R A Kittles

Summary

Affiliation: Howard University
Country: USA

Publications

  1. pmc Dual origins of Finns revealed by Y chromosome haplotype variation
    R A Kittles
    Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hum Genet 62:1171-9. 1998
  2. ncbi request reprint Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck
    R A Kittles
    Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Phys Anthropol 108:381-99. 1999
  3. ncbi request reprint Cyp17 promoter variant associated with prostate cancer aggressiveness in African Americans
    R A Kittles
    National Human Genome Center at Howard University, Washington, DC 20059, USA
    Cancer Epidemiol Biomarkers Prev 10:943-7. 2001
  4. ncbi request reprint Extent of linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in human populations: implications for prostate cancer risk
    R A Kittles
    National Human Genome Center, Howard University, 2041 Georgia Ave, Washington, DC 20060, USA
    Hum Genet 109:253-61. 2001
  5. ncbi request reprint CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?
    Rick A Kittles
    National Human Genome Center, Howard University, Washington, DC 20060, USA
    Hum Genet 110:553-60. 2002
  6. ncbi request reprint Race, ancestry, and genes: implications for defining disease risk
    Rick A Kittles
    National Human Genome Center, Howard University, Washington, D C 20060, USA
    Annu Rev Genomics Hum Genet 4:33-67. 2003
  7. ncbi request reprint Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans
    C Bonilla
    National Human Genome Center at Howard University, Washington, DC, USA
    Int J Obes (Lond) 30:715-21. 2006
  8. ncbi request reprint Conceptualizing human variation
    S O Y Keita
    National Human Genome Center, College of Medicine, Howard University, Washington, DC 20060, USA
    Nat Genet 36:S17-20. 2004
  9. ncbi request reprint DRD4 promoter SNPs and gender effects on Extraversion in African Americans
    E B Bookman
    Department of Genetics and Human Genetics, Howard University, Washington, DC 20060, USA
    Mol Psychiatry 7:786-9. 2002
  10. ncbi request reprint Identities, frequencies and origins of TMC1 mutations causing DFNB7/B11 deafness in Pakistan
    S I Kitajiri
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850 3320, USA
    Clin Genet 72:546-50. 2007

Collaborators

Detail Information

Publications28

  1. pmc Dual origins of Finns revealed by Y chromosome haplotype variation
    R A Kittles
    Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hum Genet 62:1171-9. 1998
    ..Also, a northeastern to southwestern gradient of Y haplotype frequencies provides convincing evidence for recent male migration from rural areas into urban Finland...
  2. ncbi request reprint Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck
    R A Kittles
    Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Phys Anthropol 108:381-99. 1999
    ..In contrast, high levels of genetic diversity for mtDNA and autosomal STRs may be the result of sex-biased gene flow and recent immigration to urban areas from established internal isolates within Finland...
  3. ncbi request reprint Cyp17 promoter variant associated with prostate cancer aggressiveness in African Americans
    R A Kittles
    National Human Genome Center at Howard University, Washington, DC 20059, USA
    Cancer Epidemiol Biomarkers Prev 10:943-7. 2001
    ..Our results suggest that the C allele of the CYP17 polymorphism is significantly associated with increased prostate cancer risk and clinically advanced disease in African Americans...
  4. ncbi request reprint Extent of linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in human populations: implications for prostate cancer risk
    R A Kittles
    National Human Genome Center, Howard University, 2041 Georgia Ave, Washington, DC 20060, USA
    Hum Genet 109:253-61. 2001
    ..This study represents the largest genotyping effort to be performed on the two androgen receptor trinucleotide repeat loci in diverse human populations...
  5. ncbi request reprint CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?
    Rick A Kittles
    National Human Genome Center, Howard University, Washington, DC 20060, USA
    Hum Genet 110:553-60. 2002
    ....
  6. ncbi request reprint Race, ancestry, and genes: implications for defining disease risk
    Rick A Kittles
    National Human Genome Center, Howard University, Washington, D C 20060, USA
    Annu Rev Genomics Hum Genet 4:33-67. 2003
    ..But in that context race reflects deeply confounded cultural as well as biological factors, and a careful distinction must be made between race as a statistical risk factor and causal genetic variables...
  7. ncbi request reprint Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans
    C Bonilla
    National Human Genome Center at Howard University, Washington, DC, USA
    Int J Obes (Lond) 30:715-21. 2006
    ..In this study, we evaluated the association between the functional AGRP -38C/T promoter SNP and weight-related traits, namely BMI, FM and fat-free mass (FFM), as well as diabetes status...
  8. ncbi request reprint Conceptualizing human variation
    S O Y Keita
    National Human Genome Center, College of Medicine, Howard University, Washington, DC 20060, USA
    Nat Genet 36:S17-20. 2004
    ..The quest is for a more useful approach with which to understand human biological variation, one that may provide better research designs and inform public policy...
  9. ncbi request reprint DRD4 promoter SNPs and gender effects on Extraversion in African Americans
    E B Bookman
    Department of Genetics and Human Genetics, Howard University, Washington, DC 20060, USA
    Mol Psychiatry 7:786-9. 2002
    ..01). This study provides further evidence that genetic variation within the DRD4 promoter and gender differences contribute to variation in Novelty Seeking behaviors such as Extraversion...
  10. ncbi request reprint Identities, frequencies and origins of TMC1 mutations causing DFNB7/B11 deafness in Pakistan
    S I Kitajiri
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850 3320, USA
    Clin Genet 72:546-50. 2007
    ..R34X and other mutations of TMC1 are prevalent contributors to the genetic load of deafness across a variety of populations and continents...
  11. ncbi request reprint IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans
    Wenndy Hernandez
    Cancer Biology Program, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
    Carcinogenesis 28:2154-9. 2007
    ..Our study adds clarity and further support to the previous findings, implicating serum IGFBP-3 levels and the IGFBP-3 -202 A/C SNP in prostate carcinogenesis...
  12. pmc A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y
    Leigh D Plant
    Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 116:430-5. 2006
    ..If our findings are replicated, prospective genetic testing of SIDS cases and screening with counseling for at-risk families warrant consideration...
  13. ncbi request reprint E-cadherin polymorphisms and haplotypes influence risk for prostate cancer
    Carolina Bonilla
    Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
    Prostate 66:546-56. 2006
    ..Several polymorphisms, such as the C/A variant -160 base pairs from the transcription start site, in the CDH1 gene promoter region have been associated with cancer risk, mainly in European descent populations...
  14. doi request reprint Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases
    Christiane M Robbins
    Translational Genomics Research Institute, Division of Integrated Cancer Genomics, Phoenix, Arizona 85004, USA
    Prostate 68:1790-7. 2008
    ..The RNASEL and HPC2/ELAC2 genes have been implicated in hereditary prostate cancer. Further assessment of the role of these genes in sporadic prostate cancer in African American men (AAM) is warranted...
  15. ncbi request reprint Genetic ancestry and the search for personalized genetic histories
    Mark D Shriver
    Department of Anthropology, Penn State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 5:611-8. 2004
  16. pmc Control of confounding of genetic associations in stratified populations
    Clive J Hoggart
    Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom
    Am J Hum Genet 72:1492-1504. 2003
    ..With only 32 markers informative for ancestry, the efficiency of the analysis is 70%. These methods can deal with both confounding and selection bias in genetic-association studies, making family-based designs unnecessary...
  17. ncbi request reprint COX-2 gene promoter haplotypes and prostate cancer risk
    Ramesh C K Panguluri
    National Human Genome Center at Howard University, Washington, DC 20060, USA
    Carcinogenesis 25:961-6. 2004
    ..4; CI = 0.1-0.9; P = 0.02) and European Americans (OR = 0.2; CI = 0.1-0.9; P = 0.03). These data suggest that variation of the COX-2 promoter may influence the risk and development of prostate cancer...
  18. ncbi request reprint Adjusting for population structure in admixed populations
    Carrie L Pfaff
    Genet Epidemiol 22:196-201. 2002
  19. ncbi request reprint Markers that discriminate between European and African ancestry show limited variation within Africa
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 111:566-9. 2002
    ....
  20. ncbi request reprint Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
    ..The implications and applications of ancestry estimates in biomedical research are discussed...
  21. ncbi request reprint The relationship between "race" and genetics in biomedical research
    Jada Benn Torres
    Section of Genetic Medicine, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC6091, Chicago, IL 60637, USA
    Curr Hypertens Rep 9:196-201. 2007
    ..quot; We believe that the casual use of "race" to define groups in biomedical research has contributed to our limited understanding of complex disease etiology and risk factors driving health disparities...
  22. ncbi request reprint Genetic evidence for the convergent evolution of light skin in Europeans and East Asians
    Heather L Norton
    Department of Anthropology, The Pennsylvania State University, PA, USA
    Mol Biol Evol 24:710-22. 2007
    ..These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians...
  23. ncbi request reprint Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC)
    Agnes B Baffoe-Bonnie
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Prostate 67:22-31. 2007
    ..The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected...
  24. ncbi request reprint ICAM gene cluster SNPs and prostate cancer risk in African Americans
    Hankui Chen
    Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, 494 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, OH 43210, USA
    Hum Genet 120:69-76. 2006
    ..01). Our results replicate previous findings of association of the ICAM gene cluster with prostate cancer and suggest that common genetic variation within ICAM1 and not ICAM5 may be an important risk factor for prostate cancer...
  25. ncbi request reprint Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population
    Connie J Mulligan
    Department of Anthropology, University of Florida, PO Box 117305, Gainesville, FL 32611, USA
    Hum Genet 113:325-36. 2003
    ..These data strengthen the support for ADH as a candidate locus for alcohol dependence and suggest further productive study...
  26. ncbi request reprint Human genetic diversity and the nonexistence of biological races
    Jeffrey C Long
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Hum Biol 75:449-71. 2003
    ..Surprisingly, a great deal of genetic variation within groups is consistent with each of these concepts. However, none of the race concepts is compatible with the patterns of variation revealed by our analyses...
  27. pmc Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 2:81-9. 2005
    ....
  28. pmc Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos
    Melinda C Aldrich
    University of California, San Francisco, Box 2911 Rock Hall, Mission Bay 582, 1550 4th Street, San Francisco, CA 94143 2911, USA
    Am J Epidemiol 168:1035-46. 2008
    ..Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors...