, 520 W Street, NW, Suite 2305, Adams Bldg, Washington, DC, 20059, USA
    Age (Dordr) 29:87-96. 2007
    ....
  6. ncbi request reprint Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice
    Jahn N O'Neil
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, United States
    J Chem Neuroanat 34:102-7. 2007
    ..These findings support the use of murine models of Abeta deposition to develop novel strategies for the therapeutic management of patients afflicted with AD...
  7. pmc Comparative anatomy of the locus coeruleus in humans and nonhuman primates
    Yukti Sharma
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA
    J Comp Neurol 518:963-71. 2010
    ....
  8. pmc Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats
    Yousef Tizabi
    Dept of Pharmacology, College of Medicine, Howard Univ Washington, DC 20059, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:62-9. 2010
    ..These findings further validate the use of WKY rats as an animal model of human depression and signify the importance of inherent genetic differences in final behavioral outcome of nicotine...
  9. doi request reprint Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1ΔE9 double transgenic mice
    Sara Kalifa
    Department of Physiology and Biophysics, Howard University, Washington, DC 20059, USA
    Brain Res 1376:94-100. 2011
    ..Furthermore, the study suggests a decreased CB1 receptor expression may result in diminished anti-inflammatory processes, exacerbating the neuropathology associated with Alzheimer's disease...
  10. pmc Nicotine promotes survival of cells expressing amyloid precursor protein and presenilin: implication for Alzheimer's disease
    Dwayne Brown
    Department of Pharmacology, College of Medicine, Howard University, Washington, DC, United States
    Neurosci Lett 535:57-61. 2013
    ..These results suggest differential sensitivity of cell lines representing AD pathology to the protective effects of nicotine and provide further support of therapeutic potential of nicotinic agonists in at least a subtype of AD patients...
  11. ncbi request reprint Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
    Neurotox Res 5:315-21. 2003
    ..The neuroprotective effect of nicotine against ethanol-induced toxicity in cerebellar neurons may be a contributing factor to the high incidence of smoking among alcoholics...
  12. ncbi request reprint Orexin stimulates breathing via medullary and spinal pathways
    John K Young
    Dept of Anatomy, Howard Univ College of Medicine, 520 W St, NW, Washington, DC 20059, USA
    J Appl Physiol 98:1387-95. 2005
    ..05) increase in diaphragm electromyographic activity. These data indicate that orexin regulates respiratory activity and may have a role in the pathophysiology of sleep-related respiratory disorders...
  13. ncbi request reprint Nicotine inhibits ethanol-induced toxicity in cultured cerebral cortical cells
    Yousef Tizabi
    Department of Pharmacology, College of Medicine, Howard University, Division of Internal Medicine, Howard University Hospital, 520 W Street NW, Washington, DC 20059, USA
    Neurotox Res 6:311-6. 2004
    ..The neuroprotective effect of nicotine against ethanol-induced toxicity may be a contributing factor to the high incidence of smoking among alcoholics...
  14. ncbi request reprint Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain
    Katrice D Long
    Mental Health Service Line, Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Brain Res Bull 69:626-30. 2006
    ..The results could be relevant to the development of glycinergic interventions for the treatment of neuropsychiatric disorders...
  15. ncbi request reprint Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells
    Yousef Tizabi
    Department of Pharmacology, Howard University, Washington, DC 20059, USA
    Neurotox Res 7:319-22. 2005
    ..Anti-apoptotic effects of nicotine in this model may be suggestive of potential use of nicotinic agonists in neurotoxic insults and/or neurodegenerative disorders...
  16. ncbi request reprint Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism
    Bruce A Rasmussen
    Department of Pharmacology and Physiology, George Washington University, Washington DC, USA
    Neurotox Res 13:151-61. 2008
    ..The results suggest a sustainable model of PPI impairment and possible role of nicotinic receptors in selective brain regions in this behavior...
  17. ncbi request reprint Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats
    Bruce A Rasmussen
    Department of Pharmacology and Physiology, George Washington School of Medicine, Washington DC, USA
    Psychopharmacology (Berl) 190:43-9. 2007
    ..Aspects of acute NMDA receptor antagonism limit the applications of these models...