Philipp J Keller

Summary

Affiliation: Howard Hughes Medical Institute
Country: USA

Publications

  1. ncbi Light sheet microscopy of living or cleared specimens
    Philipp J Keller
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Curr Opin Neurobiol 22:138-43. 2012
  2. ncbi Fast, high-contrast imaging of animal development with scanned light sheet-based structured-illumination microscopy
    Philipp J Keller
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Methods 7:637-42. 2010
  3. ncbi Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy
    Philipp J Keller
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 322:1065-9. 2008
  4. ncbi Nlcam modulates midline convergence during anterior neural plate morphogenesis
    Katherine E Brown
    Developmental Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 339:14-25. 2010
  5. ncbi Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy
    Raju Tomer
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Methods 9:755-63. 2012
  6. ncbi Reconstructing embryonic development
    Khaled Khairy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Genesis 49:488-513. 2011
  7. ncbi Light sheet microscopy in cell biology
    Raju Tomer
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA
    Methods Mol Biol 931:123-37. 2013
  8. ncbi Shedding light on the system: studying embryonic development with light sheet microscopy
    Raju Tomer
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Curr Opin Genet Dev 21:558-65. 2011

Collaborators

Detail Information

Publications8

  1. ncbi Light sheet microscopy of living or cleared specimens
    Philipp J Keller
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Curr Opin Neurobiol 22:138-43. 2012
    ..Here, we provide an overview of the history of light sheet microscopy, review the development of tissue clearing methods, and discuss recent technical breakthroughs that have the potential to influence the future direction of the field...
  2. ncbi Fast, high-contrast imaging of animal development with scanned light sheet-based structured-illumination microscopy
    Philipp J Keller
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Methods 7:637-42. 2010
    ..We reconstructed cell positions over time from the Drosophila DSLM-SI data and created a fly digital embryo...
  3. ncbi Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy
    Philipp J Keller
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 322:1065-9. 2008
    ..We further derive a model of germ layer formation and show that the mesendoderm forms from one-third of the embryo's cells in a single event. Our digital embryos, with 55 million nucleus entries, are provided as a resource...
  4. ncbi Nlcam modulates midline convergence during anterior neural plate morphogenesis
    Katherine E Brown
    Developmental Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 339:14-25. 2010
    ....
  5. ncbi Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy
    Raju Tomer
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Methods 9:755-63. 2012
    ..SiMView data sets provide quantitative morphological information even for fast global processes and enable accurate automated cell tracking in the entire early embryo...
  6. ncbi Reconstructing embryonic development
    Khaled Khairy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Genesis 49:488-513. 2011
    ..We argue that the substantial increase in data complexity and size requires sophisticated new strategies to data analysis to exploit the enormous potential of these new resources...
  7. ncbi Light sheet microscopy in cell biology
    Raju Tomer
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA
    Methods Mol Biol 931:123-37. 2013
    ..We furthermore describe computational tools for basic image processing and data inspection...
  8. ncbi Shedding light on the system: studying embryonic development with light sheet microscopy
    Raju Tomer
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Curr Opin Genet Dev 21:558-65. 2011
    ..We conclude with a discussion of promising future directions...