R A Kittles
Affiliation: Howard University
- Dual origins of Finns revealed by Y chromosome haplotype variationR A Kittles
Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Am J Hum Genet 62:1171-9. 1998..Also, a northeastern to southwestern gradient of Y haplotype frequencies provides convincing evidence for recent male migration from rural areas into urban Finland...
- Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneckR A Kittles
Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Phys Anthropol 108:381-99. 1999..In contrast, high levels of genetic diversity for mtDNA and autosomal STRs may be the result of sex-biased gene flow and recent immigration to urban areas from established internal isolates within Finland...
- Cyp17 promoter variant associated with prostate cancer aggressiveness in African AmericansR A Kittles
National Human Genome Center at Howard University, Washington, DC 20059, USA
Cancer Epidemiol Biomarkers Prev 10:943-7. 2001..Our results suggest that the C allele of the CYP17 polymorphism is significantly associated with increased prostate cancer risk and clinically advanced disease in African Americans...
- Extent of linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in human populations: implications for prostate cancer riskR A Kittles
National Human Genome Center, Howard University, 2041 Georgia Ave, Washington, DC 20060, USA
Hum Genet 109:253-61. 2001..This study represents the largest genotyping effort to be performed on the two androgen receptor trinucleotide repeat loci in diverse human populations...
- CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?Rick A Kittles
National Human Genome Center, Howard University, Washington, DC 20060, USA
Hum Genet 110:553-60. 2002....
- Race, ancestry, and genes: implications for defining disease riskRick A Kittles
National Human Genome Center, Howard University, Washington, D C 20060, USA
Annu Rev Genomics Hum Genet 4:33-67. 2003..But in that context race reflects deeply confounded cultural as well as biological factors, and a careful distinction must be made between race as a statistical risk factor and causal genetic variables...
- Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West AfricansC Bonilla
National Human Genome Center at Howard University, Washington, DC, USA
Int J Obes (Lond) 30:715-21. 2006..In this study, we evaluated the association between the functional AGRP -38C/T promoter SNP and weight-related traits, namely BMI, FM and fat-free mass (FFM), as well as diabetes status...
- Conceptualizing human variationS O Y Keita
National Human Genome Center, College of Medicine, Howard University, Washington, DC 20060, USA
Nat Genet 36:S17-20. 2004..The quest is for a more useful approach with which to understand human biological variation, one that may provide better research designs and inform public policy...
- DRD4 promoter SNPs and gender effects on Extraversion in African AmericansE B Bookman
Department of Genetics and Human Genetics, Howard University, Washington, DC 20060, USA
Mol Psychiatry 7:786-9. 2002..01). This study provides further evidence that genetic variation within the DRD4 promoter and gender differences contribute to variation in Novelty Seeking behaviors such as Extraversion...
- Identities, frequencies and origins of TMC1 mutations causing DFNB7/B11 deafness in PakistanS I Kitajiri
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850 3320, USA
Clin Genet 72:546-50. 2007..R34X and other mutations of TMC1 are prevalent contributors to the genetic load of deafness across a variety of populations and continents...
- IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-AmericansWenndy Hernandez
Cancer Biology Program, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
Carcinogenesis 28:2154-9. 2007..Our study adds clarity and further support to the previous findings, implicating serum IGFBP-3 levels and the IGFBP-3 -202 A/C SNP in prostate carcinogenesis...
- A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103YLeigh D Plant
Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
J Clin Invest 116:430-5. 2006..If our findings are replicated, prospective genetic testing of SIDS cases and screening with counseling for at-risk families warrant consideration...
- E-cadherin polymorphisms and haplotypes influence risk for prostate cancerCarolina Bonilla
Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
Prostate 66:546-56. 2006..Several polymorphisms, such as the C/A variant -160 base pairs from the transcription start site, in the CDH1 gene promoter region have been associated with cancer risk, mainly in European descent populations...
- Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic casesChristiane M Robbins
Translational Genomics Research Institute, Division of Integrated Cancer Genomics, Phoenix, Arizona 85004, USA
Prostate 68:1790-7. 2008..The RNASEL and HPC2/ELAC2 genes have been implicated in hereditary prostate cancer. Further assessment of the role of these genes in sporadic prostate cancer in African American men (AAM) is warranted...
- Genetic ancestry and the search for personalized genetic historiesMark D Shriver
Department of Anthropology, Penn State University, University Park, Pennsylvania 16802, USA
Nat Rev Genet 5:611-8. 2004
- Control of confounding of genetic associations in stratified populationsClive J Hoggart
Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom
Am J Hum Genet 72:1492-1504. 2003..With only 32 markers informative for ancestry, the efficiency of the analysis is 70%. These methods can deal with both confounding and selection bias in genetic-association studies, making family-based designs unnecessary...
- COX-2 gene promoter haplotypes and prostate cancer riskRamesh C K Panguluri
National Human Genome Center at Howard University, Washington, DC 20060, USA
Carcinogenesis 25:961-6. 2004..4; CI = 0.1-0.9; P = 0.02) and European Americans (OR = 0.2; CI = 0.1-0.9; P = 0.03). These data suggest that variation of the COX-2 promoter may influence the risk and development of prostate cancer...
- Adjusting for population structure in admixed populationsCarrie L Pfaff
Genet Epidemiol 22:196-201. 2002
- Markers that discriminate between European and African ancestry show limited variation within AfricaHeather E Collins-Schramm
Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
Hum Genet 111:566-9. 2002....
- Skin pigmentation, biogeographical ancestry and admixture mappingMark D Shriver
Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
Hum Genet 112:387-99. 2003..The implications and applications of ancestry estimates in biomedical research are discussed...
- The relationship between "race" and genetics in biomedical researchJada Benn Torres
Section of Genetic Medicine, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC6091, Chicago, IL 60637, USA
Curr Hypertens Rep 9:196-201. 2007..quot; We believe that the casual use of "race" to define groups in biomedical research has contributed to our limited understanding of complex disease etiology and risk factors driving health disparities...
- Genetic evidence for the convergent evolution of light skin in Europeans and East AsiansHeather L Norton
Department of Anthropology, The Pennsylvania State University, PA, USA
Mol Biol Evol 24:710-22. 2007..These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians...
- Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC)Agnes B Baffoe-Bonnie
Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Prostate 67:22-31. 2007..The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected...
- ICAM gene cluster SNPs and prostate cancer risk in African AmericansHankui Chen
Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, 494 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, OH 43210, USA
Hum Genet 120:69-76. 2006..01). Our results replicate previous findings of association of the ICAM gene cluster with prostate cancer and suggest that common genetic variation within ICAM1 and not ICAM5 may be an important risk factor for prostate cancer...
- Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian populationConnie J Mulligan
Department of Anthropology, University of Florida, PO Box 117305, Gainesville, FL 32611, USA
Hum Genet 113:325-36. 2003..These data strengthen the support for ADH as a candidate locus for alcohol dependence and suggest further productive study...
- Human genetic diversity and the nonexistence of biological racesJeffrey C Long
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
Hum Biol 75:449-71. 2003..Surprisingly, a great deal of genetic variation within groups is consistent with each of these concepts. However, none of the race concepts is compatible with the patterns of variation revealed by our analyses...
- Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variationMark D Shriver
Penn State University, University Park, Pennsylvania, USA
Hum Genomics 2:81-9. 2005....
- Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and LatinosMelinda C Aldrich
University of California, San Francisco, Box 2911 Rock Hall, Mission Bay 582, 1550 4th Street, San Francisco, CA 94143 2911, USA
Am J Epidemiol 168:1035-46. 2008..Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors...